"LIPID_ID" "CLASSIFICA" "CHEM_NA" "COMMON_NA" "SYMBOL" "GROUP_NA" "MOL_FORMULA" "FORMULA_C" "FORMULA_H" "FORMULA_O" "FORMULA_N" "FORMULA_P" "FORMULA_S" "MOL_WT" "STR_1" "STR_2" "STR_3" "STR_4" "STR_5" "STR_6" "STR_7" "STR_8" "STR_9" "STR_10" "STR_11" "REF_STR" "MELT_PT" "BOIL_PT" "OPT_ROT" "REFRA_IND" "DENSITY" "SOLUBILITY" "REF_PRP" "UV_SPEC" "IR_SPEC" "NMR_SPEC" "MS_SPEC" "NOTE_SPEC" "REF_SPC" "SOURCE" "REF_SOU" "BIOL_ACTIV" "REF_BA" "NOTE" "REF_NOTE" "ST0001" 12.00 "CHOLESTEROL GLUCURONIDE" "13" "C33H54O7" 33.00 54.00 7.00 0.00 0.00 0.00 562.00 " GlcUβ1-Cho. (REF:008)" "008/" "2800-3000 cm-1 (METHYLENE) 1600 cm-1 (CARBOXY SALT) 1000-1100 cm-1 (HYDROXY GROUP) (008)" "008/" "ST0002" 12.00 "5β-CHOLESTANE-3α,7α,26-TRIOL" "C27H48O3" 27.00 48.00 3.00 0.00 0.00 0.00 420.00 " ｲｱｲｱｲｱｯOH" " ｵ ｵ (063)" " ｱｲｫｲ" " ｵｶｽｺ" " ｱｲｫｲｱ" " ｵｶ ｶ" " ﾄｲｱﾉｱﾅ" " HO H OH" "063/" "25R体 155-157ﾟC, 25S体 138-140ﾟC(063)" "25R体 [α]25/D +15.9ﾟ, 25S体 [α]25/D +8.8ﾟ (063)" "063/" "1H-NMR(CDCl3) 18-CH3=66.0, 19-CH3=90.0, 21-CH3=91.0, 27-CH3=92.5 (in Hz) (063)" "546,531,456,441,366,351,255,73(BASE PEAK) (TMS DERIV.)(063)" "063/" "ﾋﾄ胆汁(026)" "(026)" "ST0003" 12.00 "5β-CHOLESTANE-3α,7α,25-TRIOL" "C27H48O3" 27.00 48.00 3.00 0.00 0.00 0.00 420.00 " ｲｱｲｱｲｱ" " ｵ ﾉ 合成 (064)" " ｱｲｫｲ OH" " ｵｶｽｺ" " ｱｲｫｲｱ" " ｵｶ ｶ" " ﾄｲｱﾉｱﾅ" " HO H OH" "064/" "181-183ﾟC(064)" "064/" "cm-1 3480,2925,2860,1465,1378,1160,1150,1070 AND 980 (064)" "621,546,531,456,441,366,351,255,253,131(BASE PEAK) (TMS DERIV.)(064)" "064/" "ﾋﾄ胆汁(026)" "(026)" "ST0004" 12.00 "5β-CHOLESTANE-3α,7α,24-TRIOL" "C27H48O3" 27.00 48.00 3.00 0.00 0.00 0.00 420.00 " OH" " ﾂ 合成 (063)" " ｲｱｲｱｲｱ" " ｵ ｵ" " ｱｲｫｲ" " ｵｶｽｺ" " ｱｲｫｲｱ" " ｵ ｵ ｵ" " ﾄｲｱﾉｱﾅ" " OH H OH" "063/" "24R体 125-127ﾟC, 24S体 78-79ﾟC(063)" "24R体 [α]25/D +25.8ﾟ, 24S体 [α]25/D +4ﾟ 063)" "063/" "1H-NMR 18-CH3 19-CH3 21-CH3 26,27-CH3 24R体 66.0 91.0 91.0 91.5 24S体 65.0 90.0 88.5 92.5(IN Hz)" "546,531,503,456,441,413,366,351,323,255,145(BASE PEAK),73(TMS DERIV.)(063)" "063/" "ﾋﾄ胆汁(026)" "(026)" "ST0005" 12.00 "5β-CHOLESTANE-3α,7α,24,26-TETROL" "C27H48O4" 27.00 48.00 4.00 0.00 0.00 0.00 436.00 " OH" " ﾂ 合成 (065)" " ｲｱｲｱｲｱｯOH" " ｵ ｵ" " ｱｲｫｲ" " ｵｶｽｺ" " ｱｲｫｲｱ" " ｵ ｵ ｵ" " ﾄｲｱﾉｱﾅ" " OH H OH" "065/" "NONCRYSTALLINE MATERIAL(065)" "065/" "cm-1 (CHCl3) 3350 (065)" "1H-NMR 18-CH3=0.70, 19-CH3=0.96, 21-CH3=1.00, 27-CH3=1.23(065)" "681,632,591,542,501,452,411,343,321(BASE PEAK),294,281,253,233,213(TMS DERIV.) (065)" "065/" "ﾋﾄ胆汁(065)" "(065)" "ST0006" 12.00 "5β-CHOLESTANE-3α,7α,25,26-TETROL" "C27H48O4" 27.00 48.00 4.00 0.00 0.00 0.00 436.00 " 合成 (066)" " ｲｱｲｱｲｱｯOH" " ｵ ﾉ" " ｱｲｫｲ OH" " ｵｶｽｺ" " ｱｲｫｲｱ" " ｵ ｵ ｵ" " ﾄｲｱﾉｱﾅ" " OH H OH" "066/" "200-202ﾟC(066)" "066/" "724(M+),621,531,441,364,351,343,255,253,219(BASE PEAK) (TMS DERIV.)(006/065/066)" "006/065/066/" "ﾋﾄ胆汁(065),ﾏﾅﾃｨｰ(Trichechus manatus latirostris)胆汁 (006)" "(006/065)" "ST0007" 12.00 "5β-CHOLESTANE-3α,7α,26,27-TETROL" "C27H48O4" 27.00 48.00 4.00 0.00 0.00 0.00 436.00 " 合成 (065)" " ｲｱｲｱｲｱｯOH" " ｵ ｲｰOH" " ｱｲｫｲ" " ｵｶｽｺ" " ｱｲｫｲｱ" " ｵ ｵ ｵ" " ﾄｲｱﾉｱﾅ" " OH H OH" "065/" "136.5-138ﾟC(065)" "065/" "cm-1 3300 (065)" "IH-NMR 18-CH3=0.70, 19-CH3=0.95, 21-CH3=0.93, 3β-H=3.75, 7β-H=3.97,26- AND 27-CH2=4.02 (065)" "544,529,454,364,343,281,255(BASE PEAK),253 (TMS DERIV.) (065)" "065/" "ﾋﾄ胆汁(065)" "(065)" "ST0008" 12.00 "5β-CHOLESTANE-3α,6α,7β,25,26-PENTOL" "ω-TRICHECHOL" "C27H48O5" 27.00 48.00 5.00 0.00 0.00 0.00 452.00 " ｲｱｲｱｲｱｯOH (006)" " ｵ ﾉ" " ｱｲｫｲ OH" " ｵｶｽｺ" " ｱｲｫｲｱ" " ｵ ｵ ｵ" " ﾄｲｱﾉｱｲ" " OH H ﾂ OH" " OH" "006/" "709,632,619,542,529,452,439,363,285,253,219,195(BASE PEAK)(TMS DERIV.)(006)" "006/" "ﾏﾅﾃｨｰ(Trichechus manatus latirostris)胆汁(006)" "(006)" "ST0009" 12.00 "5β-CHOLESTANE-3α,6β,7α,26-TETROL" "C27H48O4" 27.00 48.00 4.00 0.00 0.00 0.00 436.00 " ｲｱｲｱｲｱｯOH (006)" " ｵ ｵ" " ｱｲｫｲ" " ｵｶｽｺ" " ｱｲｫｲｱ" " ｵ ｵ ｵ" " ﾄｲｱﾉｱﾅ" " OH H ｵ OH" " OH" "006/" "634,544,529,489,454,441,285,253,195(BASE PEAK) (TMS DERIV.)(006)" "006/" "ﾏﾅﾃｨｰ(Trichechus manatus latirostris)胆汁(006)" "(006)" "ST0010" 12.00 "3α,12α,25-TRIHYDROXY-5β-CHOLESTAN-7-ONE" "C27H46O4" 27.00 46.00 4.00 0.00 0.00 0.00 434.00 " 合成 (027)" " HO ｲｱｲｱｲｱ" " ﾂ ｵ ﾉ" " ｱｲｫｲ OH" " ｵｶｽｺ" " ｱｲｫｲｱ" " ｵ ｵ ｵ" " ﾄｲｱﾉｱｸ" " OH H O" "027/" "188-189ﾟC(027)" "027/" "cm-1(KBr) 3350,1695(027)" "IH-NMR(PYRIDINE-d5) 18-CH3=0.77, 19-CH3=1.02, 21-CH3=1.20, 26,27-CH3=1.39, 3β-H=3.75, 12β-H=4.24(027)" "560,470,380,359,341,269,251,131(BASE PEAK) (TMS DERIV.)(027)" "027/" "脳腱黄色腫症(CEREBROTENDINOUS XANTHOMATOSIS)患者胆汁及び糞(027)" "(027)" "ST0011" 12.00 "5β-CHOLESTANE-3α,7α,12α,24,25,26-HEXOL" "C27H48O6" 27.00 48.00 6.00 0.00 0.00 0.00 468.00 " OH" " ｵ 合成 (067)" " HO ｲｱｲｱｲｱｯOH" " ﾂ ｵ ﾉ" " ｱｲｫｲ OH" " ｵｶｽｺ" " ｱｲｫｲｱ" " ｵ ｵ ｵ" " ﾄｲｱﾉｱﾅ" " OH H OH" "067/" "24R体 204-206ﾟC, 24S体 208-209ﾟC(067)" "067/" "IH-NMR 18-CH3 19-CH3 21-CH3 27-CH3 3β,7β,12β,24-H 26-H2 24R体 0.80 0.98 1.231.53 3.40-4.50 4.00 24S体 0.77 0.95 1.20 1.45 3.40-4.50 3.92 (067)" "797,681,617,591,527,501,437,411,347,343,321,253,219(BASE PEAK)(TMS DERIV.)(067)" "067/" "ﾋﾄ尿(067)，ﾋﾄ血清(055)，肝臓病患者尿(054)" "(054/055/067)" "ST0012" 12.00 "5α-CHOLESTANE-3α,7α,12α,25-TETROL" "C27H48O4" 27.00 48.00 4.00 0.00 0.00 0.00 436.00 " 合成 (027)" " HO ｲｱｲｱｲｱ" " ﾂ ｵ ﾉ" " ｱｲｫｲ OH" " ｵｶｽｺ" " ｱｲｫｲｱ" " ｵ ｵ ｵ" " ﾄｲｱﾊｱﾅ" " OH H OH" "027/" "NONCRYSTALLINE MATERIAL(027)" "027/" "IH-NMR(PYRIDINE-d5) 18-CH3=0.81, 19-CH3=0.89, 21-CH3=1.23, 26,27-CH3=1.36, 7β-H=4.05, 3β,12β-H=4.16 (027)" "343,253 (TMS DERIV.)(027)" "027/" "脳腱黄色腫症(CEREBROTENDINOUS XANTHOMATOSIS)患者尿及び糞(027)" "(027)" "ST0013" 12.00 "5β-CHOLESTANE-3α,7α,12α,22,25-PENTOL" "C27H48O5" 27.00 48.00 5.00 0.00 0.00 0.00 452.00 " OH" " ｜ 合成 (068)" " HO ｲｱｲｱｲｱ" " ﾂ ｵ ﾉ" " ｱｲｫｲ OH" " ｵｶｽｺ" " ｱｲｫｲｱ" " ｵ ｵ ｵ" " ﾄｲｱﾉｱﾅ" " OH H OH" "068/" """22R体 253-255ﾟC, 22S体 237-239ﾟC(068)" "22R体 [α]/D +32ﾟ, 22S体 [α]/D +16ﾟ (068)" "068/" "IH-NMR 18-CH3 19-CH3 21-CH3 26,27-CH3 22R体 0.84 1.00 1.40 1.44 22S体 0.86 1.00 1.39 1.40(068)" "653,563,473,453,433,383,363,343,293,261,253,171(BASE PEAK),131,81,73 (TMS DERIV.) (068)" "068/" "脳腱黄色腫症(CEREBROTENDINOUS XANTHOMATOSIS)患者胆汁及び尿(22R体のみ)(068)" "(068)" "ST0014" 12.00 "27-NOR-5β-CHOLEST-25-ENE-3α,7α,12α,24-TETROL" "C26H44O4" 26.00 44.00 4.00 0.00 0.00 0.00 420.00 " OH" " ｵ 合成 (026)" " HO ｲｱｲｱｲｷ" " ﾂ ｵ" " ｱｲｫｲ" " ｵｶｽｺ" " ｱｲｫｲｱ" " ｵ ｵ ｵ" " ﾄｲｱﾉｱﾅ" " OH H OH" "026/" "195-197ﾟC (026)" "026/" "cm-1 (KBr) 3450(OH) 1636,883(-CH=CH2)(026)" "IH-NMR(PYRIDINE-d5)18-H3=0.83, 19-H3=1.00, 21-H3=1.24, 3β-H=3.78, 7β-H=4.09, 12β-H=4.26, 24-H=4.35, 25-H=6.15, 26-H2=5.35, 5.55 (026)""" "708,618,528,481,438,349,343,294,281,253(BASE PEAK),157,129 (TMS DERIV.)(026)" "026/" "ﾋﾄ胆汁(026)" "(026)" "ST0015" 12.00 "5β-CHOLANE-3α,7α,23,24-TETROL" "C24H42O4" 24.00 42.00 4.00 0.00 0.00 0.00 394.00 " 合成 (026)" " ｲｱｲｱｯOH" " ｵ ｲ" " ｱｲｫｲ OH" " ｵｶｽｺ" " ｱｲｫｲｱ" " ｵ ｵ ｵ" " ﾄｲｱﾉｱﾅ" " OH H OH" "026/" "224.5-226.5ﾟC (026)" "026/" "cm-1 (KBr) 3350(OH)(026)" "IH-NMR(PYRIDINE-d5) 18-H3=0.74, 19-H3=0.96, 21-H3=1.11, 3β,7β,23β-H =3.4-4.5, 24-H2=3.90(026)" "579,489,399,309(BASE PEAK),283,267,255,199(TMS DERIV.)(026)" "026/" "ﾋﾄ胆汁(026)" "(026)" "ST0016" 12.00 "5β-CHOLESTANE-3α,7α,12α,23-TETROL" "C27H48O4" 27.00 48.00 4.00 0.00 0.00 0.00 436.00 " 合成 (069)" " HO ｲｱｲｱｲｱ" " ﾂ ｵ ｵ ｵ" " ｱｲｫｲ OH" " ｵｶｽｺ" " ｱｲｫｲｱ" " ｵ ｵ ｵ" " ﾄｲｱﾉｱﾅ" " OH H OH" "069/" "23R体 232-233ﾟC, 23S体 189-191ﾟC(069)" "23R体 [α]/D +52ﾟ, 23S体 [α]/D +41ﾟ　(069)" "069/" "cm-1 (KBr) 23S体 3400(OH),1080,1040,980,950,920 23R体 3340(OH),1080,1030,980,950,918 (069)" "IH-NMR(PYRIDINE-d5) 18-H3 26,27-H 19-H3 21-H3　 3β-H 7β,23-H 12β-H 23R体 0.89 1.00　1.03 1.01　1.39 3.70 4.10 4.32 23S体0.88 0.95　0.98 1.00 1.38 3.70 4.10 4.32 (069)" "724,667,634,544,454,364,253(BASE PEAK),159 (TMS DERIV) (069/070)" "069/070/" "脳腱黄色腫症患者糞便(027/070)，胆汁(027/071)，尿(027)" "(027/070/071)" "ST0017" 12.00 "5β-CHOLESTANE-3α,7α,12α,24-TETROL" "C27H48O4" 27.00 48.00 4.00 0.00 0.00 0.00 436.00 " OH" " ｵ 合成 (072/073)" " HO ｲｱｲｱｲｱ" " ﾂ ｵ ｵ" " ｱｲｫｲ" " ｵｶｽｺ" " ｱｲｫｲｱ" " ｵ ｵ ｵ" " ﾄｲｱﾉｱﾅ" " OH H OH" "072/073/" "24R体 185-185.5ﾟC, 24S体 186-186.5ﾟC(073)" "24R体 [α]25/D +39ﾟ, 24S体 [α]24/D +24ﾟ (073)" "073/" "cm-1 3500 073)" "m/e=681,634,591,544,501,454,411,364,343,321,253,145(BASE PEAK),55 (TMS DERIV.) (025)" "025/073/" "ｳｻｷﾞ胆汁(025)，ﾋﾄ胆汁(026)，脳腱黄色腫症患者糞便(027/070)，胆汁(027/071)，尿(027)" "(025/026/027/070/071)" "ST0018" 12.00 "27-NOR-5β-CHOLESTANE-3α,7α,12α,24-TETROL" "26-DEOXY-5β-RANOL" "C26H46O4" 26.00 46.00 4.00 0.00 0.00 0.00 422.00 " OH" " ｜ 合成 (034)" " HO ｲｱｲｱｲｱ" " ﾂ ｵ" " ｱｲｫｲ" " ｵｶｽｺ" " ｱｲｫｲｱ" " ｵ ｵ ｵ" " ﾄｲｱﾉｱﾅ" " OH H OH" "034/" "24R体 196ﾟC, 24S体 184ﾟC(034)" "24R体 [α]/D +36ﾟ, 24S体 [α]/D +27ﾟ (034)" "034/" "IHNMR (PYRIDINE-d5)18-H3 19-H3 26-H3 21-H3 3β,7β,12β,24-H 24R体 0.79 0.99 1.15 1.27 3.5-4.424S体 0.84 1.01 1.17 1.28 3.5-4.4 (043)""" "m/e= 530,515,501,440,433,425,411,351,343,335,321,281,253,131(BASE PEAK)(TMS DERV.) (043)" "043/" "ｳｼｶﾞｴﾙ(Rana catesbeiana)胆汁(034)，ﾆﾎﾝｱｶｶﾞｴﾙ(Rana japonica japonica)胆汁 (030)，各種ｶｴﾙ(Discoglossus pictus, Xenopus mulleri, Arthroleptis poecilo- notus？, Cardioglossa leucomystax, Aubria subsigillata, Dicroglossus occipitalis, Ptychadena aequiplicat" "(009/030/034)" "ST0019" 12.00 "27-NOR-5α-CHOLESTANE-3α,7α,12α,24-TETROL" "26-DEOXY-5α-RANOL" "C26H46O4" 26.00 46.00 4.00 0.00 0.00 0.00 422.00 " OH" " ｜ 合成 (034)" " HO ｲｱｲｱｲｱ" " ﾂ ｵ" " ｱｲｫｲ" " ｵｶｽｺ" " ｱｲｫｲｱ" " ｵ ｵ ｵ" " ﾄｲｱﾊｱﾅ" " OH H OH" "034/" "3,7,24-TRIACETATE 24R体 162ﾟC, 24S体 81ﾟC(034)" "3,7,24-TRIACETATE 24R体 +2ﾟ, 24S体 +15ﾟ (034)" "034/" "ｳｼｶﾞｴﾙ(Rana catesbeiana)胆汁(034)，ｱｶｶﾞｴﾙ科ｶｴﾙ(Rana amurensis coreana, Rana amurensis tsushimensis, Rana temporaria dybowskii, Rana temporaria coreana, Rana temporaria tsushimensis, Rana japonica japonica, Rana tagoi)胆汁(030)，各種ｶｴﾙ(Ptychadena" "(009/030/034)" "ST0020" 12.00 "5β-CHOLESTANE-3α,7α,12α-TRIOL" "C27H48O3" 27.00 48.00 3.00 0.00 0.00 0.00 420.00 " 合成 (074)" " HO ｲｱｲｱｲｱ" " ﾂ ｵ ｵ" " ｱｲｫｲ" " ｵｶｽｺ" " ｱｲｫｲｱ" " ｵ ｵ ｵ" " ﾄｲｱﾉｱﾅ" " OH H OH" "074/" "186-187.5ﾟC(074)" "+30.4ﾟ (080)" "074/080/" "m/e= 546,456,366(BASE PEAK),253 (TMS DERIV.)(075)" "075/" "脳腱黄色腫症(CEREBROTENDINOUS XANTHOMATOSIS)患者胆汁(075)，尿(027)" "027/075/" "ST0021" 12.00 "5β-CHOLEST-25-ENE-3α,7α,12α-TRIOL" "C27H46O3" 27.00 46.00 3.00 0.00 0.00 0.00 418.00 " 合成 (039)" " HO ｲｱｲｱｲｷ" " ﾂ ｵ ｵ" " ｱｲｫｲ" " ｵｶｽｺ" " ｱｲｫｲｱ" " ｵ ｵ ｵ" " ﾄｲｱﾉｱﾅ" " OH H OH" "039/" "164ﾟC(039)" "039/" "cm-1 (NUJOL) 3660(OH),1650,883(CH2=C・ ) (039)" "039/" "脳腱黄色腫症(CEREBROTENDINOUS XANTHOMATOSIS)患者胆汁(075)" "075/" "ST0022" 12.00 "27-NOR-5β-CHOLESTANE-3α,7α,12α,24,25,26-HEXOL" "C26H46O6" 26.00 46.00 6.00 0.00 0.00 0.00 454.00 " OH" " ｵ 合成 (026)" " HO ｲｱｲｱｲｱｯOH" " ﾂ ｵ ｵ" " ｱｲｫｲ OH" " ｵｶｽｺ" " ｱｲｫｲｱ" " ｵ ｵ ｵ" " ﾄｲｱﾉｱﾅ" " OH H OH" "026/" "174-175ﾟC(026)" "026/" "cm-1 (KBr) 3350(OH) (026)" "IH-NMR 18-H3=0.80, 19-H3=0.99, 21-H3=1.32, 3β,7β,12β,24,25,26-H=3.50-4.40 (026)" "m/e= 769,681,591,501,411,343,321(BASE PEAK),281,253,204,191,156,129,116 (TMS DERIV.) (026/081)""" "026/081/" "ﾋﾄ胆汁(026)，ﾋﾄ尿(067/081)，肝疾患患者尿(054)，ﾋﾄ血清(055)" "026/054/055/067/081/" "ST0023" 12.00 "5β-CHOLESTANE-3α,7α,12α,25-TETROL" "C27H48O4" 27.00 48.00 4.00 0.00 0.00 0.00 436.00 " 合成 (076)" " HO ｲｱｲｱｲｱ" " ﾂ ｵ ﾉ" " ｱｲｫｲ OH" " ｵｶｽｺ" " ｱｲｫｲｱ" " ｵ ｵ ｵ" " ﾄｲｱﾉｱﾅ" " OH H OH" "076/" "188-189ﾟC (076), 189.5-191ﾟC (077)" "+36.8ﾟ (080)" "076/077/080/" "(080)" "m/e= 724,709,634,619,544,529,454,439,364,349,131(BASE PEAK)(TMS DERIV.)(077)" "077/080/" "脳腱黄色腫症(CEREBROTENDINOUS XANTHOMATOSIS)患者糞便(027/070/077)，胆汁 (027/071/075)，尿(027/078)，ﾋﾄ胆汁(026)，ｳｻｷﾞ胆汁(025)，ｱﾘｹﾞｰﾀｰ(Alligator mississippiensis)胆汁(016)" "016/025/026/027/070/071/075/077/078/" "ST0024" 12.00 "5β-CHOLESTANE-3α,7α,12α,23,25-PENTOL" "C27H48O5" 27.00 48.00 5.00 0.00 0.00 0.00 452.00 " 合成 (079)" " HO ｲｱｲｱｲｱ" " ﾂ ｵ ｵ ﾉ" " ｱｲｫｲ OH OH" " ｵｶｽｺ" " ｱｲｫｲｱ" " ｵ ｵ ｵ" " ﾄｲｱﾉｱﾅ" " OH H OH" "079/" "23R体NON-CRYSTALLINE MATERIAL, 23S体209-210ﾟC(079)" "23S体 [α]25/D +49ﾟ (079)" "079/" "cm-1(CHCl3) 3340(OH),1075,1020,990,920,894 (079/080)" "IH-NMR(PYRIDINE-d5) 18-H3=0.82, 19-H3=0.96, 21-H3=1.38, 26,27-H3=1.44,1.50, 3β,7β,12β,23-H=3.40-4.60(079/080)" "m/e =722,667,632,577,550,542,487,460,452,397,370,362,344,307,281, 253,199,143,131(BASE PEAK)(TMS DERIV.)(079/080)" "079/080/" "脳腱黄色腫症(CEREBROTENDINOUS XANTHOMATOSIS)患者糞便(027/070/077)，胆汁 (027/071)，尿(027/078)" "027/070/071/077/078/" "ST0025" 12.00 "5β-CHOLESTANE-3α,7α,12α,24,25-PENTOL" "C27H48O5" 27.00 48.00 5.00 0.00 0.00 0.00 452.00 " OH" " ｵ 合成 (039/080)" " HO ｲｱｲｱｲｱ" " ﾂ ｵ ﾉ" " ｱｲｫｲ OH" " ｵｶｽｺ" " ｱｲｫｲｱ" " ｵ ｵ ｵ" " ﾄｲｱﾉｱﾅ" " OH H OH" "039/080/" "24R体 212-214ﾟC, 24S体 203-205ﾟC (080)" "24R体 +44.8ﾟ 24S体 +28.7ﾟ (080)" "080/" "cm-1(KBr) 3420(OH) (080)" "IH-NMR(CD3OD) 18-H3=72.4 Hz, 19-H3=92.2, 21-H3=103.6, 26,27-H3=114.4,116.8,(080)" "m/e = 812,797,722,707,681,632,617,591,543,527,501,453,437,411,363, 347,343,321,281,253,147,143,131(BASE PEAK)(TMS DERIV.) (051/080)" "051/080/" "脳腱黄色腫症(CEREBROTENDINOUS XANTHOMATOSIS)患者糞便(027/070/077/080)，胆汁(027/071)，尿(027/078)，ﾋﾄ胆汁(026)，ﾋﾄ尿(051/067)，肝疾患患者尿(054)，ﾋﾄ血清(055)" "026/027/051/054/055/070/071/077/078/080/" "ST0026" 12.00 "5β-CHOLESTANE-3α,7α,12α,24,26,27-HEXOL" "SCYMNOL" "C27H48O6" 27.00 48.00 6.00 0.00 0.00 0.00 468.00 " OH" " ｵ 合成 (047)" " HO ｲｱｲｱｲｱｯOH" " ﾂ ｵ ｲｰOH" " ｱｲｫｲ" " ｵｶｽｺ" " ｱｲｫｲｱ" " ｵ ｵ ｵ" " ﾄｲｱﾉｱﾅ" " OH H OH" "047/" "120-123ﾟC(047)" "+34ﾟ (047)" "047/" "cm-1(KBr) 3400(OH)047)" "047/" "軟骨魚類（ｻﾒ,ｴｲ）胆汁(047/048/049)" "047/048/049/" "ST0027" 12.00 "27-NOR-5β-CHOLESTANE-3α,7α,12α,24,25-PENTOL" "C26H46O5" 26.00 46.00 5.00 0.00 0.00 0.00 438.00 " OH" " ｵ 合成 (051/053)" " HO ｲｱｲｱｲｱ" " ﾂ ｵ ｵ" " ｱｲｫｲ OH" " ｵｶｽｺ" " ｱｲｫｲｱ" " ｵ ｵ ｵ" " ﾄｲｱﾉｱﾅ" " OH H OH" "051/053/" "230ﾟC (051),194-200ﾟC (053)" "051/053/" """cm-1(KBr) 3400(OH) (051), cm-1(NUJOL) 3440(OH) (053)" "IH-NMR(PYRIDINE-d5) 18-H3=0.82, 19-H3=1.00, 21-H3=1.26, 26-H3=1.52, 3β,7β,12β,24,25-H=3.55-4.40(051)" "m/e= 798,708,693,681,618,603,591,528,513,501,438,411,371,348,343,321(BASE PEAK),281,253,219,129,117 (TMS DERIV.)(051/053/082)""" "CD(053)" "051/053/082/" "ﾋﾄ尿(051/052/067/082)，ﾋﾄ血清(055)，脳腱黄色腫症(CEREBROTENDINOUS XANTHO- MATOSIS)患者尿(027)，ﾋﾄ胆汁(026)，肝疾患患者血清(056)，肝疾患患者尿(054)， ｼﾄｽﾃﾛｰﾙ血症と黄色腫を有する患者の尿及び糞便(053)，胆汁うっ滞患者尿(031),完全肝外胆汁うっ滞症患者尿(032)" "026/027/031/032/051/052/053/054/055/056/067/082/089/" "ST0028" 12.00 "24-NOR-5β-CHOLESTANE-3α,7α,12α,25-TETROL" "C26H46O4" 26.00 46.00 4.00 0.00 0.00 0.00 422.00 " ｶｽOH 合成 (083)" " HO ｲｱｲｱｲ" " ﾂ ｵ" " ｱｲｫｲ" " ｵｶｽｺ" " ｱｲｫｲｱ" " ｵ ｵ ｵ" " ﾄｲｱﾉｱﾅ" " OH H OH" "083/" "124-126ﾟC(083)" "083/" "cm-1(KBr) 3400(OH)(083)" "IH-NMR(CDCl3) 18-H3=0.65, 19-H3=0.85, 21-H3=0.95, 26,27-H3=1.16 (083)" "m/e= 620,565,530,440,384,294,253,131(BASE PEAK) (TMS DERIV.) (003/025/083)" "003/025/083/" "胆汁うっ滞患者胆汁(003)，ｳｻｷﾞ胆汁(025)，ﾋﾄ胆汁(026)" "003/025/026/" "ST0029" 12.00 "5-β-CHOLESTANE-3α,7α,12α,26,27-PENTOL" "5β-CYPRINOL" "C27H48O5" 27.00 48.00 5.00 0.00 0.00 0.00 452.00 " 合成 (084/085)" " HO ｲｱｲｱｲｱｯOH" " ﾂ ｵ ｶ" " ｱｲｫｲ ｲ" " ｵｶｽｺ OH" " ｱｲｫｲｱ" " ｵ ｵ ｵ" " ﾄｲｱﾉｱﾅ" " OH H OH" "084/085/" "173-174ﾟC (084), 175-177ﾟC(085)" "+35.5ﾟ (085)" "085/" "cm-1(NUJOL) 3400 (084)" "IH-NMR(d7-DMF) 18-H3=41.0 cps, 19-H3=52.5(086)" "084/086/" "ｱﾅｺﾞ(Conger myriaster)胆汁(087),ﾁｮｳｻﾞﾒ類胆汁(085),ﾄﾉｻﾏｶﾞｴﾙ(Rana nigromacul-ata)胆汁(088),ﾀﾞﾙﾏｶﾞｴﾙ(Rana brevipoda)胆汁(040),ｱﾌﾘｶﾂﾒｶﾞｴﾙ(Xenopus laevis) 胆汁(009/040),各種ｶｴﾙ(Discoglossus pictus, Xenopus laevis,Xenopus mulleri,Arthroleptis poecilonotus?, Pt" "(009/015/026/030/031/032/040/051/085/087/088)" "ST0030" 12.00 "26,27-DINOR-5β-CHOLESTANE-3α,7α,12α,24-TETROL" "26-DEOXY-26-NOR-5-RANOL" "C25H44O4" 25.00 44.00 4.00 0.00 0.00 0.00 408.00 " OH" " ｵ 合成 (090)" " HO ｲｱｲｱｲ" " ﾂ ｵ" " ｱｲｫｲ" " ｵｶｽｺ" " ｱｲｫｲｱ" " ｵ ｵ ｵ" " ﾄｲｱﾉｱﾅ" " OH H OH" "090/" "24R体 179-180ﾟC, 24S体 192-193ﾟC(090)" "24R体 +40ﾟ, 24S体 +33ﾟ (090)" "090/" """cm-1(KBr) 3340(OH), 1080,1030,980,950,918 (090)" "IH-NMR(PYRIDINE-d5) 18-H3=0.83, 19-H3=1.02, 21-H3=1.25, 25-H3=1.35, 3β,7β,12β,24H=3.70-4.35(090)" "m/z= 696,606,516,426,343,337,253 (TMS DERIV.)(090)" "090/" "ｶｴﾙ(Arthroleptis poecilonotus?, Aubria subsigillata,Dicroglossus occipitalis, Rana pipiens)胆汁(009)" "009/" "ST0031" 12.00 "5,6α-EPOXY-5α-CHOLESTA-3β-OL" "CHOLESTEROL α-EPOXIDE" "C27H46O2" 27.00 46.00 2.00 0.00 0.00 0.00 402.00 " (REF:008)" " ＼／＼／＼／" " ｜ ｜" " ／ｪ／＼" " ｜ ｶ ｶ" " ／ｪ／＼／ｼｼ" " ｜ ｜ ｜" " ﾕ＼ﾋ＼／" "HO Oﾄ" "008/" "CHOLESTEROL α-EPOXIDEの単離およびGC-MS(008) TMS-ETHER誘導体でのGLC-MS分析(009/010)" "008/009/010/" "高コレステロール症の患者の血清中に存在(010)食品の調理中や貯蔵中に生成(011)健常人血清中にも存在(012)" "010/011/012/" "内因性癌原性物質(013/014)" "013/014/" "異性体に5,6β-EPOXY-5β-CHOLESTA-3β-OL(CHOLESTEROLβ-OXIDE)が存在する. (008/009)" "008/009/" "ST0032" 12.00 "5-CHOLESTENE-3β,7α-DIOL (7α-HYDROXYCHOLESTEROL)" "C27H46O2" 27.00 46.00 2.00 0.00 0.00 0.00 402.00 " (REF:176/177)" " ﾅ／＼／＼／" " ｵ ＼" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼／" " ｵ ｵ ｵ" " ﾕ＼／ｸ／ﾅ" " HO OH" "176/177/" "DIBENZOATE : 171-172.5ﾟC(178), 172.5-173.5ﾟC(179)" "IN CHCl3, DIBENZOATE : [α]26/D = +94.3ﾟ(178), [α]20/D = +95ﾟ(179)" "178/179/" "GC-EI-MS(TMS) M/E=546[M], 456[M-HOTMS] (177)" "177/" "牛肝臓脂質中。(179) コレステロールの自動酸化。(178/180/181/182/183) 卵黄脂質の光酸化。(176)ラット肝ミクロソームとコレステロールとの反応物中。(177/184/185）バター及びチーズ脂肪中。(186)乾燥卵粉末中。(187/188)" "179/178/180/181/182/183/176/177/184/185/186/187/188/" "コレステロール酸化物の生体毒性 : 細胞毒性(CYTOTOXITY)。(189/190/191/192), リンパ毒性(ANGIOTOXICITY)。(193), 突然変異誘発性(MUTAGENICITY)。(194/195/196), 発ガン性(CARCINOGENICITY)。(197), その他。(198/199/200/201)" "189/190/191/192/193/194/195/196/197/198/199/200/201/" "ST0033" 12.00 "5-CHOLESTENE-3β,7β-DIOL (7β-HYDROXYCHOLESTEROL)" "C27H46O2" 27.00 46.00 2.00 0.00 0.00 0.00 402.00 " (REF:176/177)" " ﾅ／＼／＼／" " ｵ ＼" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼／" " ｵ ｵ ｵ" " ﾕ＼／ｸ／ﾔ" " HO OH" "176/177/" "167 - 171ﾟC (202)" "[α]27/D = -91.2ﾟ (202)" "202/" "スペクトル (176)" "GC-EI-MS(TMS)M/E=546[M], 456[M-HOTMS] (177)" "176/177/" "豚肝臓脂質中。(203) 妊娠した馬の血清中。(202)コレステロールの自動酸化。(178/180/181/182/183) 卵黄脂質の光酸化。(176)ラット肝ミクロソームとコレステロールとの反応物中。(177/185)バター及びチーズ脂肪中。(186) 乾燥卵粉末中。(18" "203/202/178/180/181/182/183/176/177/185/186/187/188/" "コレステロール酸化物の生体毒性 : 細胞毒性(CYTOTOXITY)。(189/190/191/192), リンパ毒性(ANGIOTOXICITY)。(193), 突然変異誘発性(MUTAGENICITY)。(194/195/196), 発ガン性(CARCINOGENICITY)。(197), その他。(198/199/200/201)""" "189/190/191/192/193/194/195/196/197/198/199/200/201/" "ST0034" 12.00 "7-KETO-5-CHOLESTEN-3β-OL (7-KETOCHOLESTEROL)" "C27H44O2" 27.00 44.00 2.00 0.00 0.00 0.00 400.00 " (REF:177)" " ﾅ／＼／＼／" " ｵ ＼" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼／" " ｵ ｵ ｵ" " ﾕ＼／ｸ／ｸ" " HO O" "177/" "170 - 172ﾟC (178), 165 - 167ﾟC (204)" "[α]23/D = -104ﾟ (IN CHCl3) (178)" "178/204/" "GC-EI-MS(TMS) (177)" "177/" "コレステロールの自動酸化。(178/181/182/183) コレステロールのＸ線照射生成物。(204)卵黄脂質の光酸化。(176)ラット肝ミクロソームとコレステロールとの反応物中。(177/185) 乾燥卵粉末中。(187)" "178/181/182/183/204/176/177/185/187/" "コレステロール酸化物の生体毒性 : 細胞毒性(CYTOTOXITY)。(189/190/191/192), リンパ毒性(ANGIOTOXICITY)。(193), 突然変異誘発性(MYTAGENICITY)。(194/195/196), 発ガン性(CARCINOGENICITY)。(197),その他。(198/199/200/201)" "189/190/191/192/193/194/195/196/197/198/199/200/201/" "ST0035" 12.00 "5α,6α-EPOXYCHOLESTAN-3β-OL (5α,6α-EPOXYCHOLESTEROL)" "C27H46O2" 27.00 46.00 2.00 0.00 0.00 0.00 402.00 " (REF:177/205/206/207)" " ﾅ／＼／＼／" " ｵ ＼" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼／" " ｵ ｵ ｵ" " ﾕ＼／ﾊ／" " HO Oﾄ" "177/205/206/207/" "GC-EI-MS (205/207) GC-EI-MS(TMS) M/E=474[M], 459[M-CH3], 384[M-HOTMS], 366, 351 (177/206) GC-EI-MS(AFTER REDUCTION, TMS)(205)" "177/205/206/207/" "コレステロールの自動酸化。(181/182/183) ヒト血清中。(205) ラット肝ミクロソームとコレステロールとの反応物中。(177/185)ラット肝亜細胞とコレステロールとの反応物中。(206) ウシ肝ミクロソームとコレステロールとの反応物中。(207)バター及びチーズ" "181/182/183/205/177/185/206/207/186/187/" "コレステロール酸化物の生体毒性 : 細胞毒性(CYTOTOXITY)。(189/190/191/192), リンパ毒性(ANGIOTOXICITY)。(193), 突然変異誘発性(MUTAGENICITY)。(194/195/196), 発ガン性(CARCINOGENICITY)。(197), その他。(198/199/200/201)" "189/190/191/192/193/194/195/196/197/198/199/200/201/" "ST0036" 12.00 "5β,6β-EPOXYCHOLESTAN-3β-OL (5β,6β-EPOXYCHOLESTEROL)" "C27H46O2" 27.00 46.00 2.00 0.00 0.00 0.00 402.00 " (REF:206/207/208)" " ﾅ／＼／＼／" " ｵ ＼" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼／" " ｵ ｵ ｵ" " ﾕ＼／ﾚ／" " HO Oﾕ" "/206/207/208/" "OH GROUP : 3600cm-1 (208/176)" "EI-MS (208) GC-EI-MS(207) GC-EI-MS(TMS) M/E=474[M], 459[M-CH3], 384[M-HOTMS], 366, 351(206)" "206/207/208/" "コレステロールの自動酸化。(181/182/183/208) 卵黄脂質の光酸化。(176) ヒト血清中。(205)ラット肝ミクロソームとコレステロールとの反応物中。(185) ラット肝亜細胞とコレステロールとの反応物中。(206) ウシ肝ミクロソームとコレステロールとの反応" "181/182/183/208/176/205/185/206/207/186/187/" "コレステロール酸化物の生体毒性 : 細胞毒性(CYTOTOXITY)。(189/190/191/192), リンパ毒性(ANGIOTOXICITY)。(193), 突然変異誘発性(MUTAGENICITY)。(194/195/196), 発ガン性(CARCINOGENICITY)。(197), その他。(198/199/200/201)" "189/190/191/192/193/194/195/196/197/198/199/200/201/" "ST0037" 12.00 "CHOLESTANE-3β,5α,6β-TRIOL (3β,5α,6β-TRIHYDROXYCHOLESTANOL)" "C27H48O3" 27.00 48.00 3.00 0.00 0.00 0.00 420.00 " (REF:206)" " ﾅ／＼／＼／" " ｵ ＼" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼／" " ｵ ｵ ｵ" " ﾕ＼／ﾊ／" " HO OH ﾐ" " OH" "206/" "228 - 235ﾟC (204)" "[α]16/D = -49.1±2ﾟ(IN CHCl3) (204)" "204/" "GC-EI-MS(TMS) M/E=636[M], 546[M-HOTMS], 456, 403, 367, 321, 217(206)" "206/" "コレステロールのＸ線照射による生成物中。(204) コレステロールの自動酸化。(181/182/183/)卵黄脂質の光酸化。(176)ヒト血清中。(205)ラット肝亜細胞とコレステロールとの反応物中。(206) ウシ肝ミクロソームとコレス" "204/181/182/183/176/205/206/207/187/" "コレステロール酸化物の生体毒性 : 細胞毒性(CYTOTOXITY)。(189/190/191/192), リンパ毒性(ANGIOTOXICITY)。(193), 突然変異誘発性(MUTAGENICITY)。(194/195/196) 発ガン性(CARCINOGENICITY)。(197), その他。(198/199/200/201)" "189/190/191/192/193/194/195/196/197/198/199/200/201/" "ST0038" 12.00 "5-CHOLESTENE-3β,7α,12α-TRIOL (3β,7α,12α-TRIHYDROXYCHOLESTANOL)" "C27H46O3" 27.00 46.00 3.00 0.00 0.00 0.00 418.00 " (REF:209)" " HO ﾅ／＼／＼／" " ﾂ ｵ ＼" " ／＼ﾇ＼" " ｵｶｽｺ" " ／＼ｮ＼／" " ｵ ｵ ｵ" " ﾕ＼／ｸ／ﾅ" " HO OH" "209/" "194 - 195ﾟC (209)" "[α]23/D = -60ﾟ(IN CHCl3) (209)" "209/" "EI-MS M/E=382[M-2xH2O], 364[M-3xH2O], 251(209)" "209/" "コレステロールとラット肝ホモジネートとの反応物中。(209/210)" "209/210/" "コレステロール酸化物の生体毒性 : 細胞毒性(CYTOTOXITY)。(189/190/191/192), リンパ毒性(ANGIOTOXICITY)。(193), 突然変異誘発性(MUTAGENICITY)。(194/195/196), 発ガン性(CARCINOGENICITY)。(197), その他。(198/199/200/201)" "189/190/191/192/193/194/195/196/197/198/199/200/201/" "ST0039" 12.00 "5-CHOLESTENE-3β,22-DIOL (22-HYDROXYCHOLESTEROL)" "C27H46O2" 27.00 46.00 2.00 0.00 0.00 0.00 402.00 " OH (REF:211)" " ｵ" " ﾅ／＼／＼／" " ｵ ＼" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼／" " ｵ ｵ ｵ" " ﾕ＼／ｸ／" " HO" "211/" "GC-EI-MS(TMS)M/E=546[M], 531[M-CH3], 475[M-(CH2)2CH(CH3)2], 173 (211)" "211/" "幼児の便中。(211)" "209/210/" "コレステロール酸化物の生体毒性 : 細胞毒性(CYTOTOXITY)。(189/190/191/192), リンパ毒性(ANGIOTOXICITY)。(193), 突然変異誘発性(MUTAGENICITY)。(194/195/196), 発ガン性(CARCINOGENICITY)。(197),その他。(198/199/200/201)" "189/190/191/192/193/194/195/196/197/198/199/200/201/" "ST0040" 12.00 "5-CHOLESTENE-3β,24-DIOL (24-HYDROXY-CHOLESTEROL)" "C27H46O2" 27.00 46.00 2.00 0.00 0.00 0.00 402.00 " OH (REF:211)" " ｵ" " ﾅ／＼／＼／" " ｵ ＼" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼／" " ｵ ｵ ｵ" " ﾕ＼／ｸ／" " HO" "211/" "GC-EI-MS(TMS) M/E=546[M], 503[M-CH(CH3)2], 456[M-HOTMS], 413[503-HOTMS], 159, 145 (211)""" "211/" "幼児の便中。(211)" "209/210/" "コレステロール酸化物の生体毒性 : 細胞毒性(CYTOTOXITY)。(189/190/191/192), リンパ毒性(ANGIOTOXICITY)。(193), 突然変異誘発性(MUTAGENICITY)。(194/195/196), 発ガン性(CARCINOGENICITY)。(197),その他。(198/199/200/201)" "189/190/191/192/193/194/195/196/197/198/199/200/201/" "ST0041" 12.00 "5-CHOLESTENE-3β,25-DIOL (25-HYDROXYCHOLESTEROL)" "C27H46O2" 27.00 46.00 2.00 0.00 0.00 0.00 402.00 " (REF:185)" " ﾅ／＼／＼／" " ｵ ｶ＼" " ／＼ｮ＼ HO" " ｵｶｽｺ" " ／＼ｮ＼／" " ｵ ｵ ｵ" " ﾕ＼／ｸ／" " HO" "185/" "GC-EI-MS(TMS) (185)" "185/" "ラット肝ミクロソームとコレステロールとの反応物中。(185) コレステロールの固体状態での自動酸化。(183/212)乾燥卵粉末中。(187)" "185/183/212/187/" "コレステロール酸化物の生体毒性 : 細胞毒性(CYTOTOXITY)。(189/190/191/192), リンパ毒性(ANGIOTOXICITY)。(193), 突然変異誘発性(MUTAGENICITY)。(194/195/196), 発ガン性(CARCINOGENICITY)。(197), その他。(198/199/200/201)" "189/190/191/192/193/194/195/196/197/198/199/200/201/" "ST0042" 12.00 "5-CHOLESTENE-3β,26-DIOL (26-HYDROXY-CHOLESTEROL)" "C27H46O2" 27.00 46.00 2.00 0.00 0.00 0.00 402.00 " (REF:185/211)" " OH" " ﾅ／＼／＼／" " ｵ ＼" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼／" " ｵ ｵ ｵ" " ﾕ＼／ｸ／" " HO" "185/211/" "GC-EI-MS(TMS) M/E=546[M], 531[M-CH3], 456[M-HOTMS], 417,255,129 (185/211)" "185/211/" "ラット肝ミトコンドリアとコレステロールとの反応物中。(213/214) 幼児の便中。(211) ラット肝ミクロソームとコレステロールとの反応物中。(185)" "213/214/211/185/" "コレステロール酸化物の生体毒性 : 細胞毒性(CYTOTOXITY)。(189/190/191/192), リンパ毒性(ANGIOTOXICITY)。(193), 突然変異誘発性(MUTAGENICITY)。(194/195/196), 発ガン性(CARCINOGENICITY)。(197),その他。(198/199/200/201)" "189/190/191/192/193/194/195/196/197/198/199/200/201/" "ST0043" 12.00 "3,5-CHOLESTADIEN-7-ONE" "C27H42O" 27.00 42.00 1.00 0.00 0.00 0.00 382.00 " (REF:178)" " ﾅ／＼／＼／" " ｵ ＼" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼／" " ｵ ｵ ｵ" " ｸ／ｸ／ｸ" " O" "178/" "109 - 111ﾟC (178)" "[α]24/D = -266ﾟ (178)" "178/" "λmax = 280nm, ε=23000(IN ETHANOL) (178)" "178/" "コレステロールの自動酸化。(178/180/181/183)" "178/180/181/183/" "ST0044" 12.00 "4,6-CHOLESTADIEN-3-ONE" "C27H42O" 27.00 42.00 1.00 0.00 0.00 0.00 382.00 " (REF:205)" " ﾅ／＼／＼／" " ｵ ＼" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼／" " ｵ ｵ ｵ" " ｷ＼ｷ＼ｷ" " O" "205/" "λmax = 287nm (205)" "GC-EI-MS (205)" "205/" "コレステロールの自動酸化。(181) ヒト血清中。(205)" "181/205/" "ST0045" 12.00 "4-CHOLESTEN-3-ONE" "C27H44O" 27.00 44.00 1.00 0.00 0.00 0.00 384.00 " (REF:205)" " ﾅ／＼／＼／" " ｵ ＼" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼／" " ｵ ｵ ｵ" " ｷ＼ｷ＼／" " O" "205/" "λmax = 241nm (205)" "GC-EI-MS (205)" "205/" "コレステロールの自動酸化。(181) ヒト血清中。(205)" "181/205/" "ST0046" 12.00 "5-STIGMASTENE-3β,7α-DIOL (7α-HYDROXY-β-SITOSTEROL)" "C29H50O2" 29.00 50.00 2.00 0.00 0.00 0.00 430.00 " ／ (REF:177/215)" " ｵ" " ﾅ／＼／＼／" " ｵ ＼" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼／" " ｵ ｵ ｵ" " ﾕ＼／ｸ／ﾅ" " O OH" "177/215/" "EI-MS M/E=430[M], 415[M-CH3], 412[M-H2O], 289, 229 (215) GC-EI-MS(TMS) (177)" "177/215/" "ラット肝ミクロソームとβ−シトステロールとの反応物中。(177/185) β−シトステロールの自動酸化。(215)" "177/185/215/" "ST0047" 12.00 "5-STIGMASTENE-3β,7β-DIOL (7β-HYDROXY-β-SITOSTEROL)" "C29H50O2" 29.00 50.00 2.00 0.00 0.00 0.00 430.00 " ／ (REF:177/215)" " ｵ" " ﾅ／＼／＼／" " ｵ ＼" " ／＼ｫ＼" " ｵｶｽｺ" " ／＼ｫ＼／" " ｵ ｵ ｵ" " ﾕ＼／ｸ／ﾔ" " HO OH" "177/215/" "EI-MS M/E=430[M], 415[M-CH3], 412[M-H2O], 289, 229 (215) GC-EI-MS(TMS) (177)" "177/215/" "ラット肝ミクロソームとβ−シトステロールとの反応物中。(177/185) β−シトステロールの自動酸化。(215)" "177/185/215/" "ST0048" 12.00 "7-KETO-5-STIGMASTENE-3β-OL (7-KETO-β-SITOSTEROL)" "C29H48O2" 29.00 48.00 2.00 0.00 0.00 0.00 428.00 " ／ (REF:177)" " ｵ" " ﾅ／＼／＼／" " ｵ ＼" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼／" " ｵ ｵ ｵ" " ﾕ＼／ｸ／ｸ" " HO O" "177/" "GC-EI-MS(TMS) (177)" "177/" "ラット肝ミクロソームとβ−シトステロールとの反応物中。(177/185) β−シトステロールの自動酸化。(215)" "177/185/215/" "ST0049" 12.00 "5,6-EPOXYSTIGMASTAN-3β-OL (5,6-EPOXY-β-SITOSTEROL)" "C29H50O2" 29.00 50.00 2.00 0.00 0.00 0.00 430.00 " ／ (REF:177/206/215)" " ｵ" " ﾅ／＼／＼／" " ｵ ＼" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼／" " ｵ ｵ ｵ" " ﾕ＼／･／" " HO Oｩ" "177/206/215/" "EI-MS M/E=430[M], 415[M-CH3], 412[M-H2O], 289, 299 (215)GC-EI-MS(TMS) (177/206)" "177/206/215/" "ラット肝ミクロソームとβ−シトステロールとの反応物中。(177/185)β−シトステロールの自動酸化。(215)ラット肝亜細胞とβ−シトステロールとの反応物中。(206)" "177/185/215/206/" "ST0050" 12.00 "5-STIGMASTENE-3β,5α,3β-TRIOL" "C29H52O3" 29.00 52.00 3.00 0.00 0.00 0.00 448.00 " ／ (REF:206)" " ｵ" " ﾅ／＼／＼／" " ｵ ＼" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼／" " ｵ ｵ ｵ" " ﾕ＼／ﾊ／" " HO HO ﾐ" " OH" "206/" "GC-EI-MS(TMS) M/E=664[M], 574[M-HOTMS], 484[M-2xHOTMS], 431, 395, 349, 217 (206)" "206/" "ラット肝亜細胞とβ−シトステロールとの反応物中。(206)" "206/" "ST0051" 12.00 "4-STIGMASTEN-3-ONE" "C29H48O" 29.00 48.00 1.00 0.00 0.00 0.00 412.00 " ／ (REF:215)" " ｵ" " ﾅ／＼／＼／" " ｵ ＼" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼／" " ｵ ｵ ｵ" " ｴ＼ｷ＼／" " O" "215/" "EI-MS M/E=397[M-CH3], 271[M-C10H21], 229(215)" "215/" "β−シトステロールの自動酸化。(215)" "215/" "ST0052" 12.00 "5-STIGMASTEN-3-ONE" "C29H48O" 29.00 48.00 1.00 0.00 0.00 0.00 412.00 " ／ (REF:215)" " ｵ" " ﾅ／＼／＼／" " ｵ ＼" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼／" " ｵ ｵ ｵ" " ｴ＼／ｸ／" " O" "215/" "EI-MS M/E=412[M], 397[M-CH3],229 (215)" "215/" "β−シトステロールの自動酸化。(215)" "215/" "ST0053" 12.00 "4-STIGMASTENE-3,6-DIONE" "C29H46O2" 29.00 46.00 2.00 0.00 0.00 0.00 426.00 " ／ (REF:215)" " ｵ" " ﾅ／＼／＼／" " ｵ ＼" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼／" " ｵ ｵ ｵ" " ｴ＼ｷ＼／" " O ｾ" " O" "215/" "EI-MS M/E=411[M-CH3], 275[M-C10H21], 243 (215)" "215/" "β−シトステロールの自動酸化。(215)" "215/" "ST0054" 12.00 "4-STIGMASTENE-3β,26-DIOL (26-HYDROXY-β-SITOSTEROL)" "C29H50O2" 29.00 50.00 2.00 0.00 0.00 0.00 430.00 " ／ (REF:185)" " ｵ OH" " ﾅ／＼／＼／" " ｵ ＼" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼／" " ｵ ｵ ｵ" " ﾕ＼／ｸ／" " HO" "185/" "GC-EI-MS(TMS) M/E=574[M], 559[M-CH3], 484[M-HOTMS],445,255,129(185)" "185/" "ラット肝ミクロソームとβ−シトステロールの反応物中。(185)" "185/" "ST0055" 12.00 "24[R]-5-ERGOSTENE-3β,7α-DIOL (7α-HYDROXY-CAMPESTEROL)" "C28H48O2" 28.00 48.00 2.00 0.00 0.00 0.00 416.00 " (REF:185)" " ﾁ" " ﾅ／＼／＼／" " ｵ ＼" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼／" " ｵ ｵ ｵ" " ﾕ＼／ｸ／ﾅ" " HO OH" "185/" "GC-EI-MS(TMS)(185)" "185/" "ラット肝ミクロソームとカンペステロールとの反応物中。(185)" "185/" "ST0056" 12.00 "24[R]-5-ERGOSTENE-3β,7β-DIOL (7β-HYDROXY-CAMPESTEROL)" "C28H48O2" 28.00 48.00 2.00 0.00 0.00 0.00 416.00 " (REF:185)" " ﾁ" " ﾅ／＼／＼／" " ｵ ＼" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼／" " ｵ ｵ ｵ" " ﾕ＼／ｸ／ﾖ" " HO OH" "185/" "GC-EI-MS(TMS)(185)" "185/" "ラット肝ミクロソームとカンペステロールとの反応物中。(185)" "185/" "ST0057" 12.00 "7-KETO-24[R]-5-ERGOSTEN-3β-OL (7-KETO-CAMPESTEROL)" "C28H46O2" 28.00 46.00 2.00 0.00 0.00 0.00 414.00 " (REF:185)" " ｵ" " ﾅ／＼／＼／" " ｵ ＼" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼／" " ｵ ｵ ｵ" " ﾕ＼／ｸ／ｸ" " HO O" "185/" "GC-EI-MS(TMS)(185)" "185/" "ラット肝ミクロソームとカンペステロールとの反応物中。(185)" "185/" "ST0058" 12.00 "24[R]-5-ERGOSTEN-3β,26-DIOL (26-HYDROXY-CAMPESTEROL)" "C28H48O2" 28.00 48.00 2.00 0.00 0.00 0.00 416.00 " (REF:185)" " ｵ OH" " ﾅ／＼／＼／" " ｵ ＼" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼／" " ｵ ｵ ｵ" " ﾕ＼／ｸ／" " HO" "185/" "GC-EI-MS(TMS)M/E=560,545,470,431,255,129(185)" "185/" "ラット肝ミクロソームとカンペステロールとの反応物中。(185)" "185/" "ST0059" 12.00 "5α-CHOLESTAN-3β-OL" "CHOLESTANOL" "C27H48O" 27.00 48.00 1.00 0.00 0.00 0.00 388.00 " ﾅｱｲｱｲｱ" " ﾓH ｵ" " ｱｲｫｲ" " ｵｶｽｺ" " ｱｲｫｲｱﾂ" " ｵ ｵ ｵH" " ﾕｲｱﾊｱ" " OH H" "142ﾟC ACETATE M.P. 111ﾟC(001)" "[α]/D +24ﾟ ACETATE [α]/D +13ﾟ (001)" "001/" "IH-NMR(CDCl3) (002), 13C-NMR(CDCl3) (004)" "ACETATE 430(25)M+,415(9),370(58),355(23),317(6),275(30),257(37),215(100) (003)" "002/003/004/" "動物組織(001)，海産無脊椎動物(005),ﾅｽ科植物(006),ﾅﾀﾈ油(006)" "001/005/006/" "ST0060" 12.00 "5β-CHOLESTAN-3β-OL" "COPROSTANOL" "C27H48O" 27.00 48.00 1.00 0.00 0.00 0.00 388.00 " ﾅｱｲｱｲｱ" " ﾓH ｵ" " ｱｲｫｲ" " ｵｶｽｺ" " ｱｲｫｲｱﾂ" " ｵ ｵ ｵH" " ﾕｲｱﾚｱ" " OH H" "101ﾟC ACETATE M.P. 89ﾟC(001)" "[α]/D +28ﾟ （001)" "001/" "IH-NMR(CDCl3) (002)" "388(76)M+,373(94),370(24),355(53),331(24),316(6),288(15),262(12),257(9), 233(97),215(100)(007)" "002/007/" "ﾋﾄや肉食動物のﾌﾝ(001)" "001/" "ST0061" 12.00 "CHOLEST-5-EN-3β-OL" "COLESTEROL" "C27H46O" 27.00 46.00 1.00 0.00 0.00 0.00 386.00 " ﾅｱｲｱｲｱ" " ﾓH ｵ" " ｱｲｫｲ" " ｵｶｽｺ" " ｱｲｫｲｱﾂ" " ｵ ｵ ｵH" " ﾕｲｱｸｱ" " OH" "149ﾟC ACETATE M.P. 116ﾟC(001)" "[α]/D -39ﾟ ACETATE [α]/D -47ﾟ (001)" "001/" "IH-NMR(CDCl3) (008), 13C-NMR(CDCl3) (004)" "388(98)M+,371(46),368(64),353(52),301(56),275(100),273(36),260(12),255(50),247(40),246(12),231(42),229(36),213(68) ACETATE 368(100)M+-HOAc,353(28),275(4),260(13),255(22)247(26),229(3),216(18) (009)""" "004/008/009/" "動物(001),高等植物(006)" "001/006/" "ST0062" 12.00 "(24R)-24-METHYLCHOLEST-5-EN-3β-OL" "CAMPESTEROL" "C28H48O" 28.00 48.00 1.00 0.00 0.00 0.00 400.00 " ﾁ" " ﾅｱｲｱｲｱ" " ﾓ ｵ" " ｱｲｫｲ" " ｵｶｽｺ" " ｱｲｫｲｱﾂ" " ｵ ｵ ｵH" " ﾕｲｱｸｱ" " OH" "158ﾟC (001)" "[α]/D +33ﾟ (001)" "001/" "IH-NMR(CDCl3) (008), 13C-NMR(CDCl3) (004)""" "400(100)M+,385(50),382(62),367(50),315(60),289(65),274(14),273(50),261(20), 255(82),246(10),231(44),229(25),213(74)(009)" "004/008/009/" "海産無脊椎動物(005),高等植物(006)" "005/006/" "ST0063" 12.00 "(24S)-24-METHYLCHOLEST-5-EN-3β-OL" "22-DIHYDROBRASSICASTEROL" "C28H48O" 28.00 48.00 1.00 0.00 0.00 0.00 400.00 " ﾂ" " ﾅｱｲｱｲｱ" " ﾓH ｵ" " ｱｲｫｲ" " ｵｶｽｺ" " ｱｲｫｲｱﾂ" " ｵ ｵ ｵH" " ﾕｲｱｸｱ" " OH" "ACETATE MP 151-152ﾟC(007)" "007/" "IH-NMR(CDCl3) (008),13C-NMR(CDCl3) (004)" "004/008/" "海産無脊椎動物(005),高等植物(006)" "005/006/" "ST0064" 12.00 "(24E,24S)-24-METHYLCHOLESTA-5,22-DIEN-3β-OL" "CRINOSTEROL" "C28H46O" 28.00 46.00 1.00 0.00 0.00 0.00 398.00 " ﾁ" " ﾅｱｹｱｲｱ" " ﾓH ｵ" " ｱｲｫｲ" " ｵｶｽｺ" " ｱｲｫｲｱﾂ" " ｵ ｵ ｵH" " ﾕｲｱｸｱ" " OH" "160.5-161.5ﾟC ACETATE MP 156-157ﾟC(010)" "010/" "1H-NMR(CDCl3) (010), 13C-NMR(CDCl3) (004)" "398(100)M+,383(13),380(18),365(18),355(9),337(22),300(49),271(56),255(96), 213(37)(010)" "004/010/" "海産無脊椎動物(005),ｱﾌﾞﾗﾅ科植物種子(006)" "005/006/" "ST0065" 12.00 "(22E,24R)-24-METHYLCHOLESTA-5,22-DIEN-3β-OL" "BRASSICASTEROL" "C28H46O" 28.00 46.00 1.00 0.00 0.00 0.00 398.00 " ﾂ" " ﾅｱｹｱｲｱ" " ﾓH ｵ" " ｱｲｫｲ" " ｵｶｽｺ" " ｱｲｫｲｱﾂ" " ｵ ｵ ｵH" " ﾕｲｱｸｱ" " OH" "151-152ﾟC ACETATE MP 157-158ﾟC(010)" "010/" "1H-NMR(CDCl3) (010), 13C-NMR(CDCl3) (004)" "398(100)M+,383(16),380(19),365(18),355(11),337(28),300(56),271(65),255(94),213(34)(010)" "004/010/" "海産無脊椎動物(005),ｱﾌﾞﾗﾅ科植物種子(006)" "005/006/" "ST0066" 12.00 "24-METHYL-5,24(28)-DIEN-3β-OL" "24-METHYLENECHOLESTEROL(CHALINASTEROL)" "C28H46O" 28.00 46.00 1.00 0.00 0.00 0.00 398.00 " ｾ" " ﾅｱｲｱｲｱ" " ﾓH ｵ" " ｱｲｫｲ" " ｵｶｽｺ" " ｱｲｫｲｱﾂ" " ｵ ｵ ｵH" " ﾕｲｱｸｱ" " OH" "142ﾟC (001) ACETATE MP 136-138ﾟC(011)" "001/011/" "ACETATE 1H-NMR(CDCl3) (011), ACETATE 13C-NMR(CDCl3) (004)" "398(100)M+-HOAC,365(15),396(46),281(17),272(5),259(9),255(11),253(30),228(10),213(23),211(9),201(6)(007)" "004/007/011/" "無脊椎動物(005),ﾅｽ科植物種子(006),ｳﾘ科植物(006),ﾅﾀﾈ油(006)" "005/006/" "ST0067" 12.00 "(24R)-24-ETHYLCHOLEST-5-EN-3β-OL" "SITOSTEROL" "C29H50O" 29.00 50.00 1.00 0.00 0.00 0.00 414.00 " ｱ" " ﾁ" " ﾅｱｲｱｲｱ" " ﾓH ｵ" " ｱｲｫｲ" " ｵｶｽｺ" " ｱｲｫｲｱﾂ" " ｵ ｵ ｵH" " ﾕｲｱｸｱ" " OH" "140ﾟC (001) ACETATE MP 122-124ﾟC(012)" "[α]/D -37ﾟ (001)" "001/012/" "1H-NMR(CDCl3) (008), 13C-NMR(CDCl3) (013)" "414(100)M+,399(45),396(54),381(42),329(50),303(70),275(18),273(54),255(60),246(12),231(58),229(25),213(78)(009)" "008/009/013/" "海産無脊椎動物(005),高等植物(006)" "005/006/" "ST0068" 12.00 "(22E,24S)-24-ETHYLCHOLESTA-5,22-DIEN-3β-OL" "STIGMASTEROL" "C29H48O" 29.00 48.00 1.00 0.00 0.00 0.00 412.00 " ｱ" " ﾁ" " ﾅｱｹｱｲｱ" " ﾓH ｵ" " ｱｲｫｲ" " ｵｶｽｺ" " ｱｲｫｲｱﾂ" " ｵ ｵ ｵH" " ﾕｲｱｸｱ" " OH" "170ﾟC (001) ACETATE MP 122-124ﾟC(012)" "[α]/D -49ﾟ (001)" "001/012/" "1H-NMR(CDCl3) (008), 13C-NMR(CDCl3) (013)" "412(78)M+,397(8),394(6),379(7),369(24),351(31),327(4),314(3),301(2),299(54),273(26),271(73),255(100),253(22),246(4),231(18),229(20),211(12) (009)""" "008/009/013/" "海産無脊椎動物(005),高等植物(006)" "005/006/" "ST0069" 12.00 "(24(28)E)-24-ETHYLCHOLESTA-5,24(28)-DIEN-3β-OL" "FUCOSTEROL" "C29H48O11" 29.00 48.00 11.00 0.00 0.00 0.00 572.00 " ｲ" " ｳ" " ﾅｱｲｱｲｱ" " ﾓH ｵ" " ｱｲｫｲ" " ｵｶｽｺ" " ｱｲｫｲｱﾂ" " ｵ ｵ ｵH" " ﾕｲｱｸｱ" " OH" "124ﾟC (001) ACETATE MP 119-120ﾟC(014)" "[α]/D -40ﾟ (001)" "001/014/" "ACETATE 1H-NMR(CDCl3) (008), 13C-NMR(CDCl3) (004)" "ACETATE 394(80)M+-HOAc,379(8),296(100),281(23),273(3),255(6),253(11),229(3),228(11),227(4),213(11)(014)" "004/008/014/" "米ﾇｶ油(006),ﾅｽ科植物種子(006),ｵﾘｰﾌﾞ油(006),褐藻(015)" "006/015/" "ST0070" 12.00 "[24(28)Z]-24-ETHYLCHOLESTA-5,24(28)-DIEN-3β-OL" "ISOFUCOSTEROL" "C29H48O" 29.00 48.00 1.00 0.00 0.00 0.00 412.00 " ｱ" " ｾ" " ﾅｱｲｱｲｱ" " ﾓH ｵ" " ｱｲｫｲ" " ｵｶｽｺ" " ｱｲｫｲｱﾂ" " ｵ ｵ ｵH" " ﾕｲｱｸｱ" " OH" "134ﾟC (001) ACETATE MP 137-138ﾟC(014)" "014/" "ACETATE 1H-NMR(CDCl3) (008), 13C-NMR(CDCl3) (004)" "ACETATE 394(40)M+-HOAc,379(5),296(100),281(13),273(2),255(13),253(6),229(3),228(7),227(3),213(9)(014)" "004/008/014/" "海産無脊椎動物(005),高等植物(006)" "005/006/" "ST0071" 12.00 "(24S)-24-ETHYLCHOLESTA-5,25-DIEN-3β-OL" "CLEROSTEROL" "C29H48O" 29.00 48.00 1.00 0.00 0.00 0.00 412.00 " ｱ" " ﾂ" " ﾅｱｲｱｲｴ" " ﾓH ｵ" " ｱｲｫｲ" " ｵｶｽｺ" " ｱｲｫｲｱﾂ" " ｵ ｵ ｵH" " ﾕｲｱｸｱ" " OH" "147ﾟC ACETATE MP 142ﾟC (016)" "[α]/D -50.5ﾟ ACETATE [α]/D -59ﾟ (016)" "016/" "ACETATE 1H-NMR(CDCl3) (008), ACETATE 13C-NMR(CDCl3) (004)" "412(100)M+,397(26),394(59),379(37),328(17),314(37),310(12),299(37),273(26),271(21),255(37),231(26),229(33),213(63)(017)" "004/008/017/" "緑藻(005),ｳﾘ科植物(006),ﾅﾀﾈ油(006),ｸﾏﾂﾂﾞﾗ科植物(018)" "005/006/018/" "ST0072" 12.00 "(24R)-24-ETHYL-5α-CHOLEST-7-EN-3β-OL" "22-DIHYDROSPINASTEROL(SCHOTTENOL)" "C29H50O" 29.00 50.00 1.00 0.00 0.00 0.00 414.00 " ｱ" " ﾁ" " ﾅｱｲｱｲｱ" " ﾓH ｵ" " ｱｲｫｲ" " ｵｶｽｺ" " ｱｲｫｲｱﾂ" " ｵ ｵｳ H" " ﾕｲｱﾊｱ" " OH" "145ﾟC(001)ACETATE MP 158.5-159.5ﾟC(019)" "[α]/D +11ﾟ (001)" "001/019/" "ACETATE 1H-NMR(CDCl3) (008), ACETATE 13C-NMR(CDCl3) (004/013)" "414(88)M+,399(32),396(3),381(8),273(29),255(100),246(17),229(41)(019)" "004/008/013/019/" "ｺﾑｷﾞ胚芽油(001),海産無脊椎動物(005),ｳﾘ科植物(006),ﾂﾊﾞｷ科植物(006),ﾋﾏﾜﾘ油 (006)" "001/005/006/" "ST0073" 12.00 "(22E,24S)-24-ETHYL-5α-CHOLESTA-7,22-DIEN-3β-OL" "SPINASTEROL" "C29H48O" 29.00 48.00 1.00 0.00 0.00 0.00 412.00 " ｱ" " ﾁ" " ﾅｱｹｱｲｱ" " ﾓH ｵ" " ｱｲｫｲ" " ｵｶｽｺ" " ｱｲｫｲｱﾂ" " ｵ ｵｳ H" " ﾕｲｱﾊｱ" " OH H" "172ﾟC (001) ACETATE MP 182-183ﾟC(019)" "[α]/D -4ﾟ (001)" "001/019/" "1H-NMR(CDCl3) (008), 13C-NMR(CDCl3) (004/013)" "412(21)M+,397(13),379(3),369(17),351(9),271(100),255(63),246(27),229(28)(019)" "004/008/013/019/" "海産無脊椎動物(005),ｳﾘ科植物(006),ﾎｳﾚﾝｿｳ(006),ﾂﾊﾞｷ科植物(006)" "005/006/" "ST0074" 12.00 "[24(28)Z]-24-ETHYL-5α-CHOLESTA-7,24(28)-DIEN-3β-OL" "AVENASTEROL" "C29H48O" 29.00 48.00 1.00 0.00 0.00 0.00 412.00 " ｱ" " ｾ" " ﾅｱｲｱｲｱ" " ﾓH ｵ" " ｱｲｫｲ" " ｵｶｽｺ" " ｱｲｫｲｱﾂ" " ｵ ｵｳ H" " ﾕｲｱﾊｱ" " OH H" "148-151ﾟC ACETATE MP 159-161ﾟC (020)" "[α]/D +12.7ﾟ ACETATE [α]/D +10.7ﾟ (020)" "020/" "ACETATE 1H-NMR(CDCl3) (008)" "ACETATE 454(3)M+,439(5),379(6),356(38),341(7),327(4),313(100),296(21),288(9),281(11),273(6),255(19),253(41),228(11),213(27),201(8)(021)" "008/021/" "高等植物(006),ｳﾘ科植物種子(020),ｷｸ科植物種子(022)" "006/020/022/" "ST0075" 12.00 "(22E,24R)-24-METHYLCHOLESTA-5,7,22-TRIEN-3β-OL" "ERGOSEROL" "C28H44O" 28.00 44.00 1.00 0.00 0.00 0.00 396.00 " ﾂ" " ﾅｱｹｱｲｱ" " ﾓH ｵ" " ｱｲｫｲ" " ｵｶｽｺ" " ｱｲｫｲｱﾂ" " ｵ ｵｳ H" " ﾕｲｱｸｱ" " OH" "168ﾟC (001) ACETATE MP 176.5-178ﾟC(023)" "[α]/D -132ﾟ (001)" "001/023/" "λmax 282nm (logε=4.08) (024)" "ACETATE 1H-NMR(CDCl3) (025), 13C-NMR(CDCl3) (004)" "ACETATE 438(7)M+,378(68),363(74),351(11),337(10),253(68),251(38),237(18),235(15),213(14),157(100)(007)" "004/007/025/" "酵母(001),軟体動物(005)" "001/005/" "ST0076" 12.00 "4α-METHYL-5α-CHOLEST-7-EN-3β-OL" "LOPHENOL" "C28H48O" 28.00 48.00 1.00 0.00 0.00 0.00 400.00 " ﾅｱｲｱｲｱ" " ﾓH ｵ" " ｱｲｫｲ" " ｵｶｽｺ" " ｱｲｫｲｱﾂ" " ｵ ｵｳ H" " ﾕｲｱﾊｱ" " OH(30)ﾂH" "149-151ﾟC ACETATE MP 119-121ﾟC (026)" "[α]/D +5ﾟ ACETATE [α]/D +28ﾟ (026)" "026/" "1H-NMR(CDCl3) (008) , ACETATE 13C-NMR(CDCl3) (004)" "ACETATE 442(100)M+,427(25),382(11),367(12),329(11),287(8),269(64),243(19), 227(34)(027)" "004/008/027/" "ﾗｯﾄのﾌﾝ(001),ﾕﾘ科植物(006),ﾅｽ科植物(006),ｻﾎﾞﾃﾝ(026)" "001/006/026/" "ST0077" 12.00 "4α,24-DIMETHYL-5α-CHOLESTA-7,24(28)-DIEN-3β-OL" "GRAMISTEROL(24-METHYLENELOPHENOL)" "C29H48O" 29.00 48.00 1.00 0.00 0.00 0.00 412.00 " ｾ" " ﾅｱｲｱｲｱ" " ﾓH ｵ" " ｱｲｫｲ" " ｵｶｽｺ" " ｱｲｫｲｱﾂ" " ｵ ｵｳ H" " ﾕｲｱﾊｱ" " OH(30)ﾂH" "162-163ﾟC ACETATE MP 132-134ﾟC (028)" "[α]/D +2.9ﾟ ACETATE [α]/D +24.3ﾟ (028)" "028/" "ACETATE 1H-NMR(CDCl3) (008), ACETATE 13C-NMR(CDCl3) (004)" "412(24)M+,397(17),394(4),379(6),328(26),314(9),310(6),285(100),269(20),267 (15),260(9),245(8),241(11) (028)""" "004/008/028/" "高等植物(006),ｺﾑｷﾞ胚芽油(028)" "006/028/" "ST0078" 12.00 "[24(28)Z]-4α-METHYL-24-ETHYL-5α-CHOLESTA-7,24(28)-DIEN-3β-OL" "CITROSTADIENOL" "C30H50O" 30.00 50.00 1.00 0.00 0.00 0.00 426.00 " ｱ" " ｾ" " ﾅｱｲｱｲｱ" " ﾓH ｵ" " ｱｲｫｲ" " ｵｶｽｺ" " ｱｲｫｲｱﾂ" " ｵ ｵｳ H" " ﾕｲｱﾊｱ" " OH(30)ﾂH" "160-162ﾟC ACETATE MP 147-149ﾟC (028)" "[α]/D +8.5ﾟ ACETATE [α]/D +31.5ﾟ (028)" "028/" "ACETATE 1H-NMR(CDCl3) (008), ACETATE 13C-NMR(CDCl3) (004)" "ACETATE 468(4)M+,453(4),393(6),379(48),355(6),327(100),310(20),302(7),295(10),287(4),269(15),267(34),243(6),242(10),241(10),227(20) (029)""" "004/008/029/" "高等植物(006),ｺﾑｷﾞ胚芽油(028),ｸﾞﾚｰﾌﾟﾌﾙｰﾂ果皮油(029)" "006/028/029/" "ST0079" 12.00 "4α,14α,24-TRIMETHYL-5α-CHOLESTA-8,24(28)-DIEN-3β-OL" "OBTUSIFOLIOL" "C30H50O" 30.00 50.00 1.00 0.00 0.00 0.00 426.00 " ｾ" " ﾅｱｲｱｲｱ" " ﾓH ｵ" " ｱｲｫｲ" " ｵｶｽｺ" " ｱｲｫｹｱﾂ" " ｵ ｵｶ (32)" " ﾕｲｱﾊｱ" " OH(30)ﾂH" "134-135ﾟC (030) ACETATE MP 111-113ﾟC(031)" "[α]/D +68.2ﾟ ACETATE [α]/D +102ﾟ (030)" "030/031/" "ACETATE 1H-NMR(CDCl3) (008), ACETATE 13C-NMR(CDCl3) (004)" "ACETATE 468(60)M+,453(100),408(4),393(24),369(9),341(2),324(3),301(9),287(22),227(20)(032)" "004/008/032/" "高等植物(006),ﾄｳﾀﾞｲｸﾞｻ科植物乳液(030)" "006/030/" "ST0080" 12.00 "4α,14α,24-TRIMETHYL-9β,19-CYCLO-5α-CHOLEST-24(28)-EN-3β-OL" "CYCLOEUCALENOL" "C30H50O" 30.00 50.00 1.00 0.00 0.00 0.00 426.00 " ｾ" " ﾅｱｲｱｲｱ" " ﾓH ｵ" " ｱｲｫｲ" " ｺ ｶｽｺ" " ｱｲｫｲｱﾂ" " ｵ ｵｶ" " ﾕｲｱﾊｱ" " OH ﾂH" "140ﾟC ACETATE MP 112-113ﾟC(033)" "[α]/D +45ﾟ ACETATE [α]/D +62ﾟ (033)" "033/" "ACETATE 1H-NMR(CDCl3) (034), 13C-NMR(CDCl3) (004)" "ACETATE 468(7)M+,453(8),408(100),393(51),384(5),365(7),343(5),300(10),285(3),283(13)(032)" "004/032/034/" "高等植物(006),ﾕｰｶﾘ樹(033),米ﾇｶ油(035)" "006/033/035/" "ST0081" 12.00 "5α-LANOSTA-8,24-DIEN-3β-OL" "LANOSTEROL" "C30H50O" 30.00 50.00 1.00 0.00 0.00 0.00 426.00 " ﾅｱｲｱｹｱ" " ﾓ ｶ" " ｱｲｫｲ" " ｵｶｽｽｵ" " ｱｲｫｹｱﾂ" " ｵｶ ｶ (32)" " ﾕｲｱﾊｱ" " HO ﾄﾔH" " (30) (31)" "140ﾟC (036) ACETATE MP 133-135ﾟC(037)" "[α]/D +58ﾟ (036)" "036/037/" "1H-NMR(CDCl3) (038),13C-NMR(CDCl3) (038)" "ACETATE 468(79)M+,453(100),408(10),393(62),315(5),301(13),297(5),255(11),241(14),229(10) (039)""" "038/039/" "ﾅｽ科植物種子(006),ﾅﾀﾈ油(006),酵母(023/024),羊毛脂(024)" "006/023/024/" "ST0082" 12.00 "5α-LANOSTA-7.9(11),24-TRIEN-3β-OL" "AGNOSTEROL" "C30H48O" 30.00 48.00 1.00 0.00 0.00 0.00 424.00 " ﾅｱｲｱｹｱ" " ﾓH ｶ" " ｱｲｫｲ" " ｾｶｽｽｵ" " ｱｲｫｲｱﾂ" " ｵｶ ｳ (32)" " ﾕｲｱﾊｱ" " HO ﾄﾔH" " (30) (31)" "169ﾟC (036) ACETATE MP 172.5-174.5ﾟC(038)" "[α]/D +69ﾟ (036)" "036/038/" "λmax=237,244,251nm(024)" "1H-NMR(CDCl3) (038),13C-NMR(CDCl3) (038)" "024/038/" "羊毛脂(024)" "024/" "ST0083" 12.00 "9β,19-CYCLO-5α-LANOST-24-EN-3β-OL" "CYCLOARTENOL" "C30H50O" 30.00 50.00 1.00 0.00 0.00 0.00 426.00 " ﾅｱｲｱｹｱ" " ﾓH ｶ" " ｱｲｫｲ" " ｺ ｶｽｽｵ" " ｱｲｫｲｱﾂ" " ｵｶ ｶ (32)" " ﾕｲｱﾊｱ" " HO ﾄﾔH" " (30) (31)" "115ﾟC ACETATE MP 122-124ﾟC(040)" "[α]/D +54ﾟ ACETATE [α]/D +59.5ﾟ (040)" "040/" "ACETATE 1H-NMR(CDCl3)(041), 13C-NMR(CDCl3) (043)" "426(55)M+,411(53),408(72),393(60),365(24),339(25),315(9),286(57),175(44), 97(100)(042)" "041/042/043/" "高等植物(006)" "006/" "ST0084" 12.00 "24-METHYL-9β,19-CYCLO-5α-LANOST-24(28)-EN-3β-OL" "27-METHYLENECYCLOARTENOL" "C30H52O" 31.00 52.00 1.00 0.00 0.00 0.00 440.00 " ｾ" " ﾅｱｲｱｲｱ" " ﾓH ｶ" " ｱｲｫｲ" " ｺ ｶｽｽｵ" " ｱｲｫｲｱﾂ" " ｵｶ ｶ (32)" " ﾕｲｱﾊｱ" " HO ﾄﾔH" " (30) (31)" "122ﾟC (036) ACETATE MP 116-118ﾟC(039)" "[α]/D +43ﾟ (036)" "036/039/" "ACETATE 1H-NMR(CDCl3) (044), ACETATE 13C-NMR(CDCl3) (006/043)" "440(49)M+,425(40),422(50),407(46),379(14),353(13),315(10),300(58),175(49), 107(100)(042)" "006/042/043/044/" "高等植物(006)" "006/" "ST0085" 12.00 "(24R)-24-METHYL-5α-CHOLESTAN-3β-OL" "CAMPESTANOL" "C28H50O" 28.00 50.00 1.00 0.00 0.00 0.00 402.00 " (REF: )" " ﾑ" " ﾅ／＼／＼／" " ｶﾄH ｶ" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼ﾋ" " ｵ ｵｶ H" " ﾕ＼／ﾊ／" " HO H" "147-148ﾟC ACETATE 146ﾟC(045)" "+31ﾟ (001)" "045/001/" "ACETATE 1H-NMR(CDCl3) 3-CH=4.684(TT),3-Oac=2.019(S),18-CH3=0.646(S),19-CH3= 0.816(S),21-CH3=0.893(D),26-CH3=0.848(D),27-CH3=0.799(D),28-CH3=0.768(D)(018)" "ACETATE:444[M+](17%),429(2%),384(31%),369(16%),330(2%),317(1%),315(1%),276(33%),275(21%),257(6%),230(14%),215(100%),201(19%),147(34%),81(53%)(046)" "018/046/" "クサギ属植物(018), アマチャヅル(047), ヤマノイモ葉部むかご(048)" "018/047/048/" "ST0086" 12.00 "(24S)-24-METHYL-5α-CHOLESTAN-3β-OL" "ERGOSTANOL" "C28H50O" 28.00 50.00 1.00 0.00 0.00 0.00 402.00 " (REF: )" " ﾂ" " ﾅ／＼／＼／" " ｶﾄH ｶ" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼ﾋ" " ｵ ｵｶ H" " ﾕ＼／ﾊ／" " HO H" "146ﾟC ACETATE 146-147ﾟC(045)" "+16ﾟ (001)" "045/001/" "ACETATE 1H-NMR(CDCl3) 3-CH=4.684(TT),3-Oac=2.019(S),18-CH3=0.646(S),19-CH3=0.816(S),21-CH3=0.902(D),26-CH3=0.852(D),27-CH3=0.781(D),28-CH3=0.772(D)(007)" "ACETATE: 444[M+](48%), 429(12%), 384(47%), 369(34%), 276(35%), 275(43%), 230(27%), 217(26%), 216(51%), 215(100%), 201(20%) (049)" "007/049/" "クサギ属植物(018), アマチャヅル(047), ヤマノイモ葉部むかご(048)" "018/047/048/" "ST0087" 12.00 "(24R)-24-ETHYL-5α-CHOLESTAN-3β-OL" "STIGMASTANOL" "C29H52O" 29.00 52.00 1.00 0.00 0.00 0.00 416.00 " ／ (REF: )" " ﾁ" " ﾅ／＼／＼／" " ｶﾄH ｶ" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼ﾋ" " ｵ ｵｶ H" " ﾕ＼／ﾊ／" " HO H" "138ﾟC (001) ACETATE 130-133ﾟC (048)" "+25ﾟ (001)" "001/048/" "ACETATE 1H-NMR(CDCl3) 3-CH=4.683(TT),3-Oac=2.018(S),18-CH3=0.648(S),19-CH3=0.817(S),21-CH3=0.904(D),26-CH3=0.833(D),27-CH3=0.814(D),29-CH3=0.843(T)(007)" "FREE:416[M+](10%), 401(3%), 290(6%), 257(3%), 248(7%), 233(98%), 215(100%), 201(11%) ACETATE:458[M+](57%), 443(4%), 398(47%), 383(21%), 344(3%), 317(2%), 290 (13%), 276(37%), 275(30%), 257(8%), 230(30%), 215(100%), 201(19%) (007)""" "007/" "ヤマノイモ葉部むかご(048),海綿動物(050),トウモロコシ(051),ウリ科植物(052)" "048/050/051/052/" "ST0088" 12.00 "(24S)-24-ETHYL-5α-CHOLESTAN-3β-OL" "PORIFERASTANOL" "C29H52O" 29.00 52.00 1.00 0.00 0.00 0.00 416.00 " ／ (REF: )" " ﾂ" " ﾅ／＼／＼／" " ｶﾄH ｶ" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼ﾋ" " ｵ ｵｶ H" " ﾕ＼／ﾊ／" " HO H" "143ﾟC (001) ACETATE 135-136ﾟC (053)" "+25ﾟ (001)" "001/053/" "ACETATE 1H-NMR(CDCl3) 3-CH=4.684(TT),3-Oac=2.017(S),18-CH3=0.647(S),19-CH3=0.817(S),21-CH3=0.908(D),26-CH3=0.827(D),27-CH3=0.809(D),29-CH3=0.851(T)(054)" "ACETATE:458[M+](18%), 443(2%), 398(32%), 383(13%), 344(3%), 276(23%), 275(21%), 257(6%), 230(15%), 215(100%), 201(17%)(046)" "054/046/" "海綿動物(053), 変形菌類(055)" "053/055/" "ST0089" 12.00 "(22E)-CHLESTA-5,22-DIEN-3β-OL" "22-DEHYDROCHOLESTEROL" "C27H44O" 27.00 44.00 1.00 0.00 0.00 0.00 384.00 " (REF: )" " ﾅ／ｹ／＼／" " ｶﾄH ｶ" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼ﾋ" " ｵ ｵｶ H" " ﾕ＼／ｸ／" " HO" "ACETATE 145-149ﾟC (056)" "056/" "ACETATE 1H-NMR(CDCl3) 3-CH=4.602(M),3-Oac=2.030(S),6-CH=5.370(BRD),18-CH3= 0.692(S),19-CH3=1.020(S),21-CH3=1.010(D),22-CH=5.207(DD),23-CH=5.208(DD), 26-CH3 AND 27-CH3=0.858(D) AND 0.862(D) (007)" "FREE:384[M+](30%),369(9%),366(49%),351(16%),300(48%),285(12%),282(11%),273(25%),271(26%),255(100%),213(25%) ACETATE:366[M+-HOAc](100%), 351(11%), 282(7%), 255(55%), 245(6%), 228(7%) 213(12%) (017)""" "007/017/" "ホタテガイ(001), ナタネ種子(017), 海綿動物(050), アミミドロ(056)" "001/017/050/056/" "ST0090" 12.00 "CHLESTA-5,24-DIEN-3β-OL" "DESMOSTEROL" "C27H44O" 27.00 44.00 1.00 0.00 0.00 0.00 384.00 " (REF: )" " ﾅ／＼／ｹ／" " ｶﾄH ｶ" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼ﾋ" " ｵ ｵｶ H" " ﾕ＼／ｸ／" " HO" "121ﾟC (001) ACETATE 94-96ﾟC (056)" "-41ﾟ (001)" "001/056/" "ACETATE 1H-NMR(CDCl3) 3-CH=4.603(M),3-Oac=2.030(S),6-CH=5.374(BRD),18-CH3=0.678(S),19-CH3=1.018(S),21-CH3=0.936(D),24-CH=5.090(T),26-CH3=1.681(S), 27-CH3=1.601(S) (007)""" "ACETATE:366[M+-HOAc](51%), 351(11%), 253(23%), 213(10%), 145(24%), 69(100%)(046)" "007/046/" "甲殻類(001), ラット皮膚(001), 線虫類(046), ウリ科植物(052),アミミドロ(056),ワタ(057)" "001/046/052/056/057/" "ST0091" 12.00 "(24S)-24-ETHYLCHOLEST-5-EN-3β-OL" "CLIONASTEROL" "C29H50O" 29.00 50.00 1.00 0.00 0.00 0.00 414.00 " ／ (REF: )" " ﾂ" " ﾅ／＼／＼／" " ｶﾄH ｶ" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼ﾋ" " ｵ ｵｶ H" " ﾕ＼／ｸ／" " HO" "138ﾟC (001), ACETATE 143-144ﾟC (053)" "-42ﾟ (001)" "001/053/" "ACETATE 1H-NMR(CDCl3) 3-CH=4.604(M),3-Oac=2.031(S),6-CH=5.375(BRD),18-CH3=0.678(S),19-CH3=1.020(S),21-CH3=0.926(D),26-CH3=0.831(D),27-CH3=0.812(D), 29-CH3=0.855(T) (058)" "ACETATE:396[M+-HOAc](100%),381(22%),288(15%),275(15%),255(18%),213(18%)(007)" "058/007/" "海綿動物(001/050/053), クサギ属植物(018), ウリ科植物(047/052), リュウキュウベンケイ属植物(059)" "001/050/053/018/047/052/059/" "ST0092" 12.00 "(22E,24R)-24-ETHYLCHOLESTA-5,22-DIEN-3β-OL" "PORIFERASTEROL" "C29H48O" 29.00 48.00 1.00 0.00 0.00 0.00 412.00 " ／ (REF: )" " ﾂ" " ﾅ／ｹ／＼／" " ｶﾄH ｶ" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼ﾋ" " ｵ ｵｶ H" " ﾕ＼／ｸ／" " HO" "156ﾟC (001)" "-49ﾟ (001)" "001/" "ACETATE 1H-NMR(CDCl3) 3-CH=4.604(M),3-Oac=2.031(S),6-CH=5.373(BRD),18-CH3=0.695(S),19-CH3=1.021(S),21-CH3=1.025(D), 22-CH=5.164(DD),23-CH=5.022(D), 26-CH3=0.844(D), 27-CH3=0.792(D) ,29-CH3=0.812(T) (056)" "FREE : 412[M+](100%),397(13%),394(14%),379(17%),369(25%),351(39%),327(5%), 314(16%), 300(36%), 283(13%), 271(56%), 255(59%), 253(14%), 241(9%), 239(8%), 231(8%), 229(6%) (007)""" "056/007/" "海綿動物(001), ウリ科植物(047/052), アミミドロ(056), 黄藻類(060)" "001/047/052/056/060/" "ST0093" 12.00 "24-ETHYLCHOLESTA-5,24-DIEN-3β-OL" "24-ETHYLDESMOSTEROL" "C29H48O" 29.00 48.00 1.00 0.00 0.00 0.00 412.00 " ／ (REF: )" " ｵ" " ﾅ／＼／ｸ／" " ｶﾄH ｶ" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼ﾋ" " ｵ ｵｶ H" " ﾕ＼／ｸ／" " HO" "ACETATE 139-141ﾟC(058)" "058/" "ACETATE 1H-NMR(CDCl3) 3-CH=4.604(M),3-Oac=2.028(S),6-CH=5.374(BRD),18-CH3=0.682(S),19-CH3=1.020(S),21-CH3=0.970(D),26-CH3 AND 27-CH3=1.627(S) AND1.632(S),29-CH3=0.932(T) (058)" "ACETATE : 394[M+-HOAc](32%),379(6%),296(100%),281(23%),253(18%),228(8%),213(9%),55(81%)(046)" "058/046/" "ナス科植物(011/061), トウモロコシ(046), リュウキュウベンケイ属植物(058), マメ科植物種子(062)" "011/061/046/058/062/" "ST0094" 12.00 "(22E,24S)-24-ETHYLCHOLESTA-5,22,25-TRIEN-3β-OL" "22-DEHYDROCLEROSTEROL" "C29H46O" 29.00 46.00 1.00 0.00 0.00 0.00 410.00 " ／ (REF: )" " ﾂ" " ﾅ／ｹ／＼／" " ｶﾄH ｾ" " ／＼ｮ＼ CH2" " ｵｶｽｺ" " ／＼ｮ＼ﾋ" " ｵ ｵｶ H" " ﾕ＼／ｸ／" " HO" "ACETATE 146-150ﾟC(063)" "063/" "ACETATE 1H-NMR(CDCl3) 3-CH=4.601(M),3-Oac=2.030(S),6-CH=5.370(BRD),18-CH3=0.691(S),19-CH3=1.012(S),21-CH3=1.011(D),22-CH=5.243(DD),23-CH=5.171(DD), 24-CH=2.420(Q),26-CH3=1.646(D), 27-CH3=4.694(M), 29-CH3=0.833(T) (058)" "ACETATE:452[M+](0.3%),409(0.2%),392(100%),377(3%),363(3%),282(5%),255(32%), 253(12%), 228(3%), 213(7%) (063)" "058/063/" "クサギ属植物(018/054/063) ウリ科植物(047/052)" "018/054/063/047/052/" "ST0095" 12.00 "24,25-DIMETHYLCHOLESTA-5,24(28)-DIEN-3β-OL" "24-METHYLENE-25-METHYLCHOLESTEROL" "C29H48O" 29.00 48.00 1.00 0.00 0.00 0.00 412.00 " CH2 (REF: )" " ｾ" " ﾅ／＼／＼／" " ｶﾄH ﾉ" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼ﾋ" " ｵ ｵｶ H" " ﾕ＼／ｸ／" " HO" "159-160ﾟC (064), ACETATE 150-154ﾟC (056)" "064/056/" "ACETATE 1H-NMR(CDCl3) 3-CH=4.603(M),3-Oac=2.030(S),6-CH=5.372(BRS),18-CH3=0.688(S),19-CH3=1.021(S),21-CH3=0.963(D),26-CH3=1.057(S),27-CH3=1.057(S), 28-CH2=4.659(S) AND 4.832(S),29-CH3=1.057(S) (056)" "FREE:412[M+](5%),397(11%),379(5%),314(100%),299(24%),296(12%),281(28%),271(29%),255(7%),253(10%),231(10%),229(14%),213(17%),211(17%) (064) ACETATE:394[M+-HOAc](80%),379(18%),296(100%),281(30%),253(31%),228(15%),213(19%),211(12%)(064)" "056/064/" "ヤマノイモ葉部むかご(048), アミミドロ(056), リュウキュウベンケイ属植物(058)マメ科植物種子(062), アブラナ属植物種子(064)" "048/056/058/062/064/" "ST0096" 12.00 "5α-CHOLEST-7-EN-3β-OL" "LATHOSTEROL" "C27H46O" 27.00 46.00 1.00 0.00 0.00 0.00 386.00 " (REF: )" " ﾅ／＼／＼／" " ｶﾄH ｵ" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼ﾋ" " ｵ ｵｳ H" " ﾕ＼／ﾊ／" " HO H" "126ﾟC, ACETATE 118ﾟC (001)" "+4ﾟ, ACETATE +4ﾟ (001)" "001/" "FREE : 1H-NMR(CDCl3) 3-CH=3.60(M), 7-CH=5.158(M), 18-CH3=0.531(S), 19-CH3= 0.793(S), 21-CH3=0.917(D), 26-CH3 AND 27-CH3=0.861(D) AND 0.866(D) (007)" "FREE : 386[M+](63%),371(19%),353(3%),273(36%),255(100%),246(22%),231(47%), 229(49%),213(55%),201(17%) (007) ACETATE:428[M+](94%),413(17%),368(6%),353(13%),315(12%),288(6%),273(10%), 255(89%),229(31%),213(53%),81(93%),55(100%) (046)" "007/046/" "トウモロコシ(046), 線虫類(046), 海綿動物(050), ユリ科植物(065),ナデシコ目植物 (066)" "046/050/065/066/" "ST0097" 12.00 "(24R)-24-METHYL-5α-CHOLEST-7-EN-3β-OL" "24-EPIFUNGISTEROL" "C28H48O" 28.00 48.00 1.00 0.00 0.00 0.00 400.00 " (REF: )" " ﾑ" " ﾅ／＼／＼／" " ｶﾄH ｵ" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼ﾋ" " ｵ ｵｳ H" " ﾕ＼／ﾊ／" " HO H" "148-149ﾟC, ACETATE 159ﾟC (045)" "045/" "FREE : 1H-NMR(CDCl3) 3-CH=3.60(M),7-CH=5.15(M),18-CH3=0.536(S),19-CH3= 0.800(S),21-CH3=0.916(D),26-CH3=0.852(D),27-CH3=0.804(D),28-CH3=0.775(D) (067)" "FREE : 400[M+](56%),385(26%),382(8%),367(10%),273(3%),255(100%),246(19%),229(49%) 019)ACETATE: 442[M+](40%),427(6%),382(3%),367(5%),315(7%),255(100%),229(29%),213(52%)(046)" "019/046/" "クサギ属植物(018), ナデシコ目植物 (066), ヒマワリ種子油(067)" "018/066/067/" "ST0098" 12.00 "(24S)-24-METHYL-5α-CHOLEST-7-EN-3β-OL" "FUNGISTEROL" "C28H48O" 28.00 48.00 1.00 0.00 0.00 0.00 400.00 " (REF: )" " ﾂ" " ﾅ／＼／＼／" " ｶﾄH ｵ" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼ﾋ" " ｵ ｵｳ H" " ﾕ＼／ﾊ／" " HO H" "152-153ﾟC, ACETATE 164-166ﾟC (045)" "045/" "ACETATE 1H-NMR(CDCl3) 3-CH=4.695(TT),3-Oac=2.026(S),7-CH=5.144(M),18-CH3=0.531(S),19-CH3=0.810(S),21-CH3=0.924(D),26-CH3=0.856(D),27-CH3=0.785(D), 28-CH3=0.778(D) (018)" "FREE: 400[M+](100%),385(31%),382(6%),367(7%),273(25%),255(71%),253(2%)(068)" "018/068/" "クサギ属植物(018), ウリ科植物(047/052), 海綿動物(050), 変形菌類(068)" "018/047/052/050/068/" "ST0099" 12.00 "24-METHYL-5α-CHOLESTA-7.24(28)-DIEN-3β-OL" "EPISTEROL" "C28H46O" 28.00 46.00 1.00 0.00 0.00 0.00 398.00 " CH2 (REF: )" " ｾ" " ﾅ／＼／＼／" " ｶﾄH ｵ" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼ﾋ" " ｵ ｵｳ H" " ﾕ＼／ﾊ／" " HO H" "131ﾟC(001)" "+6ﾟ (001)" "001/" "ACETATE 1H-NMR(CDCl3) 3-CH=4.695(TT),3-Oac=2.025(S),7-CH=5.148(DD),18-CH3=0.537(S),19-CH3=0.811(S),21-CH3=0.954(D),25-CH=2.231(SEPTET),26-CH3 AND 27-CH3=1.024(D) AND 1.028(D),28-CH2=4.652(S) AND 4.715(D) (054)" "ACETATE : 440[M+](1%),425(3%),365(2%),356(22%),315(2%),313(100%),255(14%), 253(9%),227(12%),213(26%) (046)" "054/046/" "ヒトデ(001), 酵母(001), 線虫類(046), クサギ属植物(054), モロコシ属植物(069)" "001/046/054/069/" "ST0100" 12.00 "(24S)-24-ETHYL-5α-CHOLEST-7-EN-3β-OL" "22-DIHYDROCHONDRILLASTEROL" "C29H50O" 29.00 50.00 1.00 0.00 0.00 0.00 414.00 " ／ (REF: )" " ﾂ" " ﾅ／＼／＼／" " ｶﾄH ｵ" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼ﾋ" " ｵ ｵｳ H" " ﾕ＼／ﾊ／" " HO H" "ACETATE 165-167ﾟC (007)" "007/" "ACETATE 1H-NMR(CDCl3) 3-CH=4.694(TT),3-Oac=2.026(S),7-CH=5.146(DD),18-CH3=0.533(S),19-CH3=0.809(S),21-CH3=0.931(D),26-CH3=0.832(D),27-CH3=0.812(D), 29-CH3=0.855(T) (058)" "ACETATE : 456[M+](100%),441(22%),396(18%),381(16%),315(10%),288(10%),273(14%),255(79%),229(30%),213(38%) (007)""" "058/007/" "ウリ科植物(047/052)" "047/052/" "ST0101" 12.00 "(22E,24R)-24-ETHYL-5α-CHOLESTA-7.22-DIEN-3β-OL" "CHONDRILLASTEROL" "C29H48O" 29.00 48.00 1.00 0.00 0.00 0.00 412.00 " ／ (REF: )" " ﾂ" " ﾅ／ｹ／＼／" " ｶﾄH ｵ" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼ﾋ" " ｵ ｵｳ H" " ﾕ＼／ﾊ／" " HO H" "169ﾟC (001)" "-1ﾟ (001)" "001/" "ACETATE 1H-NMR(CDCl3) 3-CH=4.69(M), 3-Oac=2.03(S), 7-CH=5.146(M), 18-CH3= 0.548(S),19-CH3=0.815(S),21-CH3=1.031(D),22-CH=5.169(DD),23-CH=5.032(DD), 26-CH3=0.846(D), 27-CH3=0.794(D), 29-CH3=0.818(T) (070)" "ACETATE : 454[M+](33%),439(14%),411(15%),394(3%),379(5%),351(14%),342(21%),315(21%),313(100%),300(4%),288(16%),273(10%),255(47%),241(7%),229(22%), 213(20%) (007)" "070/007/" "海綿動物(001/050), ウリ科植物(047/052)" "001/050/047/052/" "ST0102" 12.00 "5α-CHOLEST-8-EN-3β-OL" "ZYMOSTENOL" "C27H46O" 27.00 46.00 1.00 0.00 0.00 0.00 386.00 " (REF: )" " ﾅ／＼／＼／" " ｶﾄH ｵ" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮｹﾋ" " ｵ ｵｶ H" " ﾕ＼／ﾊ／" " HO H" "129ﾟC (001)" "+50ﾟ(001)" "001/" "ACETATE 1H-NMR(CDCl3) 3-CH=4.700(TT),3-Oac=2.023(S),18-CH3=0.606(S),19-CH3=0.963(S),21-CH3=0.923(D),26-CH3 AND 27-CH3=0.863(D) AND 0.867(D)(007)" "ACETATE : 428[M+](89%),413(18%),368(5%),353(16%),315(9%),255(23%),229(37%),213(46%),55(100%)(046)""" "007/046/" "線虫類(046), 海綿動物(050)" "046/050/" "ST0103" 12.00 "5α-CHOLESTA-8.24-DIEN-3β-OL" "ZYMOSTEROL" "C27H46O" 27.00 44.00 1.00 0.00 0.00 0.00 384.00 " (REF: )" " ﾅ／＼／ｹ／" " ｶﾄH ｵ" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮｹﾋ" " ｵ ｵｶ H" " ﾕ＼／ﾊ／" " HO H" "110ﾟC (001), ACETATE 106-108ﾟC (023)" "+49ﾟ(001)" "023/001/" "ACETATE 1H-NMR(CDCl3) 3-CH=4.70(M),3-Oac=2.03(S),18-CH3=0.61(S),19-CH3= 0.98(S),21-CH3=0.95(D),24-CH=5.08(T),26-CH3=1.68(S),27-CH3=1.61(S)(007)" "ACETATE : 426[M+](23%),411(10%),351(8%),315(1%),313(3%),255(3%),229(11%), 213(32%),69(100%),55(51%) (046)""" "007/046/" "酵母(001/023), 線虫類(046)" "001/023/046/" "ST0104" 12.00 "(24R)-24-ETHYL-5α-CHOLEST-8-EN-3β-OL" "C29H50O" 29.00 50.00 1.00 0.00 0.00 0.00 414.00 " ／ (REF: )" " ﾑ" " ﾅ／＼／＼／" " ｶﾄH ｵ" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮｹﾋ" " ｵ ｵｶ H" " ﾕ＼／ﾊ／" " HO H" "ACETATE 131-134ﾟC (007)" "007/" "FREE : 1H-NMR(CDCl3) 3-CH=3.62(M),18-CH3=0.605(S),19-CH3=0.947(S),21-CH3= 0.924(D),26-CH3=0.827(D),27-CH3=0.807(D),29-CH3=0.841(T)(050)""" "FREE : 414[M+](100%),399(21%),396(2%),273(10%),255(6%),246(8%),231(6%), 229(9%),213(6%)(050)" "050/" "海綿動物(050), キイチゴ(071)" "050/071/" "ST0105" 12.00 "5α-CHOLEST-8(14)-EN-3β-OL" "C27H46O" 27.00 46.00 1.00 0.00 0.00 0.00 386.00 " (REF: )" " ﾅ／＼／＼／" " ｶﾄH ｵ" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼ｷ" " ｵ ｵｶ" " ﾕ＼／ﾊ／" " HO H" "120ﾟC (001), ACETATE 73-75ﾟC (048)" "+20ﾟ (001)" "001/048/" "ACETATE 1H-NMR(CDCl3) 3-CH=4.716(TT),3-Oac=2.022(S),18-CH3=0.838(S), 19-CH3=0.704(S),21-CH3=0.929(D),26-CH3 AND 27-CH3=0.863(D) AND 0.866(D) (048)" "ACETATE : 428[M+](100%),413(18%),368(6%),353(13%),315(16%),288(7%),273(6%), 255(21%),229(42%),213(42%),81%(80%),55(83%)(046)""" "048/046/" "線虫類(046), ヤマノイモ葉部むかご(048)" "046/048/" "ST0106" 12.00 "(24R)-24-ETHYL-5α-CHOLEST-8(14)-EN-3β-OL" "C29H50O" 29.00 50.00 1.00 0.00 0.00 0.00 414.00 " ／ (REF: )" " ﾑ" " ﾅ／＼／＼／" " ｶﾄH ｵ" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼ｷ" " ｵ ｵｶ" " ﾕ＼／ﾊ／" " HO H" "117ﾟC, ACETATE 118-119ﾟC (045)" "045/" "ACETATE 1H-NMR(CDCl3) 3-CH=4.703(M),3-Oac=2.022(S),18-CH3=0.841(S),19-CH3= 0.705(S),21-CH3=0.936(D),26-CH3=0.837(D),27-CH3=0.815(D),29-CH3=0.847(T)(048)" "ACETATE : 456[M+](100%),441(9%),396(4%),381(5%),315(12%),288(7%),276(13%),255(15%),229(27%),213(22%)(048)" "048/" "ヤマノイモ葉部むかご(048)" "048/" "ST0107" 12.00 "(22E,24R)-24-ERGOSTA-5,7,9(11),22-TETRAEN-3β-OL" "9(11)-DEHYDROERGOSTEROL" "C28H42O" 28.00 42.00 1.00 0.00 0.00 0.00 394.00 " (REF: )" " ﾂ" " ﾅ／ｹ／＼／" " ｶﾄH ｵ" " ／＼ｮ＼" " ｾｶｽｺ" " ／＼ｮ＼／ﾂ" " ｵ ｵｳ H" " ﾕ＼／ｸ／" " HO" "145-147ﾟC (072)" "+147ﾟ (072)" "072/" "FREE : 311, 324, 339nm (072)" "FREE 1H-NMR(CDCl3) 3-CH=3.600(M),6-CH,7-CH AND 11-CH=5.385(M),5.496(M) AND 5.655(M),18-CH3=0.562(S),19-CH3=1.227(S),21-CH3=1.001(D),22-CH AND 23-CH= 5.182(M), 26-CH3 AND 27-CH3=0.805(D) AND 0.822(D),28-CH3=0.899(D) (072)" "FREE: 394[M+](44%),379(4%),376(51%),361(6%),333(3%),269(13%),267(4%),251(100%),249(15%),227(10%),225(10%),224(6%),223(8%),209(20%),207(6%) (072)" "072/" "海綿動物(050/072), 真菌類(073)" "050/072/073/" "ST0108" 12.00 "[24(28)E]-4α-METHYL-24-ETHYL-5α-CHOLESTA-7,24(28)-DIEN-3β-OL" "ISOCITROSTADIENOL" "C30H50O" 30.00 50.00 1.00 0.00 0.00 0.00 426.00 " ＼ (REF: )" " ｳ" " ﾅ／＼／＼／" " ｶﾄH ｵ" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼／ﾂ" " ｵ ｵｳ H" " ﾕ＼／ﾊ／" " HO ﾂH" "ACETATE 142-145ﾟC (014)" "014/" "ACETATE 1H-NMR(CDCl3) 3-CH=4.406(DT),3-Oac=2.054(S),7-CH=5.177(M),18-CH3=0.542(S),19-CH3=0.843(S),21-CH3=0.995(D),25-CH=2.201(SEPTET),26-CH3 AND 27-CH3=0.980(D) AND 0.983(D),28-CH=5.185(Q),29-CH3=1.574(D),30-CH3=0.853(D) (031)" "ACETATE : 468[M+,12%),453(10%),393(9%),370(66%),355(5%),327(100%),310(8%),302(5%),295(5%),287(4%),269(19%),267(9%),243(9%),242(5%),241(9%),227(22%)215(8%)(031)" "031/" "ナス科植物種子(014), ゴガツササゲ種子(031), オリーブ油(074)" "014/031/074/" "ST0109" 12.00 "4α,14α,24-TRIMETHYL-5α-CHOLESTA-9(11),24(28)-DIEN-3β-OL" "C30H50O" 30.00 50.00 1.00 0.00 0.00 0.00 426.00 " CH2 (REF: )" " ｳ" " ﾅ／＼／＼／" " ｶﾄH ｵ" " ／＼ｮ＼" " ｾｶｽｺ" " ／＼ｮ＼／ﾂ" " ｵ ｵｶ" " ﾕ＼／ﾊ／" " HO ﾂH" "ACETATE 105-107ﾟC (031)" "031/" "ACETATE 1H-NMR(CDCl3) 3-CH=4.368(DT),3-Oac=2.052(S),11-CH=5.300(DT),18-CH3=0.660(S),19-CH3=1.003(S),21-CH3=0.912(D),25-CH=2.236(SEPTET),26-CH3 AND 27-CH3=1.026(D) AND 1.031(D),28-CH2=4.665(S) AND 4.717(S),30-CH3=0.842(D)32-CH3=0.750(S) (031)" "ACETATE : 468[M+](16%),453(57%),425(27%),408(18%),393(89%),341(100%),301(20%),281(50%),241(34%),227(30%),215(27%),201(29%) (075)""" "031/075/" "ゴガツササゲ種子(031), バナナ果皮(034), オリーブ油(074), アメーバ(075)" "031/034/074/075/" "ST0110" 12.00 "4α,14α,24-TRIMETHYL-5α-CHOLESTA-7,9(11),24(28)-TRIEN-3β-OL" "C30H48O" 30.00 48.00 1.00 0.00 0.00 0.00 424.00 " CH2 (REF: )" " ｳ" " ﾅ／＼／＼／" " ｶﾄH ｵ" " ／＼ｮ＼" " ｾｶｽｺ" " ／＼ｮ＼／ﾂ" " ｵ ｵｳ" " ﾕ＼／ﾊ／" " HO ﾂH" "ACETATE 123-124ﾟC (076)" "076/" "ACETATE : 237,243,251nm (076)" "ACETATE 1H-NMR(CDCl3) 3-CH=4.397(DT),3-Oac=2.059(S),7-CH=5.411(D),11-CH=5.390(D),18-CH3=0.581(S),19-CH3=0.952(S),21-CH3=0.922(D),25-CH=2.238( SEPTET),26-CH3 AND 27-CH3=1.029(D) AND 1.033(D),28-CH2=4.668(S) AND 4.722 ,30-CH3=0.866(D),32-CH3=0.89" "ACETATE : 466[M+,97%),451(19%),406(8%),391(24%),367(14%),339(100%),300(22%),299(32%),298(22%),281(11%),274(14%),239(65%),227(22%),226(35%),225(30%), 213(22%),211(22) (076)""" "076/" "アマチャヅル(076), ゴガツササゲ種子(076)" "076/" "ST0111" 12.00 "9β,19-CYCLO-5α-LANOSTAN-3β-OL" "CYCLOARTANOL" "C30H52O" 30.00 52.00 1.00 0.00 0.00 0.00 428.00 " (REF: )" " ﾅ／＼／＼／" " ｶﾄH ｵ" " ／＼ｮ＼" " H2Cｪ ｶｽｺ" " ／＼ｮ＼／ﾂ" " ｵ ｵｶ" " ﾕ＼／ﾊ／" " HO ﾄﾐH" "101ﾟC (036), ACETATE 134-136ﾟC (039)" "+45ﾟ (036)" "036/039/" "ACETATE 1H-NMR(CDCl3) 3-CH=4.567(DD),3-Oac=2.051(S),18-CH3=0.959(S),19-CH2=0.338(D) AND 0.576(D),21-CH3=0.861(D),26-CH3 AND 27-CH3=0.865(D) AND 0.871(D),30-CH3=0.846(S) 31-CH3 AND 32-CH3=0.889(S) AND 0.896(S)(077)""" "ACETATE : 470[M+](1%),455(2%),410(8%),395(9%),367(3%),357(1%),355(1%),341(3%),297(6%),288(10%),273(3%),55(100%) (046)""" "077/046/" "ナス科植物種子(039), ユリ科植物(065), エゾデンダ属シダ(078)" "039/065/078/" "ST0112" 12.00 "(23E)-24-METHYL-9β,19-CYCLO-5α-LANOST-23-EN-3β-OL" "CYCLOSADOL" "C30H52O" 31.00 52.00 1.00 0.00 0.00 0.00 440.00 " ｶ (REF: )" " ﾅ／＼ｷ＼／" " ｶﾄH ｵ" " ／＼ｮ＼" " H2Cｪ ｶｽｺ" " ／＼ｮ＼／ﾂ" " ｵ ｵｶ" " ﾕ＼／ﾊ／" " HO ﾄﾐH" "132-134ﾟC, ACETATE 121-122ﾟC (079)" "+41ﾟ, ACETATE +50ﾟ (079)" "079/" "ACETATE 1H-NMR(CDCl3) 3-CH=4.54(m),3-Oac=2.05(S),18-CH3=0.96(S),19-CH2= 0.34(D) AND 0.58(D),21-CH3=0.84(D),23-CH=5.03(M),25-CH=2.80(M),26-CH3=0.84(D),27-CH3=0.84(D),28-CH3=1.61(S),30-CH3=0.85(S),31-CH3=0.90(S), 32-CH3=0.90(S)(041)" "ACETATE : 482[M+](13%),467(9%),422(68%),407(60%),385(9%),379(25%),353(20%),325(53%),300(26%),297(18%),295(11%),255(10%),241(10%),229(25%),203(74%), 107(100%) (080)""" "041/080/" "オリーブ油(074), トウモロコシ胚芽油(079/080)" "074/079/080/" "ST0113" 12.00 "24-METHYL-9β,19-CYCLO-5α-LANOST-24-EN-3β-OL" "CYCLOBRANOL" "C30H52O" 31.00 52.00 1.00 0.00 0.00 0.00 440.00 " ｶ (REF: )" " ﾅ／＼／ｹ／" " ｶﾄH ｵ" " ／＼ｮ＼" " H2Cｪ ｶｽｺ" " ／＼ｮ＼／ﾂ" " ｵ ｵｶ" " ﾕ＼／ﾊ／" " HO ﾄﾐH" "157-158ﾟC(081), ACETATE 171-173ﾟC(007)" "+38.4ﾟ (081)" "0081/007/" "ACETATE 1H-NMR(CDCl3) 3-CH=4.54(M),3-Oac=2.05(S),18-CH3=0.96(S),19-CH2= 0.34(D) AND 0.58(D),21-CH3=0.91(D),26-CH3=1.63(S),27-CH3=1.63(S),28-CH3=1.63(S),30-CH3=0.85(S),31-CH3=0.89(S),32-CH3=0.89(S) (007)" "ACETATE : 482[M+](,21%),467(11%),422(100%),407(76%),379(33%),353(26%),339(24%),338(7%),323(7%),300(27%),297(41%),285(14%) (007)" "007/" "オリーブ油(074), コメヌカ油(081), 植物油(082)" "074/081/082/" "ST0114" 12.00 "5α-LANOST-8-EN-3β-OL" "24-DIHYDROLANOSTEROL" "C30H52O" 30.00 52.00 1.00 0.00 0.00 0.00 428.00 " (REF: )" " ﾅ／＼／＼／" " ｶﾄH ｵ" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮｹ／ﾂ" " ｵ ｵｶ" " ﾕ＼／ﾊ／" " HO ﾄﾐH" "146ﾟC(001), ACETATE 119-120ﾟC(038)" "+62ﾟ (001)" "001/038/" "ACETATE 1H-NMR(CDCl3) 3-CH=4.52(DD),3-Oac=2.05(S),18-CH3=0.686(S),19-CH3=1.003(S),21-CH3=0.888(D),26-CH3=0.863(D),27-CH3=0.869(D),30-CH3=0.880(S) 31-CH3=0.882(S),32-CH3=0.874(S) (038)" "ACETATE : 470[M+](40%),455(100%),410(1%),395(60%),357(1%),315(4%),301(3%),297(9%),296(12%) (039)" "038/039/" "羊毛脂(001),ナタネ種子(027),ナス科植物種子(039), トウダイグサ科植物乳液(083)" "001/027/039/083/" "ST0115" 12.00 "5α-LANOSTA-9(11),24-DIEN-3β-OL" "PARKEOL" "C30H50O" 30.00 50.00 1.00 0.00 0.00 0.00 426.00 " (REF: )" " ﾅ／＼／ｹ／" " ｶﾄH ｵ" " ／＼ｮ＼" " ｾｶｽｺ" " ／＼ｮ＼／ﾂ" " ｵ ｵｶ" " ﾕ＼／ﾊ／" " HO ﾄﾐH" "158-159ﾟC(037), ACETATE 170-171ﾟC(019)" "+77ﾟ (036)" "037/019/036/" "ACETATE 1H-NMR(CDCl3) 3-CH=4.46(M),3-Oac=2.05(S),11-CH=5.20(M),18-CH3= 0.65(S),19-CH3=1.07(S),21-CH3=0.89(D),24-CH=5.10(M),26-CH3=1.69(S), 27-CH3=1.59(D),30-CH3=0.87(S),31-CH3=0.89(S),32-CH3=0.74(S)(007)" "ACETATE: 468[M+](43%),453(100%),408(6%),393(99%),384(8%),383(11%),355(80%),341(6%),323(7%),316(13%),315(10%),301(19%),295(20%),271(14%),257(16%), 255(17%),241(23%) (007)""" "007/" "シアー脂(019),マロニエ種子(084) LEUZEA CARTHAMOIDES(キク科)根(085)" "019/084/085/" "ST0116" 12.00 "5α-CHOLESTAN-3α-OL" "EPICHOLESTANOL" "C27H48O" 27.00 48.00 1.00 0.00 0.00 0.00 388.00 " (REF:001)" " ﾅ／＼／＼／" " ﾓH ｵ" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼／ﾂ" " ｵ ｵ ｵH" " ﾄ＼／ﾊ／" " HO H" "001/" "186-188ﾟC (086), ACETATE 96ﾟC (087)" "+34ﾟ, ACETATE +30ﾟ (087)" "086/087/" "FREE : 1H-NMR(CDCl3) 3-CH=4.03(M), 18-CH3=0.65(S), 19-CH3=0.77(S), 21-CH3=0.92(D), 26-CH3=0.87(D), 27-CH3=0.87(D) (086) ACETATE : 1H-NMR(CDCl3) 3-CH=5.01(BR.S), 3-Oac=2.05(S),18-CH3=0.65(S), 19-CH3=0.79(S), 21-CH3=0.90(D), 26-CH3=0.87(D), 2" "FREE : 388[M+](78%),373(67%),370(7%),355(52%),331(3%),262(26%),248(12%),234(65%),233(100%),230(9%),219(17%),217(34%),215(98%),201(15%)(007)""" "086/007/" "海綿動物(ESPERIOPSIS EDWARDII)(088)" "088/" "ST0117" 12.00 "(22E)-5α-CHOLEST-22-EN-3β-OL" "C27H46O" 27.00 46.00 1.00 0.00 0.00 0.00 386.00 " (REF:091)" " ﾅ／＼／＼／" " ﾓH ｵ" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼／ﾂ" " ｵ ｵ ｵH" " ﾕ＼／ﾊ／" " HO H" "091/" "121ﾟC, ACETATE 106ﾟC (089)" "+12ﾟ, ACETATE 0ﾟ (089)" "089/" "ACETATE:1H-NMR(CDCl3):3-CH=4.68(M), 18-CH3=0.66(S), 19-CH3=0.82(S), 21-CH3=0.99(D), 22-CH=5.2-5.32(M), 23-CH=5.2-5.32(M), 26-CH3=0.86(D), 27-CH3=0.85(D) (090)" "FREE: 386[M+](25%),302(100%),287(35%),273(85%),257(91%),255(25%),233(13%),215(25%),201(13%) (007) ACETATE : 428[M+](35%),368(25%),344(65%),327(15%),315(35%),284(35%), 269(18%),257(100%),255(36%) (091)""" "090/007/091/" "海綿動物(AXINELLA CANNABINA)(050),ホタテガイ(PATINOPECTEN YESSOENSIS)(089),海綿動物(HYMENIACIDON PERLEVE)(091), ナマコ(STICHOPUS JAPONICUS)(092)" "050/089/091/092/" "ST0118" 12.00 "24-METHYL-5α-CHOLEST-24(28)-EN-3β-OL" "C28H48O" 28.00 48.00 1.00 0.00 0.00 0.00 400.00 " (REF:091)" " ｾ" " ﾅ／＼／＼／" " ﾓH ｵ" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼／ﾂ" " ｵ ｵ ｵH" " ﾕ＼／ﾊ／" " HO H" "091/" "110-115ﾟC, ACETATE 123-125ﾟC (091)" "091/" "FREE:1H-NMR(CDCl3): 18-CH3=0.65(S), 19-CH3=0.82(S), 21-CH3=0.94(D), 26-CH3=1.02(D), 27-CH3=1.02(D), 28-CH2=4.68 (092)" "FREE : 400[M+](4%),385(5%),367(0.8%),316(100%),301(36%),273(63%),259(5%), 255(10%),246(6%),233(21%),215(32%),203(10%),201(8%) (050) ACETATE: 442[M+](1%),427(1%),358(46%),343(11%),315(21%),298(2%),283(4%),255(11%),215(23%), 55(100%)" "092/050/046/" "線虫類(MELOIDOGYNE INCOGNITE, MELOIDOGYNE ARENARIAI, PRATYLENCHUS AGILIS) (046/094),トウモロコシ(046), 海綿動物(AXINELLA CANNABINA) (050), 海綿動物 (HYMENIACIDON PERLEVE)(091), ホタテガイ(093), ナマコ(STICHOPUS JAPONICUS)(092), 海産単細胞藻(095)" "046/094/050/091/093/092/095/" "ST0119" 12.00 "(22E,24S)-24-ETHYL-5α-CHOLESTAN-3β-OL" "5-DIHYDROSTIGMASTEROL" "C30H50O" 30.00 50.00 1.00 0.00 0.00 0.00 426.00 " ／ (REF:012)" " ﾑ" " ﾅ／ｹ／＼／" " ﾓH ｵ" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼／ﾂ" " ｵ ｵ ｵH" " ﾕ＼／ﾊ／" " HO H" "012/" "156-157ﾟC, ACETATE 156ﾟC (096)" "096/" "ACETATE:1H-NMR(CDCl3): 3-CH=4.68(TT), 3-Oac=2.02(S), 18-CH3=0.67(S),19-CH3=0.82(S), 21-CH3=1.01(D), 22-CH=5.15(DD), 23-CH=5.01(DD), 26-CH3=0.84(D), 27-CH3=0.79(D), 29-CH3=0.80(T) (012)" "ACETATE : 456[M+](42%),441(4%),413(4%),396(21%),381(3%),358(7%),353(31%),344(32%),329(8%),316(27%),315(37%),302(10%),257(58%),255(18%), 241(10%),229(10%), 43(100%) (012)""" "012/" "トマト種子(011), クサギ属植物 (018), ウリ科植物(052), マメ科植物種子(097), ナデシコ目植物(C-24位立体配置不明) (098), 変形菌(DICTYOSTELIUM DISCOIDEUM) (096), トウモロコシ(C-24位立体配置不明) (099), 線虫類 (C-24位立体配置不明)" "011/018/052/097/098/096/099/" "ST0120" 12.00 "(24S)-24-ETHYL-5α-CHOLEST-25-EN-3β-OL" "5-DIHYDROCLEROSTEROL" "C29H50O" 29.00 50.00 1.00 0.00 0.00 0.00 414.00 " ／ (REF:054)" " ﾂ" " ﾅ／＼／＼／" " ﾓH ｾ" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼／ﾂ" " ｵ ｵ ｵH" " ﾕ＼／ﾊ／" " HO H" "054/" "ACETATE 123-125ﾟC (058)" "058/" "ACETATE:1H-NMR(CDCl3): 3-CH=4.68(TT), 18-CH3=0.64(S), 19-CH3=0.81(S), 21-CH3=0.89(D), 26-CH3=1.56(D), 27-CH=4.64(D),27-CH=4.72(DT), 29-CH3=0.80(T),3-Oac=2.02(S) (054)" "ACETATE : 456[M+](100%),441(15%),396(7%),381(15%),358(33%),343(37%), 315(98%),302(22%),283(15%),257(48%),255(59%),229(22%),215(85%)(054)" "054/" "リュウキュウベンケイ属植物(KALANCHOE PINNATA)(058),クサギ属植物 (CLERODENDRUM SCANDENS)(054)" "058/054/" "ST0121" 12.00 "(23E)-24-METHYLCHOLESTA-5,23-DIEN-3β-OL" "C28H46O" 28.00 46.00 1.00 0.00 0.00 0.00 398.00 " (REF:051)" " ｵ" " ﾅ／＼ｴ＼／" " ﾓH ｵ" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼／ﾂ" " ｵ ｵ ｵH" " ﾕ＼／ｸ／" " HO" "051/" "150-151ﾟC (100), ACETATE 127-128ﾟC (051)" "-40.2ﾟ(100), ACETATE -41ﾟ (101)" "100/051/101/" "FREE:1H-NMR(CDCl3): 3-CH=3.53(M), 6-CH=5.36(DT), 18-CH3=0.69(S),19-CH3=1.01(S), 21-CH3=0.89(D), 23-CH=5.14(T),26-CH3=0.99(D), 27-CH3=0.99(D), 28-CH3=1.55(S) (007)" "FREE : 398[M+](11%),383(9%),380(1%),314(17%),301(26%),300(17%),283(67%), 271(100%),255(6%),253(7%),241(11%),227(11%),215(32%),213(17%)(007)ACETATE: 380[M+-HOAc](97%),365(11%),296(8%),283(100%),259(6%),255(11%), 253(42%),227(8%),215(12%),213(13%),159(33%)" "007/080/" "トウモロコシ(046/051/080/101), 線虫類代謝物(102)" "046/051/080/101/102/" "ST0122" 12.00 "24-METHYLCHOLESTA-5,24-DIEN-3β-OL" "24-METHYLDESMOSTEROL" "C28H46O" 28.00 46.00 1.00 0.00 0.00 0.00 398.00 " (REF:061)" " ｵ" " ﾅ／＼／ｸ／" " ﾓH ｵ" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼／ﾂ" " ｵ ｵ ｵH" " ﾕ＼／ｸ／" " HO" "061/" "141-142ﾟC (100), ACETATE 148-149ﾟC (007)" "-46.7ﾟ (100)" "100/007/" "FREE:1H-NMR(CDCl3): 3-CH=3.53(M), 6-CH=5.35(BR.D), 18-CH3=0.68(S),19-CH3=1.01(S), 21-CH3=0.96(D), 26-CH3,27-CH3 AND 28-CH3=1.62(S) AND 1.63(S) (101)""" "FREE : 398[M+](19%),383(11%),365(7%),314(100%),299(38%),297(14%),282(25%),271(38%),255(7%),253(9%),231(12%),229(26%)(101) ACETATE : 380[M+-HOAc](100%),365(10%),338(2%),296(86%),281(23%),272(4%),259(10%),253(20%),228(12%),213(13%) (007)" "101/007/" "ナス科植物種子(011),WITHANIA SOMNIFERA(ナス科)(061),トウモロコシ(046)(101)" "011/061/046/101/" "ST0123" 12.00 "(24S)-24-METHYLCHOLESTA-5,25-DIEN-3β-OL" "CODISTEROL" "C28H46O" 28.00 46.00 1.00 0.00 0.00 0.00 398.00 " (REF:104)" " ﾂ" " ﾅ／＼／＼／" " ﾓH ｾ" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼／ﾂ" " ｵ ｵ ｵH" " ﾕ＼／ｸ／" " HO" "104/" "ACETATE 134-136ﾟC (103)" "103/" "ACETATE : 890, 1645, 1750cm-1(104)" "FREE:1H-NMR(CDCl3): 18-CH3=0.67(S), 19-CH3=1.01(S), 21-CH3=0.91(D), 26-CH3=1.64(S), 27-CH2=4.66(BR.S), 28-CH3=0.99(D)(100)" "FREE : 398[M+](100%),383(13%),380(13%),365(15%),328(6%),314(18%),300(12%),299(19%),271(31%)(100)259(5%),255(7%),253(8%),228(6%),213(9%),211(3%) (103)" "104/100/103/" "バナナ果皮 (052), リュウキュウベンケイ属植物 KALANCHOE PINNATA (058), K.MARMORATA(103), ミル（海産緑藻類）(104), ウリ科植物(105)(106),海綿動物(VERONGIA CAULIFORNIS)(107)" "052/058/103/104/105/106/107/" "ST0124" 12.00 "(23E)-24-ETHYLCHOLESTA-5,23-DIEN-3β-OL" "C29H48O" 29.00 48.00 1.00 0.00 0.00 0.00 412.00 " ／ (REF:109)" " ｵ" " ﾅ／＼ｴ＼／" " ﾓH ｵ" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼／ﾂ" " ｵ ｵ ｵH" " ﾕ＼／ｸ／" " HO" "109/" "149-151ﾟC (108), ACETATE 120-121ﾟC (058)" "108/058/" "FREE:1H-NMR(CDCl3): 3-CH=3.52(M), 6-CH=5.35(M), 18-CH3=0.69(S),19-CH3=1.01(S), 21-CH3=0.89(D), 23-CH=5.08(DD), 25-CH=2.23(M), 26-CH3=1.00(D), 27-CH3=1.00(D), 29-CH3=0.95(T)(109)" "FREE : 412[M+](40%),397(7%),394(6%),379(3%),314(43%),301(17%),300(17%),299(27%),296(8%),283(55%),271(100%),255(10%),253(14%),241(7%),229(6%),215(20%) (109)" "109/" "トウモロコシ(046), オリーブ油(074), 海綿動物(CALYX NICEAENSIS)(109)" "046/074/109/" "ST0125" 12.00 " 24,24-DIMETHYLCHOLESTA-5,25-DIEN-3β-OL" "C29H48O" 29.00 48.00 1.00 0.00 0.00 0.00 412.00 " (REF:054)" " ﾒﾄ" " ﾅ／＼／＼／" " ﾓH ｾ" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼／ﾂ" " ｵ ｵ ｵH" " ﾕ＼／ｸ／" " HO" "054/" "ACETATE 146-148ﾟC (103)" "103/" "FREE:1H-NMR(CDCl3):18-CH3=0.67(S), 19-CH3=1.01(S), 21-CH3=0.91(D), 26-CH3=1.68(S), 27-CH2=4.66(S), 28-CH=1.01(S), 29-CH3=1.01(S)(059)""" "ACETATE : 454[M+](1%),394(100%),379(8%),310(10%),281(4%),273(4%),255(11%),253(10%),228(10%),213(13%) (103)" "059/103/" "リュウキュウベンケイ属植物 KALANCHOE DAIGREMONTIANA(059), K.PETITIANA(103) クサギ属植物 CLERODENDRUM SCANDENS (054)" "059/103/054/" "ST0126" 12.00 "[24(28)Z]-24-PROPYLCHOLESTA-5,24(28)-DIEN-3β-OL" "29-METHYLISOFUCOSTEROL" "C30H50O" 30.00 50.00 1.00 0.00 0.00 0.00 426.00 " ／＼ (REF:110)" " ｾ" " ﾅ／＼／＼／" " ﾓH ｵ" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼／ﾂ" " ｵ ｵ ｵH" " ﾕ＼／ｸ／" " HO" "110/" "111-112ﾟC (110), ACETATE 107ﾟC (089)" "-27ﾟ (110), ACETATE -32ﾟ (089)" "110/089/" "FREE:1H-NMR(CDCl3):3-CH=3.54, 6-CH=5.35(M), 18-CH3=0.68(S), 19-CH3=1.01(S), 21-CH3=0.95(D), 25-CH=2.80(M), 26-CH3=0.97(D), 27-CH3=0.97(D),28-CH=5.01(DD), 30-CH3=0.94(T)(110)" "FREE : 426[M+](10%),314(100%),299(27%),296(17%),281(43%),271(14%),253(10%),229(31%),213(12%),211(24%) (089) ACETATE: 408[M+-HOAc](42%),397(7%),296(100%),281(58%),255(12%),253(30%), 228(39%),213(45%) (093)""" "110/089/093/" "カキ CRASSOSTREA VIRGINLCA (093), ホタテ貝 PATINOPECTEN YESSOENSIS (089), PLACOPECTEN MAGELLANICUS(111) ,黄藻類(110),ホヤ(HALOCYNTHIA RORETZI)(112),海綿動物(113)" "093/089/111/110/112/113/" "ST0127" 12.00 "(22E,24S)-24-METHYL-5α-CHOLESTA-7,22-DIEN-3β-OL" "STELLASTEROL" "C28H46O" 28.00 46.00 1.00 0.00 0.00 0.00 398.00 " (REF:115)" " ﾑ" " ﾅ／ｹ／＼／" " ﾓH ｵ" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼／ﾂ" " ｵ ｵｳ H" " ﾕ＼／ﾊ／" " HO H" "115/" "159-160ﾟC (114), ACETATE 181-182ﾟC (115)" "+18ﾟ(114), ACETATE +6.4ﾟ (115)" "114/115/" "FREE = 970, 3300-3400cm-1 (114) ACETATE = 967, 1663cm-1 (115)" "FREE:1H-NMR(CDCl3): 3-CH=3.60(M), 7-CH=5.16(M), 18-CH3=0.54(S), 19-CH3=0.80(S), 21-CH3=1.01(D), 22-CH AND 23-CH=5.16(M), 26-CH3=0.84(D), 27-CH3=0.82(D), 28-CH3=0.91(D) (050)" "FREE : 398[M+](22%),383(8%),365(1%),355(3%),300(13%),299(10%),271(100%),255(34%),246(25%),231(13%),229(20%),213(17%) (050) ACETATE: 440[M+](47%),425(16%),397(9%),380(6%),365(11%),342(21%),337(7%),313(100%),288(25%),273(7%),255(64%),253(14%)" "114/115/050/116/" "海綿動物 AXINELLA CANNABINA (050), ヒトデ ASTERIAS AMURENSIS(115),A.RUBENS (C-24位立体配置不明)(117),ウリ科植物(052/116)" "050/115/117/052/116/" "ST0128" 12.00 "(22E,24R)-24-METHYL-5α-CHOLESTA-7,22-DIEN-3β-OL" "5-DIHYDROERGOSTEROL" "C28H46O" 28.00 46.00 1.00 0.00 0.00 0.00 398.00 " (REF:001)" " ﾂ" " ﾅ／ｹ／＼／" " ﾓH ｵ" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼／ﾂ" " ｵｶ ｳ H" " ﾕ＼／ﾊ／" " HO H" "001/" "174-175ﾟC (114), ACETATE 185-187ﾟC (118)" "-21ﾟ (114), ACETATE -23.4ﾟ (115)" "114/118/115/" "FREE : 968, 1660, 3020, 3040, 3610cm-1 (119)""" "FREE:1H-NMR(CDCl3): 3-CH=3.60(M), 7-CH=5.15(M), 18-CH3=0.54(S), 19-CH3=0.80(S), 21-CH3=1.02(D), 22-CH AND 23-CH=5.18(M), 26-CH3=0.84(D), 27-CH3=0.82(D), 28-CH3=0.91(D) (050)" "FREE : 397[M+](16%),383(6%),355(12%),300(10%),299(7%),271(100%),255(26%),246(20%),231(10%),229(16%),213(12%) (050) ACETATE: 440[M+](53%),425(14%),397(10%),380(10%),365(10%),342(23%), 315(34%),313(100%),299(10%),288(30%),273(10%),255" "119/050/120/" "酵母(001), クサギ属植物(018), ウリ科植物(052), 海綿動物 AXINELLA CANNABINA (050), HALICLONA FLAVESCENS (121) , クロレラ CHLORELLA VULGARIS (118), C.ELLIPSOIDEA 代謝物 (119),担子菌(ASTRAEUS HYGROMETRICUS)(122)" "001/018/052/050/121/118/119/122/" "ST0129" 12.00 "24-ETHYL-5α-CHOLESTA-7,24-DIEN-3β-OL" "PEPOSTEROL" "C29H48O" 29.00 48.00 1.00 0.00 0.00 0.00 412.00 " ／ (REF:123)" " ｵ" " ﾅ／＼／ｸ／" " ﾓH ｵ" " ／＼ｮ＼" " ｜ ｶｽｽｵ" " ／＼ｮ＼／ﾂ" " ｜ ｜ ｳ H" " ﾕ＼／ﾊ／" " HO H" "123/" "130-131ﾟC (087), ACETATE 135-137ﾟC (123)" "+5.0ﾟ (087)" "087/123/" "ACETATE : 800, 930cm-1 (123)" "ACETATE:1H-NMR(CDCl3):3-CH=4.70(TT), 3-Oac=2.03(S), 7-CH=5.15(DT), 18-CH3=0.52(S), 19-CH3=0.81(S), 21-CH3=0.97(D), 26-CH3=1.63(BR.S),27-CH3=1.63(BR.S), 29-CH3=0.93(T) (007)" "ACETATE : 454[M+](3%),439(6%),379(5%),356(28%),313(100%),296(8%),255(15%),253(22%),227(8%),213(21%) (052)" "123/007/052/" "ウリ科植物(021/052),ペポカボチャ(123),リュウキュウベンケイ属植物(KALANCHOE PINNATA)(058)" "021/052/123/058/" "ST0130" 12.00 "[24(28)E]-24-ETHYL-5α-CHOLESTA-7,24(28)-DIEN-3β-OL" "ISOAVENASTEROL" "C29H48O" 29.00 48.00 1.00 0.00 0.00 0.00 412.00 " ＼ (REF:124)" " ｾ" " ﾅ／＼／＼／" " ﾓH ｵ" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼／ﾂ" " ｵ ｵｳ H" " ﾕ＼／ﾊ／" " HO H" "124/" "ACETATE 155ﾟC (007)" "007/" "ACETATE : 800, 820, 830, 900cm-1 (124)" "ACETATE:1H-NMR(CDCl3): 3-CH=4.70(TT), 3-Oac=2.03(S), 7-CH=5.15(M), 18-CH3=0.54(S), 19-CH3=0.81(S), 21-CH3=1.00(D),25-CH=2.20(SEPT.), 26-CH3=0.98(D), 27-CH3=0.98(D), 28-CH=5.18(Q), 29-CH3=1.57(D)(062)" "ACETATE : 454[M+](2%),439(4%),379(3%),356(37%),313(100%),296(7%),255(14%),253(15%),227(10%),213(21%) (052)" "026/052/" "ウリ科植物(052), BRYONIA DIOICA 根(124), マメ科植物(LATHYRUS SATIVUS)(062)" "052/124/062/" "ST0131" 12.00 "(24S)-24-ETHYL-5α-CHOLESTA-7,25-DIEN-3β-OL" "C29H48O" 29.00 48.00 1.00 0.00 0.00 0.00 412.00 " ／ (REF:125)" " ﾂ" " ﾅ／＼／＼／" " ﾓH ｾ" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼／ﾂ" " ｵ ｵｳ H" " ﾕ＼／ﾊ／" " HO H" "125/" "135-142ﾟC (125), ACETATE 160-161ﾟC (058)" "+1.2ﾟ, ACETATE ±0ﾟ (125)" "125/058/" "ACETATE : 202nm (ε= 8000)(125)" "FREE : 890, 1645, 3080cm-1 ACETATE : 890, 1645, 1736, 3080cm-1 (125)" "FREE:1H-NMR(CDCl3): 3-CH=3.60(M), 7-CH=5.16(BR.S), 18-CH3=0.53(S), 19-CH3=0.80(S), 21-CH3=0.91(D), 26-CH3=1.57(S), 27-CH2=4.69(BR.S), 29-CH3=0.80(T) (106)" "FREE : 412[M+](21%),397(10%),394(4%),379(5%),369(15%),300(20%),299(11%), 273(25%),272(19%),271(100%),255(50%),253(9%),246(21%),231(22%)(106)ACETATE:454[M+](30%),439(25%),394(9%),379(11%),341(9%),313(100%),299(7%) 288(11%),273(8%),255(30%),229(11%),228(9" "106/126/" "ウリ科植物(052/106/126), MOMORDICA CHARANTIA(125), キカラスウリ (127), ナデシコ目植物 (C-24位立体配置不明) (066), タイワンアオネカズラ(128), リュウキュウベンケイ属植物 (KALANCHOE PINNATA)(058)" "052/106/126/125/127/066/058/128/" "ST0132" 12.00 "(22E,24S)-24-ETHYL-5α-CHOLESTA-7,22,25-TRIEN-3β-OL" "25-DEHYDROCHONDRILLASTEROL" "C29H46O" 29.00 46.00 1.00 0.00 0.00 0.00 410.00 " ／ (REF:125)" " ﾂ" " ﾅ／ｹ／＼／" " ﾓH ｾ" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼／ﾂ" " ｵ ｵｳ H" " ﾕ＼／ﾊ／" " HO H" "125/" "157-161ﾟC (125), ACETATE 175-178ﾟC (052)" "+11.2ﾟ, ACETATE +7.7ﾟ (125)" "125/052/" "ACETATE : 204nm (ε= 14,200)(125)" "FREE : 890, 976, 1645, 3080cm-1 ACETATE : 890, 976, 1645, 1734, 3080cm-1 (125)" "FREE:1H-NMR(CDCl3): 3-CH=3.60(M), 7-CH=5.16(BR.S), 18-CH3=0.55(S), 19-CH3=0.80(S), 21-CH3=1.02(D), 22-CH=5.22(M), 23-CH=5.22(M), 26-CH3=1.65(S), 27-CH2=4.71(S), 29-CH3=0.83(T) (106" "FREE : 410[M+](31%),395(8%),392(4%),381(5%),300(14%),273(30%),272(30%), 271(100%),255(14%),246(10%),231(10%),229(10%)213(14%) (106) ACETATE : 452[M+](20%),437(7%),423(9%),392(7%),363(8%),342(20%),313(100%), 299(8%),288(6%),255(48%),229(17%)" "106/126/" "ウリ科植物 (052/106/126), MOMORDICA CHARANTIA(125), ナデシコ目植物 (C-24位 立体配置不明) (066)" "052/106/126/125/066/" "ST0133" 12.00 "24,25-DIMETHYL-5α-CHOLESTA-7,24(28)-DIEN-3β-OL" "C29H48O" 29.00 48.00 1.00 0.00 0.00 0.00 412.00 " (REF:129)" " ｾ" " ﾅ／＼／＼／" " ﾓH ｶｼ" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼／ﾂ" " ｵ ｵｳ H" " ﾕ＼／ﾊ／" " HO H" "129/" "167-168ﾟC, ACETATE 145-146ﾟC (129)" "129/" "ACETATE : 795, 822, 890, 1245, 1735cm-1 (129)" "FREE:1H-NMR(CDCl3): 3-CH=3.60(M), 7-CH=5.16(M), 18-CH3=0.55(S), 19-CH3=0.80(S), 21-CH3=0.97(D), 26-CH3=1.06(S), 27-CH3=1.06(S), 28-CH2=4.66(BR.S) AND 4.84(BR.S), 29-CH3=1.06(S) (129)" "FREE : 412[M+](9%),397(14%),314(41%),299(9%),285(5%),271(100%),255(13%), 246(11%),231(13%),227(10%) ACETATE : 454[M+](9%),439(12%),379(4%),356(43%),342(9%),313(100%),296(4%),288(6%),281(4%),273(6%),255(14%),253(6%),227(14%),213(20%) (129)""" "129/" "アレチウリ(129)" "129/" "ST0134" 12.00 "24-METHYL-5α-CHOLESTA-8,24(28)-DIEN-3β-OL" "FECOSTEROL" "C28H46O" 28.00 46.00 1.00 0.00 0.00 0.00 398.00 " (REF:001)" " ｾ" " ﾅ／＼／＼／" " ﾓH ｵ" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮｹ／ﾂ" " ｵ ｵ ｵH" " ﾕ＼／ﾊ／" " HO H" "001/" "130-132ﾟC (071), BENZOATE 130-132ﾟC (130)" "+51ﾟ(071), BENZOATE +42.5ﾟ (130)" "071/130/" "FREE : 1270, 2960, 3350cm-1 (131)" "FREE:1H-NMR(CDCl3): 3-CH=3.61(M), 18-CH3=0.62(S), 19-CH3=0.95(S), 21-CH3=1.01(D), 26-CH3=1.04(D), 27-CH3=1.04(D),28-CH2=4.66(BR.S) AND 4.71(BR.S) (131)""" "FREE : 398[M+](100%),384(73%),380(8%),365(18%),314(7%),299(19%),281(4%), 271(64%),255(17%),246(23%),231(49%),213(58%) (132) ACETATE : 440[M+](100%),380(64%),356(7%),315(10%),313(49%),296(3%), 273(32%),255(31%),253(30%),213(100%) (071)" "131/132/071/" "キイチゴ培養組織(071), PICHIA属酵母(023), ケカビ(MUCOR HIEMALIS)(133), ハイイロカビ（BOTRYTIS CINEREA)代謝物(132)" "071/023/133/132/" "ST0135" 12.00 "(22E,24S)-24-ETHYL-5α-CHOLESTA-8,22-DIEN-3β-OL" "C29H48O" 29.00 48.00 1.00 0.00 0.00 0.00 412.00 " ／ (REF:050)" " ﾑ" " ﾅ／ｹ／＼／" " ﾓH ｵ" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮｹ／ﾂ" " ｵ ｵ ｵH" " ﾕ＼／ﾊ／" " HO H" "050/" "ACETATE 151-153ﾟC (052)" "052/" "FREE:1H-NMR(CDCl3): 3-CH=3.62(M), 18-CH3=0.62(S), 19-CH3=0.95(S), 21-CH3=1.03(D), 22-CH=5.14(DD), 23-CH=5.02(DD), 26-CH3=0.85(D), 27-CH3=0.80(D), 29-CH3=0.81(T) (050)" "FREE : 412[M+](100%),397(25%),394(4%),379(5%),369(7%),314(5%),299(5%),273(46%),271(31%),257(14%),255(19%),246(35%),229(36%),213(11%)(050)ACETATE:454[M+](100%),439(24%),411(11%),394(4%),379(13%),341(3%), 315(42%),313(53%),299(11%),288(53%)" "050/007/" "海綿動物(AXINELLA CANNABINA)(050), ウリ科植物(052)" "050/052/" "ST0136" 12.00 "(24R)-24-METHYL-5α-CHOLEST-8(14)-EN-3β-OL" "C28H48O" 28.00 48.00 1.00 0.00 0.00 0.00 400.00 " (REF:134)" " ﾑ" " ﾅ／＼／＼／" " ﾓH ｵ" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼ｷ" " ｵ ｵ ｵ" " ﾕ＼／ﾊ／" " HO H" "134/" "ACETATE:1H-NMR(CDCl3): 3-CH=4.72(TT), 3-Oac=2.02(S),18-CH3=0.84(S),19-CH3=0.70(S), 21-CH3=0.93(D), 26-CH3=0.85(D),27-CH3=0.80(D), 28-CH3=0.78(D) (048)" "FREE : 400[M+](100%),385(32%),382(13%),367(6%),273(21%),255(15%), 231(15%),229(29%),213(18%)(003) ACETATE : 442[M+](100%),427(16%),382(3%),367(7%),315(11%),308(7%),288(3%), 255(16%),229(25%),213(20%) (048)" "048/003/" "ヤマイモムカゴ(048), ウリ科植物種子(097), 海産双鞭毛藻類(134)" "048/097/134/" "ST0137" 12.00 "(24S)-24-METHYL-5α-CHOLEST-8(14)-EN-3β-OL" "C28H48O" 28.00 48.00 1.00 0.00 0.00 0.00 400.00 " (REF:119)" " ﾂ" " ﾅ／＼／＼／" " ﾓH ｵ" " ／＼ｮ＼" " ｵｶｽｺ" " ／＼ｮ＼ｷ" " ｵ ｵ ｵ" " ﾕ＼／ﾊ／" " HO H" "119/" "133-134ﾟC (119), ACETATE 109.5-111ﾟC (135)" "+11ﾟ (119)" "119/135/" "FREE : 3610cm-1 (119)" "ACETATE:1H-NMR(CDCl3): 3-CH=4.72(TT), 3-Oac=2.03(S),18-CH3=0.84(S),19-CH3=0.71(S), 21-CH3=0.94(D), 26-CH3=0.86(D), 27-CH3=0.79(D), 28-CH3=0.79(D) (025)" "ACETATE : 442[M+](100%),427(16%),382(3%),367(7%),315(11%),308(7%),288(3%), 225(16%),229(25%),213(20%) (048)""" "025/048/" "土壌アメーバ(ACANTHAMOEBA POLYPHAGA)(025), ヤマイモムカゴ(048), マメ科植物種子(097), CHLORELLA ELLIPSOIDEA 代謝物(119)" "025/048/097/119/" "ST0138" 12.00 "14α-METHYL-9β,19-CYCLO-5α-CHOLEST-24-EN-3β-OL" "24-DEHYDROPOLLINASTANOL" "C28H46O" 28.00 46.00 1.00 0.00 0.00 0.00 398.00 " (REF:136)" " ﾅ／＼／ｹ／" " ﾓH ｵ" " H2 ／＼ｮ＼" " Cｰｵｶｽｺ" " ／＼ｮ＼／ﾂ" " ｵ ｵ ｵ" " ﾕ＼／ﾊ／" " HO H" "136/" "112-113ﾟC, ACETATE 81-82ﾟC (136)" "+58ﾟ, ACETATE +38ﾟ (136)" "136/" "FREE : 3040, 3610cm-1 ACETATE : 1733, 3040cm-1 (136)" "FREE:1H-NMR(CDCl3): 18-CH3=0.96(S), 19-CH2=0.07(D) AND 0.43(D), 21-CH3=0.89(D), 26-CH3=1.69(BR.S), 27-CH3=1.60(BR.S),32-CH3=0.89(S) (137)" "FREE : 398[M+](36%),383(52%),380(43%),365(43%),286(30%),270(13%), 268(12%),231(17%),217(17%),205(28%),69(100%) (136) ACETATE : 440[M+](5%),425(2%),380(28%),311(3%),297(2%),286(2%),269(6%), 267(5%),231(3%),227(3%),213(3%),205(6%),201(5%),43(100%) (138)" "136/137/138/" "花粉(136), WRIGHTIA TINCTORIA 種子(138), ハシラサボテン(CEREUS GIGANTEUS) (139)" "136/138/139/" "ST0139" 12.00 "14α,24-DIMETHYL-9β,19-CYCLO-5α-CHOLEST-24(28)-EN-3β-OL" "24-METHYLENEPOLLINASTANOL" "C29H48O2" 29.00 48.00 2.00 0.00 0.00 0.00 428.00 " (REF:034)" " ｾ" " ﾅ／＼／＼／" " ﾓH ｵ" " H2 ／＼ｮ＼" " Cｰｵｶｽｺ" " ／＼ｮ＼／ﾂ" " ｵ ｵ ｵ" " ﾕ＼／ﾊ／" " HO H" "034/" "115-116ﾟC (136), ACETATE 56-57ﾟC (034)" "+47ﾟ, ACETATE +28ﾟ (136)" "136/034/" "FREE : 885, 1658, 3040, 3080, 3610cm-1 ACETATE : 885, 1635, 1735, 3040cm-1 (136)" "ACETATE:1H-NMR(CDCl3): 3-CH=4.80(M), 3-Oac=2.03(S), 18-CH3=0.96(S), 19-CH2=0.08(D) AND 0.44(D), 21-CH3=0.90(D), 26-CH3=1.03(D), 27-CH3=1.03(D), 28-CH2=4.66(D) AND 4.71(S), 32-CH3=0.90(S) (034)" "FREE : 412[M+](79%),397(84%),394(100%),379(68%),300(57%),287(34%), 269(28%) (140) ACETATE : 454[M+](12%),439(7%),411(4%),394(95%),379(45%),351(6%),329(5%), 300(6%),269(28%),267(14%),213(8%),55(100%) (0" "136/034/140/" "バナナ(034/140),マメ科植物(VIGNA MUNGO)種子(097), 花粉(136), キュウリ茎, 葉部(141)" "034/140/097/136/141/" "ST0140" 12.00 "(24R)-14α-METHYL-24-ETHYL-5α-CHOLEST-9(11)-EN-3β-OL" "C30H52O" 30.00 52.00 1.00 0.00 0.00 0.00 428.00 " ／ (REF:141)" " ﾑ" " ﾅ／＼／＼／" " ﾓH ｵ" " ／＼ｮ＼" " ｾｶｽｺ" " ／＼ｮ＼／ﾂ" " ｵ ｵ ｵ" " ﾕ＼／ﾊ／" " HO H" "141/" "ACETATE 97-98ﾟC (141)" "141/" "ACETATE:1H-NMR(CDCl3): 3-CH=4.68(M), 3-Oac=2.02(S), 11-CH=5.29(DT),18-CH3=0.66(S), 19-CH3=0.98(S), 21-CH3=0.88(D), 26-CH3=0.84(D), 27-CH3=0.82(D), 29-CH3=0.85(T) (007)" "ACETATE : 470[M+](31%),455(100%),410(3%),395(24%),329(3%),287(5%),273(6%), 269(7%),261(8%),227(8%),213(7%) (141)""" "007/141/" "マメ科植物種子(097), キュウリ茎,葉部(141)" "097/141/" "ST0141" 12.00 "CHOLEST-4-EN-3β-OL" "ALLOCHOLESTEROL,COPROSTENOL,4:5-COPROSTEN-3-OL" "C27H46O" 27.00 46.00 1.00 0.00 0.00 0.00 386.00 " (REF:001/002)" " ＼／＼" " ｵｶｽ／" " ／＼ﾇ＼ ＼" " ｵｶｽｺ" " ／＼ﾇ＼／" " ｵ ｵ ｵ" " ／＼ｷ＼／" " HO" "001/002/" "132ﾟ(ETHER-METHANOL) (002)" "[α]23/D=+43.7ﾟ(C=1 IN BENZENE)(002)" "ベンゼン,アセトン,エーテル,クロロホルム,ジオキサン,ピリジンによく溶ける。 メタノール,エタノールにも溶ける。(002)" "002/" "調製(001/002)｡ コレステロールからの分離(003)｡ ジギトニンと反応し，沈澱する(004)｡90%トリクロル酢酸によって深紅色を呈する(002)｡ ROSENHEIM反応，SALKOWSKI反応，LIEBERMANN-BURCHARD反応が陽性(002)｡" "001/002/003/004/" "ST0142" 12.00 "3α-HYDROXY-5α-ANDROSTAN-17-ONE" "ANDROSTERONE,CIS-ANDROSTERONE,3α-HYDROXY-17-ANDROSTANONE/ANDROSTAN-3(α)-OL-17-ONE3(α)-HYDROXYETIOALLOCHOLAN-17-ONE3-EPIHYDROXYETIOALLOCHLAN-17-ONE" "C19H30O2" 19.00 30.00 2.00 0.00 0.00 0.00 290.00 " (REF:005/006)" " O" " ｾ" " ／＼ﾇ＼" " ｵｶｽｺ" " ／＼ﾇ＼／" " ｵ ｵ ｵ" " ﾄ＼／ﾊ／" " HO H" "005/006/" "185-185.5ﾟC (006)" "[α]15/D=+87.8ﾟ±1.5ﾟ,[α]15/5461=+107.3ﾟ±1.5ﾟ(C=1.5379 IN DIOXAN)(006)" "ほとんどの有機溶媒に可溶。水にはほとんど溶けない。(007)" "006/007/" "MAX.: 292.5±1.0 nmMIN.: 232.5±2.5 nm (ETHANOL)(008)" "008/" "雄尿(005/006)から単離｡ 精巣，肝で生合成される｡" "005/006/" "アンドロゲンの一種で，胎生期の性分化，生殖器官(前立腺，精嚢，副精巣，精管，外陰部)の機能維持，二次性徴の発現，精子形成，骨格筋におけるタンパク質同化作用の促進などの作用がある｡ アンドロゲン作用は，テストステロンの1／10 (精嚢重量法)｡２日間の投与で去勢雄鶏の" "コレステロールからの合成(009/010)｡ジギトニンで沈澱しない(007)｡肝で, ５α−アンドロスタン−３α，１７β−ジオールに代謝されて排出される｡尿中には, グルクロン酸抱合体として排出される｡ エピアンドロステロンは３β−水酸基を持つ異性体である｡" "009/010/007/" "ST0143" 12.00 "16-(ACETYLOXY)-3,14-DIHYDROXYBUFA-20,22-DIENOLIDE, 3β,14,16β-TRIHYDROXY-5β-BUFA-20,22-DIENOLIDE 16-ACETATE" "BUFOTALIN" "C26H36O6" 26.00 36.00 6.00 0.00 0.00 0.00 444.00 " (REF:011/012/013/014/015/016)" " ｧｧ" " ／ｦｦ＼ｧO" " ｶｸｽ ／" " ／＼ﾇ＼ O" " ｵｶｽｺ＼" " ／＼ﾇ＼ｬ OCOCH3" " ｵ ｵ ｵOH" " ／＼／＼／" " HO" "011/012/013/014/015/016/" "269-272ﾟC(3-ACETATE),233ﾟC(FREE)(013)" "[α]20/D=+5.4ﾟ(C=0.5 IN CHCl3)(013)" "アルコール,クロロホルムに可溶。(017)" "013/017/" "MAX : 300 nm (015)" "100mHz:PYRONE RING PROTONS,δ6-17(Ha,DOUBLET,Jab=9Hz,Jac=1Hz),8.04(Hb,QUARTETJab=9Hz,Jbc=2.7Hz),7.24(Hc),WHILE RING D 17α-PROTON Hd APPEARED AS A DOUBLET AT δ2.72,J=9Hz.BECAUSE Jed AND Jef WERE BOTH 9Hz,He CORRESPONDED TO ASEXTET ET AT δ5.54 WITH Jeg=　A SINGLET AT δ4.15(Hh) WAS DIAGNOSTIC FOR A/B RING STEREOCHEMISTRY.(016)" "M/E: 444(M,5%)(M FOR C26H36O6-444);384(M-60,100%);336(M-60-18,61%);351(M-60-18-15,9%);348(M-60-36,10%);341(M-60-43,80%);323(M-60-43-18, 68%). METASTABLEION PEAKS AT M/E 332.0(440→384),349.0(384→366),AND 303.0(384→341) WERE OBSERVED.(016)" "015/016/" "ヒキガエル（ガマ）の皮腺分泌物（がま毒）主成分，ブホトキシンの構成成分(011/012/013/014/015/016/017)｡" "011/012/013/014/015/016/017/" "ブホトキシンは, 古来より心臓毒として知られている｡ 特にシナヒキガエル(Bufo bufo gargorizans)の分泌物を乾燥したものは, センソという名で漢薬として用いら れている｡ ブホトキシンの加水分解によってブホタリンとスベリルアルギニン(subenylarginine)に分解する。日本" "ネコでの最小致死量=390μg/kg｡ 溶媒和した結晶｡ 154ﾟCで湿潤し, 分解点23ﾟC｡ 合成法(018)" "018/" "ST0144" 12.00 "(25R)-5α-SPIROSTAN-3β,6α-DIOL" "CHLOROGENIN" "C27H44O4" 27.00 44.00 4.00 0.00 0.00 0.00 432.00 " O H (REF:019/020/021/022)" " ﾄ＼ｽｽｵ" " ﾂ ﾄ ／ﾅ" " ｶｼｻｼｼ＼／" " ／＼ﾇ＼／O" " ｵｶｽｺ" " ／＼ﾇ＼／ﾂ" " ｵ ｵ ｵH" " ／＼／ﾊ／" " HO H ﾂ" " OH" "019/020/021/022/" "273-276ﾟ,154-155ﾟ(DIACETATE)(023)" "[α]24/546 = -52ﾟ(CHCl3 OR ISOPROPANOL)(023)" "チゴゲニンほどメタノールに溶けない。チゴゲニンよりイソプロパノールに溶ける｡(023)" "023/" "PMR(δ)(PYRIDINE): 0.83(19-Me),0.86(18-Me),1.12d(21-Me,J=7Hz),1.05d(27-Me, J=7Hz),3.30d(26-H2,J=11Hz),3.39dd(26-H2,J=11,3Hz), 4.45ddd(16-H,J=7,7,7Hz), 3.70m(3H AND 6H) (024)" "M+ AT M/E 432 (024)" "024/" "メキシコ産リュウゼツラン類の植物の根(AMOLE,CALIFORNIA SOAP PLANT,CHLOROGALUM POMERIDIANUM)(025) """ "025/" "魚類を殺したり，気絶させたりする（そうやって捕獲した魚類を食用に供しても問 題はない。）のに用いられるサポニン。" "チゴゲニンへの変換(023)｡ジギトニンと反応する(019)｡" "023/019/" "ST0145" 12.00 "DIHYDROXYCHOLESTEROL, 3β-HYDROXYCHOLESTAN, 5α-CHOLESTAN-3β-OL" "CHOLESTANOL, β-CHOLESTANOL" "C27H48O" 27.00 48.00 1.00 0.00 0.00 0.00 388.00 " (REF:026/027)" " ＼／＼" " ｶ ｶｽ／" " ／＼ﾇ＼ ＼" " ｵｶｽｺ" " ／＼ﾇ＼／" " ｵ ｵ ｵ" " ／＼／ﾊ／" " HO H" "026/027/" "141.5-142ﾟC(026)" "[α]22/D=+28.8ﾟ(026)" "1gがだいたい100mlのアルコール,200mlのメタノールに溶ける。加熱アルコール， エーテル，クロロホルムによく溶ける。(028)" "026/028/" "N,M,R: 9.20(19-H), 9.36(18-H)(029)" "029/" "動物細胞でコレステロールとともに微量存在(030)｡ 人糞，胆石，卵(028)｡海綿の主要なステロール(030)｡" "030/028/" "不明。" "ジギトニンで沈澱する。コレステロールの還元で生成(026/027)｡ コプロステノンから生成(031)｡コレステロールのＢ環の二重結合が飽和になったもので，哺乳動物の正常組織に存 在するが，コレステロールの1/400〜1/500くらいの微量である。コレステロールが 腸内" "026/027/031/" "ST0146" 12.00 "5β-CHOLESTAN-3β-OL" "CHOLESTEROL, 3β-CHOLESTANOL,STERCORIN" "C27H48O" 27.00 48.00 1.00 0.00 0.00 0.00 388.00 " (REF:032/033/034)" " ＼／＼" " ｶ ｶｽ／" " ／＼ﾇ＼ ＼" " ｵｶｽｺ" " ／＼ﾇ＼／" " ｵ ｵ ｵ" " ／＼／ﾉ／" " HO H" "032/033/034/" "101ﾟC(メタノール)(035)" "[α]18/D=+28ﾟ(C=1.8 IN CHCl3)(036)" "エーテル，クロロホルム，ベンゼンに可溶。メタノールにわずかに可溶 (1g/145ml MeOH)。水に可溶(036)。" "035/036/" "ヒト(032/034),ラット(033),食肉獣(036)の糞｡" "032/034/033/036/" "不明。" "コプロステノン(COPROSTENONE)からの調製法(035/037) コプロステノール(COPROSTENOL)からの調製法(002/038/039/040) コレステロールからの調製法(041)｡コレステロールの二重結合が飽和されたもの。コレスタノールの異性体である。内 因性コレステロールと腸管内" "036/035/037/002/038/039/040/041/" "ST0147" 12.00 "CHOLEST-5,7-DIEN-3β-OL" "7-DEHYDROCHOLESTEROL,PROVITAMIN D3" "7-DHC" "C27H44O" 27.00 44.00 1.00 0.00 0.00 0.00 384.00 " (REF:042)" " ＼／＼" " ｶ ｶｽ／" " ／＼ﾇ＼ ＼" " ｵｶｽｺ" " ／＼ﾇ＼／" " ｵ ｵｳ" " ／＼／ｸ／" " HO" "042/" "149-150ﾟ(043)" "[α]20/D=-122.5ﾟ(BENZENE),-113.6ﾟ(CHCl3)(043/045)" "エーテル，クロロホルムに可溶。メタノールに少し溶ける。水に不溶。(045)" "043/045/" "λ,nm(ε): MIN.230(150),MAX.262.5(740),MAX.271(1040),MIN.276(883), MAX.281.5(1075),MIN.288(553),MAX.293(615),MAX.321(36) (008)" "E(1%/1cm)(λ,nm): 39.1(2300),193(2625),271(2710),230(2760),280(2815), 144(2880),160(2930),0.9(3210)(046)" "008/046/" "動物の組織(047),ブタ皮膚(048),エッチュウバイBUCCINUM UNDATUM(HORNED SNAIL)(049/050)" "047/048/049/050/" "紫外線照射によって，コレカルシフェロール（ビタミンD3）に変換される。コレステロール生合成の前段階物質でもある。 抗くる病活性を持つ。(051/052)" "051/052/" "７−デヒドロコレステロールはネズミ肝から分離されている。工業的には，コレステロールエステルにＮ−ブロモスクシンイミドを働かせ、７− ブロモコレステロールを中間体として合成する。ブタの皮膚では総ステロールの ５％を占める。 ジギトニンと反応してジギトニ" "053/054/055/" "ST0148" 12.00 "CHOLEST-5,24-DIEN-3β-OL" "DESMOSTEROL,24-DEHYDROCHOLESTEROL,DESMESTEROL" "C27H44O" 27.00 44.00 1.00 0.00 0.00 0.00 384.00 " (REF:056/057/058)" " ＼／＼" " ｶ ｶｧ／" " ／＼ﾇ＼ ＼" " ｵｶｽｺ" " ／＼ﾇ＼／" " ｵ ｵｶ" " ／＼／ｸ／" " HO" "056/057/058/" "120.5-121.0ﾟC(METHANOL)117-118ﾟC,120-122ﾟC(057/059/060)" "(↑057/059/060)" "[α]/D=-37.9ﾟ,[α]27/D=-40.2(C=1 IN CHCl3)(057)" "エーテル，ベンゼン，クロロホルム，エタノールに可溶。(061)" "057/059/060/061/" "MAX.: 320mμ(E1%/1cm 240), 433mμ(E1%/1cm 154), MIN.: 256mμ(E1%/1cm 93), 393mμ(E1%/1cm 109), (7x10-7 M IN 97% 硫酸) (057)" "1125, 1012, 900cm-1(THP ETHER) (057/058/060)" "NMR 41(18-CH3), DOUBLET CENTERED AT 51(J=6Hz,21-CH3), 61(19-CH3), 97 AND 102(26.27 METHYLS), 210(3α-H) AND 303(24-H), 320(6-H)(057/058/060)" "M/E: 91(31%), 93(48%), 95(52%), 105(37%), 107(41%), 109(33%), 117(12%),119(44%), 121(34%), 123(15%), 129(100%), 130(17%), 131(20%), 133(26%), 135(17%), 143(20%), 145(32%), 147(22%), 149(13%), 159(25%), 161(18%), 173(12%), 213(13%), 245(12%)," "057/058/060/" "ニワトリ胚(057),紅色植物(058),ネズミ皮膚(056),フジツボ(059) """ "057/058/056/059/" "24位の二重結合が還元されて，コレステロールとなり，利用される。" "コレステロールの生合成前駆物質。コレステロールと共存している場合が多く，分 別結晶，カラムクロマトグラフィーによって単離する。 合成法(060/062/063/064)" "060/062/063/064/" "ST0149" 12.00 "2,3,14,22,25-PENTAHYDROXYCHOLEST-7-EN-6-ONE" "α-ECDYSONE" "C27H44O6" 27.00 44.00 6.00 0.00 0.00 0.00 464.00 " OH (REF:065/066)" " H ﾂ" " ﾅｫ＼／＼／" " ｶ ﾉ" " ／＼ﾇ＼ OH" " HO ｵｶｽｺ" " ＼／＼ﾇ＼／ﾂ" " ｵ ｵｳ OH" " ／＼ｬ＼／" " HO H ｾ" " O" "065/066/" "238-239ﾟC(067/068)" "[α]20/578 = +62ﾟ(067)" "エタノールに可溶。(065)" "065/067/068/" "MAX: 243nm(ε=11600) 293mμ(ε=15800) (065/068)" "IR in KBr(cm-1): 1658, 1652 (069)" "νmax 73(18-H), 107(19-H), 124 AND 131(21-H), 138(26-H AND 27-H)CPS (070)" "M/E(t-190ﾟ): 446(3%), 428(29), 418(2), 413(2), 410(3), 372(3), 359(4), 348(8), 330(15), 315(18), 300(23), 279(17), 267(5), 255(8), 250(13), 249(10), 99(100), 81(61) (071)""" "065/068/069/070/071/" "カイコ(BOMBYX MORI)(072)エゾデンダ(POLYPODIUM VULGARE L. シダ類の１種)(073)ワラビ(PTERIDIUM AQUILIUM (L.))(074)" "072/073/074/" "昆虫や甲殻類など，節足動物の脱皮や変態を誘導するホルモン。 主に脂肪体などで20R位がヒドロキシル化されて20-ヒドロキシエクジソン（β−エ クジソン）となる。培養細胞系や成虫原基を用いた検定法によると，20-ヒドロキシエクジソンの活性はエクジソンの200〜500倍であ" "071/074/070/068/075/" "ST0150" 12.00 "2,3,14,20,22,25-HEXAHYDROXYCHOLEST-7-EN-6-ONE" "β-ECDYSONE,20-HYDROXYECDYSONE,ECDYSTERONE,CRUSTECDYSONE, ISOINOKOSTERONE," "C27H44O7" 27.00 44.00 7.00 0.00 0.00 0.00 480.00 " OH (REF:065/076/077/078/079)" " OH ﾂ" " ﾅｫ＼／＼／" " ｶ ﾉ" " ／＼ﾇ＼" " HO ｵｶｽｺ" " ＼／＼ﾇ＼／ﾂ" " ｵ ｵｳ OH" " ／＼ｬ＼／" " HO H ｾ" " O" "065/076/077/078/079/" "240-242ﾟC(METHANOL-ETHYLACETATE)(079)" "[α]28/D = +63ﾟ(C=1.0,MeOH)(080)" "メタノール，エタノールに可溶。(080)" "079/080/" "MAX : 243nm(ε= 10300) 240nm(ETHANOL,ε= 12670) 242nm(METHANOL,ε= 12400) (067/079/077)" "νKBr/MAX 1656, 1615, 1387, 1229, 1053, 917, 878 cm-1 (079)" "NMR(PYRIDINE-d5) 1.07(19-H), 1.20(18-H), 1.36(26- AND 27-H), 1.56(21-H), 6.17(7-H) (079)" "M/E: 480(ECDYSON+O), 462(M-H2O), 444(M-2H2O), 426(M-3H2O), 408(M-4H2O)(077)" "067/079/077/" "カイコ(BOMBYX MORI)(077) ザリガニ(JASUS LALNDEI)(078) 牛膝(ACHYRANTHIS RADIX)(PHYTOECDYSONEとして)(080)マキ(PODOCARPUS ELATUS，針葉樹類，オーストラリア材木)(081) マメヅタ(LEMMAPHYLLUM MICROPHYLLUM)(082) エンレイソウ(TRILLIUM SMALLI)(082)" "077/078/080/081/082/" "079/083/084/085/" "ST0151" 12.00 "3-HYDROXYESTRA-1,2,5(10),7-TETRAEN-17-ONE" "EQUILIN, 1,3,5,7-ESTRATETRAEN-3-OL-17-ONE" "C18H20O2" 18.00 20.00 2.00 0.00 0.00 0.00 268.00 " (REF:086/087)" " O" " ｳ" " ／＼ﾇ＼" " ｵｶｽｺ" " ｴ＼／＼／" " ｵｳ ｳ" " ／ｸ／＼／" " HO" "086/087/" "237-239ﾟC(087),238-240ﾟC(088),237-240ﾟC(089)" "[α]15/D=+308(DIOXANE)(088), [α]25/D=+304ﾟ(DIOXANE)(087), [α]/D=+295ﾟ(C=1,EtOH)(089)" "087/088/089/" "UV MAX : 283-285nm (090) 282nm(EtOH)(089)" "logε= 3.36(282nm) (089)" "089/" "妊娠馬尿(088/091)" "088/091/" "エストロゲン活性を示す｡ ラットの皮下注射による生物検定法で調べると,エストロンより弱いがエストリオールよりはるかに強い｡ エストロンの1／20の生物活性｡" "酢酸からコレステロールが合成される際の中間体であるファルネシルピロリン酸か ら生合成される｡ コレステロールからは生合成されない｡ 19-ノルテストステロンアセテートから４種類の中間体を経て合成することができる。(089) また，より手に入りやすいジエノン化合物から" "089/092/093/094/095/096/" "ST0152" 12.00 "(3β,22E)-ERGOSTA-5,7,22-TRIEN-3-OL" "ERGOSTEROL,ERGOSTERIN,PROVITAMIN D2" "C28H44O" 28.00 44.00 1.00 0.00 0.00 0.00 396.00 " (REF:097)" " ｵ" " ＼／ｹ／＼／" " ｵ ｵ" " ／＼ﾇ＼" " ｵｶｽｺ" " ／＼ｫﾊ／" " ｵｶ Hｳ" " ／＼／ｸ／" " HO" "097/" "168ﾟC(ALCOHOL)(098)" "bp0.01 = 250ﾟC(098)" "[α]20/D=-135ﾟ(C=1.2 in CHCl3), [α]20/546=-171ﾟ(CHCl3)(099)" "加熱クロロホルム, ベンゼンに可溶｡ メタノール, エタノール, エーテル, 軽石油エーテルに少し溶ける｡ 水に不溶｡ (050)" "098/099/050/" "λMAX.nm(ε); 262(6940); 271(10000); 282(10600); 293(6060).λMIN.nm(ε); 230(1430); 263(6850); 275.5(8580); 289(5450); 317.5(35) (008)" "E 1%/1cm(λ.A); 36.1(2300); 175(2620); 173(2630); 253(2710); 217(2755); 268(2820); 138(2890); 158(2930); 0.8(3175) (046)" "008/046/" "麦角，酵母，クロレラ，カビ(100/101) 最も量の多いミコステロール（菌類ステロール）で, 細胞や菌子体膜の重要な構成 成分｡ ある種の原生動物（トリパノソーマや土壌アメーバ）, 原始的な維管束植物ヒカゲノカズラ類, LYCOPODIUM COMPLANATUM）でも合成されている｡" "088/091/" "紫外線照射によって，エルゴカルシフェロール（ビタミンＤ2）を形成する。従って，抗くる病活性を持つ。" "紫外線照射によってエルゴステロールの5,7-ジエンステロール骨格は,9,10位間で開裂し, プレエルゴカルシフェロール（プレビタミンＤ2）になる｡ ついで熱依存性の異性化反応によってエルゴカルシフェロールとなる｡ ジギニンと分子化合物を形成する｡ この反応は遊離ステロ" "ST0153" 12.00 "(17β)-ESTRA-1,3,5(10)-TRIENE-3,17-DIOL" "β-ESTRADIOL,CIS-ESTRADIOL,ESTRADIOL, 3,17-EPIDIHYDROXYESTRATRIENE,DIHYDROFOLLICULAR HORMONE, DIHYDROFOLLICULIN,DIHYDROXYESTRIN, DIHYDROTHEELIN, COMPUDOSE 365,DIHYDROMENFORMON, DIMENFORMON, DIOGYN, ESTROVITE, FEMESTRAL, GYNERGON, GYNOESTRYL, LAMDIOL, MACRODIOL, OESTERGON, OVAHORMON, OVASTEROL,OVOCYCLIN, OVOCLIN PROFOLIOL, PROGYNON-DH., PERLATANOL, PRIMOFOL," "C18H24O2" 18.00 24.00 2.00 0.00 0.00 0.00 272.00 " (REF:103)" " OH" " ｵ" " ／＼ﾇ＼" " ｵｶｽｺ" " ｴ＼／＼／" " ｵｳ ｶ" " ／ｸ／＼／" " HO" "103/" "173-179ﾟC(104)" "[α]25/D=+76-+83ﾟ(DIOXANE)(104)" "水にほとんど不溶。アルコール，アセトン，ジオキサン，など有機溶媒に可溶。植物油には，わずかしか溶けない。(104)" "104/" "MAX : 225, 280nm (104)" "ε=2120(281nm), E1%/1cm=78 (105)" "104/105/" "哺乳動物の卵巣，胎盤，精巣，副腎皮質など。(104)" "104/" "最も強力なエストロゲン｡ １ｍｇ＝10,000ＩＵ｡ 卵巣の成熟した卵胞および妊娠した場合胎盤で合成・分泌される｡ エストロゲンは雌の動物において付属性腺（子宮，腟，外陰部）の発育と生殖に必要なホルモン｡ 排卵直前に血中濃度が最高になる｡ 排卵後はエ" "ST0154" 12.00 "ESTRA-1,3,5(10)-TRIENE-3,16,17-TRIOL" "ESTRIOL, 1,3,5-ESTRATRIENE-3β,16α,17β-TRIOL, 3,16α,17β-TRIHYDROXY-Δ1,3,5-ESTRATRIENE16α-HYDROXYESTRADIOL, FOLLICULAR HORMONE HYDRATE, OESTRIOL, TRIHYDROXYESTRIN, AACIFEMINE, COLPOGYN,DESTRIOL, GYNASAN, HORMOMED, KLIMAX E, KLIMORAL,OEKOLP, ORTHO-GYNEST, OVESTERIN, OVESTIN,OVO-VINCES, THEELOL, TRIDESTRIN,TRIOVEX" "C18H24O3" 18.00 24.00 3.00 0.00 0.00 0.00 288.00 " (REF:108/109)" " OH" " ｵ OH" " ／＼ﾇ＼ﾄ" " ｵｶｽｺ" " ｴ＼／＼／" " ｵｳ ｶ" " ／ｸ／＼／" " HO" "108/109/" "282ﾟC(ALCOHOL),268.5-269.5ﾟC(MeOH) (110/111)" "[α]25/D=+58ﾟ±5ﾟ(110/111)" "水に不溶。アルコール，ジオキサン，クロロホルム，エーテル，植物油に可溶。ピリジンによく溶ける。(112)" "110/111/112/" "MAX : 280nm (113)" "E1%/1cm=75,ε=2150(280nm) (113)" "113/" "妊婦尿(114/115)，胎盤(116/117)，ネコヤナギ(118)" "114/115/116/117/118/" "エストロゲンの一種で,その作用はエストラジオール,エストロンに比べ,非経口投与でははるかに弱いが,経口投与では三者のうち最も強い｡ エストリオールは子宮体部よりむしろ頚部に作用し，頚管の開大と頚管腺の分泌を旺盛にし, 出産を容易にする｡" "部分合成(111), 合成(119/120) ジギトニンで沈澱する。妊婦尿中に多量に存在し, その90%以上は, グルクロン酸その他の抱合体として存在するが, 抱合体を含めた尿中全エストリオール値は, 妊娠末期には１日30mgと他の 二者の和の10倍にも達する｡ 胎児の成長に伴い," "111/119/120/" "ST0155" 12.00 "3-HYDROXYESTRA-1,3,5(10)-TRIEN-17-ONE" "ESTRONE, OESTRONE, THEELIN, FOLLICULIN,1,3,5-ESTRATRIEN-3-OL-17-ONE,FOLLICULAR HORMONE, TOKOKIN, THELYKININ,KETOHYDROXYESTRIN, HIESTRONE, MENFORMON,FOLLESTRINE,FOLLIDRIN,FOLLICUNODIS,HORMOFOLLIN,OESTRIN, OESTROFORM,OVIFOLLIN,PERLATAN,KETODESTRIN,UNDEN. GLANDUBOLIN,CRISTALLOVAR,DESTRONE,ENDOFOLLICULINA,ESTROL,FEMIDYN,FOLIKRIN,OVEX,KOLPON,CRINOVARYL,FOLISAN,DISYNFORMON,HORMOVARINE,OESTROPEROS,WYNESTRON,THELESTRIN,KESTRONE,ESTRUSOL,ESTRUGENONE,FEMESTRONE INJ.,FOLIPEX," "C18H22O2" 18.00 22.00 2.00 0.00 0.00 0.00 270.00 " (REF:121/122)" " OH" " ｳ" " ／＼ﾇ＼" " ｶ Hｶｽｺ" " ｴ＼／ﾊﾇﾂ" " ｵｳ Hｶ H" " ／ｸ／＼／" " HO" "121/122/" "254.5-256ﾟC(ACETONE),240ﾟC(AZOATE) (123/124)" "[α]22/D=+152ﾟ(123)" "3g/100ml水(25ﾟC),1gが96%アルコール(15ﾟC)250ml,沸騰アルコール50ml,アセトン50ml(15ﾟC),クロロホルム110ml(15ﾟC),沸騰ベンゼン145mlに可溶｡ジオキサン, ピリジン,水酸化アルカリの水溶液に可溶｡エーテル,植物油には少ししか溶けない｡(125)" "123/124/125/" "MAX : 282,296nm(p-DIOXANE,ε=2300,2130); 300,450nm(CONC.H2SO4); 239,293nm(0.1M NaOH)(125)" "IR νMAX(CHCl3):1693cm-1(METHYL ETHER)(126)" "NMR(CCl4)δ:1.08(3H,s,-CH3), 3.69(3H,s,OCH3), 6.39-6.72(2H,m,C2H), 7.08(1H,d,J=9Hz,C,H) (METHYL ETHER) (126)" "M/E 298(M+) (METHYL ETHER) (126)" "E1%/1cm=77(280nm,ε=2080)(105)" "125/126/105/" """妊婦,婦馬尿,卵胞液,ヒト胎盤,雄ウシ・種ウマ尿,ヤシの実油,ナツメヤシ花粉粒, (121/122/124/127)モグハット(MOGHAT,124)" "121/122/124/127/" "エストロゲンの一種。発情作用を示す。しかし，エストラジオール−17βより弱 い。" "ジギトニンで沈澱する。アンドロステンジオンから卵巣，胎盤，ウマ精巣などのアロマターゼによって酸素 とＮＡＤＰＨの存在下で合成される｡ ＮＡＤＰＨの存在下, 17β−ヒドロキシステロイドデヒドロゲナーゼによって, エストロゲン活性が約８倍のエストラジオール に変" "128/129/123/130/131/132/133/134/126/135/" "ST0156" 12.00 "(3β,4α,5α,24Z)-4-METHYLSTIGMASTA-7,24(28)-DIEN-3-OL" "α-SITOSTEROL, CITROSTADIENOL" "C30H50O" 30.00 50.00 1.00 0.00 0.00 0.00 426.00 " ／ (REF:136/137/138)" " ｾ" " ＼／＼／＼／" " ｵ ｵ" " ／＼ﾇ＼" " ｶ ｶｽｺ" " ／＼ｫ＼／" " ｵ ｵｳ" " ／＼／ﾊ／" " HO ﾃ H" "136/137/138/" "164-166ﾟC(FREE),137ﾟC(ACETATE),168-172ﾟC(BENZOATE)(136/139)" "[α]28/D=-1.7(C=2 in CHCl3),[α]25/D=-1.7(ACETATE)(136/139)" "アルコール,ベンゼン, ピリジンに可溶｡(139)" "136/139/" "M/Eか200以上の%: M(3),M-15(3),M-(15+18)(-),M-98(57),M=(98+15)(8), M-(98+18)(3),M-127(3),M-(98+15+18)(4),M-141(100), M-(139+18)(8),M-(141+18)(7),M-165(10),M-181(6), M-(165+18)(3),M-184(2),M-185(3),M-(181+18)(9)(140)""" "140/" "麦芽油(141/139)，コーン油(142)植物全般(143)" "141/139/142/143/" "ジギトニンと反応して沈澱する(143)。シトロスタジエノールと同一(144/145)。立体化学(140)" "143/144/145/140/" "ST0157" 12.00 "(3β)-STIGMAST-5-EN-3-OL" "β-SITOSTEROL, 22:23-DIHYDROSTIGMASTEROL" "C29H50O" 29.00 50.00 1.00 0.00 0.00 0.00 414.00 " C2H5 (REF:146/147/143)" " ｵ" " ＼／＼／＼／" " ｵ ｵ" " ／＼ﾇ＼" " ｶ ｶｽｺ" " ／＼ｫ＼／" " ｵ ｵｶ" " ／＼／ｸ／" " HO" "146/147/143/" "140ﾟC, 127-128ﾟC(ACETATE)(143), 136-137ﾟC(147)" "[α]25/D=-37ﾟC(C=2 in CHCl3)(143),-41ﾟC(ACETATE)(147)" "143/147/" "TMS誘導体(分子量486): 129(100%), 357(98%), 396(66%), 121(58%), 145(45%),215(42%) (148)" "148/" "麦芽油，コーン油(142) ライ麦油(149) 綿実油(150)トール油(151)ダイズ，カラバルマメ，コメ胚芽(152)カスカラ(RHAMNUS PURSHIANA)，クロウメモドキ属の植物(153)シンコナ（キナノキの樹皮)" "142/149/150/151/152/153/" "抗高コレステロール血症剤，前立腺腫の治療に用いられる(154/155/156)。 立体特異的合成(157)。コレステロール吸収の阻害(158/159)誘導発ガンの阻害(160)｡ 代表的な植物ステロール｡ 高等植物に広く分布｡ 通常カンペステロール, スチグマ ステロールなどと共存している。" "154/155/156/157/158/159/160/" "ST0158" 12.00 "(3β,24S)-STIGMAST-5-EN-3-OL" "γ-SITOSTEROL, CLIONASTEROL" "C29H50O" 29.00 50.00 1.00 0.00 0.00 0.00 414.00 " ／ (REF:161)" " ﾁ" " ＼／＼／＼／" " ｵ ｵ" " ／＼ﾇ＼" " ｶ ｶｽｺ" " ／＼ｫ＼／ﾂ" " ｵ ｵｶ H" " ／＼／ｸ／" " HO" "161/" "147-148ﾟC(ALCOHOL)(162/163/164)" "[α]20/D=-43ﾟC(C=1.9 in CHCl3)(162/163/164)" "162/163/164/" "ダイズ油の主要なステロール(162) コーン油(141)" "162/141/" "β−シトステロールとは，C-24での立体配置が異なる(165)。異性体特異的な合成(157)。" "165/157/" "ST0159" 12.00 "(3β,22E)-STIGMASTA-5,22-DIEN-3-OL" "STIGMASTEROL,ANTI-STIFFNESS FACTOR, 3β-HYDROXY-24-ETHYL-Δ5,22-CHOLESTADIENE" "C29H48O" 29.00 48.00 1.00 0.00 0.00 0.00 412.00 " (REF:166/167/168/169)" " ＼／ｹ" " ｵｶｽ／" " ／＼ﾇ＼ｶ ＼" " ｶ ｶｽｺ ＼" " ／＼ｫ＼／" " ｵ ｵｶ" " ／＼／ｸ／" " HO" "166/167/168/169/" "144.0-144.6ﾟC(ACETATE),170ﾟC(FREE)(170/171/172)" "[α]22/D=-51ﾟC(C=2 in CHCl3),[α]20/D=-55.6ﾟ(ACETATE,C=2,in CHCl3)(171/172)" "水に不溶。通常の有機溶媒に可溶。(172)" "170/171/172/" "TMS : 484(22%), 394(35%), 255(63%),145(32%),133(38%),129(100%)(148)" "148/" "カラバル豆(PHYSOSTIGMA VENENOSUM)(173) インゲン豆(PHASEOLUS VULGARIS)(174) トウモロコシ，ココナッツ，ナタネ，コメヌカ，ダイズの各油(170/175/176) 植物界に広く分布。" "173/174/170/175/176/" "ANTISTIFFNESS FACTOR （抗硬直因子）(177)。" "177/" "ステロイドホルモンの工業的合成の重要な出発材料。植物界に広く分布し，β−シトステロールやカンペステロールと共存する場合が多 い。 酢酸エステルの四臭化物がエーテルに溶けにくいことを利用して他のステロールか ら分離精製する。(178)" "178/" "ST0160" 12.00 "17β-HYDROXYANDROST-4-EN-3-ONE" "TESTOSTERONE,Δ4-ANDROSTEN-17β-OL-3-ONE,TRANS-TESTOSTERONE, GENO-CRISTAUX GREMY,MALESTRONE(AMPS), ORQUISTERON,PERCUTACRINE ANDROGENIQUE, PRIMOTEST,PRIMOTESTON, SUSTANON, MERTESTATE," "C19H28O2" 19.00 28.00 2.00 0.00 0.00 0.00 288.00 " (REF:179/180/181/182/183)" " OH" " ｵ" " ／＼ﾇ＼" " ｶ ｶｽｺ" " ／＼ｫ＼／" " ｵ ｵｶ" " ｴ＼ｷ＼／" " O" "179/180/181/182/183/" "154-154.5ﾟC(179)" "[α]24/D=+109ﾟ(C=4 in ALC.)(179)" "水に不溶。アルコール，エーテル，他の有機溶媒に可溶。(184)" "179/184/" "MAX : 238nm(logε= 4.23) (181/185)" "E 1%/1cm = 582(240nm,ε= 16800) (186)" "181/185/186/" "雄牛睾丸(187)などの間質細胞（ライディヒ細胞）から産生される主要なホルモン (184)。睾丸から微量に単離される。" "187/184/" "0.015mg =１IU。ラット（メス）腹腔内投与によるＬＤ100＝325mg／kg。精巣から分泌される代表的なアンドロゲン（雄性ホルモン）で，胎生期の性分化， 生殖器官（前立腺，精嚢，副精巣，精管，外陰部）の機能維持、二次性徴の発現， 精子形成，骨格筋などにおけるタ" "ST0161" 12.00 "21-(ACETYLOXY)-3β-HYDROXYPREGN-5-EN-20-ONE, 3β,21-DIHYDROXYPREGN-5-EN-20-ONE 21-ACETATE; 5-PREGNENE-3β,21-DIOL-20-ONE21-ACETATE; 21-ACETOXY-5-PREGNEN-3-OL-20-ONE; 3-HYDROXY-21-ACETOXY-5-PREGNEN-20-ONE" "21-ACETOXYPREGNENOLONE,ACETOXANON" "A.O.P." "C23H34O4" 23.00 34.00 4.00 0.00 0.00 0.00 374.00 " CH2OCOCH3 (REF:188)" " |" " CO" " H3C ｵ" " ／＼ﾇ＼" " H3C ｵｶｽｺ" " ／＼ﾇ＼／" " ｵｶ ｶ" " ／＼／ｸ／" " HO" "188/" "184-185ﾟC (188)" "エーテル、ペンタンにほんのわずかに溶ける。クロホルム、トルエンに溶ける。(188)" "188/" "・DESOXYCORTICOSTERONE ACETATE合成の中間体(188) ・合成法(188)" "188/" "抗炎症作用(188)" "188/" "ST0162" 12.00 "[8S-(5α,8α,9β,10α,13α,14β,17α)]-17-ETHYLHEXADECAHYDRO-10,13-DIMETHYL-1H-CYCLOPENTA[A]PHENANTHRENE" "ALLOPREGNANE,5α-PREGNANE" "C21H36" 21.00 36.00 0.00 0.00 0.00 0.00 288.00 " CH3 (REF:189/190/191/192)" " |" " CH2" " H3C |" " ／＼ﾇ＼" " H3C ｵｶｽｺ" " ／＼ﾇ＼／" " ｵｶ ｶ" " ＼／ﾊ／" " H" "189/190/191/192/" "84-85ﾟC(ACETONE+METHANOL) (189)" "[α]/D=+18.0ﾟ(C=1.388 in CHLOROFORM) (190/191)" "クロロホルム、メタノールに可溶。(189/190/191/192) 石油エーテルに可溶。(193)" "189/190/191/192/193/" "・CORTICOSTERONEから調製(189) ・ALLOPREGNAN-3-ONEから調製(190)・CONESSINEの分解による(192)・3β-及び3α-DIMETHYLAMINOPREGNANESのHOFMANN分解による(194)" "189/190/192/194/" "ST0163" 12.00 "3α,17,21-TRIHYDROXY-5α-PREGNANE-11,20-DIONE" "ALLOTETRAHYDROCORTISONE,REICHSTEIN'S SUBSTANCE DEHYDRO-C" "C21H32O5" 21.00 32.00 5.00 0.00 0.00 0.00 364.00 " CH2OH (REF:195)" " ｵ" " CO OH" " O H3C ﾓ" " ｸ／＼ﾇ＼" " H3C ｵｶｽｺ" " ／＼ﾇ＼／" " ｵｶ ｶ" " ﾄ＼／ﾊ／" " HO H" "195/" "212-214ﾟC (195)" "[α]25/D=+94.2ﾟ±1.5ﾟ(C=1.45 IN DIOXANE AS 3α,21-DIACETATE) (195)" "195/" "・牛副腎(195) ・3α,21-DIACETATEとしての合成(196)" "195/196/" "ST0164" 12.00 "5 -ANDROSTANE" "ANDROSTANE, 5α-ANDROSTANE, ETIOALLOCHOLANE" "C19H32" 19.00 32.00 0.00 0.00 0.00 0.00 260.00 " (REF:192)" "ｵ" " CH3" " ／＼ﾇ＼" " H3C ｵｶｽｺ" " ／＼ﾇ＼／" " ｵｶ ｶ" " ＼／ﾊ／" " H" "192/" "50-50.5ﾟC (ACETONE-METHANOL) (199)" "[α]16/D=+2ﾟ±2ﾟC(C=1.22 IN CHLOROFORM) (199)" "アセトン,エタノール,メタノール,エーテル,石油エーテル,クロロホルムに可溶｡ (199)" "199/" "・アンドロスタンジオンから調製(197) ・アンドロスタン-3,17-ジオールから調製(198) ・Δ16-アンドロステンから合成(199)" "197/198/199/" "ST0165" 12.00 "3,11-DIHYDROXYANDROSTAN-17-ONE, ANDROSTANE-3β,11β-DIOL-17-ONE" "C19H30O3" 19.00 30.00 3.00 0.00 0.00 0.00 306.00 " (REF:200/201/202)" "ｵ" " O" " HO H3C ｾ" " ＼／＼ﾇ＼" " H3C ｵｶｽｺ" " ／＼ﾇ＼／" " ｵｶ ｶ" " ／＼／ﾊ／" " HO H" "200/201/202/" "235-238ﾟC (ACETONE+ETHER) (200)" "[α]20/D=+84.5ﾟ(ETHANOL);[α]19/D=+81.3ﾟ(DIOXANE);[α]19/545=+105ﾟ(DIOXANE)(200/201/202)" "200/201/202/" "M/E=450(M+),435(M-15),394(M-56),360(M-90),345(M-(90+15)),270(M-2x90), 255(M-[(2x90)+15]),214(M-[(2x90)+56]),199(M-[(2x90)+56+15]),156. (203)" "203/" "・ALLOPREGNANE-3β,11β,17α,20β,21-PENTOL(REICHSTEIN'S SUBSTACE A) の分解産物 (200) ・副腎皮質(201)" "200/201/" "δ-アミノレブリン酸シンターゼの誘導(202)" "202/" "ジギトニンで沈澱(200) TLC,ガスクロマトグラフィー(203) 逆相HPLC(204)" "200/203/204/" "ST0166" 12.00 "ANDROST-5-ENE-3β,17β-DIOL, Δ5-ANDROSTENE-3β,17β-DIOL" "ANDROSTENEDIOL" "C19H30O2" 19.00 30.00 2.00 0.00 0.00 0.00 290.00 " (REF:179)" "ｵ" " OH" " H3C ｵ" " ／＼ﾇ＼" " H3C ｵｶｽｺ" " ／＼ﾇ＼／" " ｵｶ ｶ" " ／＼／ｸ／" " HO" "179/" "177-178ﾟC(179), 178ﾟC(205), 182-183ﾟC(181)" "[α]18/D=-55.5ﾟ(C=0.4 IN ISOPROPANOL) (179/205)" "イソプロパノールに可溶、水に不溶。(205)" "179/181/205/" "・DEHYDROANDROSTERONEから調製(179/205/181)" "179/181/205/" "ST0167" 12.00 "Δ5-ANDROSTENE-3β,16α-DIOL, 5-ANDROSTENE-3β,16α-DIOL" "C19H30O2" 19.00 30.00 2.00 0.00 0.00 0.00 290.00 " (REF:206)" " CH3 OH" " ／＼ﾇ＼ﾄ" " H3C ｵｶｽｺ" " ／＼ﾇ＼／" " ｵｶ ｶ" " ／＼／ｸ／" " HO" "206/" "216-217ﾟC(AQUEOUS METHANOL)(206)" "[α]22/D=-110ﾟ(C=1.09 IN 95% ETHANOL),[α]24.5/D=-67ﾟ(C=0.80 IN DIOXANE)(206)" "206/" "・調製(206)" "206/" "・精神安定剤(TRANQUILIZER)(206)" "206/" "ST0168" 12.00 "4-ANDROSTENE-3,17-DIONE" "ANDROTEX" "C19H26O2" 19.00 26.00 2.00 0.00 0.00 0.00 286.00 " (REF:207/208/209/210)" " O" " H3C ｾ" " ／＼ﾇ＼" " H3C ｵｶｽｺ" " ／＼ﾇ＼／" " ｵｶ ｶ" " ｷ＼ｷ＼／" " O" "207/208/209/210/" "142-144ﾟC(ACETONE),173-174ﾟC(HEXANE) (208/209)" "[α]30/D=+191ﾟ(ALC),[α]18/D=+185ﾟ,[α]17/D=+197.4ﾟ(CHLOROFORM)(210)" "[α]17/D=+2.26ﾟ(210)" "クロロホルムに可溶。(210)" "208/209/210/" "UV MAX : 235nm (CHLOROFORM)(208)" "208/" "副腎皮質(但しREICHSTEIN'S SUBSTANCE Sの酸に由来する可能性あり)(207) ・5-DEHYDROANDROSTERONEから調製(208/209)・4-ANDROSTEN-17-OLから調製(211)・5-ANDOROSTEN-3-OL17-ONEから調製(210) ・5.6-DIBROMOANDROSTANE-3,17-D" "207/208/209/210/211/212/" "ST0169" 12.00 "3α-HYDROXY-5α-ANDROST-16-ENE, ANDROST-16-EN-3α-OL, Δ16-ANDROSTEN-3α-OL" "C19H30O1" 19.00 30.00 1.00 0.00 0.00 0.00 274.00 " (REF:213/199/214)" " H3C" " ／＼ﾇｹ" " H3C ｵｶｽｺ" " ／＼ﾇ＼／" " ｵｶ ｶ" " ﾄ＼／ﾊ／" " HO H" "199/213/214/" "142.5-143ﾟC (213)" "[α]20/D=+13.1ﾟ(±2ﾟ)(C=0.957 in CHLOROFORM)(213), [α]16/D=+13.9(±2ﾟ)(C=0.936 in CHLOROFORM)(199)" "[α]20/D=+0.125ﾟ,[α]16/D=+0.13ﾟ(±0.02ﾟ)(213/199)" "クロロホルム。(213)" "199/213/" "M/E 346(M), 331(M-15), 256(M-90), 241(M-(90+15))(214)" "214/" "・ブタ睾丸(213)・ヒト男性腋窩汗(ANDROGEN活性はなし)(214)・フランスショウロ(TRUFFLE,TUBER MELANOSPORUM)(215)・調製(199/218)" "199/213/214/215/218/" "・ブタの人工受精での発情を促進(216)・ブタの性誘引因子としての生理的役割(216)" "216/" "Kagi-Miescher テストで青色を呈する。(217) 雄ブタ睾丸でのin ViVO代謝(218) RADIOIMMUNOASSAY(219) レセプターの研究(220) ・組織における生合成研究(221/222) ・フランスショウロ(TRUFFLE,美味名キノコの一" "217/218/219/220/221/222/223/" "ST0170" 12.00 "3β,22,23-TRIHYDROXY-7-OXOSTIGMASTA-5,24(28)-DIEN-29-OIC ACID γ-LACTONE, (20S,22S,23R)-3β,22,23-TRIHYDROXY-7-OXOSTIGMASTA-5,24(28)-DIEN-29-OIC ACID γ-LACTONE" "ANTHERIDIOL" "C29H42O5" 29.00 42.00 5.00 0.00 0.00 0.00 470.00 " HO H CH3 (REF:224/225/226)" "ｵ H3C ﾅﾁ ｵ" " ﾅ／＼ｽｽ／＼" " H3C ｵﾕ ｳ CH3" " ／＼ﾇｹ O＼／" " H3C ｵｶｽｺ ｾ" " ／＼ﾇ＼／ O" " ｵｶ ｶ" " ﾄ＼／ｸ／ｹ" " HO O" "224/225/226/" "250-255ﾟC (224)" "温メタノールに可溶、クロロホルムにわずかに可溶、水にほとんど不溶" "224/" "UV MAX(ETHANOL):220nm(ε=17,000)(224)" "νKBr/MAX:3,390, 1,742, 1,672cm-1. これは、ヒドロキシル基とカルボニル基の存在を示す。水素化によってカルボニルピークは1,770と1,710cm-1へシフトする。 これはα-β-不飽和化γ-ラクトンと、α-β-不飽和化ケトンの存在を示す。(224)""" "2つのｵﾚﾌｨﾝﾌﾟﾛﾄﾝ(5.69と5.77ppm), C-18とC-19ﾒﾁﾙ基(0.70,1.20ppm), C-26とC-27ﾒﾁﾙ基(7Hz間を置いて1.17と1.22ppmに集まったﾀﾌﾞﾚｯﾄ), C-21ﾒﾁﾙ基はC-19,C-26,C-27 ﾒﾁﾙ基によって引き起こされるコンプレックスマルチプレットに隠れている｡更に,C-22のシングルプロトンは,C-23の" "C29H42O5(M+=470), 344, 326, 298, 287, 269, 251 これを無水酢酸とピリミジンで処理すると DIACETETE(M+=554) を生じる。 これは M/E 494,434 を示す。(224/227)""" "224/225/227/" "ACHLYA BISEXUALIS(水生菌類の一種)(228)・単離及び性質(228)・結晶の単離(224)・合成(227)・立体化学(229)・立体化学及び合成別法(230/231)" "224/227/228/229/230/231/" "・わずか20pg/mlの濃度でも,非常に特異性の高い生物活性をもつ。(224) ・雌株から分泌され,雄株に造精器(ANTHERIDIAL HYPHAE)の形成を持たらす。(224) ・植物界で初めて見出されたステロイド性ホルモン(228)" "224/228/" "総説(232/233)" "232/233/" "ST0171" 12.00 "17β-[[3-(DIMETHYLAMINO)PROPYL]-METHYLAMINO]ANDROST-5EN-3β-OL, N-METHYL-N-[3(DIMETHYLAMINO)PROPYL]-17β-AMINOANDROST-5-EN-3β-OL; 20,25-DIAZACHOLESTEROL;" "AZACOSTEROL,DIAZASTEROL" "C25H44ON2" 25.00 44.00 1.00 2.00 0.00 0.00 388.00 " H3C (REF:234)" "ｵ ＼ ／＼" " N ｶｽ" " H3C ｵ N(CH3)2" " ／＼ﾇ＼" " H3C ｵｶｽｺ" " ／＼ﾇ＼／" " ｵｶ ｶ" " ／＼／ｸ／" " HO" "234/" "146-148ﾟC (ACETONE+METHANOL)(234)" "[α]25/D=-54.5ﾟ(234)" "無水エーテル、イソプロピルアルコール(234)" "234/" "・3β-HYDROXYANDROST-5-EN-17-ONEからの合成法(234) ・二塩酸塩の調製｡(234)" "234/" "高コレステロール血症の治療に効果がある。経口投与 0.5mg/kg体重で 15% 減少, 3mg/kg体重で 35% 減少。(234)" "234/" "ST0172" 12.00 "16,17-BUTYLIDENEBIS(OXY)-11,21-DIHYDROXYPREGNA-1,4-DIENE-3,20-DIONE, (R,S)-11β,16α,17,21-TETRAHYDROXYPREGNA-1,4-DIENE-3,20-DIONE CYCLIC 16,17-ACETAL WITH BUTYRALDEHYDE" "BUDESONIDE,S-1320,PREFERID,PULMICORT,RHINOCORT,SPRIROCORT" "C25H34O6" 25.00 34.00 6.00 0.00 0.00 0.00 430.00 " CH2OH (REF:235)" " ｵ" " O=C O｢｢CHCH2CH2CH3" " HO H3Cｶﾄ Oｭ" " ＼／＼ﾇ＼ﾄ" " ｵｶｽｺ" " ｴ＼／＼／" " ｵｶ ｶ" " ｴ＼ｷ＼／" " O" "235/" "221-232ﾟC (235)" "[α]25/D=+98.9ﾟ(C=0.28 IN METHYLENE CHLORIDE)(235)" "235/" "・合成(235)" "235/" "・抗炎症作用(235) ・薬理作用(236) ・ゼンソクへの使用(238)" "235/236/238/" "エマピー,不純物定量への HPLC の利用(237)" "237/" "ST0173" 12.00 "3,14-DIHYDROXYBUFA-20,22-DIENOLIDE" "BUFALIN" "C24H34O4" 24.00 34.00 4.00 0.00 0.00 0.00 386.00 " (REF:239/240/241)" " ／ｦ＼" " H3Cｶｸｽ／ｦO" " ／＼ﾇ＼ O" " H3C ｵｶｽｺ" " ／＼ﾇ＼ｬ" " ｵｶ ｶ OH" " ／＼／ﾉ／" " HO H" "239/240/241/" "242-243ﾟC(METHANOL/CHLOROFORM)(240/241/242)" "[α]/D=-20ﾟ(239)" "アルコール、クロロホルム(239)" "240/241/242/239/" """νMAX 3080, 2945, 1725, 1640, 1545 cm-1(241)""" "pmr(100MHz) 0.71 AND 0.96(18 AND 19 METHYLS), 4.14(3α PROTON), 6.25(DOUBLET,Ha,J=10Hz), 7.28(PARTIALLY MASKED DOUBLET,Hc,J=2Hz), 8.85(QUARTET,Hb,J=10 AND 2Hz)(241)" "M+ 386, 368, 350, 325, 250, 232, 214, 207, 203, 147 (241)" "241/" "・CHINESE TOAD(BUFO BUFO GARGARIZANS)の毒(239) ・JAPANESE TOAD(BUFO VULGARIS FORMOSUS)の皮膚から 3-SALFATE 体として分離。 (243)・14α-ヒドロキシコルテクソロンから合成(240) ・DIGITOXIGENINから合成(241) ・20-KETOPREGNANEから合成(246)" "239/240/241/243/246/" "・強心性ステロイド(239) ・神経筋ブロック(244/245)" "239/244/245/" "ST0174" 12.00 "3,14,16-TRIHYDROXYBUFA-20,22-DIENOLIDE" "BUFOGENIN B, DESACETYLBUFOTALIN" "C24H34O5" 24.00 34.00 5.00 0.00 0.00 0.00 402.00 " (REF:247)" " ／ｦ＼" " H3Cｶｸｽ／ｦO" " ／＼ﾇ＼ O" " H3C ｵｶｽｺ＼" " ／＼ﾇ＼ｬ OH" " ｵｶ ｶ OH" " ／＼／＼／" " HO" "247/" "210-223ﾟC(247)" "[α]19/D=+30ﾟ(C=1.039 IN DIOXANE)(247)" "ジオキサンに可溶,クロロホルム,メタノール,アセトンにほとんど溶けない｡(247)" "247/" "・漢方薬(Ch'an Su, BUFO ASIATICUS = BUFO GARGARIZANS CANTER という CHINESE TOAD から得られる),又は BUFOTALIN から得られる。(247) ・BUFOTALINから合成(247)" "247/" "・強心性ステロイド(247)" "247/" "ST0175" 12.00 "17-HYDROXY-7,17-DIMETHYLANDROST-4-EN-3-ONE, 7β,17α-DIMETHYLTESTOSTERONE" "CALUSTERONE, U-22550, METHOSARB" "C21H32O2" 21.00 32.00 2.00 0.00 0.00 0.00 316.00 " (REF:248)" " HO CH3" " H3Cｶﾄ" " ／＼ﾇ＼" " H3C ｵｶｽｺ" " ／＼ﾇ＼／" " ｵｶ ｶ" " ｴ＼ｷ＼／＼" " O CH3" "248/" "127-129ﾟC(ACETONE)(248)" "[α]/D=+57ﾟ(CHCl3)(248)" "248/" "UV MAX (ALCOHOL): 243nm (248)" "248/" "合成(248)" "248/" "・抗癌剤(248)" "248/" "ST0176" 12.00 "(24R)-ERGOST-5-EN-3β-OL" "CAMPESTEROL" "C28H48O" 28.00 48.00 1.00 0.00 0.00 0.00 400.00 " (REF:249/250)" " H3C" " ＼／＼ CH3" " H3Cｶ ｶｽ／" " ／＼ﾇ＼ ﾂ＼" " H3C ｵｶｽｺ CH3 CH3" " ／＼ﾇ＼／" " ｵｶ ｶ" " ／＼／ｸ／" " HO" "249/250/" "157-158ﾟC(ACETONE)(249)" "[α]23/D=-33ﾟ(22.5mg IN 5mlCHLOROFORM)(249)" "249/" "・ナタネ油,大豆油,麦芽油に少量みられる｡(249)" "249/" "ST0177" 12.00 "STIGMASTA-7,22-DIEN-3-OL" "CHONDRILLASTEROL" "C29H48O" 29.00 48.00 1.00 0.00 0.00 0.00 412.00 " CH2CH3 (REF:251)" " H3C ﾂ CH3" " ﾅ／ｹ／＼／" " H3Cｶ ｵ" " ／＼ﾇ＼ CH3" " H3C ｵｶｽｺ" " ／＼ﾇ＼／" " ｵｶ ｳ" " ﾕ＼／ﾊ／" " HO H" "251/" "168-169ﾟC(CHLOROFORM-METHANOL)(251)" "[α]24/D=-2ﾟ(CHLOROFORM)(251)" "クロロホルム,メタノール(251)" "251/" "・緑藻類(SCENEDESMUS OBLIQUUS(TURPIN)KUETZ,SCENEDESMACEAE)から分離できる。(251)" "251/" "α-SPINASTEROL の立体異性体(251)" "251/" "ST0178" 12.00 "N20,N20-DIMETHYL-5α-PREGNANE-3β,20-DIAMINE; 3β-AMINO-20α-DIMETHYLAMINO-5α-PREGNANE." "CHONEMORPHINE" "C23H42" 23.00 42.00 0.00 2.00 0.00 0.00 346.00 " CH3 (REF:252/253/254/255)" " ﾂ" " HC-N(CH3)2" " H3C ﾁ" " ／＼ｮ＼" " H3C ｵｶｽｺ" " ／＼ｮ＼／" " ｵｶ ｶ" " ﾕ＼／ﾊ／" " H2N H" "252/253/254/255/" "149ﾟC(255)" "[α]/D=+25ﾟ(CHLOROFORM,C=1)(255)" "クロロホルム,エーテルに溶ける｡(255)" "255/" """・CHONEMORPHA MACROPHYLLA G.DON, CH.FRAGRANS ALSTON, CH.PENANGENSIS RIDL., APCYNACEAE の樹皮や葉から抽出(252/253/254) ・ACETOXY-3α-BISNORALLO CHOLANIQUE から合成｡(255)" "252/253/254/255/" "立体化学(256)" "256/" "ST0179" 12.00 "16-(ACETYLOXY)-14,15-EPOXY-3,5-DIHYDROXYBUFA-20,22-DIENOLIDE; 14,15β-EPOXY-3β,5,16β-TRIHYDROXY-5β-BUFA-20,22-DIENOLIDE 16-ACETATE" "CINOBUFOTALIN" "C26H34O7" 26.00 34.00 7.00 0.00 0.00 0.00 458.00 " (REF:257)" " ／ｦ＼" " H3Cｶｸｽ／ｦO" " ／＼ﾇ＼" " H3C ｵｶｽｺ＼" " ／＼ﾇ＼／｡ OCOCH3" " ｵｶ ｶ O" " ／＼／ﾉ／" " HO OH" "257/" "259-262ﾟC(ACETONE)(257)" "[α]20/D=+11ﾟ(257)" "257/" "UV MAX: 295nm(log ε=3.72)(257)" "257/" "・CHINESE TOAD(BUFO ASIATICUS=BUFO GARGARIZANS CANTOR)から調製される漢方薬 CH'AN SU から単離(247)" "247/" "ST0180" 12.00 "Δ25-5β,20β,22α-SPIROSTENDIOL-(1β,3β)" "CONVALLAMAROGENIN" "C27H42O4" 27.00 42.00 4.00 0.00 0.00 0.00 430.00 " H3C O ｰ CH2 (REF:258/259)" " ﾅｽｽﾄ ＼ｽｽｷ" " ｶ ｶｼｼ＼ ／" " H3Cｶ O ＼／" " HO ／＼ﾇ＼／" " ｶ CH3ｵｶｽｺ" " ／＼ﾇ＼／" " ｵｶ ｶ" " ／＼／＼／" " HO" "258/259/" "259-261ﾟC(CHLOROFORM+METHANOL)(259)" "[α]27/D=-79.1ﾟ(C=1.02 IN CHLOROFORM)(258)" "メタノール,クロロホルム,エタノール(258)" "259/258/" "νNUJOL/MAX : 3095, 1655, 877cm-1 (ビニル型二重結合に相当) 3350, 3295cm-1(259)" "259/" "・スズラン(CONVALLARIA MAJALIS L.)の根(259)" "259/" "ST0181" 12.00 "3β-[(6-DEOXY-α-L-MANNOPYRANOSYL)OXY]-5,14-DIHYDROXY-19-OXO-5β-CARD-20(22)-ENOLIDE" "CONVALLATOXIN" "C29H42O10" 29.00 42.00 10.00 0.00 0.00 0.00 550.00 " O (REF:260/261/262)" " ｷ" " ｴｻ" " H3Cｶ＼ O" " ／＼ﾇ＼ｼ" " OHC ｵｶｽｺ" " ／＼ﾇ＼／ｵ" " ｵ ｵｶ OH" " ／＼／ﾉ／" " Man-O OH" "260/261/262/" "235-242ﾟC(METHANOL+ETHER)(260/261)" "[α]22/D=-1.7ﾟ±3ﾟ(C=0.65 IN MeOH) ; [α]25/D=-9.4ﾟ±3ﾟ(C=0.72 IN DIOXANE) (260/261)" "アルコール,アセトンに可溶｡クロロホルム,エチルアセテート,水(1:2000)に,わずかに溶ける｡エーテル,石油エーテルには不溶｡(260/261)" "260/261/" "・谷間ユリ（スズラン）(CONVALLARIA MAJALIS L.,LILIACEAE)の花(263) ・ANTIARIS TOXICARIA LESCH, MORACEAE(264)・ORNITHOGALUM UMBELLATUM L., LILIACEAE(265)・ストロファンチジンとアセトブロム ラムノースから合成(266)" "263/264/265/266/" "・強心薬(263)" "263/" "ST0182" 12.00 "17α,21-DIHYDROXY-4-PREGNENE-3,11,20-TRIONE,17-HYDROXY-11-DEHYDROCORTICOSTERONE; 11-DEHYDRO-17-HYDROXYCORTICOSTERONE; Δ4-PREGNENE-17α,21-DIOL-3,11,20-TRIONE" "CORTISONE" "C21H28O5" 21.00 28.00 5.00 0.00 0.00 0.00 360.00 " CH2OH (REF:267/268/269/270)" " ｵ" " O=C OH" " O H3Cｶﾄ" " ｹ／＼ﾇ＼" " H3C ｵｶｽｺ" " ／＼ﾇ＼／" " ｵ ｵｶ" " ｴ＼ｷ＼／" " O" "267/268/269/270/" "220-224ﾟC(95% ETHANOL)(267/268/269/270)" "[α]25/D=+209ﾟ(C=1.2 IN 95%ETHANOL);[α]25/546=+248ﾟ(C=0.1 TO 0.2 IN ETHANOL); [α]25/546=+269ﾟ(C=0.125 IN BENZENE)(270/271)" "冷メタノール,エタノール,アセトンによく溶ける｡エーテル,ベンゼン,クロロホルムには,少し溶ける｡水には,ほとんど溶けない｡(267/268/269/270)" "267/268/269/270/271/" "UV MAX: 237nm(ε=14,000)(270)" "270/" "・副腎(267/268/269/270) ・デオキシコール酸からモノ酢酸として合成(272) ・調製法の改良(273/274/275/276/277/278/279/280/281/282/283/284)・立体特異的全合成(285)(コルチゾン酢酸として)｡" "267/268/269/270/272/273/274/275/276/277/278/279/280/281/282/283/284/285/" "・糖質コルチコイドとして作用｡(270)" "270/" "ST0183" 12.00 "17α-HYDROXY-4-PREGNENE-3,11,20-TRIONE-21-DIHYDROGEN PHOSPHATE" "CORTISONE PHOSPHATE" "C21H29OP" 21.00 29.00 8.00 0.00 1.00 0.00 439.00 " CH2―O―PO3H2 (REF:286/287)" " ｵ" " O=C OH" " O H3Cｶﾄ" " ｹ／＼ﾇ＼" " H3C ｵｶｽｺ" " ／＼ﾇ＼／" " ｵ ｵｶ" " ｴ＼ｷ＼／" " O" "286/287/" "198-204ﾟC(286/287)" "ナトリウム塩は水に可溶｡ジメチルエステルは,水に不溶｡(286/287)" "286/287/" "UV MAX (METHANOL): 238nm(ε=15,200) (WATER): 244nm(ε=15,900)(286)" "286/" "・沸騰アセトニトリル中で銀二水素リン酸と置換反応を行う事により,17α-HYDROXY -21-IODO-4-PREGNENE-3,11,30-TRIONE から調製(286/287)" "286/287/" "ST0184" 12.00 "12-[(3,4-DIMETHYL-1-OXO-2-PENTENYL)OXY]-3,8,14-TRIHYDROXYPREGN-5-EN-20-ONE" "CYNANCHOGENIN" "C28H42O6" 28.00 42.00 6.00 0.00 0.00 0.00 474.00 " CH3 CH3 (REF:288/289/290/291)" " | ｵ" "(CH3)2-CH-C=CH-COO C=O" " ｶH3C ﾂ" " ／＼ﾇ＼" " H3C ｵOHｵｺ" " ／＼ﾇｪｬｼ" " ｵ ｵｶ OH" " ／＼／ｸ／" " HO" "288/289/290/291/" "165-167ﾟC(ETHER+PETR ETHER)(289)" "[α]22/D=-39.5ﾟ(C=1.24 IN 90% ETHANOL)(289)" "石油エーテル,エタノール｡(289)" "289/" "UV MAX (ETHANOL):218 nm(logε=4)(288)" "λKBr/MAX cm-1: ν/OH:3480, ν/C=O:1700, ν/C=C:1638(288)" "文献292/293のFig.1を参照｡(292/293)" "288/292/293/" "･Cynanchum caudatum Max., Asclepiadaceae の根から分離｡(288)" "288/" "LIEBERMAN-BURCHARD 反応は,ピンクから黄(289) 84%H2SO4で,褐色からバイオレット(289) 三塩化アンチモンで緑(289) テトラニトロメタンで黄色(289)" "289/" "ST0185" 12.00 "6-CHLORO-1,2-DIHYDRO-17-HYDROXY-3'H-CYCLOPROPA[1,2]PREGNA-1,4,6-TRIENE-3,20-DIONE; 6-CHLORO-6-DEHYDRO-17α-HYDROXY-1,2α-METHYL-ENEPROGESTERONE; 6-CHLORO-1,2α-METHYLENE-4,6-PREGNADIEN-17α-OL-3,20-DIONE" "CYPROTERONE" "C22H27O3" 22.00 27.00 3.00 0.00 0.00 0.00 339.00 " CH3 (REF:294)" " ｵ" " O=C OH" " H3C ﾓ" " ／＼ﾇ＼" " H2Cﾅ CH3ｵｶｽｺ" " ﾃ／＼ﾇ＼／" " ｵ ｵｶ" " ｴ＼ｷ＼ｷ" " O ｵ" " Cl" "294/" "237.5-240ﾟC(ETHYL ACETATE)(294)" "294/" "UV MAX (METHANOL): 281nm(ε=17,280)(ACETATE)(294)" "294/" "遊離アルコールとして調整" "・抗アンドロゲン活性(ACETATEとして)(294)" "294/" "ヒト体内での代謝(294)" "294/" "ST0186" 12.00 "21-HYDROXYPREGN-4-ENE-3,11,20-TRIONE; Δ4-PREGNEN-21-OL-3,11,20-TRIONE; 17-(1-KETO-2-HYDROXYETHYL)-Δ4-ANDROSTEN-3,11-DIONE;" "11-DEHYDROCORTICOSTERONE, SUBSTANCE A" "C21H28O4" 21.00 28.00 4.00 0.00 0.00 0.00 344.00 " CH2OH (REF:269/295)" " ｵ" " C=OH" " O H3C ｵ" " ｸ／＼ﾇ＼" " H3C ｵｶｽｺ" " ／＼ﾇ＼／" " ｵ ｵｶ" " ｴ＼ｷ＼／" " O" "269/295/" "178-180ﾟC(AQ.ACETONE)(295)" "[α]25/546=+299ﾟ,347ﾟ(C=0.23 IN BENZENE),[α]25/D=+258ﾟ(ALC.)(296)" "比較的ベンゼンに溶ける｡(295)" "295/296/" "λ MAX = 237.5nm(ACETATE),E%=386 (296)""" "296/" "・副腎皮質に見られる｡ 1000lbsの BEEF GLANDS から 333mg とれる｡(295) ・デオキシコール酸からの合成(297)・3α-アセトキシ-11-ケトビスノルコラン酸から合成(272/296)・3α-アセチル-11-ケトリトコール酸メチルエステルから合成(298)" "272/295/296/297/298/" "ST0187" 12.00 "ERGOSTA-5,7,9(11),22-TETRAEN-3β-OL" "DEHYDROERGOSTEROL" "C28H42O" 28.00 42.00 1.00 0.00 0.00 0.00 394.00 " (REF:299/300)" " H3C" " ＼／ｹ CH3" " H3C ｵｶｽ／" " ／＼ﾇ＼ｶ ＼" " H3C ｾｶｽｺ CH3 CH3" " ／＼ﾇ＼／" " ｵ ｵｳ" " ／＼／ｸ／" " HO" "299/300/" "146ﾟC(300)" "bp0.5=230ﾟC (300)" "[α]15/D=+149.2ﾟ(C=1.9 IN CHLOROFORM)(300)" "1gが800mlのメタノールに溶ける｡エーテル,クロロホルム,ベンゼンにもよく溶ける｡(300)" "300/" "λ MAX : 342.0, 325.5, 311.0, 296 nm(301)" "301/" "エルゴステロールからの調整(299)イソピロカルシフェロールからの調整(300)" "ST0188" 12.00 "STIGMASTA-5,7-DIEN-3β-OL" "7-DEHYDROSITOSTEROL" "C29H48O" 29.00 48.00 1.00 0.00 0.00 0.00 412.00 " (REF:302)" " H3C" " ＼／＼ CH3" " H3C ｵｶｽ／" " ／＼ﾇ＼ｶ ＼" " H3C ｵｶｽｺ C2H5 CH3" " ／＼ﾇ＼／" " ｵ ｵｳ" " ／＼／ｸ／" " HO" "302/" "144-145ﾟC(302)" "[α]21/D=-116ﾟ(C=2 IN CHLOROFORM)(302)" "メタノール,アルコールにわずかに可溶｡他の通常の有機溶媒によく溶ける｡水には不溶｡(302)" "302/" "ERGOSTEROLとほぼ同じ吸収スペクトル｡(302)" "302/" "・大豆油 β-SITOSTEROL から分離｡(302)" "302/" "ST0189" 12.00 "17-(ACETYLOXY)-6-CHLOROPREGNA-1,4,6-TRIENE-3,20-DIONE; 6-CHLORO-17-HYDROXYPREGNA-1,4,6-TRIENE-3,20-DIONE ACETATE; 1,6-BISDEHYDRO-6-CHLORO-17α-ACETOXYPROGESTERONE;" "DELMADINONE ACETATE" "DMA" "C23H27O4" 23.00 27.00 4.00 0.00 0.00 0.00 367.00 " H3C (REF:303/304/305)" " ｵ" " O=C OCOCH3" " H3C ﾓ" " ／＼ﾇ＼" " H3C ｵｶｽｺ" " ｴ＼ﾇ＼／" " ｵ ｵｶ" " ｴ＼ｷ＼ｷ" " O ｵ" " Cl" "303/304/305/" "168-170ﾟC(303)" "[α]/D=-83ﾟ(CHLOROFORM)(303)" "303/" "UV MAX (ETHANOL): 229, 258, 297nm(log ε=4.00, 4.00, 4.03)(303)" "303/" "調整(303)" "303/" "・経口プロゲステロン活性＝35(CLAUBERG ASSAY)(303) ・抗エストロゲン作用(304/305)" "303/304/305/" "犬猫における生殖行動の調節への応用(306)" "306/" "ST0190" 12.00 "6,9-DIFLUORO-11,17,21-TRIHYDROXY-16-METHYLPREGNA-1,4-DIENE-3,20-DIONE; 6α,9α-DIFLUORO-16β-METHYL-Δ1,4-PREGNADIENE-11β,17α,21-TRIOL-3,20-DIONE; 6α,9α-DIFLUORO-16β-METHYLPREDNISOLONE." "DIFLORASONE" "C22H28O5" 22.00 28.00 5.00 0.00 0.00 0.00 372.00 " CH2OH (REF:307/308)" " ｵ" " O=C OH" " HO H3C ﾓ" " ＼／＼ﾇ＼ｽ" " H3C ｵｶｽｺ CH3" " ｴ＼ﾇﾊ／" " ｵ ｵF ｵ" " ｴ＼ｷ＼／" " O ﾂ" " F" "307/308/" "遊離アルコール、21-ACETATEの調整" "・PSORIASIS(乾癬)においてアラキドン酸, ヒドロキシエイコサテトラエン酸を減少させる。(309)" "309/" "ST0191" 12.00 "21-(ACETYLOXY)-6,9-DIFLUORO-11-HYDROXY-17-(1-OXOBUTOXY)PREGNA-1,4-DIENE-3,20-DIONE; 6α,9-DIFLUORO-11β,17,21-TRIHYDROXYPREGNA-1,4-DIENE-3,20-DIONE 21-ACETATE 17-BUTYRATE; 6α,9α-DIFLUOROPREDNISOLONE-21-ACETATE-17-BUTYRAT" "DIFLUPREDNATE" "C27H34O7" 27.00 34.00 7.00 0.00 0.00 0.00 470.00 " CH2OCOCH3 (REF:310/311/312)" " ｵ" " O=C OCOCH2CH2CH3" " HO H3C ﾓ" " ＼／＼ﾇ＼" " H3C ｵｶｽｺ" " ｴ＼ﾇﾊ／" " ｵ ｵF ｵ" " ｴ＼ｷ＼／" " O ﾂ" " F" "310/311/312/" "191-194ﾟ(METHYLENE CHLORIDE/ETHER/PETR ETHER)(312)" "[α]22/D=+31.7ﾟ(C=0.5 IN DIOXANE)(312)" "312/" "UV MAX(ETHANOL): 237-238nm(E1%/1cm 320) (312)" "312/" "調整" "・抗炎症作用(310/311/312/313/314)" "310/311/312/313/314/" "ST0192" 12.00 "(25R)-5α-SPIROSTAN-3β,15β-DIOL" "DIGALOGENIN" "C27H44O4" 27.00 44.00 4.00 0.00 0.00 0.00 432.00 " H3C O ｰ H (REF:315)" " ﾅｽｽﾄ ＼ｽｽｵ" " ｵｶｼｼ＼ ／ﾅ" " H3C ｵ O ＼／ CH3" " ／＼ﾇ＼／" " H3C ｵｶｽｺ" " ／＼ﾇ＼／ﾂ ＼" " ｵ ｵ ｵH OH" " ／＼／ﾊ／" " HO H" "315/" "218.5-220.5ﾟC(METHANOL)(315)" "[α]21/D=-75ﾟ(CHCl3)(315)" "クロロホルム,メタノール(315)" "315/" "カルボニル結合なし｡水酸基を２つ持つ 25α-SAPOGENIN｡(315)" "315/" "・DIGITALIS PURPUREAの種(315)" "315/" "ST0193" 12.00 "3β,12β,14,16β-TETRAHYDROXY-5β-CARD-20(22)-ENOLIDE; 12-HYDROXYGITOXIGENIN;" "DIGINATIGENIN" "C23H34O6" 23.00 34.00 6.00 0.00 0.00 0.00 406.00 " O (REF:316/317/318/319/320/321)" " ｴ" " HO ｴｻ" " ｶ CH3･ｺ" " ／＼ﾇ＼" " H3C ｵｶｽｺｼOH" " ／＼ﾇ＼／＼" " ｵ ｵ ｵ OH" " ／＼／＼／" " HO" "316/317/318/319/320/321/" "157ﾟC(CHCl),154-156ﾟC(H2O)(316/319)" "[α]20/D=+34ﾟ(METHANOL)(319)" "メタノール,クロロホルム,ピリジン(316/319)" "316/319/" "UV MAX(ETHANOL):218nm(log ε=4.18)(98%w/w H2SO4):230, 310, 390, 490nm (E 1%/1cm 160, 130, 210, 85) (319)" "3-6μに特徴的なピーク(318/319)" "その他の分光データ[M]/D=+138(321)" "319/318/321/" "・DIGITALIS LANATA の DIGINATIN の非糖部(316) ・D.PURPUREA, D.THAPSI, D.SIBIRICA, D.LUTEA, D.AMBIGUA, S.MERTONENSIS には無い｡(316)・DIGINATIN の加水分解による(316) ・ギトキシゲニンからの合成(318/319)" "316/318/319/" "・強心剤(316)" "316/" "リン酸中で強い蛍光を持ち, C16に水酸基を持つ強心配糖体に特有の反応(316)" "316/" "ST0194" 12.00 "(25R)-5α-SPIROSTAN-2α,3β,15β-TRIOL" "DIGITOGENIN" "C27H44O5" 27.00 44.00 5.00 0.00 0.00 0.00 448.00 " CH3 O ｰ H (REF:322/323/324/325/326/327)" " ﾃ ﾄ ＼ｽｽｵ" " ｶｼｻｼｼ＼ ／ﾅ" " H3Cｶ O ＼／ CH3" " ／＼ﾇ＼／" " HO H3C ｵｶｽｺ" " ﾅ／＼ﾇ＼／ ＼" " ｵ ｵ ｵ OH" " ／＼／ﾊ／" " HO H" "322/323/324/325/326/327/" "280-283ﾟC(327)" "[α]19/D=-81ﾟ(C=1.4 IN CHLOROFORM)(327)" "水に不溶｡30%クロロホルムに可溶｡35%沸騰アルコールに可溶｡ 100%アルコール(20ﾟ)に可溶｡(327)" "327/" "λCHCl3/MAX :2.81, 2.90 (HYDROXYL) 10.22, 10.90, 11.14, 11.53μ(SPIROKETAL)(327)" "327/" "ジギトニンのアグリコン(322)" "322/" "濃硫酸処理でも無色(327)" "327/" "ST0195" 12.00 "3,14-DIHYDROXYCARD-20(22)-ENOLIDE; Δ20,22-3,14,21-TRIHYDROXYNORCHOLENIC ACID LACTONE;" "DIGITOXIGENIN" "C23H34O4" 23.00 34.00 4.00 0.00 0.00 0.00 374.00 " O (REF:328/329/330/331/332/333/334/335)" " ｴ" " ｴｻ" " H3Cｶ＼ｽO" " ／＼ｮ＼" " H3C ｵｶｽｺ" " ／＼ｮ＼／ﾀ" " ｵ ｵ ｵOH" " ﾕ＼／ﾚ／" " HO H" "328/329/330/331/332/333/334/335/" "253ﾟC(40% ALC.)(331/336)" "[α]17/D=+19.1ﾟ(C=1.36 IN METHANOL)(331/336)" "アルコール,クロロホルム,アセトンに可溶｡エチルアセテートにわずかに溶ける｡ エーテル,水にはほとんど溶けない｡(331)" "331/336/" "APOCINACAE の種(337) ・メチル3β-アセトキシ-14β-ハイドロキシ-5β−エチアネイト(II)から合成(336)・15α-ヒドロキシコルテクソンから合成(338)・21-ヒドロキシ-20-ケトステロイドから合成(339) ・新しい合成法(340) ・デオキシコール酸からの合成" "336/337/338/339/340/341/" "・強心剤(336)" "336/" "ST0196" 12.00 "3,12,14-TRIHYDROXYCARD-20(22)-ENOLIDE; Δ20,22-3β,12β,14,21-TETRAHYDROXYNORCHOLENIC ACID LACTONE." "DIGOXIGENIN" "C23H34O5" 23.00 34.00 5.00 0.00 0.00 0.00 390.00 " O (REF:342/343/344/345)" " ｴ" " HO ｴｻ" " ﾒ CH3･ｽO" " ／＼ｫ＼" " H3C ｵｶｽｺ" " ／＼ｫ＼／ｵ" " ｵ ｵ ｵOH" " ﾕ＼／･／" " HO H" "342/343/344/345/" "222ﾟC(342)" "[α]20/546=+27.0ﾟ(C=1.77 IN METHANOL)(342)" "342/" "ジゴキシン (DIGOXIN:DIGITALIS LANATAの葉から得られる強心性配糖体)のアグリコン(非糖質部分),ジゴキシンの加水分解による｡(342) ・デオキシコール酸からの合成(346)" "342/346/" "ST0197" 12.00 "ESTRA-1,3,5(10),7-TETRAENE-3,17-DIOL" "DIHYDROEQUILIN" "C18H22O2" 18.00 22.00 2.00 0.00 0.00 0.00 270.00 " (REF:347)" " OH OH" " H3C ｵ H3C ﾂ" " ／＼ｫ＼ ／＼ﾇ＼" " ｵｶｽｺ ｶｽｺ" " ｴ＼／＼／ ／" " ｵｳ ｳ α-FORM" " ／ｸ／＼／ β-FORM" " HO" "347/" "17β-FORM:174.5-174.6ﾟC(ACETONE)17α-FORM: 205.5-205.6ﾟC(30% ETHANOL)(347/348)" "17β-FORM:[α]20/D=+220ﾟ(DIOXANE),17α-FORM:[α]20/D=+213ﾟ(ETHANOL)(347/348)" "アルコール,エーテル,ベンゼン(347/348)" "347/348/" "281nm(ε=1,955)(347)" "8-15μの謂所フィンガープリント領域で,α-ジヒドロエキリンと異なる｡(347)" "347/" "･17α-FORM,17β-FORM 共に妊娠馬尿より分離(349) 17α-FORM,17β-FORM 共に,EQUILIN(妊娠馬尿中に分布)の還元によっても, 得られる｡(347)" "347/349/" "エストロンの1/50の活性を有する｡(347)" "347/" "ST0198" 12.00 "9,10-SECOERGOSTA-5,7,22-TRIEN-3β-OL" "DIHYDROTACHYSTEROL" "C28H46O" 28.00 46.00 1.00 0.00 0.00 0.00 398.00 " (REF:350)" " H3C" " ＼／ｹ CH3" " H3Cｶ ｶｽ／" " ／＼ｫ＼ｶ ＼" " H3C ｵｶｽｺ CH3 CH3" " ／＼ｵ＼／" " ｵｶ ｳ" " ／＼／ｸ／" " HO" "350/" "125-127ﾟC(90% METHANOL)(350)" "[α]22/D=+97.5ﾟ(CHLOROFORM)(350)" "水に不溶,有機溶媒に可溶｡(350)" "350/" "UV MAX : 242, 251, 261nm (E1%/1cm 870, 1010, 650)(350)" "350/" "・TACHYSTEROLの還元により調製(350)" "350/" "生体内で血液カルシウム上昇の効果(350)" "350/" "ST0199" 12.00 "4,23-DIMETHYLERGOST-22-EN-3-OL,4α-METHYL-5α(H)-Δ22-23,24-DIMETHYLCHOLESTAN-3β-OL." "DINOSTEROL" "C30H52O" 30.00 52.00 1.00 0.00 0.00 0.00 428.00 " CH3 (REF:351/352)" " H3C ﾂ CH3" " ﾅ／ｹ／＼／" " H3Cｶ ｶ ｵ" " ／＼ｮﾊ CH3 CH3" " H3C ｵｶ H ｵ" " ／＼ｮ＼／ｼｼ" " ｵｶ ｶ" " ﾕ＼／ﾊ／" " HO ﾃ H" " CH3" "351/352/" "220-222ﾟC(METHANOL-CHLOROFORM)(351)" "[α]/D=±5ﾟ(C=0.6 IN CHCl3)(351)" "クロロホルム,メタノール,エーテル(351/352)" "351/352/" "100MHz, SEVEN ALKYL LINKED METHYL SIGNALS(δ0.70(3H,s), 0.80(3H,d,J=7Hz), 0.84(3H,s),0.85(3H,d,J=7Hz),0.94(6H,d,J=6.5Hz,ISOPROPYL),0.95(3H,d,J=6Hz)), OLEFINIC PROTON SIGNAL(δ4.87(1H,q,J=1.2,10Hz)),PROTON SIGNAL DVE TO ASECONDARY ALCOHOL(δ3.10(1H,m)" "M/E 428(26),387(15),370(10),316(65),303(24),287(100),271(67)(351/352/353)" "351/352/353/" "・有毒な渦鞭毛虫類 : GONYAULAX TAMARENSIS から得られる｡ 生物発生上,重要なマリンステロール(351) ・黒海の腐泥から抽出｡(353)・立体特異的合成(354)" "351/353/354/" "GLC における, コレステロールに対する相対保持時間は, 1.59(1%OV-17, 240ﾟC)(352) X線結晶学による構造決定(352)" "352/" "ST0200" 12.00 "(25R)-SPIROST-5EN-3β-OL" "DIOSGENIN" "C27H42O3" 27.00 42.00 3.00 0.00 0.00 0.00 414.00 " CH3 O ｰ H (REF:355/356/357)" " ﾂ ﾄ ＼ｽｽｵ" " ｶｼｻｼｼ＼ ／ﾅ" " H3Cｶ O ＼／ CH3" " ／＼ｫ＼／" " H3C ｵｶｽｺ" " ／＼ｫ＼／" " ｵｶ ｶ" " ／＼／ｸ／" " HO" "355/356/357/" "204-207ﾟC(ACETONE)(355/358)" "[α]25/D=-129ﾟ(C=1.4 IN CHCl3)(358)" "通常の有機溶媒に可溶,酢酸にも可溶(355)" "355/358/" "・ヤマノイモ属DIOSCOREA(359/360) ・エンレイソウ属TRILLIUM (355/360) ・BETHの根(全ステロイドサポゲニンの35-60%)(361)・YAMOGENINから調製(363) ・立体特異的簡易合成法(363)" "355/356/359/360/361/363/" "プレグネノロン,プロゲステロンへ転換できる｡(362)" "362/" "C25 立体配座の決定(356)" "356/" "ST0201" 12.00 "CHOLEST-5-EN-3α-OL" "EPICHOLESTENOL" "C27H48" 27.00 48.00 0.00 0.00 0.00 0.00 372.00 " (REF:364/365)" " H3C" " ＼／＼ CH3" " H3Cｶ ｶｽ／" " ／＼ﾇ＼ ＼" " H3C ｵｶｽｺ CH3" " ／＼ﾇ＼／" " ｵｶ ｶ" " ﾄ＼／ｸ／" " HO" "364/365/" "141.5ﾟC(ALCOHOL)(364)" "[α]30/D=-35ﾟ(C=1 IN ALCOHOL)(364)" "364/" "・合成(365) ・新しいエピマー化による調製(366)" "365/366/" "ST0202" 12.00 "ESTRA-1,3.5(10)-TRIENE-3,16β,17β-TRIOL ; Δ1,3,5-ESTRATRIENE-3,16β,17β-TRIOL" "16-EPIESTRIOL" "C18H24O3" 18.00 24.00 3.00 0.00 0.00 0.00 288.00 " (REF:367/368/369)" " OH" " H3Cｶ" " ／＼ﾇ＼ｽOH" " ｵｶｽｺ" " ｴ＼／＼／" " ｵｳ ｶ" " ／ｸ／＼／" " HO" "367/368/369/" "289-291ﾟC(METHANOL+BENZENE)(369)" "[α]15/D=+76ﾟ(C=0.297 IN ETHANOL)(369)" "369/" "妊娠の尿,人の胎盤(367/369)" "367/369/" "エストロゲン活性(367)" "367/" "ST0203" 12.00 "3-HYDROXYESTRA-1,3,5,7,9-PENTAEN-17-ONE; 11,12,13,14,15,16-HEXAHYDRO-3-HYDROXY-13-METHYL-17H-CYCLOPENTA[A]PHENANTHREN-17-ONE; 1,3,5:10,6,8-ESTRA-PENTAEN-3-OL-17-ONE." "EQUILENIN" "C18H18O2" 18.00 18.00 2.00 0.00 0.00 0.00 266.00 " (REF:371/372)" " O" " H3C ｾ" " ／＼ﾇ＼" " ｵｶｽｺ" " ｴ＼／ｹ／" " ｵｳ ｶ" " ／ｸ／＼ｷ" " HO" "371/372/" "258-259ﾟC(DIL ALC.)(371)" "[α]16/D=+87ﾟ(12.8mg/1.8ml IN DIOXANE)(371)" "0.63g/100ml ALCOHOL(18ﾟC),2.5g/100ml ALCOHOL(BOILING)(371)" "371/" "UV MAX(ETHANOL): 231, 270, 282, 292, 325, 340nm(logEmolar=3.85, 3.87, 3.74, 3.58, 3.68, EACH)(372)" "372/" "・妊娠馬から分離(371)・1-NAPHTHYLAMINE-6-SULFONIC ACID(CLEVE'S ACID)から調製された7-METHOXY-1-KETO-1,2,3,4-TETRAHYDROPHENANTHRENを出発物質として全合成(371/372/373)・1-KETO-1,2,3,4-TETRAHYDROPHENANTHRENEからの合成(374) ・1-KETO-2-METHYL-7-METHOXY-" "094/095/371/372/373/374/375/376/377/" "強いエストロゲン活性を持つ｡(371)" "371/" "ST0204" 12.00 "ESTRA-1,3,5-(10)-TRIENE-3,17-DIOL" "β-ESTRADIOL,(+)-ESTRADIOL" "C18H24O2" 18.00 24.00 2.00 0.00 0.00 0.00 272.00 " (REF:103/378/106)" " OH" " H3C ｵ" " ／＼ﾇ＼" " ｵｶｽｺ" " ｴ＼／＼／" " ｵｳ ｶ" " ／ｸ／＼／" " HO" "103/106/378/" "173-179ﾟC(378/106)" "[α]25/D=+76 to +83ﾟ(DIOXANE)(378/106)" "水に不溶,アルコールに可溶,アセトン,ジオキサン,他有機溶媒に可溶,ベジタブルオイルに,わずかに溶ける｡(378/106)" "106/348/" "UV MAX : 225, 280nm(379)" "379/" "・妊娠馬の尿(103)・豚卵巣濾胞液(103)・1,3-DIHYDROBENZO[C] THIOPHENE-2,2-DIOXIDEからのENANTIOSELECTIVEな合成｡(107)" "103/107/" "・哺乳類における最も強いエストロゲン(103)" "103/" "VALERATEとしての物理化学的性質, 合成, 分析法(380)" "380/" "ST0205" 12.00 "β-ESTRADIOL-3-BENZOATE" "ESTRADIOL BENZOATE" "C25H28O3" 25.00 28.00 3.00 0.00 0.00 0.00 376.00 " (REF:381/382)" " OH" " H3C ｵ" " ／＼ﾇ＼" " ｵｶｽｺ" " ｴ＼／＼／" " ｵｳ ｶ" " ／ｸ／＼／" "C6H5-COO" "381/382/" "191-196ﾟC(ALCOHOL)(381)" "[α]25/D=+58ﾟto +63ﾟ(C=2 IN DIOXANE)(381)" "アルコール,アセトン,ジオキサンに可溶｡ エーテル,ベジタブルオイルにわずかに可溶｡(381/382)" "381/382/" "妊娠馬の尿(103)、ブタ卵巣濾胞液(103)由来の -ESTRADIOLから調整" "・エストロゲン活性(381/382)" "381/382/" "ジギトニンと反応し沈澱する｡(381)" "381/" "ST0206" 12.00 "ESTRA-1,3,5(10)-TRIENE-3,17-DIOL 3-[BIS(2-CHLOROETHYL)CARBAMATE]; ESTRADIOL 3-BIS(2-CHLOROETHYL)CARBAMATE; ESTRA-1,3,5(10)TRIENE-3,17β-DIOL 3-[N,N-BIS(2-CHLOROETHYL)CARBAMATE];" "ESTRAMUSTINE" "C23H31O3N" 23.00 31.00 3.00 1.00 0.00 0.00 369.00 " (REF:383)" " OH" " H3C ｵ" " ／＼ﾇ＼" " ｵｶｽｺ" " ｴ＼／＼／" " ｵｳ ｶ" " ／ｸ／＼／" "(ClCH2CH2)2NCOO" "383/" "104-105ﾟC(BENZENE-PETR ETHER)(383)" "[α]20/D=+50ﾟ(IN DIOXANE)(383)" "383/" "UV MAX(ALCOHOL): 270.7, 276.5 nm (383)" "383/" "調整(383)" "・抗腫瘍薬(383)" "383/" "ST0207" 12.00 "3-HYDROXYESTRA-1,3,5(10)-TRIEN-17-ONE; 1,3,5-ESTRATRIEN-3-OL-17-ONE;" "ESTRONE" "C18H22O2" 18.00 22.00 2.00 0.00 0.00 0.00 270.00 " (REF:123/130)" " O" " H3C ｾ" " ／＼ﾇ＼" " ｶ Hｶｽｺ" " ｴ＼／ﾊｫﾂ" " ｵｳ Hｶ H" " ／ｸ／＼／" " HO" "123/130/" "dl-FORM:251-254ﾟ(ACETONE),d-FORM: 254.5-256ﾟ(ACETONE)(123) 254.5-256ﾟ(ACETONE)(123)" "[α]22/D=+152ﾟ(C=0.995 IN CHCl3)(123)" "水に可溶(25ﾟ):0.003g/100ml｡15ﾟC:96%ｱﾙｺｰﾙ250ml,ｱｾﾄﾝ50ml,110mlｸﾛﾛﾎﾙﾑに,1gのESTRONE可溶｡BOILING:ｱﾙｺｰﾙ50ml,ﾍﾞﾝｾﾞﾝ145mlに,1gのESTRONE可溶｡ｼﾞｵｷｻﾝ,ﾋﾟﾘｼﾞﾝ,FIXED ALKALIHYDROXIDEに可溶｡ｴｰﾃﾙ,ﾍﾞｼﾞﾀﾌﾞﾙｵｲﾙにもわずかに可溶｡(123)" "123/" "UV MAX: 283-285nm (384)" "Ref.385,Fig.2参照｡(385)" "384/385/" "・妊婦,妊娠馬,多くの動物の濾胞液,ヒトの胎盤,雄牛や種馬の尿,PALM-KERNEK OIL (121/386) ・MOGHAT(CLOSSOSTEMON BRUGUIERI,STERCULIACEAE)の根, EGYPTIAN DATE PALM(PHOENIX DACTYLIFERA)の花粉(387)・コレステロールからの合成(123)・19-NORSTER" "121/123/135/386/387/388/389/" "・エストロゲン活性(121/386)" "121/386/" "ジギトニンと反応して,沈澱する｡(123)" "123/" "ST0208" 12.00 "19-NOR-17α-PREGNA-1,3,5(10)-TRIEN-20-YNE-3,17-DIOL, 17α-ETHYNYL-1,3,5(10)-ESTRATRIENE-3,17β-DIOL" "ETHINYL ESTRADIOL" "C20H24O2" 20.00 24.00 2.00 0.00 0.00 0.00 296.00 " (REF:390)" " HO C舛H" " H3Cｶﾄ" " ／＼ﾇ＼" " ｶ Hｶｽｺ" " ｴ＼／ﾊｫﾂ" " ｵｳ Hｶ H" " ／ｸ／＼／" " HO" "390/" "145-146ﾟC(391)" "[α]/D=+1ﾟ(IN DIOXAN)(391)" "水に不溶｡1に対し6のｴﾀﾉｰﾙ,4のｴｰﾃﾙ,5のｱｾﾄﾝ,4のｼﾞｵｷｻﾝ,20のｸﾛﾛﾎﾙﾑの割合で可溶｡ ﾍﾞｼﾞﾀﾌﾞﾙｵｲﾙ,FIXED ALKALIHYDROXIDES溶液にも可溶｡(391)" "391/" "UV MAX(ETHANOL) : 281nm(ε=2040±60)(392)" "(392)" "392/" "・ESTRONEから調製(391)" "391/" """・エストロゲン活性(ヒト,動物のホルモン療法に利用される)(391)" "391/" "性質(392)" "392/" "ST0209" 12.00 "17α-HYDROXYPREGN-4-EN-20-YN-3-ONE; 17α-ETHYNYLTESTOSTERONE; 17α-ETHYNYL-17β-HYDROXY-4-ANDROSTEN-3-ONE; 17α-ETHINYLTESTOSTERONE; 17α-ETHYNYL-4-ANDROSTEN-17β-OL-3-ONE;" "ETHISTERONE" "C21H28O2" 21.00 28.00 2.00 0.00 0.00 0.00 312.00 " (REF:391)" " HO C舛H" " H3Cｶﾄ" " ／＼ﾇ＼" " H3Cｶ ｶｽｺ" " ／＼ｫ＼／" " ｵｶ ｶ" " ｴ＼ｷ＼／" " O" "391/" "269-275ﾟC(391)" "[α]23/D=+23.8ﾟ(DIOXANE),[α]25/D=-32.0ﾟ(PYRIDINE)(391)" "水に不溶｡ｱﾙｺｰﾙ,ｱｾﾄﾝ,ｴｰﾃﾙ,ｸﾛﾛﾎﾙﾑ,ﾍﾞｼﾞﾀﾌﾞﾙｵｲﾙにわずかに溶ける｡(391)" "391/" "UV MAX(METHANOL) : 241nm(E1%/1cm 513)(391)" "391/" "デヒドロエピアンドロステロンへアセチレンを加え、Oppenauer酸化を行って調整(391)" "ST0210" 12.00 "19-NOR-PREGN-4EN-20-YNE-3,17-DIOL; 17α-ETHYNYL-19-NORANDROST-4-ENE-3β,17β-DIOL; 17α-ETHYNYL-4-ESTRENE-3β,17β-DIOL;" "ETHYNODIOL" "ED" "C20H28O2" 20.00 28.00 2.00 0.00 0.00 0.00 300.00 " (REF:393)" " HO C舛H" " H3Cｶﾄ" " ／＼ﾇ＼" " ｶ ｶｽｺ" " ／＼／＼／" " ｵｶ ｶ" " ／＼ｷ＼／" " HO" "393/" "147-149ﾟC(393)" "[α]/D=-39ﾟ(EtOH)(393)" "アルコールに可溶｡(393)" "393/" "特に強い吸収はない。(393)" "νKBr/MAX 3300cm-1(393)" "393/" "合成(393) 3-ACETATE,17-ACETATE,DIACETATEとして調整(393)" "393/" "・プロゲステロン活性(393)" "393/" "ST0211" 12.00 "STIGMASTA-5,24(28)-DIEN-3-OL" "FUCOSTEROL" "C29H48O" 29.00 48.00 1.00 0.00 0.00 0.00 412.00 " H3C (REF:394/395)" " ＼" " H3C ｳ CH3" " ＼／＼／＼／" " H3C ｵ ｵ" " ／＼ﾇ＼ CH3" " H3C ｵｶｽｺ" " ／＼ﾇ＼／" " ｵｶ ｶ" " ／＼／ｸ／" " HC" "394/395/" "124ﾟC(METHANOL)(394)" "220-230ﾟC/0.2mm.(394)" "[α]20/D=-38.42ﾟ(C=5 IN CHLOROFORM)(394)" "ほとんどの有機溶媒に可溶｡(394)" "394/" "・Fucus vesiculosus L.,Fucaceae から分離(394) ・MARINE BROWN ALGAE(PHAEOPHYCEAE)から分離(396)・3β-HYDROXY-20-ISO-Δ5-CHOLENIC ACID から合成(397)" "394/396/397/" "GLC (140)" "140/" "ST0212" 12.00 "3-AMINO-5-PREGNAN-20-ONE, 3α-AMINO-20-OXO-5α-PREGNANE" "FUNTUMINE" "C21H35ON" 21.00 35.00 1.00 1.00 0.00 0.00 317.00 " CH3 (REF:398/399/400/401)" " |" " C=O" " H3C ｵ" " ／＼ﾇ＼" " H3C ｵｶｽｺ" " ／＼ﾇ＼／" " ｵｶ ｶ" " ﾄ＼／＼／" " H2N" "398/399/400/401/" "126ﾟC(ETHYL ACETATE)(401)" "[α]/D=+95ﾟ(C=1.7,CHCl3)(401)" "通常の有機溶媒に可溶｡(400/401)" "400/401/" "・Funtumia latifolia ξtapf.,Apocynaceae より分離(400) ・Halorrhena febrifuga (402)" "400/402/" "ラット肝癌に有効(401)" "401/" "ST0213" 12.00 "3β,11α,14-TRIHYDROXY-5β-BUFA-20,22-DIENOLIDE" "GAMABUFOTALIN" "C24H34O5" 24.00 34.00 5.00 0.00 0.00 0.00 402.00 " (REF:403/404)" " ／ｦｦ＼" " HO H3Cｶｸｽ ／ｦO" " ﾅ／＼ﾇ＼ O" " H3C ｵｶｽｺ" " ／＼ﾇ＼／ｵ" " ｵｶ ｶ OH" " ﾄ＼／ﾉ／" " HO H" "403/404/" "254ﾟC(ALCOHOL+ETHER)(404)" "[α]18/D=+1.26ﾟ(C=0.793 IN METHANOL)(404)" "クロロホルム,アセトン,水にわずかに溶ける｡メタノールにはいくらか溶ける｡(404)" "404/" "UV MAX ABOUT 300nm(404)" "404/" "・ヒキガエル:Japanese toad(gama:Bufovulgaris formosus)(405) ・Chinese toad(Bufo asiaticus=Bufo gargarizans Cantor)(247)" "405/247/" "・ジギタリス様活性(406)" "406/" "ST0214" 12.00 "(25R)-3β-HYDROXYSPIROST-5-EN-12-ONE; 20α,22A,25D-SPIROST-5-EN-3β-OL-12-ONE" "GENTROGENIN,BOTOGENIN" "C27H40O4" 27.00 40.00 4.00 0.00 0.00 0.00 428.00 " CH3 O ｰ H (REF:407/408)" " ﾃｽｽﾄ ＼ｽｽｵ" " O ｵｶｼｼ＼ ／ﾅ" " ｳ CH3ｵ O ＼／ CH3" " ／＼ﾇ＼／" " H3C ｵｶｽｺ" " ／＼ﾇ＼／" " ｵｶ ｶ" " ﾄ＼／ｸ／" " HO" "407/708/" "215-216ﾟC(METHANOL)(407)" "[α]28/D=-56ﾟ(C=1.02 IN CHCl3)(407)" "407/" "・ヤマノイモ属 Dioscorea mexicana (ﾒｷｼｺﾔﾏﾉｲﾓ)(407) ・ヤマノイモ属 Dioscorea spiculiflora, Dioscoreaceae(409)" "407/409/" "薬理学的に活性をもつステロイド合成のための前駆物質(407)" "407/" "ST0215" 12.00 "(25R)-5α-SPIROSTAN-2α,3β-DIOL" "GITOGENIN,DIGIN" "C27H44O4" 27.00 44.00 4.00 0.00 0.00 0.00 432.00 " CH3 O ｰ H (REF:322/410/411/412/413/326)" " ﾃｽｽﾄ ＼ｽｽｵ" " ｵｶｼｼ＼ ／ﾅ" " CH3ｵ O ＼／ CH3" " ／＼ﾇ＼／" " HO H3C ｵｶｽｺ" " ﾅ／＼ﾇ＼／ﾂ" " ｵｶ ｶ H" " ﾄ＼／ﾊ／" " HO H" "322/410/411/412/413/326/" "266-268ﾟC(411)" "[α]20/D=-75ﾟ(C=1.02 IN CHCl3)(414)" "クロロホルム,熱したアルコールに可溶｡冷たいエチルアセテート,エーテルにわずかに可溶｡水には不溶｡(414)" "411/414/" "GENERAL ABSORPTION 230-320nm 領域｡(414)" "414/" "・DIGITALIS PURPUREAの種 (410) ・ジトニン(GITONIN)を dil.HClで加熱して得られる｡(322)" "410/322/" "強心剤(410)" "410/" "ジギトニンで, 沈澱せず｡ (322) ジギトニンで, 沈澱する｡(411)" "322/411/" "ST0216" 12.00 "3β,14,16β-TRIHYDROXY-5β-CARD-20(22)-ENOLIDE; Δ20,22-3,14,16,21-TETRAHYDROXYNORCHOLENIC ACID LACTONE." "GITOXIGENIN" "C23H34O5" 23.00 34.00 5.00 0.00 0.00 0.00 390.00 " O (REF:415/416)" " ｴ" " ｴｻ" " ﾉｽO" " CH3ｵ OH" " ／＼ﾇ＼／" " H3C ｵｶｽｺ" " ／＼ﾇ＼ｬ" " ｵｶ ｶ OH" " ／＼／＼／" " HO" "415/416/" "234ﾟC(416)" "[α]20/545=+38.5ﾟ(C=0.68 IN METHANOL)(415)" "アルコール,アセトン,エチルアセテートにわずかに可溶｡(415/416)" "416/415/" "MAX(96% H2SO4):310,485,520nm(416)" "416/" "・ジトキシン(GITOXIN)のアグリコン(415) ・水＋アルコール＋HClの中で, ジトキシンを還流させて得られる｡(415)" "415/" "強心作用(417)" "417/" "415/" "ST0217" 12.00 "20,24-EPOXY-3,25-DIHYDROXY-9-METHYL-19-NOR-9β-LANOST-5-EN-11-ONE" "GRATIOGENIN" "C30H48O4" 30.00 48.00 4.00 0.00 0.00 0.00 472.00 " H3C CH3 (REF:418/419)" " ｪｼｻｽ|" " ｶ｡ C-OH" " O CH3ｵO |" " ｹ／＼ﾇ＼ CH3" " H3C ｵｶｽｺ" " ／＼ﾇ＼／ﾂ" " ｵｶ ｶ CH3" " ／＼／ｸ／" " HO ／＼" " H3C CH3" "418/419/" "191-196ﾟC(418), 202-203ﾟC(419)" "[α]20/D=+168ﾟ(C=1.193 IN CHCl3),[α]20/D=+151ﾟ(C=0.863 IN MeOH)(418), [α]25/D=+175±3ﾟ(CHCl3)(419)" "メタノール,エタノール,クロロホルム,アセトン,ピリジンに可溶｡水,エーテル,石油エーテルには不溶｡(418/419)" "418/419/" "UV MAX: 290mμ(log ε=2.0)(EtOH)(418)" "3620, 3588, 1691 cm-1(419)" "M/E = 105,109,119,127,135,143,172,173,175,192,309,327,371,413,439,454,472(419)" "CD(C=0.69g/l):λ(Δε)=340(O), 317(+3.65,INFLEX10N), 305(+5.60,PLATEAU), 298(+5.80), 240mμ(O)(419)""" "418/419/" "・GRATIOLA OFFICINALIS L.の塊茎｡(418)・GRATIOLA OFFICINALIS L. 由来の GRATIOSIDEを加水分解して得られる｡(418)" "418/" "415/" "ST0218" 12.00 "(25R)-3β-HYDROXY-5α-SPIROSTAN-12-ONE" "HECOGENIN" "C27H42O4" 27.00 42.00 4.00 0.00 0.00 0.00 430.00 " CH3 O ｰ H (REF:357/358)" " ﾃｽｽﾄ ＼ｽｽｵ" " O ｵｶｼｼ＼ ／ﾅ" " ｳ CH3ｵ O ＼／ CH3" " ／＼ﾇ＼／" " H3C ｵｶｽｺ" " ／＼ﾇ＼／" " ｵｶ ｶ" " ﾄ＼／ﾊ／" " HO H" "357/358/" "264-266ﾟC(358)" "[α]/D=+8ﾟ(CHCl3)(358)" "エーテル,酢酸エチル,ベンゼン,アセトン(358)" "358/" "・植物, 特にリュウゼツラン属の種｡ (357) ・単離調製法(357) ・18ステップを経て, ISOANDROSTERONEを TIGOGENINと NEOTIGOGENINの混合物へ変換し, 更に HECOGENINなどの STEROIDAL SAPOGENINへ変換｡(358)" "357/358/" "ST0219" 12.00 "ESTRA-5,7,9-TRIENE-3β,17β-DIOL" "HEXAHYDROEQUILENIN" "C18H24O2" 18.00 24.00 2.00 0.00 0.00 0.00 272.00 " (REF:420/421)" " OH" " CH3ｵ" " ／＼ﾇ＼" " ｵｶｽｺ" " ／＼／ｹ／" " ｵ ｾｶ" " ／＼／＼ｷ" " HO" "420/421/" "168-168.5ﾟC(420)" "[α]23/D=-5±4ﾟ(0.945% IN ETHANOL)(420)" "420/" "・妊娠馬尿中の単離物質から調製｡(420)・EQUILENINを酸エタノール中で水素化する事によっても調製｡(421)" "420/421/" "・高いエストロゲン活性を示す｡ (ﾗｯﾄ)(420)" "420/" "ジギトニンと反応して沈澱せず｡ (420) 240ﾟに加熱しても,Δ5,7,9-ESTRTRIENOL-3-ONE-17 のように赤色を呈さない(421)" "420/421/" "ST0220" 12.00 "CHOLEST-5-ENE-3β,24-DIOL." "24-HYDROXYCHOLESTEROL" "C27H46O2" 27.00 46.00 2.00 0.00 0.00 0.00 402.00 " (REF:422/423)" " H3C" " ＼／＼ CH3" " CH3ｵｶｽ／" " ／＼ﾇ＼ｶ ＼" " H3C ｵｶｽｺ OH CH3" " ／＼ﾇ＼／" " ｵ ｵｶ" " ／＼／ｸ／" " HO" "422/423/" "24β-EPIMER:175-176ﾟC(422), 24α-EPIMER:182-183ﾟC(424)" "24β-EPIMER: [α]20/D=-48.2ﾟ(C=1.06 IN CHCl3)(423), 24α-EPIMER: [α]20/D=-26.8ﾟ(C=0.672 IN CHCl3)(424)" "422/424/423/" "・馬の脳からβ-ISOMERの単離｡ (422) ・牛の脊髄からβ-ISOMERの単離｡ (423)" "422/423/" "２つのSTEREOISOMERがある。 CHOLEST-5-ENE-3β,24β-DIOL. CHOLEST-5-ENE-3β,24α-DIOL(424) 24β-EPIMERを, CEREBROSTENEDIOL, 又は CEREBROSTEROL とも言う｡(422)" "422/424/" "ST0221" 12.00 "CHOLEST-5-ENE-3,25-DIOL; Δ5-CHOLESTENE-3β,25-DIOL." "25-HYDROXYCHOLESTEROL" "C27H46O2" 27.00 46.00 2.00 0.00 0.00 0.00 402.00 " (REF:425/426/427)" " H3C" " ＼／＼ CH3" " CH3ｵｶｽｺｽ" " ／＼ﾇ＼ ＼OH" " H3C ｵｶｽｺ CH3" " ／＼ﾇ＼／" " ｵ ｵｶ" " ／＼／ｸ／" " HO" "425/426/427/" "178-180ﾟC(425/426)" "[α]25/D=-39.0ﾟ(C=1.05 IN CHCl3)(425/426)" "425/426/" "(CHCl3) 3620(OH), 1050, 1020, 960, 930, 910cm-1.(427/428)" "(CDCl3)δ5.33(m,H-6); 3.48(m,-CH-O); 1.19(s,H3C-C(26) AND H3C-C(27));1.00(s,H3C-C(19)); 0.92(d,J=7Hz,CH3); 0.67(s,H3C-C(18)) MOLECULAR ION M/E 402(427/428/429)" "427/428/429/" "・コレステロール標品に微量混在｡ (422) ・3β-ACETOXY-5-CHOLESTENE-25-ONE をメチルマグネシュウムで処理して調製｡ (425/426)" "422/425/426/428/429/432/433/435/" "VITAMINN D3 代謝中間体, 25-HYDROXYCHOLECALCIFEROL や 1,25-DIHYDROXYCHOLECALCIFEROL の合成に重要｡ (427/428/430/431/432)" "427/428/430/431/432/" "ST0222" 12.00 "8α-ESTRA-1,3,5(10)-TRIENE-3,17β-DIOL; Δ1,3,5-8α-EPIESTRATRIENE-3,17β-DIOL; 8α-ESTRADIOL; 8-EPIESTRA-DIOL; 8-ISOESTRADIOL-17β" "ISOESTRADIOL, 8α-ESTRADIOL" "C18H24O2" 18.00 24.00 2.00 0.00 0.00 0.00 272.00 " (REF:086)" " OH" " CH3ｵ" " ／＼ﾇ＼" " ｶ Hｶｽｺ" " ｴ＼／ﾊﾈﾂ" " ｵｳ H ｵH" " ／ｸ／＼／" " HO" "086/" "α-FORM:181ﾟC(DIL METHANOL+CHCl3), dl-FORM:213.5-214ﾟC(DIL METHANOL)(086)" """α-FORM:[α]20/D=+18ﾟ(16mg IN 2ml DIOXANE),[α]21/D=+28ﾟ(Alc)(086/436)" "メタノール,クロロホルム(086)" "086/436/" "λMAX 269mμ(log ε=2.66), 278mμ(log ε=2.49)(436/385)" "436/385/" "・DIHYDROEQUILINの高圧水素化により調製｡(086)・2800PSIと85ﾟで RANEYニッケルを用いてEQUILENINを水素化して調製｡(436) ・立体化学 (385)と dl-EQUILENINから dl型の調製｡(385)" "086/385/436/" "ST0223" 12.00 "9β-ERGOSTA-5,7,22-TRIEN-3β-OL;" "9β-ERGOSTEROL, ISOPYROCALCIFEROL" "C28H44O" 28.00 44.00 1.00 0.00 0.00 0.00 396.00 " CH3 (REF:437)" " H3C ｵ CH3" " ＼／ｹ／＼／" " H3C ｵ ｵ" " ／＼ﾇ＼ CH3" " ｶ ｶｽｺ" " ／＼ﾇﾉ／" " ｵｶ Hｳ" " ／＼／ｸ／" " HO" "437/" "112-115ﾟC(ETHER-METHANOL)(437)" "[α]20/D=+332ﾟ,[α]20/546=+415ﾟ(C=1.5 IN CHCl3)(437)" "クロロホルム(437)" "437/" "UV MAX:262, 280nm(437)" "437/" "分布(437)" "ジギトニンと反応して沈澱する｡ (437)" "437/" "ST0224" 12.00 "SOLANID-5-ENE-3β,18-DIOL," "ISORUBIJERVINE, 18-HYDROXYSOLANIDINE" "C27H43O2N" 27.00 43.00 2.00 1.00 0.00 0.00 413.00 " H3C (REF:438/439/440/441/442/443)" " ﾅｽｽ／＼" " ｵｶ ｶ" " HOCH2ｵ N ｶ" " ／＼ﾇ＼／＼／ﾅ" " H3Cｶ ｶｽｺ CH3" " ／＼ﾇ＼／" " ｵｶ ｶ" " ／＼／ｸ／" " HO" "438/439/440/441/442/443/" "235-237ﾟC(ALCOHOL)(438), 236-238ﾟC(442)" "[α]25/D=+6.5ﾟ(C=0.97 IN ABS.ETHANOL)(438)" "ピリジン,アルコール,クロロホルム(438/439/440)" "438/439/440/442/" "・シュロソウ属 (Veratrum Liliaceae)の多くの種から得られる｡ (438) ・V.ALBUM, V.VIRIDE から分離｡ (438)・RUBIJERVINEの単離過程で分離される｡(438)" "438/" "ジギトニンで沈澱｡ (439) 水素化によって 1,2-CYCLOPENTENOPHENA THRENEが出来る｡(439) SOLANIDINE へ変換する事によって HYDROXY-SOLANIDINEとして ISORUBIJERVINE構造を確定｡(440) Ｘ線分析によって, (22R:NS)- 配座が明らかになった｡(442)" "439/440/442/" "ST0225" 12.00 "17α-METHYL-5-ANDROSTENE-3β,17β-DIOL," "METHANDRIOL" "MAD" "C20H32O2" 20.00 32.00 2.00 0.00 0.00 0.00 304.00 " (REF:444/445)" " HO CH3" " H3C ﾓ" " ／＼ﾇ＼" " H3Cｶ ｶｽｺ" " ／＼ﾇ＼／" " ｵｶ ｶ" " ／＼／ｸ／" " HO" "444/445/" "205.5-206.5ﾟC(ETYLACETATE)(444/445)" "[α]20/D=-73ﾟ(ALCOHOL),[α]21/D=-84.5ﾟ(C=0.977, CHCl3)(445)" "水に不溶,有機溶媒にわずかに可溶(444/445)" "444/445/" "MAX.mμ(E1%/1cm):235(141),309(155),355(136),390(168)[I],438(373),497(209). MIN.mμ(E1%/1cm):226(136),258(105),335(123),372(123),478(145). (446)" "1.08(C18),1.08(C19),2.55(M,C4),5.39(M,C6),1.38(C20) (447)" "446/447/" "・3β-HYDROXY-5-ANDROSTEN-17-ONEへMETHYL MAGNESIUM IODIDEを作用させて調製｡ (444/445)" "444/445/" "・アナボリックステロイドとして作用｡ (444)" "444/" "ST0226" 12.00 "17β-HYDROXY-17-METHYLAN-DROSTA-1,4-DIEN-3-ONE; 17α-METHYL-17β-HYDROXYANDROSTA-1,4-DIEN-3-ONE; 1-DEHYDRO-17α-METHYLTESTOSTERONE" "METHANDROSTENOLONE." "C20H28O2" 20.00 28.00 2.00 0.00 0.00 0.00 300.00 " (REF:448)" " HO CH3" " H3C ﾓ" " ／＼ﾇ＼" " H3Cｶ ｶｽｺ" " ｴ＼ﾇ＼／" " ｵｶ ｶ" " ｴ＼ｷ＼／" " O" "448/" "163-164ﾟC(ACETONE+ETHER)(448)" "[α]26/D=0ﾟ(C=1.150 IN CHCl3)(448)" "クロロホルム(448)" "448/" "UV MAX : 245nm(ε=15,600)(448)" "IN METHYLENECHLORIDE: 2.74μ, 5.98μ, 6.14μ, 6.21μ, 7.29μ, 7.52μ, 8.86μ, 9.23μ, 10.68μ, 10.83μ, 11.28μ, 12.23μ.(448)" "M/D +356(DIOXAN)(448)" "448/" "・17α-METHYLTESTSTERONE の微生物の脱水素化により調製｡(448)・17α-METHYLTESTSTERONE を SeO2で還元して調製｡(449)" "448/449/" "・ANDROGEN 活性(同化促進作用)(448)" "448/" "ST0227" 12.00 "11β-METHOXY-19-NOR-17α-PREGNA-1,3,5(10)-TRIEN-20-YNE-3,17-DIOL; 3,17-DIHYDROXY-11β-METHOXY-19-NOR-17α-PREGNA-1,3,5-TRIEN-20-YNE; 17α-ETHYNYL-11β-METHOXYESTRA-1,3,5(10)-TRIENE-3,17β-DIOL;11β-METHOXY-17α-ETHYNYL-Δ1,3,5(10)-ESTRATRIENE-3,17β-DIOL; 11β-METHOXY-17α-ETHYNYLESTRADIOL;" "MOXESTROL" "C21H26O3" 21.00 26.00 3.00 0.00 0.00 0.00 326.00 " (REF:450)" " HO C舛H" " CH3O H3C ﾓ" " ＼／＼ﾇ＼" " ｶ ｶｽｺ" " ｴ＼／＼／" " ｵｳ ｶ" " ／ｸ／＼／" " HO" "450/" "280ﾟC(450)" "[α]20/D=+29ﾟ(C=0.6 IN EtOH)(450)" "450/" "UV MAX(ETHANOL) : 280nm(ε1%/1cm=58.4)(450)" "450/" "調整" "・エストロゲン活性を示す｡ (450)" "450/" "ST0228" 12.00 "19-NORERGOSTA-5,7,9,22-TETRAEN-3β-OL." "NEOERGOSTEROL" "C27H40O" 27.00 40.00 1.00 0.00 0.00 0.00 380.00 " (REF:451/452/453)" " H3C" " ＼／ｹ CH3" " H3C ｵｶｽ／" " ／＼ﾇ＼ｶ ＼" " ｶ ｶｽｺ CH3 CH3" " ／＼ｴ＼／" " ｵｶ ｳ" " ／＼／ｸ／" " HO" "451/452/453/" "152-154ﾟC(451/453)" "[α]17/D=-11ﾟ(C=2 IN CHCl3)(451)" "水に不溶,有機溶剤に可溶｡(451/452/453)" "451/453/452/" "265-270nm に吸収極大(ETHER) (451)" "νCS2MAX : 3600cm-1(HYDROXY), 970cm-1(SIDE CHAIN DOUBLE BOND), 809cm-1(AROMATIC RING)(453)" "451/453/" "・ジギトニンで沈澱物生成｡(451) ・エルゴステロールから調製｡(451/452/453)" "451/452/453/" "立体化学｡ (454)" "454/" "ST0229" 12.00 "1β,3β,5,11α,14,19-HEXAHYDROXY-5β-CARD-20(22)-ENOLIDE" "OUABAGENIN, G-STROPHANTHIDIN" "C23H34O8" 23.00 34.00 8.00 0.00 0.00 0.00 438.00 " O (REF:262/455)" " ｴ" " ｴｻ" " HO OH CH3ﾉ O" " HOｶﾃ／＼ﾇ＼ｼ" " ｶ CH2ｵｶｽｺ" " ／＼ﾇ＼ｬ" " ｵｶ ｶ OH" " ／＼／ﾉ／" " HO OH" "262/455/" "235-238ﾟC(MONOHYDRATE FROM WATER),255-256ﾟC(ANHYDR.)(262/456)" "[α]17/D=+11.32ﾟ(C=1.27)(262)" "+0.288ﾟ(262)" "約10mlの沸騰水に1g可溶｡ 室温において1%以下の可溶性｡ 希アルコールにも可溶｡ 無水アルコールには不溶｡(262)" "262/456/" "・Strophanthus gratus から得られる配糖体, ウアバイン(ouabain)(262) ・OUABAINをアセトン中塩酸処理して得られる｡(262)" "262/" "・ネコにおける LD50, カエルにおける MEAN SYSTOLIC DOSE｡ (455)" "455/" "OUABAGENIN のステロール構造の証明｡ (456)" "456/" "ST0230" 12.00 "3β,5,14-TRIHYDROXY-5β-CARD-20(22)-ENOLIDE" "PERIPLOGENIN,19-DESOXOSTROPHANTHIDINE" "C23H34O5" 23.00 34.00 5.00 0.00 0.00 0.00 390.00 " O (REF:457/458/459/460/461)" " ｴ" " ｴｻ" " H3C ﾉ O" " ／＼ﾇ＼ｼ" " H3C ｵｶｽｺ" " ／＼ﾇ＼ｬ" " ｵｶ ｶ OH" " ／＼／ﾉ／" " HO OH" "457/458/459/460/461/" "235ﾟC(457/458),135-140ﾟC(FROM MeOH-H2O)(461)" "[α]27/D=+31.5ﾟ(C=1.04 IN ALCOHOL),[α]20/D=+29.8ﾟ(C=1 IN METHANOL)(457/458)" "アルコール,クロロホルムに可溶｡ エーテル：水(1:2500)にわずかに可溶｡ ベンゼン,石油エーテルに不溶｡ (457/458)" "457/458/461/" "・Periploca graece の樹皮,木部 (457) ・Strophanthus eminii Asch et Pax. Apocynaceae (458) ・数種の STROPHANTHUS GENUS(461)・STROPHANTHUS EMINII ASCH. ET PAX.,APOCYNACEAEの STROPHANTHIDINEに伴って調製される｡(457) ・PERIPLOCINを加水分解すると,PER" "457/458/461/462/" "ST0231" 12.00 "11,17,21-TRIHYDROXYPREGNA-1,4-DIENE-3,20-DIONE; 1,4-PREGNADIENE-3,20-DIONE-11β,17α,21-TRIOL; 1,4-PREGNADIEN-11β,17α,21-TRIOL-3,20-DIONE; 3,20-DIOXO-11β,17α,21-TRIHYDROXY-1,4-PREGNADIENE" "PREDNISOLONE, METICORTELONE" "C21H28O5" 21.00 28.00 5.00 0.00 0.00 0.00 360.00 " CH2OH (REF:463/464)" " ｵ" " O=C OH" " HO H3C ﾓ" " ＼／＼ﾇ＼" " H3C ｵｶｽｺ" " ｴ＼ﾇ＼／" " ｵｶ ｶ" " ｴ＼ｷ＼／" " O" "463/464/" "240-241ﾟC(463/464)" "[α]25/D=+102ﾟ(DIOXANE)(463/464)" "水にわずかに可溶｡ 1gが約30mlのアルコール, 約180mlのクロロホルム, 約50mlの アセトンに可溶｡ メタノールとジオキサンに可溶｡(465)" "463/464/465/" "UV MAX(METHANOL): 242nm (ε=15,000;A1%/1cm=414)(463/464)" "λ Nujol/MAX : 2.96(OH), 5.82(20-CARBONYL), 6.04, 6.19 AND 6.25(Δ1,4-DIENE-3-ONE)(463/464)" "463/464/" "・CORYNEBACTERIUM SIMPLEX によってコルチゾールから生成｡ (465)" "465/" "・天然のコルチコステロイドよりも抗炎症薬として有効｡ (465) ・副腎摘出マウスにおける EOSINOPENIC RESPONSE, 肝グリコーゲン貯留法, 無処理マウスにおける胸腺退化法によって, 天然コルチゾン, ヒドロコルチゾンの３倍から４倍の グルココルチコイド" "465/464/" "ST0232" 12.00 "17,21-DIHYDROXYPREGNA-1,4-DIENE-3,11,20-TRIONE; 1,4-PREGNADIENE-17α,21-DIOL-3,11,20-TRIONE" "PREDNISONE, METICORTEN" "C21H26O5" 21.00 26.00 5.00 0.00 0.00 0.00 358.00 " CH2OH (REF:463/464)" " ｵ" " O=C OH" " O H3C ﾓ" " ｸ／＼ﾇ＼" " H3C ｵｶｽｺ" " ｴ＼ﾇ＼／" " ｵｶ ｶ" " ｴ＼ｷ＼／" " O" "463/464/" "233-235ﾟC(463/464)" "[α]25/D=+172ﾟ(DIOXANE)(463/464)" "ほんのわずかに水に可溶｡ 1gが約150mlのアルコール, 約200mlのクロロホルムに可溶｡ メタノールとジオキサンにもわずかに可溶｡(465)" "463/464/465/" "UV MAX(METHANOL): 238nm (ε=15,500)(463/464)" "λ Nujol/MAX : 3.04(OH), 5.84(11- AND 20-CARBONYLS), 5.98, 6.16 AND 6.21(Δ1,4-DIENE-3-ONE)(463/464)" "463/464/" "・CORYNEBACTERIUM SIMPLEX によってコルチゾンから生成｡ (465)" "465/" "・抗炎症作用(465),天然のコルチコステロイドより有効｡ ・副腎摘出マウスにおける EOSINOPENIC RESPONSE, 肝グリコーゲン貯留法, 無処理マウスにおける胸腺退化法によって, 天然コルチゾン, ヒドロコルチゾンの３倍から４倍の グルココルチコイド 活性が確かめられ" "465/464/" "ST0233" 12.00 "11,21-DIHYDROXY-17-[(1-OXOPENTYL)-OXY]PREGNA-1,4-DIENE-3,20-DIONE; 11β,17,21-TRIHYDROXYPREGNA-1,4-DIENE-3,20-DIONE 17-VALERATE; PREDNISOLONE 17-VALERATE" "PREDNIVAL" "C26H36O6" 26.00 36.00 6.00 0.00 0.00 0.00 444.00 " CH2OH (REF:466)" " ｵ" " O=C OOC(CH2)3CH3" " HO H3C ﾓ" " ＼／＼ﾇ＼" " H3C ｵｶｽｺ" " ｴ＼ﾇ＼／" " ｵｶ ｶ" " ｴ＼ｷ＼／" " O" "466/" "210-213ﾟC(METHANOL)(466)" "[α]/D=+3.5ﾟ(DIOXANE)(466)" "466/" "・17α,21-CYCLIC ORTHOESTERSから調製｡(466)" "466/" "・糖質コルチコイド｡ (466)" "466/" "ST0234" 12.00 "9β,10α-ERGOSTA-5,7,22-TRIEN-3β-OL." "LUMISTEROL" "C28H44O" 28.00 44.00 1.00 0.00 0.00 0.00 396.00 " CH3 (REF:437/467/468)" " H3C ｵ CH3" " ＼／ｹ／＼／" " H3C ｵ ｵ" " ／＼ﾇ＼ CH3" " H3C ｵｶｽｺ" " ｴ＼ﾈﾉ／" " ｵｶ Hｳ" " ／＼／ｸ／" " HO" "437/467/468/" "118ﾟC(437)" "[α]19/D=+191.5ﾟ, [α]19/546=+235.4ﾟ(C=2 IN ACETONE)(437)" "水に不溶, 有機溶媒に可溶｡ (437)" "437/" "279nm (ε=8,500) (468/469)" "468/469/" "・エルゴステロールのベンゼンｰアルコール溶液を紫外線照射して得られる｡(437)" "437/" "ST0235" 12.00 "5β-PREGNANE; 17β-ETHYLETIOCHOLANE." "PREGNANE" "C21H36" 21.00 36.00 0.00 0.00 0.00 0.00 288.00 " CH3 (REF:470)" " ｵ" " CH2" " H3C ｵ" " ／＼ﾇ＼" " H3C ｵｶｽｺ" " ／＼ﾇ＼／" " ｵｶ ｶ" " ＼／ﾉ／" " H" "470/" "83.5ﾟC(METHANOL)(470)" "[α]19/D=+20ﾟ(C=2 IN CHCl3),[α]20/D=+19.6ﾟ(IN CHCl3)(470)" "d15/4=1.032(470)" "クロロホルム, メタノール (470)" "470/" "・ヒト妊婦尿｡ (470) ・PREGNANETRIOL-B から調製｡(471)・Δ5-3-OXY-21-ACETOXY-PREGNENON-20 から調製｡(189)" "470/471/189/" "・アンドロゲン活性｡ (470)" "470/" "ST0236" 12.00 "(3α,5β,20S)-PREGNANE-3,20-DIOL" "PREGNANEDIOL" "C21H36O2" 21.00 36.00 2.00 0.00 0.00 0.00 320.00 " CH3 (REF:114/472)" " ｵ" " CHOH" " H3C ｵ" " ／＼ﾇ＼" " H3C ｵｶｽｺ" " ／＼ﾇ＼／" " ｵｶ ｶ" " ﾄ＼／＼／" " HO" "114/472/" "239ﾟC(ACETONE OR ETHANOL)(472)" "[α]20/D=+27.4ﾟ(C=0.7 IN ALCOHOL)(472)" "有機溶媒にわずかにとける｡ (472)" "472/" "・プロゲステロンの代謝産物｡ 妊婦尿に多く分布 (ﾋﾄ, ｳｼ, ｳﾏ, ﾁﾝﾊﾟﾝｼﾞｰ)(114/472/473)" "114/472/473/" "ジギトニンと反応して, 沈澱物なし｡ (472) プロゲステロン合成材料｡ (473)" "472/473/" "ST0237" 12.00 "3,20-PREGNANEDIONE" "C21H32O2" 21.00 32.00 2.00 0.00 0.00 0.00 316.00 " CH3 (REF:474)" " ｵ" " C=O" " H3C ｵ" " ／＼ﾇ＼" " H3C ｵｶｽｺ" " ／＼ﾇ＼／" " ｵｶ ｶ" " ｴ＼／ﾉ／" " O H" "474/" "123ﾟC(474)" "水に不溶｡ 通常の有機溶媒に可溶｡ (474)" "474/" "・妊娠馬尿｡ (474) ・ヒト妊娠尿｡ (475) ・4,11-PREGNA DIEN-3,20-DIONEから調製｡(476)" "474/475/476/" "・アンドロジェン活性｡ (474/475)" "474/475/" "ST0238" 12.00 "3α-HYDROXY-5β-PREGNAN-20-ONE, PREGNAN-3α-OL-20-ONE" "C21H34O2" 21.00 34.00 2.00 0.00 0.00 0.00 318.00 " CH3 (REF:477)" " ｵ" " C=O" " H3C ｵ" " ／＼ﾇ＼" " H3C ｵｶｽｺ" " ／＼ﾇ＼／" " ｵｶ ｶ" " ﾄ＼／ﾉ／" " HO H" "477/" "149.5ﾟC(HEXANE)(477/478)" "[α]13/D=+109ﾟ(C=0.98 IN ETHANOL)(477/478)" "477/478/" "・妊婦, 妊娠豚の尿｡ (477) ・SODIUM PREGNANEDIOL GLUCURONIDATEの加水分解によって得られる｡(478)" "477/478/" "ジギトニンと反応しても沈澱せず｡ (477)" "477/" "ST0239" 12.00 "3β-HYDROXY-5β-PREGNAN-20-ONE." "PREGNAN-3β-OL-20-ONE." "C21H34O2" 21.00 34.00 2.00 0.00 0.00 0.00 318.00 " CH3 (REF:479)" " ｵ" " C=O" " H3C ｵ" " ／＼ﾇ＼" " H3C ｵｶｽｺ" " ／＼ﾇ＼／" " ｵｶ ｶ" " ／＼／ﾉ／" " HO H" "479/" "149ﾟC(dil.ALCOHOL)(479)" "エーテルに可溶(479)" "479/" "・PREGNANDIONE からの調製｡(479) ・天然 PREGNANDIOL からの調製｡(479)" "479/" "ジギトニンと反応して沈澱物形成｡ (479) PREGNAN-3α-OL-20-ONE とは, エピ異性体の関係にある｡(479)" "479/" "ST0240" 12.00 "20α-HYDROXY-5β-PREGNAN-3-ONE." "PREGNAN-20α-OL-3-ONE." "C21H34O2" 21.00 34.00 2.00 0.00 0.00 0.00 318.00 " CH3 (REF:480)" " ｵ" " CHｪOH" " H3C ｵ" " ／＼ﾇ＼" " H3C ｵｶｽｺ" " ／＼ﾇ＼／" " ｵｶ ｶ" " ｴ＼／ﾉ／" " O H" "480/" "152ﾟC(ACETONE)(480)" "480/" "・PREGNANOLON-ACETATE から調製｡(480)" "480/" "・アンドロゲン活性｡ (481)" "481/" "ST0241" 12.00 "20β-HYDROXY-5β-PREGNAN-3-ONE." "PREGNAN-20β-OL-3-ONE." "C21H34O2" 21.00 34.00 2.00 0.00 0.00 0.00 318.00 " CH3 (REF:481)" " ｵ" " CH−OH" " H3C ｵ" " ／＼ﾇ＼" " H3C ｵｶｽｺ" " ／＼ﾇ＼／" " ｵｶ ｶ" " ｴ＼／ﾉ／" " O H" "481/" "172ﾟC(dil.ACETONE)(481)" "メタノールに可溶｡ (481)" "481/" "・ヒト妊娠尿｡ (481) ・PREGNANDIOL-3(α),20(α)から合成される PREGNANDIOL-3(β),20(β)をアセチル化, 部分ケン化, 酸化, 加水分解によって得られる．(481)" "481/" "・高いアンドロゲン活性｡ (481)" "481/" "PREGNAN-20α-OL-3-ONEの C20-OHの異性体｡ (481) 融点は, 20α異性体(152ﾟC)より高い(172ﾟC)｡(481)" "481/" "ST0242" 12.00 "20,21-DIHYDROXYPREGN-4-ENE-3,11-DIONE" "4-PREGNENE-20,21-DIOL-3,11-DIONE, SUBSTANZ T" "C21H30O4" 21.00 30.00 4.00 0.00 0.00 0.00 346.00 " CH2OH (REF:482)" " ｵ" " HOCH" " O H3C ｵ" " ｹ／＼ﾇ＼" " H3C ｵｶｽｺ" " ／＼ﾇ＼／" " ｵｶ ｶ" " ｴ＼ｷ＼／" " O" "482/" "約210ﾟC(482)" "[α]20/D=+176ﾟ(ACETONE)(482)" "482/" "240 mμ(log ε=約4.2) ケト基の存在による｡ (482)" "482/" "・副腎｡ (482)" "482/" "ST0243" 12.00 "11β,17,20β,21-TETRAHYDROXYPREGN-4-EN-3-ONE; 17-(1,2-DIHYDROXYETHYL)ANDROSTEN-3-ONE-11,17-DIOL" "4-PREGNENE-11β,17α,20β,21-TETROL-3-ONE" "C21H32O5" 21.00 32.00 5.00 0.00 0.00 0.00 364.00 " CH2OH (REF:483/295)" " ｵ" " HOCH OH" " HO H3C ﾓ" " ＼／＼ﾇ＼" " H3C ｵｶｽｺ" " ／＼ﾇ＼／" " ｵｶ ｶ" " ｴ＼ｷ＼／" " O" "295/483/" "[α]20/D=+87ﾟ(ALCOHOL), [α]10/D=+120ﾟ(C=2 ALCOHOL)(483)" "483/" "UV MAX : 240nm (483)" "483/" "・副腎皮質｡ (483)・単離｡(484)" "483/484/" "ST0244" 12.00 "17,20,21-TRIHYDROXYPREGN-4-ENE-3,11-DIONE" "4-PREGNENE-17α,20β,21-TRIOL-3,11-DIONE" "C21H30O5" 21.00 30.00 5.00 0.00 0.00 0.00 362.00 " CH2OH (REF:484/485)" " ｵ" " HOCH OH" " O H3C ﾓ" " ｹ／＼ﾇ＼" " H3C ｵｶｽｺ" " ／＼ﾇ＼／" " ｵｶ ｶ" " ｴ＼ｷ＼／" " O" "484/485/" "208-209ﾟC(ACETONE+ETHER)(485)" "485/" "・副腎｡ (485)" "485/" "ST0245" 12.00 "17α,20β,21-TRIHYDROXYPREGN-4-EN-3-ONE; 17-(1,2-DIHYDROXYETHYL)-Δ4-ANDROSTEN-3-ON-17α-OL; 17α-PREGNENETRIOLONE,4-PREGNEN-17α,20β,21-TRIOL-3-ONE" "17α-PREGNENETRIOLONE" "C21H32O4" 21.00 32.00 4.00 0.00 0.00 0.00 348.00 " CH2OH (REF:486)" " ｵ" " HOCH OH" " H3C ﾓ" " ／＼ﾇ＼" " H3C ｵｶｽｺ" " ／＼ﾇ＼／" " ｵｶ ｶ" " ｴ＼ｷ＼／" " O" "486/" "190ﾟC(METHANOL)(486)" "[α]/D=+63ﾟ(C=1 IN DIOXANE)(486)" "ジオキサン,クロロホルム,メタノールに可溶｡ (486)" "486/" "UV MAX : 240nm(log ε=4.1)(486)" "486/" "・17-ETHYNYLTESTOSTERONEからの合成｡(486)" "486/" "ST0246" 12.00 "3β-METHOXYPREGN-5-EN-20-ONE." "PREGNENOLONE METHYL ETHER" "C22H34O2" 22.00 34.00 2.00 0.00 0.00 0.00 330.00 " CH3 (REF:487)" " ｵ" " C=O" " H3C ｵ" " ／＼ﾇ＼" " H3C ｵｶｽｺ" " ／＼ﾇ＼／" " ｵｶ ｶ" " ／＼／ｸ／" " CH3O" "487/" "123.5ﾟC(anhydro OR dil.METHANOL)(487/488)" "[α]18/D=+18ﾟ(C=1.085 IN CHCl3)(487)" "+0.19(5)ﾟ(487)" "メタノール,クロロホルム (487)" "487/488/" "・調製法｡(487/489)・各種 3β-メトキシ-Δ5-ステロイドの合成｡(488)" "487/488/489/" "・抗炎症作用｡ (488)" "488/" "ST0247" 12.00 "3β,26-DIHYDROXY-5α-FUROST-20(22)-EN-12-ONE" "PSEUDOHECOGENIN, 4-HECOGENIN" "C27H42O4" 27.00 42.00 4.00 0.00 0.00 0.00 430.00 " CH3 HO CH3 (REF:357/490)" " ｶ ／＼＼ｽﾄ" " O ｶｦｦｵ ＼／" " ｾｶ O" " ／＼／＼／" " H3C ｵｶｽｺ" " ／＼ﾇ＼／" " ｵｶ ｶ" " ／＼／ﾊ／" " HO H" "357/490/" "190-191ﾟC(490)" "[α]20/D=+103ﾟ(C=1.5 IN CHCl3), +96ﾟ(C=1 IN DIOXANE)(490)" "490/" "UV MAX(ETHANOL): 213nm(ε=6,400)(490)" "νNIJOL/MAX : 3320(HYDROXY),1706(KETONE),1688cm-1(VINYL ETHER)(490)" "490/" "・HECOGENINの加水分解により調製｡(357)" "357/" "ST0248" 12.00 "10α-ERGOSTA-5,7,22-TRIEN-3β-OL; 9α-LUMISTA-5,7,22-TRIEN-3β-OL" "PYROCALCIFEROL, 9α-LUMISTEROL" "C28H44O" 28.00 44.00 1.00 0.00 0.00 0.00 396.00 " CH3 (REF:491/437/492)" " H3C ｵ CH3" " ＼／ｹ／＼／" " H3Cｶ ｵ" " ／＼ﾇ＼ CH3" " H3C ｵｶｽｺ" " ／＼ﾈﾊ／ﾂ" " ｵｶ Hｳ H" " ／＼／ｸ／" " HO" "491/437/492/" "93-95ﾟC(491)" "[α]20/D=+512ﾟ,[α]20/546=+624ﾟ(C=0.15 IN ALCOHOL)(491)" "アルコール(491)" "491/" "274, 294mμ(491)" "491/" "分布(437)" "C-9 と C-10においてエルゴステロールと立体配座が異なる｡ (437)" "437/" "ST0249" 12.00 "Δ5-3β-12α-DIHYDROXYSOLANIDENE, SOLANID-5-ENE-3β,12α-DIOL" "RUBIJERVINE, RUBIGERVINE" "C27H43O2N" 27.00 43.00 2.00 1.00 0.00 0.00 413.00 " H3C (REF:493/494/495/442)" " ﾅ ／＼" " HO ｶｼｻ ｵ" " ﾃ CH3ｵ N ｵ" " ／＼ﾇ＼／＼／ﾅ" " H3C ｵｶｽｺ CH3" " ／＼ﾇ＼／" " ｵｶ ｶ" " ／＼／ｸ／" " HO" "493/494/495/442/" "240-246ﾟC(493)" "[α]25/D=+19.0ﾟ(C=1 ETHANOL)(493)" "水には, わずかしか溶けない｡ エタノール, メタノール, ベンゼン, クロロホルム に可溶｡ エーテル, 石油エーテルに少し溶ける｡ (493)" "493/" "1048, 1028, 1016, 1003cm-1, 1048が最も強い｡ (495)" "495/" "Veratrum Liliaceaeのさまざまな種から単離(493)" "構造のＸ線解析｡ (442)" "442/" "ST0250" 12.00 "(25R)-SPIROST-5-ENE-1β,3β-DIOL" "RUSCOGENIN, RUSCORECTAL" "C27H42O4" 27.00 42.00 4.00 0.00 0.00 0.00 430.00 " CH3 O H (REF:496/497)" " ﾃ ﾄ ＼ｽｽｵ" " ｶｼｻｼ＼ ／ﾅ" " CH3ｵ O ＼／ CH3" " HO ／＼ﾇ＼／" " ｶ CH3ｵｶｽｺ" " ／＼ﾇ＼／ﾂ" " ｵｶ ｶ H" " ／＼／ｸ／" " HO" "496/497/" "205-210ﾟC(乾燥無水物)(496/497)" "[α]19/D=-127ﾟ(496/497)" "496/497/" "ν MAX : 898, 922cm-1(強度同じ)(497)""" "497/" "・RUSCUS ACULEATUS L.(RUSCOGENIN と NEORUSCOGENIN を1:1で産生)(497) ・SANSEVIERIA TRIFASCIATA (498)" "497/498/" "・HEMORROIDSの治療｡(497)" "497/" "ST0251" 12.00 "3β,11α,14-TRIHYDROXY-5β-CARD-20(22)-ENOLIDE" "SARMENTOGENIN" "C23H34O5" 23.00 34.00 5.00 0.00 0.00 0.00 390.00 " ｴO (REF:499)" " ｴｻ" " ･ O" " HO CH3ｵｼ" " ﾅ／＼ﾇ＼" " H3C ｵｶｽｺ" " ／＼ﾇﾊ／ｵ" " ｵｶ Hｶ OH" " ／＼／＼／" " HO" "499/" "265-275ﾟC(499/500)" "[α]19/D=+21.1ﾟ±4ﾟ(C=0.521 IN METHANOL)(499/500)" "アルコール,メタノール,ピリジンに可溶｡ アセトン,クロロホルムにほとんど溶けない｡ ベンゼン,エーテルには不溶｡ (499/500)" "499/500/" "230nm(E 1%/1cm=460,98%H2SO4)(500),415nm(E 1%/1cm=430,98%H2SO4)(500)" "500/" "・STROPHANTHUS SARMENTOSUS (499)" "499/" "・強い配糖体, SARMENTOSIDE Bの成分｡ (501)" "501/" "ST0252" 12.00 "(25S)-SPIROSTAN-3β-OL" "SARSASAPOGENIN, PARIGENIN" "C27H44O3" 27.00 44.00 3.00 0.00 0.00 0.00 416.00 " CH3 O CH3 (REF:502/503/504/505/506/507/508)" " ﾃ ﾄ ＼ｽｽｵ" " ｶｼｻｼ＼ ／ﾅ" " H3C ｵ O ＼／ H" " ／＼ﾇ＼／" " H3C ｵｶｽｺ" " ／＼ﾇ＼／" " ｵｶ ｶ" " ／＼／＼／" " HO" "502/503/504/505/506/507/508/" "199-199.5ﾟ(502)" "[α]25/D=-75ﾟ, [α]25/=-89ﾟ(C=0.5 IN CHCl3)(503)" "アルコール,アセトン,ベンゼン,クロロホルムに可溶｡(502)" "502/503/" "(Asym.-CH2-),2910,2873(Sym.-CH3),2864(Sym.-CH3),2935.(ACETATEとして)(509)" "326c.p.s(C-19ﾒﾁﾙ基),338c.p.s(C-18ﾒﾁﾙ基),321-326c.p.s.(C-21,C-27ﾒﾁﾙ基)(508)" "509/508/" "・SARSAPARILLAの根｡ (502) ・SARSAPARILLAの根から抽出されるサポニンを加水分解して得られる｡(502)" "502/" "DIGITONINで沈澱｡ (502) 側鎖の立体配座｡(504/505/506/507)" "502/504/505/506/507/" "ST0253" 12.00 "7β,8-EPOXY-3β,11α,14-TRIHYDROXY-12-OXO-5β-CARD-20(22)-ENOLIDE" "SARVEROGENIN" "C23H30O7" 23.00 30.00 7.00 0.00 0.00 0.00 418.00 " O (REF:510/511/512/513)" " ｴ" " O ｴｻ" " HO ｳ CH3･ O" " ﾅ／＼ﾇ＼ｼ" " H3C ｵｶｽｺ" " ／＼ﾇ＼／ｵ" " ｵｶ OﾘｵOH" " ／＼／＼／" " HO" "510/511/512/513/" "232-234ﾟ(510/511)" "[α]15/D=+44.5ﾟ±2(C=1.1683 IN METHANOL),[α]23/D=+49.5ﾟ(METHANOL)(510)" "水,メタノール,クロロホルムに可溶｡(510)" "510/511/" "UV MAX : 218, 277.5nm(log ε=4.2, 1.83)(511)" "886-777cm-1(7.8-ｴﾎﾟｷｼ 14β-ﾋﾄﾞﾛｷｼﾙ)(513)" "δ5.03(C-3),δ5.63(11β-PROTON),δ3.93,δ3.43,δ3.20,δ2.83,δ2.6,δ1.31, δ1.13,δ1.08,δ1.06.(514)" "M=418; 400[M-18]; 382[400-18]; 372[400-28(CO?)]; 364[382-18]; 354[372-18 又は382-28(CO)]; 339[354-15(CH3)](513)" "511/513/514/" "・STROPHANTHUS SARMENTOSUS の種｡ (510) ・S.COURMONTII の種｡ (515/516)・S.AMBOENSIS, S.INTERMEDIUS の種｡ (511)・SARVEROSIDEのアグリコン｡(510)" "510/511/515/516/" "ST0254" 12.00 "3β,14-DIHYDROXYBUFA-4,20,22-TRIENOLIDE" "SCILLARENIN" "C24H32O4" 24.00 32.00 4.00 0.00 0.00 0.00 384.00 " O O (REF:517/518/519)" " ｣｢ｴ" " ｾｶ" " ﾉｷ" " ／＼ﾇ＼" " H3C ｵｶｽｺ" " ／＼ﾇ＼／ｵ" " ｵｶ ｶ OH" " ／＼ｷ＼／" " HO" "517/518/519/" "232-238ﾟ(METHANOL)(517/518)" "[α]20/D=-16.8ﾟ(C=0.357 METHANOL),[α]20/D=+17.9ﾟ(C=0.39,CHCl3)(517/518/519)" "クロロホルム,メタノール(517/518/519)" "517/518/519/" "UV MAX : 300nm(log ε=3.72)(517/518)" "ACETATEとして図示｡(519)" "517/518/519/" "・URGINEA BURKEI BAKER,LILIACEAE.(518) ・SCILLA MARITIMA の球根｡ (520)・PROSCILLARIDIN A の酵素的分解によって調製されるアグリコン｡(517)" "517/518/520/" "・強心剤｡ (517) ・ネコでの LD50=0.1567mg/kg (518/520)" "517/520/" "ST0255" 12.00 "6β-(ACETYLOXY)-3β-(β-D-GLUCOPYRANOSYLOXY)-8,14-DIHYDROXYBUFA-4,20,22-TRIENOLIDE." "SCILLIROSIDE" "C32H44O12" 32.00 44.00 12.00 0.00 0.00 0.00 620.00 " O O (REF:521/522/523)" " ｣｢ｴ" " ｾｶ" " ﾉｷ" " ／＼ﾇ＼" " H3C ｵｶｽｺ" " ／＼ﾇ＼／＼" " ｵｶ ｶ＼ OH" " ／＼ｷ＼／ OH" "C6H11O5-O ｵ" "(GLUCOSE) OCOCH3" "521/522/523/" "168-170ﾟ(HEMIHYDRATE)(521)" "[α]20/D=-59ﾟ〜-60ﾟ(METHANOL,C=1)(521)" "低級アルコール, エチレングリコール, ジオキサン, 氷酢酸に可溶｡ 水, アセトン,クロロホルム, 酢酸エチルにわずかに可溶｡ エーテル, 石油エーテルに不溶｡ (521)" "521/" "λMAX: 300nm(log ε=3.73,96%ETHANOL), 295,505nm(E1%/1cm 260, 315, 98%H2SO4)(521)" "521/" "・URGINEA MARITIMA(L.) BAKER, LILIACEAE(ユリ科)の海荵(かいそう) (地中海沿岸地方原産のユリ科の植物｡ 観賞用として栽培されることがあるが,そのタマネギのような球根は以前は強心剤・利尿剤に用いられた｡ (521)" "521/" "・雄ネズミにおける経口投与で, LD50=0.7mg/kg 体重｡ (521) ・強心剤, 利尿剤｡ (521)" "521/" "グルコシド｡ (521) 構造の訂正｡ (522)" "522/" "ST0256" 12.00 "4-METHYLSTIGMASTA-7,24(28)-DIEN-3-OL" "α-SITOSTEROL, CITRSTADIENOL ,24-ETHYLIDENE-LOPHENOL" "C30H50O" 30.00 50.00 1.00 0.00 0.00 0.00 426.00 " ／CH3 (REF:139/136/137/144)" " H3C ｾ CH3" " ＼／＼／＼／" " ｵ ｵ" " ／＼ﾇ＼ CH3" " H3C ｵｶｽｺ" " ／＼ﾇ＼／" " ｵｶ ｳ" " ／＼／ﾊ／" " HO ﾂ" " CH3" "139/136/137/144/" "164-166ﾟ(ALCOHOL)(139/136)" "[α]28/D=-1.7ﾟ(C=2,CHCl3)(139/136)" "アルコール,クロロホルム (139/136)" "139/136/" "209mμ(ε=5,500)(137)" "137/" "・麦芽油, コーン油｡(142), 柑橘類｡ (137)・最も普遍的な植物ステロール｡ (142) ・合成法｡(138)・24(28)二重結合におけるシスートランス異性体｡(145/140)" "137/138/140/142/145/" "ジギトニンで沈澱｡ (139)" "139/" "ST0257" 12.00 "SOLANID-5-EN-3β-OL" "SOLANIDINE, SOLATUBINE" "C27H43ON" 27.00 43.00 1.00 1.00 0.00 0.00 397.00 " H3C H (REF:524/525/526)" " ﾅｽ ﾈ＼" " ｵｻ ｶ" " H3C ｵ N ｶ" " ／＼ﾇ＼／＼／ﾅ" " H3C ｵｶｽｺ CH3" " ／＼ﾇ＼／" " ｵｶ ｶ" " ／＼／ｸ／" " HO" "524/525/526/" "218-219ﾟ(CHLOROFORM-METHANOL)(524/527/528)" "[α]21/D=-29ﾟ(C=0.5,CHCl3)(527/528)" "ベンゼン, クロロホルムに自由に溶ける｡ アルコール, メタノールに少し溶ける｡ エーテル, 水にほとんど溶けない｡ (524/527/528)" "524/527/528/" "・SOLANUM TUBEROSUM(POTATO), S.NIGRUM(WOODY-NIGHT-SHADE), S.LYCOPERSICUM (TOMATO) 由来のソラニンのアグリコンとして存在｡ (525) ・EDEMISSIDINEからの合成｡(528)・・ETOMATIDE-5-EN-3β-OLからの合成｡(528)・立体特異的合成｡(529)" "525/527/528/529/" "・アルカロイドの一種, ソラニンのアグリコンとして作用｡ (525)" "525/" "ジギトニンで沈澱｡ (524) セレンによる脱水素反応によってステロイド骨格の証明｡ (524) 立体化学｡(526/442)" "524/526/442/" "ST0258" 12.00 "3-AMINO-16,23-EPOXY-16,28-SECO-SOLANIDAN-23-OL/3β-AMINO-22,26-IMINO-16β,23-OXIDO-5α,22α,23β,25α,-CHOLESTAN-23-OL; 3β-AMINO-22,26-IMINO-16β,23-OXIDO-5α,22R,23S,25R-CHOLESTAN-23-OL" "SOLANOCAPSINE, SOLANOCAPSIN" "C27H46O2N2" 27.00 46.00 2.00 2.00 0.00 0.00 430.00 " HN／＼ﾄCH3 (REF:530/531/532)" " H3C ｵｶ" " ﾅ／＼／" " H3C ｵｶ＼" " ／＼ﾇ＼／O OH" " H3C ｵｶｽｺ" " ／＼ﾇ＼／ﾂ" " ｵｶ ｶ H" " ／＼／ﾊ／" " H2N H" "530/531/532/" "213-215ﾟ(MONOHYDRATE)(531)" "[α]20/D=+26.3ﾟ(C=1.80), [α]20/D=+24.9ﾟ(C=2.13 METHANOL)(531)" "メタノール, クロロホルム (531/532)" "531/532/" "(CHCl3) 3587, 3355(NH-原子振動), 3305, 1280, 1245, 1218, 1205, 1160, 1140, 1113, 1096, 1078, 1057, 1040, 1018, 1008, 965, 950, 926, 908, 880, 870, 800, 767, 698 cm-1 (531)""" "531/" "・SOLANUM PSEUDOCAPSICUM (530/531) ・S.CAPSICASTRUM, S.HENDERSONII.(531)・SOLAFLORIDINE((25R)-22,26-EPIMINO-5α-CHOLEST-22(N)-EN-3β,16α-DIOL)からの合成｡(533) ・O(3),O(16)-DIACETYL-SOLAFLORIDINEからの合" "530/531/533/534/" "・アルカロイド｡ (530)" "530/" "ジギトニンで沈澱｡ (532) 立体化学｡ (532)" "532/" "ST0259" 12.00 "SPIROSOL-5-EN-3β-OL, SOLASOD-5-EN-3β-OL; Δ5-20βF,22αF,27-AZASPIROSTEN-3β-OL/3β-HYDROXY-22(27)-IMINO-25α-5-FUROSTENE" "SOLASODINE, SOLANCARPIDINE, SOLANIDINE-S, PURAPURIDINE" "C27H43O2N" 27.00 43.00 2.00 1.00 0.00 0.00 413.00 " H3C H H (REF:535)" " ﾃ ﾄN ＼ｽｽｵ" " ｶｼｻｼ＼ ／ﾅ" " H3Cｶ O ＼／ CH3" " ／＼ﾇ＼／" " H3C ｵｶｽｺ" " ／＼ﾇ＼／ﾂ" " ｵｶ ｶ H" " ／＼／ｸ／" " HO" "535/" "200-202ﾟ(METHANOL)(536/537)" "[α]25/D=-98ﾟ(C=0.14,METHANOL),[α]/D=-113ﾟ(CHCl3)(536/537)" "ベンゼン, ピリジン, クロロホルムに自由に溶ける｡ アルコール, メタノール, アセトンに可溶｡ エーテルに不溶｡(536/537)" "536/537/" "10.3, 10.4, 11.2, 11.5μ(AZAOXASPIRANE BANDS)(536)" "536/" "・SOLANUM 属のナス・ジャガイモ｡ (535) ・SOLASONINEのアグリコン｡(535) ・DIOSGENIN ACETATEからの合成｡(536)・(22S:25R)-16β-ACETOXY-22,26-ACETIMINO-5α-CHOLESTAN-3β-OL からの合成｡ (537) ・26-CARBOMETHOXY(22R,25S)22-NITRO-5-CHOLESTEN-3β-OL" "535/536/537/538/" "・アルカロイド｡ (535)" "535/" "ステロイド剤合成の出発物質｡ (536)" "536/" "ST0260" 12.00 "STIGMASTA-7,22-DIEN-3-OL" "α-SPINASTEROL, α-SPINASTERIN, BESSISTEROL, HITODESTEROL" "C29H48O" 29.00 48.00 1.00 0.00 0.00 0.00 412.00 " CH2CH3 (REF:539/540/541)" " H3C ﾁ CH3" " ﾅ／ｹ／＼／" " H3Cｶ ｵ" " ／＼ﾇ＼ CH3" " H3C ｵｶｽｺ" " ／＼ﾇ＼／" " ｵｶ ｳ" " ﾕ＼／ﾊ／" " HO H" "539/540/541/" "168-169ﾟ(ALCOHOL+PETROLEUM ETHER)(539/540)" "[α]25/D=-3.6ﾟ±0.5ﾟ(C=2.8,CHCl3),[α]23/D=-1.8ﾟ(541)" "539/540/541/" "・ホウレンソウ｡ (539) ・スイカ・コロシント｡ (540) ・7-DEHYDROSTIGMASTERYL BENZOATEからの合成｡(541)" "539/540/541/" "・DROSPHILA のソノラン砂漠種の成長, 成熟, 繁殖に必要｡ (542)" "542/" "ジギトニンで沈澱｡ (539)" "539/" "ST0261" 12.00 "7-(ACETYLTHIO)-17-HYDROXY-3-OXO-PREGN-4-ENE-21-CARBOXYLIC ACID γ-LACTONE/17-HYDROXY-7-MERCAPTO-3-OXO-17α-PREGN-4-ENE-21-CARBOXYLIC ACID γ-LACTONE,7-ACETATE;3-(3-OXO-7α-ACETYLTHIO-17β-HYDROXY-4-ANDROSTEN-17α-YL)PROPIONIC ACID γ-LACTONE" "SPIRONOLACTONE" "C24H32O4" 24.00 32.00 4.00 0.00 0.00 1.00 416.00 " ｽｽｴO (REF:543/544/545)" " ｵ ｵ" " ｵ O" " ﾅ／" " ／＼／＼" " H3C ｵｶｽｺ" " ／＼ﾇ＼／" " ｵｶ ｶ" " ｴ＼ｷ＼／ﾅ" " O SOCCH3" "543/544/545/" "134-135ﾟ(METHANOL)(543)" "[α]20/D=-33.5ﾟ(CHCl3)(543)" "水に不溶,ほとんどの有機溶媒に可溶｡(543)" "543/" "UV MAX : 238nm(ε=20,200)(543)" "8.78 p.p.m(C10-CH3)(544)" "ROTATORY DISPERTION CURVE:[φ]=-2540,λ=345mμ(544)" "544/" "調整(543)" "・利尿剤(Diuretic)｡ (543) ・アルドステロン拮抗薬(ALDOSTERONE ANTAGONIST)として有効｡ 0.4mgでラットに経口投与した場合, 12μgのDESOXYCORTICOSTERONEの副腎摘出ラットの尿におけるナトリウム-カリウムの比率に対する影響を 50%阻止する｡ ステロイド 17-スピロラク" "543/" "分子量 416.59 (543) 立体異性体(7β-SCOCH3) (544) 代謝中間体の分離，同定｡ (546) Ｘ線回折による構造解析｡ (545)" "543/544/546/545/" "ST0262" 12.00 "2,6,10,15,19,23-HEXAMETHYL-2,6,10,14,18,22-TETRACOSAHEXAENE" "SQUALENE, SPINACENE, SUPRAENE" "C30H50" 30.00 50.00 0.00 0.00 0.00 0.00 410.00 " H3C ／＼ CH3 (REF:547/548/549/550/551/552)" " ｪ ｳ／" " ／＼ ｸｶ" " H3Cｶ ?ｳ ｶ CH3" " ／ｪ ｹｵﾉ／" " ｵ ｾ ｵCH3" " ｸ ＼／" " ／＼" " H3C CH3" "547/548/549/550/551/552/" "約-75ﾟ(547)" "bp/25=285ﾟ,bp/2=240ﾟ,bp/0.15=203ﾟ(547)" "n20/D=1.4965(547)" """0.8655/13ﾟ/13ﾟ, 0.8538/20ﾟ/20ﾟ, 0.8596/18ﾟ/18ﾟ(547""" "水に不溶｡エーテル,石油エーテル,四塩化炭素,アセトンなどに溶ける｡ アルコール,氷酢酸にわずかに溶ける｡ (547)" "547/" "天然と合成の比較｡ 9-11μ,12μ付近の特徴的ピークが一致｡ (553)" "モル屈折 139.6, 139.8, 139.9 (547)" "553/547/" "・板鰓類(サメ・エイ)の肝油｡ (547) ・CENTROPHORUS GRANULOSUS, SPINAX NIGER, SCYMNORHINUS LICHIA. (548)・ゲラニオールを用いた合成｡(553)・立体異性体特異的合成 (ALL-TRANS-2,6,10,15,19,23-HEXAMETHYLTETRACOSA-2,6,10,14,18,22-HEXAENE)(554/556)" "547/548/553/554/556/557/558/559/" "・殺菌剤 (547) ・コレステロール生合成中間体｡ (554)" "547/554/" "油状でかすかに臭う｡ (547) VISCOSITY は,25ﾟCで 12cps.(547) 引火点 約200ﾟC｡ (547) 薬品合成中間体｡ (547) 有機色素,合成ゴム，アロマー，表面活性化剤の合成中間体｡ (551/552) ・IODINE VALUE 377.6 (547) 肝油中の 50-80% を占める｡ (547)" "547/551/552/555/" "ST0263" 12.00 "DIHYDRO-β-SITOSTEROL" "STIGMASTANOL, β-SITOSTANOL, FUCOSTANOL" "C29H52O" 29.00 52.00 1.00 0.00 0.00 0.00 416.00 " (REF:147)" " H3C" " ＼／＼ CH3" " H3C ｵｶｽｽ／" " ／＼ﾇ＼ｶ ＼" " H3C ｵｶｽｺ C2H5 CH3" " ／＼ﾇ＼／" " ｵｶ ｶ" " ／＼／＼／" " HO" "147/" "138-139ﾟ(MONOHYDRATE,CRYSTALS), 144-145ﾟ(DRY)(147)" "[α]20/D=+25ﾟ(C=1.1 IN CHCl3)(147)" "メタノール,クロロホルム (147)" "147/" "・β-シトステロールからの調製｡(147) ・β-シトステノンからの調製｡(560)" "147/560/" "ST0264" 12.00 "STIGMASTA-5,22-DIEN-3β-OL; 3β-HYDROXY-24-ETHYL-Δ5,22-CHOLESTADIENE" "STIGMASTEROL" "C29H48O" 29.00 48.00 1.00 0.00 0.00 0.00 412.00 " (REF:176/167/168/169)" " H3C" " ＼／ｹ CH3" " H3C ｵｶｽｽ／" " ／＼ﾇ＼ｶ ＼" " H3C ｵｶｽｺ C2H5 CH3" " ／＼ﾇ＼／" " ｵｶ ｶ" " ／＼／ｸ／" " HO" "176/167/168/169/" "170ﾟ(176)" "[α]22/D=-51ﾟ(C=2 IN CHCl3)(176)" "水に不溶｡通常の有機溶媒に可溶｡ (176)" "176/" "・ダイズやカラバル豆から抽出されるフィトステロール混合物から単離される｡(176)" "176/" "・抗硬直因子として作用｡ (176)" "176/" "ST0265" 12.00 "7β,8-EPOXY-3β,14-DIHYDROXY-5β-CARD-20(22)-ENOLIDE" "TANGHINIGENIN" "C23H32O5" 23.00 32.00 5.00 0.00 0.00 0.00 388.00 " O (REF:561/562)" " ｴ" " ｴｻ" " H3C ﾉ O" " ／＼ﾇ＼ｼ" " H3C ｵｶｽｺ" " ／＼ﾇ＼／ｵ" " ｵｶ ｶ OH" " ／＼／ﾉ／" " HO H" "561/562/" "187-188ﾟC(ACETON+PETROLEUM ETHER)(561)" "[α]25/D=+14.1ﾟ(C=1.138 IN CHCl3)(561)" "クロロホルム" "561/" "UV MAX : 217nm(log ε=4.22)(561)" "11.29-11.39μと12.81-12.87μの領域における KBrの２つのバンドは7.8-ｵｷｼﾗﾝﾘﾝｸﾞと14β-ﾋﾄﾞﾛｷｼ基の組み合わせによると考えられる。(562)" "3-O-ACETYL-TANGHINIGENIN のNMRｽﾍﾟｸﾄﾙ｡ (562)" "561/562/" "・CERBERA TANGHININ の種子｡ (561) ・TANGHININのアグリコン｡(561)" "561/" "・猫における LD50=1.016±0.0876mg/kg 体重｡ (562)" "562/" "ST0266" 12.00 "3α,17α,21-TRIHYDROXY-5β-PREGNANE-11,20-DIONE; 3α,17α,21-PREGNANETRIOL-11,20-DIONE/11,20-PREGNANEDIONE-3α,17α,21-TRIOL" "TETRAHYDROCORTISONE" "THE." "C21H32O5" 21.00 32.00 5.00 0.00 0.00 0.00 364.00 " CH2OH (REF:563/564)" " ｵ" " OC OH" " O H3C ﾓ" " ｹ／＼ﾇ＼" " H3C ｵｶｽｺ" " ／＼ﾇ＼／" " ｵｶ ｶ" " ﾄ＼／＼／" " HO" "563/564/" "190ﾟC(Anhyd. ETHANOL)(564)" "[α]25/D=+85.0ﾟ(C=1.0 IN 100% EtOH)(564)" "アルコール,酢酸エチル(564)" "564/" "1041cm-1に特徴あるバンド｡ (564)" "564/" "・通常, 哺乳類のコーチゾーン (CORTISONE) の代謝産物｡ (563)" "563/" "STREPTOMYCES SP. を用いる事によってコルチゾンのＡ−リングの還元の結果、得られる｡ (564)" "564/" "ST0267" 12.00 "12-URESEN-3β-OL" "α-AMYLIN, α-AMYRENOL" "C30H50O" 30.00 50.00 1.00 0.00 0.00 0.00 426.00 " (REF:005/049/109)" " ﾂ" " ﾒ／＼" " ｵｶ" " ／ｹ／ﾚ／" " ｵｶ Hｶﾔ" " ／＼ｮ＼ｮﾊ／" " ｵｶ ｶ" " ﾕ＼／＼／" " HO ／＼" "005/049/109/" "185-186ﾟC (109/005/049)" "243ﾟ(0.7mmHg) (005/109)" "[α]17/D=+83.5ﾟ(CHCl3),[α]17/D=+91.6ﾟ(C=1.3 in BENZENE) (005/109)" "ETHER, BENZEN, CHLOROFORM, GLACIAL ACETIC ACID, PETROLEUM ETHERにわずかにとける(005)" "005/049/109/" "緑色植物門被子植物綱キク目の Artemesia Vulgaris と Lactuca denticulate を多く含む多くの種の構成成分" "アルコールから針状結晶。その他の文献: 047/048/049/" "047/048/049/" "ST0268" 12.00 "12-URESEN-3β-ACETOXIDE" "C32H52O2" 32.00 52.00 2.00 0.00 0.00 0.00 468.00 " (REF:005/049/059/109)" " ﾂ" " ﾒ／＼" " ｵｶ" " ／ｹ／ﾚ／" " ｵｶ Hｶﾔ" " ／＼ｮ＼ｮﾊ／" " O ｵｶ ｶ" " ｾ ﾕ＼／＼／" " CH3-C-O ／＼" "005/049/059/109/" "225-227ﾟC (005/109)" "[α]18/D=+77ﾟ(C6H6),[α]20/D=+76.35ﾟ(C=0.572 in CHCl3) (005/109)" "005/109/" "1H-NMR: 2.033(Ac), 4.500(CH-O), 5.117(OLEFINIC H) (059)" "059/" "緑色植物門被子植物綱キク目の Artemesia vulgaris を含む多くの種の構成成分" "石油エーテルから葉状結晶。その他の文献: 047/048/050/" "047/048/050/" "ST0269" 12.00 "12-URESEN-3β-METHOXIDE" "C30H52O" 31.00 52.00 1.00 0.00 0.00 0.00 440.00 " (REF:046/109)" " ﾂ" " ﾒ／＼" " ｵｶ" " ／ｹ／ﾚ／" " ｵｶ Hｶﾔ" " ／＼ｮ＼ｮﾊ／" " ｵｶ ｶ" " ﾕ＼／＼／" " CH3-O ／＼" "046/109/" "221-223ﾟC (046/109)" "046/109/" "M/Z: 440, 218, 203 (046)" "046/" "緑色植物門被子植物類イネ目の Cortaderia toetoe の構成成分" "結晶性。その他の文献: 047/048/050/" "047/048/050/" "ST0270" 12.00 "12-URESEN-3-ONE" "α-AMYROSE, α-AMYRENONE" "C30H48O" 30.00 48.00 1.00 0.00 0.00 0.00 424.00 " (REF:046/109)" " ﾂ" " ﾒ／＼" " ｵｶ" " ／ｹ／ﾚ／" " ｵｶ Hｶﾔ" " ／＼ｮ＼ｮﾊ／" " ｵｶ ｶ" " ｴ＼／＼／" " O ／＼" "046/109/" "121-126ﾟC (046/109)" "046/109/" "MeOH から結晶化。その他の文献: 047/048/050/" "047/048/050/" "ST0271" 12.00 "12-OLEANEN-3β-OL" "β-AMYRIN, β-AMYRENOL" "C30H50O" 30.00 50.00 1.00 0.00 0.00 0.00 426.00 " (REF:005/109)" " ＼／" " ／＼" " ｵｶ" " ／ｹ／ﾚ／" " ｵｶ Hｶﾔ" " ／＼ｮ＼ｮﾊ／" " ｵｶ ｶ" " ﾕ＼／＼／" " HO ／＼" "005/109/" "197-197.5ﾟC (005/109)" "260ﾟ(0.8mmHg) ( )" "[α]19/D=+88.4ﾟ(CHCl3),[α]19/D=+99.8ﾟ(C=1.3 in BENZEN) (005/109)" "005/109/" "石油エーテルかアルコールから針状結晶。その他の文献: 047/050/051/052/053/054/055/056/057/" "047/050/051/052/053/054/055/056/057/" "ST0272" 12.00 "12-OLEANEN-3β-ACETOXIDE" "C32H52O2" 32.00 52.00 2.00 0.00 0.00 0.00 468.00 " (REF:005/049/109)" " ＼／" " ／＼" " ｵｶ" " ／ｹ／ﾚ／" " ｵｶ Hｶﾔ" " ／＼ｮ＼ｮﾊ／" " O ｵｶ ｶ" " ｾ ﾕ＼／＼／" " CH3-C-O ／＼" "005/049/109/" "238-241ﾟC (005/109)" "[α]17/D=+81.4ﾟ(CHCl3),[α]17/D=+79ﾟ(C=0.9 in BENZEN) (005/109)" "005/109/" "1H-NMR : 2.041(Ac), 4.500(CH-O), 5.183(OLEFINIC H) (059)" "石油エーテルから柱形結晶。その他の文献: 047/050/051/052/053/054/055/056/057/" "047/050/051/052/053/054/055/056/057/" "ST0273" 12.00 "12-OLEANEN-3β-METHOXIDE" "C30H52O" 31.00 52.00 1.00 0.00 0.00 0.00 440.00 " (REF:046/109)" " ＼／" " ／＼" " ｵｶ" " ／ｹ／ﾚ／" " ｵｶ Hｶﾔ" " ／＼ｮ＼ｮﾊ／" " ｵｶ ｶ" " ﾕ＼／＼／" " CH3-O ／＼" "046/109/" "246-248ﾟC (046/109)" "046/109/" "M/Z: 440, 218, 203 (046)" "046/" "結晶性。その他の文献: 047/050/051/052/053/054/055/056/057/" "047/050/051/052/053/054/055/056/057/" "ST0274" 12.00 "12-OLEANEN-3β-PALMITOXIDE" "BALANOPHORIN" "C46H80O2" 46.00 80.00 2.00 0.00 0.00 0.00 664.00 " (REF:005/109)" " ＼／" " ／＼" " ｵｶ" " ／ｹ／ﾚ／" " ｵｶ Hｶﾔ" " ／＼ｮ＼ｮﾊ／" " O ｵｶ ｶ" " ｾ ﾕ＼／＼／" "CH3-(CH2)14-C-O ／＼" "005/109/" "75-77ﾟC (005/109)" "[α]20/D=+67.9ﾟ(CHCl3),[α]15/D=+54.5ﾟ(C=1.1 in BENZEN) (005/109)" "005/109/" "CHCl3/MeOH中で結晶化。その他の文献: 047/050/051/052/053/054/055/056/057/" "047/050/051/052/053/054/055/056/057/" "ST0275" 12.00 "12-OLEANEN-3-ONE" "β-AMYRONE" "C30H48O" 30.00 48.00 1.00 0.00 0.00 0.00 424.00 " (REF:109)" " ＼／" " ／＼" " ｵｶ" " ／ｹ／ﾚ／" " ｵｶ Hｶﾔ" " ／＼ｮ＼ｮﾊ／" " ｵｶ ｶ" " ｴ＼／＼／" " O ／＼" "109/" "177-179ﾟC (109)" "[α]/D=+107.2ﾟ(CHCl3) (109)" "109/" "MeOHから結晶化。その他の文献: 047/050/051/052/053/054/055/056/057/" "047/050/051/052/053/054/055/056/057/" "ST0276" 12.00 "13-OLEANEN-3β-OL" "δ-AMYRIN" "C30H50O" 30.00 50.00 1.00 0.00 0.00 0.00 426.00 " (REF:109)" " ＼／" " ／＼" " ｵｶ" " ／＼ｴ＼／" " ｵｶ ｶﾔ" " ／＼ｮ＼ｮﾊ／" " ｵｶ ｶ" " ﾕ＼／＼／" " HO ／＼" "109/" "212-213.5ﾟC (109)" "[α]20/D=-50.5ﾟ (109)" "109/" "MeOHから結晶化。その他の文献: 047/058/" "047/058/" "ST0277" 12.00 "13-OLEANEN-3-ONE" "δ-AMYRONE" "C30H48O" 30.00 48.00 1.00 0.00 0.00 0.00 424.00 " (REF:109)" " ＼／" " ／＼" " ｵｶ" " ／＼ｴ＼／" " ｵｶ ｶﾔ" " ／＼ｮ＼ｮﾊ／" " ｵｶ ｶ" " ｴ＼／＼／" " O ／＼" "109/" "198-201ﾟC (109)" "[α]20/D=-12ﾟ (109)" "109/" "EtOHから結晶化。その他の文献: 047/058/" "047/058/" "ST0278" 12.00 "3β-[(6-DEOXY-α-L-MANNOPYRANOSYL)-OXY]-14,16β-DIHYDROXY-19-OXO-5β-CARD-20(22)-ENORIDE" "ADONITOXIN,ADOVERN" "C29H42O10" 29.00 42.00 10.00 0.00 0.00 0.00 550.00 " (REF:565/566/567)" "565/566/567/" "238-240ﾟC(566)" "566/" "1640, 1756, 1726cm-1(566)" "λmax=218mμ(logε=4.10),λmax=219mμ(logε=4.3)(565/566)" "565/566/" "植物, Adonis Vernalis L.,Ranunculaceae から単離｡(565/566)" "565/566/" "分子量 550,63(565)" "565/" "ST0279" 12.00 "ANDROST-4-ENE-3,11,17-TRIONE" "ADRENOSTERONE,REICHSTEIN'S SUBSTANCE G" "C19H24O3" 19.00 24.00 3.00 0.00 0.00 0.00 300.00 " (REF:568/569)" "568/569/" "220-224ﾟC(ALCOHOL)(483)" "[α]20/D=+262ﾟ±3ﾟ(無水ｱﾙｺｰﾙ);[α]25/5461=+364ﾟ±5ﾟ(C=0.18% in 無水ｱﾙｺｰﾙ)(483/271)" "水に可溶，9.85(23ﾟ),15.2(37ﾟ)mg/100ml ｱﾙｺｰﾙ,ｱｾﾄﾝ,ｴｰﾃﾙに可溶｡(568)" "483/271/568/" "UVmax : 235nm (483)" "483/" "ウシ副腎皮質(271/270/483)" "271/270/483/" "ANDROGEN活性を持つ｡(483/270/271/198/295)" "483/270/271/198/295/" "分子量 300.38 Dm(g･cm-3)1.264, Dx(g･cm-3)1.253, SPACE GROUP P212121, Z 4, a(A)* 9.263, b(A)* 26.531, c(A)* 6.477,β(ﾟ) -, V(A3) 1592, SOLVENT METHANOL ACETONE, *±0.009A (569) ･全合成(6-METHOXY α-TETRALONEから)(568) ･REICHSTEIN'S SUBSTANCE E, Faから調製(198/295) ･結晶解析(569) ･ADRENOSTERONE-1,2-3Hの正常人及びHYPOTHYROID患者での代謝(570)" "198/295/568/569/570/" "ST0280" 12.00 "11β,21-DIHYDROXY-3,20-DIOXOPREGN-4-EN-18-AL;3,20-DIKETO-11β,18-OXIDO-4-PREGNENE-18,21-DIOL" "ALDOSTERONE,ELEKTROCORTIN,ELECTROCORTIN,ALDOCORTIN" "C21H28O5" 21.00 28.00 5.00 0.00 0.00 0.00 360.00 " (REF:571/572/573/574/575)" "571/572/573/574/575/" "164-169ﾟC(HYDRATED,105ﾟ)(574)" "[α]23/D=+152.2ﾟ(ANHYDR;C=2 in ｱｾﾄﾝ) [α]25/D=+161ﾟ(C=0.1 in ｸﾛﾛﾎﾙﾑ)(571/574)" "574/572/" "UVmax : 240nm (logε=4.20 for the MONOHYDRATE;εmol 15,000 for the ANHYDR)(574)" "HYDROXYL BAND AT 2.92μ,Δ4-3-KETO BAND AT 6.05 AND 6.18μ, SATURATED CARBONYL AT 5.87μ(574)" "574/" "副腎皮質から分泌される無機質コルチコイドの一種｡(579)" "579/" "ADRENOCORTICAL STEROIDは, 電解質と水の代謝を調整する｡ ZONA GLOMERULOSA(糸球帯)で,生合成され, 主にアルブミンによって輸送される｡ 成年男子では,１日に通常400μg分泌される｡ ACTH,成長ホルモン,血しょうNa,K,そしてレニン-アンギオテンシン系に影響されて分泌｡ Na+,Cl-,HCO3-の再吸収,K+の利尿の要因となる｡ ラットでのURINARY SODIUM RETENTION ASSAYで分析すると0.05-0.01μgで活性を検出できる｡ これと同レベルをDESOXYCORTICOSTERONE ACETATEで得る場合,少なくても16μgが必要である｡(579)" "579/" "分子量 360,44 単離(571/572/573/574) 全合成(577) CORTICOSTERONEからの３段階合成 (578)" "571/572/573/574/577/578/" "ST0281" 12.00 "3α,21-DIHYDROXY-5α-PREGNANE-11,20-DIONE 21-ACETATE; 21-ACETOXY-3α-HYDROXY-5α-PREGNANE-11,20-DIONE" "ALFADOLONE ACETATE,ALPHADOLONE ACETATE,GR 2/1574" "C23H34O5" 23.00 34.00 5.00 0.00 0.00 0.00 390.00 " (REF:580)" "580/" "175-177ﾟ(ACETONE-HEXANE)(580)" "[α]26/D=+97ﾟ(C=1.02 in CHLOROFORM)(580)" "580/" "νMAX(Nujol)3500, 1755, 1718, 1200cm-1(580)" "BLUE-TETRAZOLIUM反応は,強陽性｡(580)" "580/" "5α-ANDROSTANE-3,17-DIONEから調製｡(580)" "580/" "麻酔剤の成分｡(580)" "580/" "分子量 390,52(580)" "580/" "ST0282" 12.00 "3α-HYDROXY-5α-PREGNANE-11,20-DI-ONE" "ALFAXALONE,ALPHAXALONE,GR 2/234" "C21H32O3" 21.00 32.00 3.00 0.00 0.00 0.00 332.00 " (REF:196)" "196/" "172-174ﾟ(ETHER)(196/580)" "[α]26/D=+113.4ﾟ±2ﾟ(C=1.2 in CHLOROFORM)(196/580)" "196/580/" "Ref.No.196 Fig.1(196)" "196/" "HECOGENINから調製｡(196)" "196/" "麻酔剤の成分(STEROID I)として, GLAXO CT1341注射液に 21-ACETOXY-3α-HYDROXY-5α-PREGNANE-11,20-DIONE(STEROID II)などとともに含まれる｡AD50 1.79, LD50 54.7(mg/kg MICE)(581) ヒトでの予備臨床試験,安定した麻酔状態｡(583)" "581/583/" "分子量 332.49 3-ACETATE, m.P.155-156ﾟ(580)" "580/" "ST0283" 12.00 "16α,17-DIHYDROXYPREGN-4-ENE-3,20-DIONE;16α,17-DIHYDROXYPROGESTERONE;4-PREGNENE-16α,17α-DIOL-3,2-DIONE" "ALGESTONE,ALPHASONE" "C21H30O4" 21.00 30.00 4.00 0.00 0.00 0.00 346.00 " (REF:584/585/586/587)" "584/585/586/587/" "225ﾟ(ETHANOL+DICHLOROMETHANE)(585)" "[α]22/D=+95ﾟ(C=0.81 in CHCl3) (585) [α]24/D=+97ﾟ (586)" "585/586/" "UVmax:240nm(ε=16,600)(585), λmax:241-242mμ(ε=15,200)(586)" "νNuiol/max 3390, 1711, 1612, 1081cm-1(586)" "[Μ]/D+336(586)" "585/586/" "16-DEHYDROPROGESTERONEから調製｡(585)" "585/" "ACETONIDEとして局所の抗炎症作用｡(588)" "588/" "ACETONIDEの調製｡(585/588) m.P. 176-177ﾟ,[α]20/D=+49ﾟ(C,1.25)(C23H32O5,H2O)" "585/588/" "ST0284" 12.00 "16α,17-DIHYDROXYPREGN-4-ENE-3,20-DIONE CYCLIC ACETAL WITH ACETOPHENONE/16α,17α-DIHYDROXYPROGESTERONE ACETOPHENIDE" "ALGESTONE ACETOPHENIDE,ALPHASONE ACETOPHENIDE ,P-DHP,BOVITROL, DELADROXONE,DROXONE" "C29H36O4" 29.00 36.00 4.00 0.00 0.00 0.00 448.00 " (REF:588)" "588/" "150-151ﾟ(95% ETHANOL)(588)" "[α]23/D=+51ﾟ(CHCl3)(588)" "588/" "16α,17α-DIHYDROXYPROGESTERONEから調製｡(588)" "588/" "PREGESTAGENとして不活性な16α,17α-DIHYDROXYPROGESTERONEと違い、そのACETONIDEはPROGESTERONEの3倍の作用を示す｡又,ANDROGEN活性,抗ANDROGEN活性,ESTROGEN活性,抗DCA活性,CORTICOID活性は投与した量では見られない｡(588)" "588/" "分子量 448.58 沸騰する無機酸に安定｡(588)" "588/" "ST0285" 12.00 "17-(2-PROPENYL)ESTR-4-EN-17β-OL;17α-ALLYLESTR-4-EN-17β-OL;17α-ALLYL-17-HYDROXY-19-NOR-4-ANDROSTENE/17-HYDROXY-17α-ALLYL-4-ESTRENE" "ALLYLESTRENOL,GESTANIN,GESTANOL,ORAGESTON,GESTANYN,GESTANON,TURINAL" "C21H32O" 21.00 32.00 1.00 0.00 0.00 0.00 300.00 " (REF:589/590)" "589/590/" "79.5-80ﾟ(589/590)" "水に不溶｡ｱﾙｺｰﾙ,ｴｰﾃﾙ,ｱｾﾄﾝ,ｸﾛﾛﾎﾙﾑに可溶｡(589/590)" "589/590/" "ヒトで,PROGESTIN(PROGESTAGEN)活性を持ち,胎盤機能を刺激する事で妊娠維持機能を示す｡(589) PREGNENOLONE 3β-OL-DEHYDROGENASE-Δ5-4-ISOMERASE系を阻害(ヒト)｡(590)" "589/590/" "分子量 300.47 酸化されやすい｡(589)" "589/" "ST0286" 12.00 "URS-12-EN-3β-OL" "α-AMYRIN,α-AMYRENOL,VIMINALOL" "C30H50O" 30.00 50.00 1.00 0.00 0.00 0.00 426.00 " (REF:592/593/594/595/596)" "592/593/594/595/596/" "186ﾟ(ALCOHOL)(597/598)" "bp0.7 243ﾟC(597)" "[α]17/D=+91.6ﾟ(C=1.3 in BENZENE)(597/598)" "22parts 98% alc.で可溶｡ ｴｰﾃﾙ,ﾍﾞﾝｾﾞﾝ,ｸﾛﾛﾎﾙﾑ,氷酢酸に可溶｡ 石油ｴｰﾃﾙにわずかに可溶｡(597)" "597/598/" "STRONG TERMINAL METHYLENE ABSORPTION AT 887cm-1(599)" "599/" "植物。 Ficus Variegata Blume, Moraceae, Balanophora elongata Blume, Balanophoraceae, Erythroxylum coca Lam. Var. Novogranatense Morris, Var Spruceanum Burck, Erythroxylaceaeからのラテックスの中,ゴムの木のラテックスの中で,主にアセテートとして生ずる｡(591)" "591/" "分子量 426.70 URSOLIC ACIDからの形成｡ (597) BOSWELLIC ACIDからの形成｡(598) GLYCYRRHETIC ACIDからの部分合成と立体化学｡(599)" "597/598/599/" "ST0287" 12.00 "OLEAN-12-EN-3β-OL,3β-HYDROXYOLEAN-12-ENE" "β-AMYRIN,β-AMYRENOL" "C30H50O" 30.00 50.00 1.00 0.00 0.00 0.00 426.00 " (REF:600/601/602/603/604)" "600/601/602/603/604/" "197-197.5ﾟC(PETR ETHER or ALC.)(605)" "bp0.8 260ﾟC(605)" "[α]19/D=+99.8ﾟ(C=1.3 in BENZENE)(605)" "α-FORMより,溶解性は低い｡ 37PARTSの98%アルコールに可溶｡(605)" "605/" "植物。Α-AMYRINと伴に,BARANOPHORA ELONGATA BLUME, BALANOPHORACEAE,ERYTHROXYLUM COCA LAM, VAR NOVOGRANATENSE MORRIS, VAR SPRUCEANUM BURCK, ERYTHROXYLACEAE,FICUS VARIEGATA BLUME, MORACEAEの乳液に存在｡(600/601/602/603/604)" "600/601/602/603/604/" "分子量 426.70 δ-AMYRENEからβ-AMYRINへの変換｡(605) 生物形成型全合成｡(606) SQUALENEからの生合成機構｡(607/608)" "605/606/607/608/" "ST0288" 12.00 "17-HYDROXY-6α-METHYLPREGN-4-EN-20-ONE/6α-METHYL-4-PREGNEN-17α-OL-20-ONE" "ANAGESTONE" "C22H34O2" 22.00 34.00 2.00 0.00 0.00 0.00 330.00 " (REF:613)" "613/" "190-193ﾟC(METHANOL+DICHLOROMETHANE)(613)" "[α]20/D=+51ﾟ(in CHLOROFORM)(613)" "613/" "・ACETATEとして PROGESTIN作用(ウサギへ経口投与,子宮への影響)(612) ・妊ステロイドとして長期間服用した場合,乳腺に結節が形成される｡(ビーグル犬)(611) ・避妊ステロイドとして長期間服用した場合,悪性腫瘍が乳腺に形成される｡(ビーグル犬) ・血中のESTRADIOL,ETHYNYLESTRADIOLがより速やかに除去される傾向になる｡(赤毛ザルでMESTRANOLと伴に用いた場合) (610) ・赤毛ザル乳腺の形態への影響｡(610)" "609/610/611/612/" "分子量 330.49(613)" "613/" "ST0289" 12.00 "17-METHYL-5α-ANDROSTANO[3,2-C]-ISOXAZOL-17β-OL;2,3,3a,3b,4,5,5a,6,10,10a,10b,11,12,12a,TETRADECAHYDRO-1,10a,12a-TRIMETHYL-1H-CYCLOPENTA[7,8]PHENANTHRO[2,3-C]ISOXAZOL-1-OL;17β-HYDROXY-17α-METHYLANDROSTANO[3,2-C]ISOXAZOLE; 17α-METHYLANDROSTAN[3,2-C]ISOXAZOL-17β-OL" "ANDROISOXAZOLE,NEO-PENDEN" "C21H31O2N" 21.00 31.00 2.00 1.00 0.00 0.00 329.00 " (REF:614)" "614/" "169-170ﾟC(614)" "[α]/D=+19ﾟ(614)" "614/" "UVmax(ETHANOL):226nm(logε=3.71)(614)" "614/" "高い同化促進作用を持つ｡ ANDROGEN作用は低い｡ (614)" "614/" "分子量 329.47" "ST0290" 12.00 "3β,11β-DIHYDROXY-5α-ANDROSTAN-17-ONE" "ANDROSTANE-3β,11β-DIOL-17-ONE,REICHSTEIN'S SUBSTANCE A" "C19H30O3" 19.00 30.00 3.00 0.00 0.00 0.00 306.00 " (REF:200/207/615)" "200/207/615/" "235-238ﾟC(ACETONE+ETHER)(200)" "[α]20/D=+84.5ﾟ±3ﾟ(C=1.04 in ETHANOL) [α]19/D=+81.3ﾟ(DIOXANE) [α]19/545=+105ﾟ(DIOXANE)(200)" "200/" "ALLOPREGNANE-3β,11β,17α,20β,21-PENTOL(REICHSTEIN'S SUBSTANCE A)の分解物として最初得られたが(200),後に副腎皮質から少量抽出された｡(207/615)" "200/207/615/" "分子量 306.43 ジギトニンと反応して, 沈殿物生成｡(200)" "200/" "ST0291" 12.00 "Δ5-ANDROSTENE-3β-16α-DIOL" "5-ANDROSTENE-3β,11α-DIOL,CETADIOL" "C19H30O2" 19.00 30.00 2.00 0.00 0.00 0.00 290.00 " (REF:206)" "206/" "216-217ﾟC(METHANOL aq.)(206)" "[α]22/D=-110ﾟ(C=1.09 in 95%ETHANOL),[α]24.5/D=-67ﾟ(C=0.80 in DIOXAN)(206)" "206/" " 3.16-DI-P-TOLUENESULFONATEの形成後､C3での水解, P-TOLUENESULFONATE ACETATE 交換反応によってC16でのエピマー化によって5-ANDROSTENE-3β,16β-DIOLから調製｡ 又は,5-ANDROSTEN-3β-OL-16-ONE(HEMIHYDRATE)を出発物質として, 3β-ACETOXY-5-ANDROSTEN-16β-OL, 更にC16 でのトシル化, エピマー化による方法もある｡(206)" "206/" "精神安定薬｡ ANDROGEN活性, 筋増量活性は無い｡(206)" "206/" "分子量 290.43 (206)" "206/" "ST0292" 12.00 "3-[(6-DEOXY-β-D-GLUCOPYRANOSYL)OXY]-5,12,14-TRIHYDROXY-19-OXOCARD-20(22)-ENOLIDE" "α-ANTIARIN" "C29H42O11" 29.00 42.00 11.00 0.00 0.00 0.00 566.00 " (REF:616/619/620)" "616/619/620/" "220-235ﾟC(617)" "[α]17/D=-3.9ﾟ±2ﾟ(C=0.905 in METHANOL)(617)" "水, アルコールに可溶｡ エーテルにも少しとける｡(617)" "617/" "UVmax:305,217nm(logε=1.8,4.08)(617/618)" "617/618/" "植物。 コーパス樹 Antiaris toxicaria Lesch., Moraceae (インドネシア)のラテックス(毒矢の毒)から単離｡(616/617/618)" "616/167/168/" "LD50 in CATS(ANHYDR.) ; 0.116mg/kg I.v.(617/618/621)" "617/618/621/" "分子量 566.63 (616)" "616/" "ST0293" 12.00 "2α,3β,23-TRIHYDROXYURS-12-EN-28-OIC ACID O-6-DEOXY-α-L-MANNOPYRANOSYL-(1→4)-O-β-D-GULUCOPYRANOSYL-(1→6)-O-β-D-GLUCOPYRANOSYL ESTER" "ASIATICOSIDE,MADECASSOL" "C48H78O19" 48.00 78.00 19.00 0.00 0.00 0.00 958.00 " (REF:622)" "622/" "235-238ﾟC(622)" "[α]20/D=-14ﾟ(alc.)(622)" "622/" "植物。 Centella asiatica(L.) Urban, Umbelliferae(セリ科)のアクティブ成分｡ MERK 記述 Trisaccharide mojety linked to the aglycone:asiatic acid (622)" "622/" "創傷治療｡(622)" "622/" "分子量 959.15 ラットにおける代謝｡ CAECAL MICROFLORA による加水分解｡(623)" "623/" "ST0294" 12.00 "BATRACHOTOXININ A 20-(2,4-DIMETHYL-1H-PYRROLE-3-CARBOXYLATE)/3α,9α-EPOXY-14β,18β-(EPOXYETHANO-N-METHYLIMINO)-5β-PREGNA-7,16-DIENE-3β,11α,20α-TRIOL,20α-ESTER WITH 2,4-DIMETHYLPYRROLE-3-CARBOXYLIC ACID" "BATRACHOTOXIN" "C30H42O6N2" 31.00 42.00 6.00 2.00 0.00 0.00 538.00 " (REF:624/625/626)" "624/625/626/" "[α]/589=+5-10ﾟ,[α]/300=-260ﾟ(625)" "625/" "Uvmax(METHANOLIC HCl):262,234nm(logε=3.70,3.99),END ABSORPTION(626)" "A SHARP ABSORPTION BAND AT 5.9μ(AMIDOCARBONYL GROUP), 1695, 1250cm-1(624/625)" "0.85, 1.48(DOUBLET), 2.25, 2.2 ; 2.25 ; 2.45, 2.35, 3.40(2H), 5.6-6.3(-3H), 8.74BROAD(<0.4H)(625)" "MOL,WT,399,2413(C24H33NO4 9RINGS OR DOUBLE BONDS),CH17/17(CARBON SKELETON C17 (POTENTIALLY)HIGHLY UNSATURATED OH-GROUPS IN RING SYSTEM),NO INTENSE C4H7NO(NOT RING A OF SAMAN.DARINE),NO INTENSE C6H12NO(NOT RING F NO TOMATIDINE) C4H10NO,C7H6-8NO,C7H8NO2(NO WITHIN 4C,NO2 WITHIN 7C)(625/626)" "624/625/626/" "植物。 Columbian arrow poison frog(KOKOI FROG), genus Phyllobates bicolor の皮フから抽出｡(624)" "624/" "STEROIDAL ALKALOIDSの中で, もっとも毒性が強い｡ 損傷していない皮フでは, 毒液は無効｡しかし,持続性の鋭い痛みの原因となる｡ さらに,消耗性疾患(口腔内の傷,消化管の潰瘍をもつ時でさえ)毒素にさらすと危険である｡ 毒性は, SELECTIVEで,IRREVERSIBLEな Na イオンの膜透過性の増加による｡ LD50=1.15-2.7μg/kg mice(関連する化合物の中でも最も毒性が強い)(625/626)" "625/626/" "分子量 538.69, Rf=0.60,ED50=0.37μg/kg mice, (625) COLOR REACTIONS (1)IODOPLATINATE, + (2)EHRLICH REACTION,RED (3)DIMETHYLAMINOCINNAMALDEHYDE,BLUE. ・反応による化学特性一覧 ・BATRACHOTOXININ Aからの部分合成｡(626) ・二次元 TLC による関連化合物からの分離｡(626)" "625/626/" "ST0295" 12.00 "1,2,3,4,7a,10,11,11a,12,13-DECAHYDRO-14-(1-HYDROXYETHYL)-2,11a-DIMETHYL-7H-9,11b-EPOXY-13a,5a-PROPENOPHENANTHRO[2,1-F][1,4]OXAZEPINE-9,12(8H)-DIOL;3α,9α-EPOXY-14β,18β-(EPOXYETHANO-N-METHYLIMINO)-5β-PREGNA-7,16-DIENE-3β,11α,20α-TRIOL" "BATRACHOTOXININ A" "C24H35O5N" 24.00 35.00 5.00 1.00 0.00 0.00 417.00 " (REF:624/625/630/631)" "624/625/626/" "END ABSORPTION(625)" "1645cm-1(625)" "0.85,1.42,2.30,2.66,3.42(-2H),5.5-6.3(-4H)(REFERENCE TMS δ=0.0,SOLVENT CDCl3); 0.85(19-CH3),1.90(d)(6.5)(21-CH3),2.48(s)(N-CH3),2.89(s)(18-CH2),3.22(d)(18)(H-11),4.57(q)(6.5)(H-20),5.72(t)(2)(H-7), 6.24(dd)(2.5,5)(H-16)(TMS,δ=0.0,CDCl3)(626)" "M/E ION 399 C24H33NO4,370 C23H32NO3,(342)(C22H32NO3),312 C20H24O3,294 C20H22O2,286 C18H22O3,279 C19H19O2,276 C20H20O,261 C19H17O,224 C16H16O,219 C17H15,(206)? ,184 C13H12O,(166)C10H16NO,88 C4H10NO,71 C4H9N (626)" "625/626/" "植物。 Columbian arrow poison frogs(KOKOI FROG),genus Phyllobates bicolor の皮膚｡ (624) PREPARATIVE TLCによって,BATRACHOTOXIN,BATRACHOTOXININ B, Cと分離｡(625) PHYLLOBATES AVROTAENIAの皮膚｡(630)" "624/625/630/" "CARDIOTOXIN｡ LD50 I,v,in mice: 1mg/kg(BATRACHOTOXINの 1/10)｡ 4種の主要な TOXIC STEROIDAL ALKALOIDS の中で最も毒性が弱い｡(625)" "625/" "分子量 288.26, Rf=0.54 COLOR REACTIONS (1)IODOPLATINATE. + (2)EHRLICH REACTION, NONE (3)DIMETHYLAMINOCINNAMALDEHYDE, NONE (625) ・O-P-BROMOBENZOATE DERIVATIVEの結晶構造｡(631) ・部分合成(626) ・各種DERIVATIVEの毒性｡(626) そのうち 2,4,5-TRIMETHYLPYRROLE-3-CARBOXYLATE DERIVATIVEは, LD50=1μg/kg miceと,BATRACHOTOXININ Aの1000倍の毒性がある｡ ・18,20-LACTON化合物からの部分合成(632)" "625/631/626/632/" "ST0296" 12.00 "9-FLUORO-11β,17,21-TRIHYDROXY-16β-METHYLPREGNA-1,4-DIENE-3,20-DIONE/9α-FLUORO-16β-METHYLPREDNISOLONE; 16β-METHYL-9α-FLUORO-Δ1-HYDROCORTISONE; 16β-METHYL-9α-FLUOROPREDNISOLONE" "BETAMETHASONE,BETADEXAMETHASONE,FLUBENISOLONE,β-METHASONE,BETA-CORLAN,BECORT,BETAFLUORENE,BETASOLON,BETNELAN,BETNESOL TABLETS,CELESTAN,CELESTENE, CELESTONE,VISUBETA" "C22H29O5F" 22.00 29.00 5.00 0.00 0.00 0.00 373.00 " (REF:633/634/635)" "633/634/635/" "231-234ﾟC(ETHYL ACETATE)(635)" "[α]/D=+108ﾟ(ACETONE)(635)" "635/" "UVmax(METHANOL)238nm(ε=15,200)(635)" "λNujol/max 2.90, 2.95, 5.88, 6.10, 6.15, 6.20, 11.25μ" "635/" "・9α-FLUOROPREDNISOLONから合成｡ (634) ・3α-ACETOXY-16-PREGNENE-11,20-DIONEから合成｡(635)" "634/635/" "GLUCOCORTICOID,抗炎症作用(ヒト,実験動物)｡塩や水の保持特性は無い｡(633/634/635)" "633/634/635/" "分子量 392.45, 21-ACETATEとしての合成｡(634)" "634/" "ST0297" 12.00 "LUP-20(29)-ENE-3β,28-DIOL/LUP-20(30)-ENE-3β,28-DIOL" "BETULIN,TROCHOL,BETULINOL" "C30H50O2" 30.00 50.00 2.00 0.00 0.00 0.00 442.00 " (REF:636/637/638/639/640/641/642)" "636/637/638/639/640/641/642/" "248-251ﾟC(METHANOL-CHLOROFORM)(637)" "[α]/D=+15ﾟ,[α]/D=+20ﾟ(DIACETATE)(637)" "冷水,石油エーテル,二硫化炭素に少し溶ける｡ 149倍のアルコール,251倍のエーテル,113倍のクロロホルム,417倍のベンゼンに可溶｡酢酸に可溶｡(637)" "637/" "植物｡ ・シラカバの樹皮の外側部から,その他の樹皮,亜炭からも単離できる｡(636) ・LEMAIREOCEREUS GRISEUS BRITTON,ROSE,CACTACEAE(サボテン科)から抽出｡(637)" "636/637/" "分子量 442.70 (642)" "642/" "ST0298" 12.00 "17β-HYDROXY-7α,17-DIMETHYLANDROST-4-EN-3-ONE; 7α,17-DIMETHYLTESTOSTERONE" "BOLASTERONE,MYAGEN,U-19763" "C21H32O2" 21.00 32.00 2.00 0.00 0.00 0.00 316.00 " (REF:643/644)" "643/644/" "163-165ﾟC(643)" "643/" "Δ5-7-KETO STEROIDをMETHYLMAGNESIUM HALIDEやMETHYL LITHIUMと反応させて7-METHYL CARBINOLを得て一連の反応により合成する｡(643)" "643/" "ラットへ経口投与した場合, 17-METHYLTESTOSTERONE の MYOTROPIC 活性, ANDROGENIC 活性をそれぞれ１としたら, BOLASTERONEは, 7α-METHYL基のおかげでそれぞれ 13.4, 3.0 の活性がある｡MONKEYでのANABOLIC ASSAYでは, HALOTESTINよりも高い活性がある｡ 従って BOLASTERONEを用いる場合は, より少ない量で効果があるため, 臨床において肝毒素が相対的に低くなると考えられる｡(643/644)" "643/644/" "分子量 316.47 (643)" "643/" "ST0299" 12.00 "17β-HYDROXYANDROSTA-1,4-DIEN-3-ONE; 1,4-ANDROSTADIEN-17β-OL-3-ONE; 3-OXO-17β-HYDROXY-1,4-ANDROSTADIEN" "BOLDENONE,DEHYDROTESTOSTERONE" "C19H26O2F" 19.00 26.00 2.00 0.00 0.00 0.00 305.00 " (REF:449/645)" "449/645/" "164-166ﾟC(449)" "[α]25/D=+25ﾟ(CHLOROFORM)(449)" "449/" "UVmax:243-242mμ(645)" "CCl4, 3675,3500(FREE AND ASSOCIATE HYDROXY),1670(3-KETONE),1632(Δ4-DOUBLE BOND),1607cm-1(Δ1-DOUBLE BOND)(645)" "645/" "TESTOSTERONEから合成｡ 又,Δ5-17β-HYDROXY-ANDROSTEN-3-ONからも合成できる｡ (449)" "449/" "・筋肉同化作用(17-CYCLOPENTENYL ETHER(QUINBOLONE))の方が,経口投与で肝毒素は弱い｡)(645)" "645/" "分子量 286.40,弱い ZIMMERMANN 反応が見られ,エタノール−硫酸スプレーでオレンジ色を呈す｡ (645)" "645/" "ST0300" 12.00 "3β,14,16β-TRIHYDROXY-5β-BUFA-20,22-DIENOLIDE" "BUFOGENIN B,DESACETYLBUFOTALIN" "C24H34O5" 24.00 34.00 5.00 0.00 0.00 0.00 402.00 " (REF:247)" "247/" "210-223ﾟC(247)" "[α]19/D=+30ﾟ±3ﾟ(C=1.039 in DIOXANE)(247)" "クロロホルム,メタノール,アセトンに,非常にわずかにとける｡(247)" "247/" "動物｡ CHINESE TOADS(ヒキガエル)(Bufo asiaticus = Bufo gargarizans Cantor)から調製した Chinese drug より分離｡ Bufotalin の ACETYL基の除去でも得られる｡(247)" "247/" "ヒキガエル皮膚腺から分泌される毒素｡(247)" "247/" "分子量 402.51 (247)" "247/" "ST0301" 12.00 "BUFOTALIN 3-SUBEROYLARGININE ESTER" "BUFOTOXIN,VULGAROBUFOTOXIN" "C40H60O10N4" 40.00 60.00 10.00 4.00 0.00 0.00 756.00 " (REF:646/014/015/647/648/649/650)" "646/014/015/647/648/649/650/" "198-202ﾟC(647)" "[α]26/D=+2.0ﾟ±2ﾟ(C=0.9939 in MeOH)(647)" "メタノール,ピリジンに可溶｡ 無水アルコールに少し溶ける｡ 水,エーテル,アセトン,クロロホルム,石油エーテルに不溶｡(014/015/646/647/648/649/650)" "647/014/015/646/648/649/650/" "UVmax:295nm(logε=3.74)(647/014)" "647/014/" "動物｡ European toad(ヒキガエル)(BUFO VULGARIS,BUFO BUFO GARGORIZANSなどの皮腺分泌物(がま毒)｡(646/014/015/647)" "646/014/015/647/" "心臓機能を亢進する強心性ステロイド｡(646/014)" "646/014/" "分子量 756.91, 加水分解によって BUFOTALINとSUBERYLARGININEに分解する｡(014)・化学構造の修正｡ BUFOTALIN の 14-SUBEROYLARGININE ESTER ではなく, 3-(HYDROGEN SUBEROYL)-BUFOGENIN｡(648) ・酵素分解による構造決定｡ (649) ・部分合成｡(650)" "014/648/649/650/" "ST0302" 12.00 "[2α(2S,3S,4S,6R),3β,5α]-14-HYDROXY-19-OXO-3,2-[(TETRAHYDRO-3,4-DIHYDROXY-6-METHYL-2H-PYRAN-2,3-DIYL)BIS(OXY)]CARD-20(22)-ENOLIDE" "CALOTROPIN" "C29H40O9" 29.00 40.00 9.00 0.00 0.00 0.00 532.00 " (REF:651/652/653/654/655/656/657/658/659/660/661)" "223ﾟC(ALCOHOL or ETHYL ACETATE)(654/657)" "[α]18/D=+66.8ﾟ±1.0ﾟ(in METHANOL)(657)" "水,アルコールに可溶｡ エーテルに不溶｡(652/654/657)" "654/657/652/" "Uvmax:217,310nm(EtOH,logε=4.21, 1.49)(657)" "657/" "植物｡ Calotropis procera Dryand.,Asclepiadaceae(カガイモ科)(651/652/653/654) Asclepias curassavica L., Asclepiadaceae(655)の milk sap から単離｡" "651/652/653/654/655/" "・CARDIOTONIC(強心薬) 致死量：カエル 0.5γ/g BODY WT. ネコ 0.12mg/kg BODY WT.(653)" "653/655/" "分子量 532.61, APOCANNOSIDE,CYMARIN と構造がほとんど違わない｡ いずれもAPOCYNUM CANNABINUM L.(APOCYNACEAE)の抽出物から得られ, 腫瘍に対して細胞障害活性を持つ事が知られている｡ (655) ・ペーパークロマトグラフィーによって, VSCHARIDINの水解物から分離,抽出｡(657)" "655/657/" "ST0303" 12.00 "17-HYDROXY-3-OXO-17α-PREGNA-4,6-DIENE-21-CARBOXYLIC ACID γ-LACTONE;17α-(2-CARBOXYETHYL)-17β-HYDROXYANDROSTA-4,6-DIEN-3-ONE LACTONE;17α-(2-CARBOXYETHYL)-17β-HYDROXY-3-OXO ANDROSTA-4,6-DIENE LACTONE;「6-DEHYDROTESTOSTERONE-17α-PROPIONIC ACID γ-RACTONE: 3-(3-OXO-17β-HYDROXY-4,6-ANDROSTADIEN-17α-YL)-PROPIONIC ACID γ-LACTONE" "CANRENONE,PHANURANE" "C22H28O3" 22.00 28.00 3.00 0.00 0.00 0.00 340.00 " (REF:543)" "543/" "149-151ﾟC(ETHYL ACETATE)(REMELTS 165ﾟ)(543)" "[α]/D=+24.5ﾟ(CHLOROFORM)(543)" "543/" "UVmax:283nm(ε=26,700)(543)" "543/" "17-HYDROXY-3-OXO-17α-PREGN-4-ENE-21-CARBOXYLIC ACID γ-LACTONEの脱水素化で調製｡(543)" "543/" "ALDOSTERONE 拮抗物質として作用｡ 利尿剤｡ 経口投与で，副腎切除ラットでの尿中 Na,K比への12μg DESOXYCORTICOSTERONE" "543/" "分子量 340.44 (543)" "543/" "ST0304" 12.00 "6α,16β-BIS(ACETYLOXY)-3α,7β-DIHYDROXY-29-NORDAMMARA-17(20),24-DIEN-21-OIC ACID." "CEPHALOSPORIN P1" "C33H50O8" 33.00 50.00 8.00 0.00 0.00 0.00 574.00 " (REF:662/663/664/665/666)" "662/663/664/665/666/" "147ﾟC(662) 50% aq.ETHANOL C33H50O8-H2O,1/2C2H5OHについて，以下に示す｡" "[α]20/D=+28ﾟ(C=2.7 in CHLOROFORM)(662)" "クロロホルム,エタノールなどほとんどの有機溶媒に直ちに溶ける｡ヘキサン,水には少し溶ける｡(662)" "662/" "UVmax:211nm(ε=9140)(662)" "662/" "SARDINIA 近くの海からとれる Cephalosporium SP.によって産生される｡(662)" "662/" "・抗生物質。多くのグラム陽性菌,グラム陽性菌の増殖を阻害する｡ ５種類のCEPHALOSPORINS全て,HELVOLIC ACID(ASPERGILLUS FUMIGATUS によって産生される抗生剤) と共通の特性を持つ｡ 最も活性の高い CEPHALOSPORIN である P1 は, AUREOMYCINや TERRAMYCIN と同じぐらい活性がある｡ P1 は HELVOLIC ACID の２倍の活性がある(CYLINDERPLATE METHOD で, STAPH, AUREUS に 作用させた場合)｡(662)" "662/" "分子量 574.73 CEPHALOSPORIN Pには,少なくとも５つの構成要素 P1,P2,P3,P4,P5 があり, P1 がメジャーアクティブである｡P1 は,有機溶媒中で安定で, PH7.0 では水溶液中,室温でナトリウム塩として安定である｡ PH8.0ではゆっくりと不活性化されるが, PH9.6 では急速に不活性化される｡ (662) ・CEPHALOSPORIN P1は,C32H48O8 ではなく,メチル基をおそらく C8 にもう１つもち,C33H50O8 ﾄ考えられる｡(664) ・NMR や MASS からも C33H50O8 へ訂正｡(655/666)" "543/" "ST0305" 12.00 "CERBERIN,VENENIFERIN,MONOACETYLNERIIFOLIN" "C32H48O9" 32.00 48.00 9.00 0.00 0.00 0.00 576.00 " (REF:667/668/669)" "667/668/669/" "212-215ﾟC(METHANOL+WATER)(668),213ﾟC(669)" "[α]27/D=-46.9ﾟ(95%ETHYL ALCOHOL)(667),[α]19/D=-82ﾟ(CHLOROFORM)(668),[α]23/D=-79ﾟ(669)" "アルコール,クロロホルム,酢酸,ピリジンに可溶｡ 酢酸エチル,アセトン,水には少し溶ける｡ エーテル,ベンゼンにはほとんど溶けない｡(671)" "668/669/667/671/" "植物 Cerbera odollam Gaertn., Apocynaceaeの種, Tanghinia venenitera Poir., Apocynaceaeの種｡(667) Thevetia neriifolia の実｡(669)" "669/" "・有毒だが, 強心薬として利用｡(670) ・E.M.D.50(μg/kg PIGEON)=126.7±7.0 CERBEROSIDEより強力｡ LD50(μg/kg CAT)=147.0±5.7(671)" "670/671/" "分子量 576.70, TOLLENS' REAGENT 陽性｡ SODIUM NITROPRUSSIDE 陽性｡ 濃硫酸で処理すると, レモンイエローから緑の蛍光を持つワインレッドへ変わる｡ Ｍ-DINITROBENZENE と反応してVIOLET から INDIGO BLUE へ変わる(CARDIAC GLYCOSIDE の特徴)｡ LIEBERMANN-BURCHARD 試薬と反応して, EMERALD GREEN を示す｡ KELLER-KILLIANI 試験は陰性｡ シールチューブ中で, 希硫酸で処理するとCERBERIN は BENEDICT'S SOLUTION を還元する｡(671)" "671/" "ST0306" 12.00 "3β-[(O-β-D-GLUCOPYRANOSYL-(1→6)-O-β-D-GLUCOPYRANOSYL-(1→2)-6-DEOXY-3-O-METHYL-α-L-GLUCOPYRANOSYL)OXY]-14-HYDROXY-5β-CARD-20(22)-ENOLIDE" "CERBEROSIDE,THEVETIN B,THEVANIL" "C42H66O18" 42.00 66.00 18.00 0.00 0.00 0.00 858.00 " (REF:671/672)" "671/672/" "197-201ﾟC(WATER)(672)" "[α]24/D=-61.4ﾟ±1.5ﾟ(C=1.50 in METHANOL)(672)" "水, アルコール, 酢酸, ピリジンに可溶｡ 酢酸エチル, アセトンには少し溶ける｡ エーテル, ベンゼン, クロロホルムにはほとんど溶けない｡(671)" "672/671/" "植物。 Cerbera odollam Gaertn., Apocynaceae(キョウチクトウ科)の一種, Thevetia neriifolia Juss.,(Apocynaceaeの一種)｡(671)" "671/" "・強心薬｡ CERBERIN より作用は弱い｡ ・E.M.D.50(μg/kg PIGEON)=150.2±11.6, LD50(μg/kg CAT)=813.7±78(671)" "671/" "分子量 858.95, 希硫酸水解物が, BENEDICT'S SOLUTIONに陽性を示す(糖が成分である事を示す)｡ CERBERIN と同じAGLYCON｡(671/672)" "671/672/" "ST0307" 12.00 "(Z)-4α,9-EPOXYCEVANE-3β,4,12,14,16β,17,20-HEPTOL 3-(2-METHYL-2-BUTENOATE)" "CEVADINE,VERATRINE" "C32H49O9N" 32.00 49.00 9.00 1.00 0.00 0.00 591.00 " (REF:673/674/675)" "673/674/675/" "208.5-209.5ﾟC(673),214-215ﾟC(674)" "[α]20/D=+12.8ﾟ(C=3.2 in ALC.)(673)" "1gが約15mlのアルコール又はエーテルに溶ける｡ 水には,わずかにとける｡(673)" "673/674/" "短波長側に非常に強い吸収があるが,ピークを検出できない｡(673)" "エーテルリンクしたカルボニル基の存在を示す吸収｡ 水酸基が多数存在する吸収｡ (674)" "673/674/" "植物。 Schoenocaulon officinale (Schlecht & Cham.) A.Gray (Sabadilla officinarum Brandt), Liliaceae(ユリ科)の種(SABADILLA SEED)｡(673/674)" "673/674/" "・殺虫剤として利用されるSABADILLA ALKALOID の一種｡ 粘膜に刺激性がある｡ 投与により強い毒性を示す｡ 副作用強い｡(674)" "674/" "分子量 590.72 (674) ・VERACEVINE 3-(3'-BROMOANGELATE)の水素添加分解によって合成｡(675)" "674/675/" "ST0308" 12.00 "4,9-EPOXYCEVANE-3α,4β,12,14,16β,17,20-HEPTOL." "CEVINE" "C27H43O8N1" 27.00 43.00 8.00 1.00 0.00 0.00 509.00 " (REF:677/678/679/680)" "677/678/679/680/" "HYDROCHLOLIDE,247ﾟC(679)" "[α]17/D=-17.5ﾟ(aq. ALC.)(679)" "水,アルコールに可溶｡ エーテルにもわずかに溶ける｡(679)" "679/" "植物。 ・Cevadine の加水分解によって得られる ALKAMINE(AMINOALCOHOL)｡(677)" "677/" "分子量 509.65, ZYGADENINE や GERMINE などの ALKALOIDS と関連した構造｡(678) ・C16 水酸基のβ-配向, C22 水素のα-配向の決定｡(679)" "678/679/680/" "ST0309" 12.00 "6-CHOLORO-17-HYDROXY-PREGNA-4,6-DIENE-3,20-DIONE ACETATE/6-CHLORO-6-DEHYDRO-17α-HYDROXYPROGESTERONE ACETATE; 6-CHLORO-6-DEHYDRO-17α-ACETOXYPROGESTERONE; 17α-ACETOXY-6-CHLORO-6,7-DEHYDROPROGESTERONE" "CHLORMADINONE ACETATE,GESTAFORTIN,LORMIN,LUTERAN,VERTON,LUTESTRAL,LUTORAL[SYNTEX],NORMENON,MENSTRIDYL,CERO" "C23H29O4Cl" 23.00 29.00 4.00 0.00 0.00 0.00 404.00 " (REF:681/382)" "681/682/" "212-214ﾟC(METHANOL or ETHER)(681),209-211ﾟC(682)" "[α]/D=+6ﾟ(in CHCl3)(681/682)" "681/682/" "Uvmax:283.5, 286nm(ε=23,400, 22,100)(681/682)" "681/682/" "・6α,7α-OXIDO-17α-HYDROXY-PROGESTERONEから調製｡ (681) ・6α,7α-OXIDO-Δ4-PREGNEN-17α-OL-3,20-DIONE-ACETATEから調製｡(682)" "681/682/" "・Progestin 作用(ヒト), 家畜で, Progestational activity を発情期の調節に利用｡(681/682)" "681/682/" "分子量 404,94, (681/682)" "681/682/" "ST0310" 12.00 "16α-CHLORO-3-METHOXYESTRA-1,3,5(10)-TRIEN-17-ONE" "16α-CHLOROESTRONE 3-METHYL ETHER,ATHERAN,COLESTEREL" "C19H23O2Cl" 19.00 23.00 2.00 0.00 0.00 0.00 318.00 " (REF:683)" "683/" "177-179ﾟC(CHLOROFORM)(683)" "[α]/D=+161ﾟ(CHLOROFORM)(683)" "683/" "CARBON TETRACHLORIDE 中で, ESTRONE METHYL ETHER の ENOL ACETATE を CHLORINE と POTASSIUM CARBONATE と反応させて調製｡(683)" "683/" "Anticholesteremic agent(抗コレステロール血症薬)｡ ESTROGEN活性は, ESTRONの100分の1なので, 利用価値が高い｡(683)" "683/" "分子量 318.85 (683)" "683/" "ST0311" 12.00 "6α-CHLORO-17,21-DIHYDROXY-PREGNA-1,4-DIENE-3,11,20-TRIONE/6α-CHLORO-1,4-PREGNADIENE-17α,21-DIOL-3,11,20-TRIONE" "C21H25O5Cl" 21.00 25.00 5.00 0.00 0.00 0.00 392.00 " (REF:684)" "684/" "21-ACETATE C23H27ClO6,217-219ﾟC(ACETONE+HEXANE)(684)" "21-ACETATE [α]/D=+144ﾟ(CHLOROFORM)(684)" "684/" "21-ACETATE UVmax(ETHANOL):237nm(logε=4.19)(684)" "684/" "6α-CHLOROCORTISONE 21-ACETATE の SELENIUM DIOXIDE DEHYDROGENATION によって, 21-ACETATE として調製｡(684)" "684/" "・局所のグルココルチコイドとして利用｡ 副腎切除したラットへ経口投与した場合で, THYMOLYTIC ACTIVITYは, HYDROCORTISONE ACETATEを１とした場合, 4で, ANTI-INFLAMMATORY ACTIVITYは 4｡ (684)" "684/" "分子量 392.89 (684)" "684/" "ST0312" 12.00 "16,23:16,24-DIEPOXY-9,19-CYCLO-9β-LANOSTANE-3β,15α,25-TRIOL" "CIMIGENOL,CIMICIFUGOL" "C30H48O5" 30.00 48.00 5.00 0.00 0.00 0.00 488.00 " (REF:685/686/687/688)" "685/686/687/688/" "216-217ﾟC(688)" "[α]/D=+38.2ﾟ(C=1.99 in CHLOROFORM)(688)" "688/" "吸収なし｡(688)" "λKBr/max 3280cm-1(OH)(688)" "１ｺのSPLIT SIGNAL[3H,J=5-6c/SEC.)を示し, SECONDARY METHYL GROUPに帰属する｡ (685)" "C30H48O5を示すスペクトル(M/E 488)(685/688)" "468(OSMOMETER)(688)" "688/685/" "植物｡ Cimicifuga racemosa Nutt.(Actaea racemosa L.), Ranunculaceae の樹脂から抽出される XYLOSIDE の一種の TRITERPENE GENIN. (685) CIMICIFUGA ACERINA の主要成分｡ (688)" "685/688/" "分子量 488.68, 立体構造｡ (687) ・5%NaOH(MeOH)と１時間, 加熱環流するも変化認められず｡ NaIO4(MeOH) に抵抗, H2 を吸収せず, 5% HCl(MeOH) と１時間加熱環流して数種の混合物を生成, 5% AcOHと５時間加熱環流しても変化せず｡(688)" "688/" "ST0313" 12.00 "4-CHLORO-17β-HYDROXYANDROST-4-EN-3-ONE. 4-CHLOROTESTOSTERONE" "CLOSTEBOL" "C19H27O2Cl" 19.00 27.00 2.00 0.00 0.00 0.00 322.00 " (REF:689/690)" "689/690/" "188-190ﾟC(ACETONE+HEXANE)(690)" "[α]20/D=+148ﾟ(CHCl3)(690)" "690/" "UVmax(95% ETHANOL):256nm(logε=4.13)(690)" "690/" "・4α,5-OXIDOANDROSTANE-17β-OL-3-ONE ACETATE を酢酸中で塩酸処理し, 4β-CHLOROANDROSTANE-5α,17β-DIOL-3-ONE-17-ACETATE とし, 更に加熱して水を除くと得られる｡(689) ・4ξ,5ξ-OXIDOANDROSTA-17β-OL-3-ONE を,アセトン中で 1PARTの37% 塩酸で処理して調製｡(690)" "689/690/" "Anabolic 作用｡ ANABOLIC ANDROGENIC RATIO は TESTOSTERONE PROPIONATE が 0.28 のとき, ACETATE として 0.88｡ (689)" "689/" "分子量 322.89 (689)" "689/" "ST0314" 12.00 "25-(ACETYLOXY)-2-(β-D-GLUCOPYRANOSYLOXY)-16,20-DIHYDROXY-9-METHYL-19-NORLANOSTA-1,5,23-TRIENE-3,11,22-TRIONE; 2-O-β-D-GLUCOPYRANOSYLCUCURBITACIN E." "COLOCYNTHIN" "C38H54O13" 38.00 54.00 13.00 0.00 0.00 0.00 718.00 " (REF:691/692)" "691/692/" "158-160ﾟC(691/692)" "[α]/D=+50ﾟ(C=0.4 in ETHANOL)(691)" "エタノール,アセトン,クロロホルムに可溶｡ エーテル,水にはわずかに溶ける｡(691)" "691/" "UVmax : 234-236nm(logε=4.11)(691)" "α-ELATERINと同様. 3570, 3450(OH), 1725(Ac), 1685(C:C･CO), 1660, 1625, 1415(DIOSPHENOL)cm=1を示す｡ 他に,1425, 1390, 1370, 1250, 1220, 1120, 1070cm-1 (692)" "691/692/" "植物｡ Citrullus colocynthis Schred., Cucurbitaceae の実｡(691)" "691/" "・抗ガングリコシド｡ (691/692)" "691/692/" "分子量 718.81, 糖残基にはグルコースが含まれる｡ (691) ・AGLYCON は, α-ELATERIN (691/692)" "691/692/" "ST0315" 12.00 "3,16α-BIS(ACETYLOXY)ESTRA-1,3,5(10)-TRIEN-17-ONE/3,16α-DIHYDROXYESTRONE DIACETATE; 3,16α-DIACETOXY-Δ1,3,5-ESTRATRIEN-17-ONE" "COLPORMON,COLPOGYNON" "C22H26O5" 22.00 26.00 5.00 0.00 0.00 0.00 370.00 " (REF:120)" "120/" "179-180ﾟC(120)" "[α]28/D=+122ﾟ(CHLOROFORM)(120)" "120/" "[Μ]/D=+451(120)" "120/" "3β-HYDROXYANDROSTANE-17-ONE(ISOANDROSTERONE)から合成｡ (120)" "120/" "Estrogen 作用｡ (120)" "120/" "分子量 370.43, LITHIUM ALUMINUM HYDRIDE 処理によって, ESTRIOL が得られる｡ (120)" "120/" "ST0316" 12.00 "3β-(DIMETHYLAMINO)CON-5-ENINE" "CONESSINE,NERIINE,roQUESSINE,WRIGHTINE" "C24H40N2" 24.00 40.00 0.00 2.00 0.00 0.00 356.00 " (REF:693/694/695/696/697/698/699/700)" "693/694/695/696/697/698/699/700/" "127-128.5ﾟC(ACETONE)(698/699)" "[α]20/D=+25.3ﾟ(C=0.7 in 無水アルコール)(693)" "水に少し溶ける｡" "698/699/693/" "798, 826, 1665cm-1(695)" "695/" "植物｡ Holarrhena anti-dysenterica Wall.,Apocynaceae, のインド産, または, アフリカ種の H,africana A.DC., H.congolensis Stapf, H.wulfsbergii StapfH.febrifuga Klotzsch, Apocynaceae の樹皮や種｡ (693/694)" "693/694/" "antiamebic(抗アメーバ剤) (693/694)" "693/694/" "分子量 356.58, (697) ・コールタール中間体からの全合成｡ (698) ・立体特異的合成(dl-CONESSINE の全合成)(699) ・CONAN-4-EN-3-ONE からの合成 (700)" "697/698/699/700/" "ST0317" 12.00 "5β-ERGOSTANE" "COPROERGOSTANE,PSEUDOERGOSTANE" "C28H50" 28.00 50.00 0.00 0.00 0.00 0.00 386.00 " (REF:701)" "701/" "64ﾟC(ACETONE)(701)" "[α]19/D=+25.3ﾟ(C=2 in CHLOROFORM)(701)" "701/" "CHOLANIC ACID から NORCHOLYL-METHYL-KETONE を経て合成｡ (701)" "701/" "分子量 386.68, (701)" "701/" "ST0318" 12.00 "5β-CHOLESTANE" "COPROSTANE,PSEUDOCHOLESTANE" "C27H48" 27.00 48.00 0.00 0.00 0.00 0.00 372.00 " (REF:702/703/040/704/705)" "702/703/040/704/705/" "72ﾟC(ALCOHOL)(702)" "[α]11/D=+25.1ﾟ(C=2 in CHCl3)(040)" "エーテル,クロロホルムに可溶｡無水アルコールにわずかに溶ける｡(702/703/040/704/705)" "702/040/703/704/705/" "900と1070cm-1のBANDSが特徴的｡(040)" "040/" "・ETHANOL, PLATINUM, SODIUM NITRITE 存在下, CHOLEST-4-ENE をHYDROGENATION すると, COPROSTANE が55%, CHOLESTANE が45%得られる｡(040) ・Δ6-COPROSTENE の水素化による｡ (704) ・COPROSTAN-3-ONE の還元による｡ (705)" "040/704/705/" "分子量 372.65, (703)" "703/" "ST0319" 12.00 "11β,21-DIHYDROXYPREGN-4-ENE-3,20-DIONE/4-PREGNENE-11β,21-DIOL-3,20-DIONE" "CORTICOSTERONE,COMPD B;REICHSTEIN'S SUBSTANCE H,KENDALL'S COMPD B;" "C21H30O4" 21.00 30.00 4.00 0.00 0.00 0.00 346.00 " (REF:269)" "269/" "180-182ﾟC(ACETONE)(615)" "[α]15/D=+223ﾟ(C=1.1 in ALC.)(615)" "水に不溶｡ 普通の有機溶媒に可溶｡(269)" "615/269/" "UVmax:240nm(logε=Ca.4)(615)" "615/" "動物｡ Adrenal cortex(副腎皮質)の中で,主に束状層で合成｡ (269)" "269/" "ADRENOCORTICAL STEROIDとして, CORTISOL, CORTISONE と同じく, GLUCOCORTICOID の一種｡ しかし,グリコーゲン貯留作用, 抗炎症作用とも,他の二種より弱い。 副腎皮質の球状層で活性の強い 18- ヒドロキシラーゼによって強力な MINERALCORTICOID である ALDOSTERONE を合成する際の前駆体として利用される｡(615)" "615/" "分子量 346.45, concd.H2SO4でぬらすと, 橙黄色の溶液となり強い蛍光を放つ｡(615)" "615/" "ST0320" 12.00 "11β,17,21-TRIHYDROXY-6,16α-DIMETHYL-2'-PHENYL-2'H-PREGNA-2,4,6-TRIENO[3,2-C]PYRAZOL-20-ONE 21-ACETATE/1,2,3,3A,3B,7,10,10A,10B,11,12,12A-DODECAHYDRO-1,11-DIHYDROXY-2,5,10A,12A-TETRAMETHYL-7-PHENYLCYCLOPENTA[7,8]PHENANTHRO[2,3-C]PYRAZOL-1-YL HYDROXYMETHYL KETONE ACETATE/6,16α-DIMETHYL-11β,17α,21-TRIHYDROXY-2'-PHNYL[3,2-PHNYL[3,2-C]PYRAZOLO-4,6-PREGNADIEN-20-ONE 21-ACETATE" "CORTIVAZOL,MK-650;H3625;ALTIM;DIASTER;DILASTER;IDALTIM" "C32H38O5" 32.00 38.00 5.00 2.00 0.00 0.00 530.00 " (REF:706)" "706/" "160-165ﾟC and 229-230ﾟC(DOUBLE M.P.)(706)" "[α]23/D=+14ﾟ(CHCl3)(706)" "706/" "UVmax(METHANOL):283,315nm(ε=15,700, 19,000)(706)" "706/" "2-HYDROXYMETHYLENE-17α,20,20,21-BISMETHYLENEDIOXY-6,16α-DIMETHYL-4,6-PREGNADIENE-11β-OL-3-ONE の加水分解によって得られる｡ (706)" "706/" "Glucocorticoid 作用｡ 抗炎症作用｡ SISTEMIC GRANULOMA で見ると, 9α-FLUORO-16α-METHYL-1,4,6-PREGNATRIENE-11β,17α,21-TRIOL-3,20-DIONE21-ACETATE(Δ6-DEXAMETHASONE)では150の時, CORTIVAZOL は 551(雄 HOLTZMAN RATS(Ca.125g) に経口投与で毎日一週間与える)｡ ヒトリューマチ痛に対して, HYDROCORTISONE の75倍の 活性を持つ｡ ナトリウム保持活性の報告はない｡(706)" "706/" "分子量 530.66, (706)" "706/" "ST0321" 12.00 "3α,17α,20α,21-TETRAHYDROXYPREGNAN-11-ONE/3α,17α,20α,21-PREGNANETETROL-11-ONE" "CORTOLONE" "C21H34O5" 21.00 34.00 5.00 0.00 0.00 0.00 366.00 " (REF:707/708/709)" "707/708/709/" "208-209ﾟC(ACETONE)(707)" "[α]25/D=+44ﾟ(C=0.5 in ETHANOL),[α]28/D=+34.2ﾟ(ETHANOL)(707)" "707/" "動物｡ 副腎皮質｡ CORTISONE 又は, HYDROCORTISONE 又は ACTHの投与後の人の尿｡ (707)" "707/" "分子量 366.48, PREGNANE-3α,17α-DIOL-11,20-DIONE を出発材料として合成。(708) ・Δ20-ALLOPREGNENE-3β,20-DIOL DIACETATE を PERBENZOIC ACID で処理し,CRUDE OXIDATION PRODUCT を SILICA GEL で CHROMATOGRAPHし,調製する。(709)" "708/709/" "ST0322" 12.00 "25-(ACETYLOXY)-2,16,20-TRIHYDROXY-9-(HYDROXYMETHYL)-19-NORLANOSTA-5,23-DIENE-3,11,22-TRIONE" "CUCURBITACIN A" "C32H46O9" 32.00 46.00 9.00 0.00 0.00 0.00 574.00 " (REF:710/711/712/713)" "710/711/712/713/" "207-208ﾟC(ETHYL ACETATE)(710)" "[α]27/D=+97.3ﾟ(C=1.04 in ETHANOL)(710)" "710/" "UVmax(ETHANOL):229, 290nm(logε=4.03,logε=2.26), INFLEXION:330-350nm (logε=1.81-1.64)(710)" "遊離水酸基を持つ｡(νmax 3448cm-1)(711), 5.85μ(ISOLATED KETO GROUP,CARBONYL OF THE ACETYL GROUP),5.92μ,6.14μ(CARBONYL AND DOUBLE BOND OF αβ-UNSATURATED KETO GROUP)(710)" "M(X-RAY METHOD),587±16(711)" "710/711/" "植物｡ Cucurbitaceae の実。CUCUMIS MYRIOCARPUS, C.LEPTODERMIS。(710)" "710/" "CUCURBITACEAE の苦味成分。 MINIMUM LETHAL DOSE(M.L.D)0.7mg/kg ウサギ(i.v.)｡(710)" "710/" "分子量 574.434, 中性, アセチル基を1つ含む。(710)" "710/" "ST0323" 12.00 "25-(ACETYLOXY)-3,16,20-TRIHYDROXY-9-(HYDROXYMETHYL)-19-NORLANOSTA-5,23-DIENE-11,22-DIONE" "CUCURBITACIN C" "C32H48O8" 32.00 48.00 8.00 0.00 0.00 0.00 560.00 " (REF:710/711/712/713)" "710/711/712/713/" "207-207.5ﾟC(ETHYL ACETATE)(710)" "[α]27/D=+95.2ﾟ(C=1.03 in ETHANOL)(710)" "710/" "UVmax(ETHANOL):231,298nm(ε=11,100, 11,131)(712)" "νmax 1731, 1256(OAc), 1689, 1631(CO･C:C)cm-1(712)" "M(X-RAY METHOD),577±12(712)" "712/" "植物｡ Cucurbitaceae の実。CUCUMIS SATIVUS Var.HANZIL。(710/712)" "710/712/" "・CUCURBITACEAE の苦味成分(710)｡ 特にほとんどの GREENHOUSE CUCUMBERの苦味成分｡ (712) ・MEDICINAL, CYTOSTATIC,AND TOXIC｡(713)" "710/712/713/" "分子量 560.344, 中性, アセチル基を1つ含む。(710) ・4つのメチル基を持つ｡ (713)" "710/713/" "ST0324" 12.00 "25-(ACETYLOXY)-2,16,20-TRIHYDROXY-9-METHYL-19-NORLANOSTA-5,23-DIENE-3,11,22-TRIONE; 1,2-DIHYDRO-α-ELATERIN" "CUCURBITACIN B" "C32H46O8" 32.00 46.00 8.00 0.00 0.00 0.00 558.00 " (REF:710/714/715/716/717/713/718/719)" "710/714/715/716/717/713/718/719/" "184-186.5ﾟC(ABSOLUTE ALCOHOL)(714), 180-182ﾟC(710), 178-179ﾟC(715)" "[α]25/D=+88ﾟ(C=1.55 in ETHANOL)(714) [α]25/D=+87.5ﾟ(C=1.554 in 96%ETHANOL)(710) [α]25/D=+87ﾟ(C=0.89 in ABS. ETHANOL)(715)" "714/710/715/" "λmax,mμ(Ε1%/1cm):229(211),290(3.4)in NEUTRAL SOLUTION, 312(95)in ALKALINE SOLUTION.(714), γmax 228mμ(logε=4.02),marked inflection between 270 and 290mμ,280mμ(logε=2.32)(715)" "STRONG ABSORPTION MAXIMA AT 2.92, 5.82, 5.92, 6.17μ(715)" "714/715/" "植物｡ Cucurbitaceae (CUCUMIS AFRICANUS, LAGENARIA LEUCANTHA)の実から, RIMINGTON の方法を MODIFICATION して単離｡ (710) ・ECHINOCYSTIS FABACEA(MAN-ROOT, MAN-IN-THE-GROUND, 又は WILD CUCUMBER VINE)の根｡ (715)" "710/715/" "・毒性あり(M.L.D.(ウサギ),0.5mg/kg)｡ (710) ・CUCURBITACEAE の苦味成分｡ (714) ・根をせんじて, カリフォルニアインディアンは, 漁毒として使用したり, 自殺老衰や病気の年寄りを毒殺したりした｡ 薬として試用する際には種や根の抽出物を 112-24や性病に供した｡ 根には強い下痢作用がある｡ カリフォルニアでは""STOUGHTON'S BITTERS""を作るのに根の抽出物が用いられていた｡ (715)," "710/714/715/" "Ｘ線解析で,分子量 558.344｡ TOLLENS試薬を還元する。 MOLISH反応は陽性｡ 酢酸テスト陽性｡ 硫酸を含む酢酸に溶かすと赤色を呈す｡ LIEBERMANNや LIEBERMANN-BURCHARD テストでは, 酢酸中, 臭化水素と反応して BURGUNDY色を呈し, クロロホルム中で ANTIMONY PENTACHLORIDE と反応して紫色を呈する｡ FERRIC CHLORIDE や LEGAL テストでは陰性｡ ZEREVITIONV DETERMINATIONS:0.824 and 0.824%H｡(715) ・CUCURBITACINS B, D(ELATERICIN A),E(α-ELATERIN),I(ELATERICIN B)間での相互関係｡ (717) ・CUCURBITACINSの立体化学｡ (719)" "715/717/719/" "ST0325" 12.00 "2β,16β,20,25-TETRAHYDROXY-9-METHYL-19-NOR-9β,10α-LANOSTA-5,23-DIENE-3,11,22-TRIONE" "CUCURBITACIN D,ELATERICIN A." "C30H44O7" 30.00 44.00 7.00 0.00 0.00 0.00 516.00 " (REF:710/714/716/717/713/718/719)" "710/714/716/717/713/718/719/" "151-153ﾟC(ETHYLACETATE+BENZENE), 150-150ﾟC(710)" "[α]/D=+48ﾟ(C=1.5 in CHLOROFORM)(719) [α]/D=+52ﾟ(in ETHANOL)(714) [α]/D=+46ﾟ(in CHF.)(716)" "710/719/714/716/" "λmax,mμ(Ε1%/1cm):230(230)in neutral solution, 314(108)in alkaline solution.(714), λmax:232mμ(ε=9,000)(716)" "νmax : 3425, 1689, 1626, 1377, 1088, 1058, 983cm-1(716)" "714/716/" "植物｡ Cucurbitaceae (各種の CUCURBITA PEPO)などの苦い ORNAMENTAL GOURD から単離される結晶｡ 収率は0.005%で少量しか取れない｡ (710) ・CUCUMIS HIRSUTUSの根｡ (714) ・ECBALLIUM ELATERIUM L｡ (716)" "710/714/716/" "・苦味の成分, 抗腫瘍活性｡ (716)" "716/" "分子量 516.323,エタノール中で FERRIC CHLORIDE と反応しても呈色なし｡(716)・CUCURBITACINS B, D(ELATERICIN A),E(α-ELATERIN),I(ELATERICIN B)間での関係｡ (717) ・CUCURBITACINS の立体化学｡ (719)" "716/717/719/" "ST0326" 12.00 "2,3,16,20,25-PENTAHYDROXY-9-METHYL-19-NORLANOSTA-5,23-DIENE-11,22-DIONE" "CUCURBITACIN F." "C30H46O7" 30.00 46.00 7.00 0.00 0.00 0.00 518.00 " (REF:714/718)" "714/718/" "244-245ﾟC(CHLOROFORM)(714)" "[α]/D=+38ﾟ(C=1.2 in ETHANOL)(714)" "714/" "λmax,mμ(Ε1%/1cm):232(228),300(2.7)in neutral solution, unchanged in alkaline solution(714)" "νmax(inLBr) : 1690, 1629cm-1(αβ-unsaturated ketone group),1700cm-1(isolated ketone group)(718)" "714/718/" "植物｡ Cucurbitaceae (CUCUMIS ANGOLENSIS)の葉から,CHLOROFORM へ不溶な事を利用して精製｡ (714) ・CUCUMIS DINTERI COGN. の葉｡ (718)" "714/718/" "・苦み成分｡ (718)" "718/" "分子量 518.323, C30H46O7 として修正｡ TETRAZOLIUM BLUE で呈色なし｡ ・DIHYDROCUCURBITACIN D の SODIUM BOROHYDRIDE で還元すると, DIHYDROCUCURBITACIN F へ変換できる事から, CUCURBITACIN Dと Fの直接的な関係が示される｡(718)" "718/" "ST0327" 12.00 "2,16,20,25-TETRAHYDROXY-9-METHYL-19-NORLANOSTA-1,5,23-TRIENE-3,11,22-TRIONE; 1,2-DEHYDROELATERICIN A." "CUCURBITACIN I, ELATERICIN B." "C30H42O7" 30.00 42.00 7.00 0.00 0.00 0.00 514.00 " (REF:720/716/713/714/719)" "720/716/713/714/719/" "148-148.5ﾟC(714),148-149ﾟC(716)" "[α]/D=-52ﾟ(C=1.56 in CHLOROFORM)(716)" "希アルカリ,酢酸エチル,クロロホルム,ベンゼンに可溶｡(716)" "716/" "UVmax(ETHANOL):234,266nm(ε=11,000, 6,850)(716), λmax,mμ(Ε1%/1cm):234(246),269(158)in neutral solution, 232(251),314(104)in alkaline solution(714)" "νmax : 3410, 1685, 1660, 1629, 1606, 1413, 1090, 1005cm-1(716)" "716/714/" "植物｡ Ecballium elaterium(L.)A.Rich.,Cucurbitaceae の実｡ (720) CITRULLUS ECIRRHOSUS の CRUDE FOAMS｡ (716)" "716/720/" "下剤。抗腫瘍活性｡ (716)" "716/" "分子量 514.323, ペーパークロマトグラムにおいて,酢酸エチル:ベンゼン(1:1) 又はクロロホルム: ベンゼン (1:1)でCUCURBITACIN D と明確に分ける事ができる｡ クロロホルム単独で SOLVENT とした場合は明確には分かれない｡ エタノール中で,FERRIC CHLORIDE と反応して強い呈色を示す｡ (714) ・TETRACYCLIC NUCLEUS の QUATERNARY ATOMS に5つのメチル基が結合している｡ (713)・立体化学｡ (719)" "713/714/719/" "ST0328" 12.00 "25-(ACETYLOXY)-2,16,20-TRIHYDROXY-9-METHYL-19-NOR-9β,10α-LANOSTA-1,5,23-TRIENE-3,11,22-TRIONE" "CUCURBITACIN E, α-ELATERIN" "C32H44O8" 32.00 44.00 8.00 0.00 0.00 0.00 556.00 " (REF:720/713/714/719)" "720/713/714/719/" "232-233ﾟC(720),234.5ﾟC(714)" "[α]/D=-62ﾟ(CHLOROFORM)(714),[α]/D=-59ﾟ(C=0.7 in CHF.)(720)" "アルコールに少し溶け,水には不溶｡ 石油エーテル,クロロホルムに可溶｡" "710/714/720/" "STRONGPEAK AT 234mμ(ε=11,700),SHOULDER AT 267mμ(ε=8,350)(720)" "νmax : 3450, 1723, 1683, 1660, 1627, 1412, 1370, 1130, 1090, 990cm-1(720)" "720/" "植物｡ Ecballium elaterium(L.)A.Rich.,Cucurbitaceae(SQUIRTING CUCUMBER)の実｡ (720)" "720/" "・実のジュースは,古来,ELATERIUMの名で強力な下剤として用いられてきた｡ THE BRITISH PHARMACOPEIAにも収録されている｡ また, 腫瘍としてSARCOMA 37 をマウスの筋肉へ移植した場合, β-ELATERINとともに腹腔内に投与すれば非常に強い抗腫瘍活性を示す｡ 単独で皮下投与した場合は,有意な抗腫瘍活性は示さない｡(720)" "720/" "分子量 556.344, NaOH の添加で紫外部スペクトルの shoulder(267mμ)が消失し,新しいピークが 318mμ(ε= 5,000) が形成される｡ この bathochromic shift は, 酸によって可逆である｡ エタノール中で FERRIC CHLORIDE と反応して強い呈色を示す｡ (720) ・TETRACYCLIC NUCLEUSのQUATERNARY ATOMSへ5つのメチル基が結合している｡(713) ・立体化学｡ (719)" "720/713/719/" "ST0329" 12.00 "2,16,20,24,25-PENTAHYDROXY-9-METHYL-19-NORLANOST-5-ENE-3,11,22-TRIONE" "CUCURBITACIN G" "C30H46O8" 30.00 46.00 8.00 0.00 0.00 0.00 534.00 " (REF:714)" "714/" "149-150ﾟC(714)" "[α]/D=+84ﾟ(C=1.5 in CHLOROFORM)(714)" "クロロホルム,ベンゼンに可溶｡(714)" "714/" "λmax.,mμ(Ε1%/1cm):282(4.2) in neutral solution, 314(99) in alkaline solution.(714)" "714/" "植物｡ Cucumis hirsutus Sond., Cucurbitaceae の根｡ (714)" "714/" "・苦味成分｡ (714)" "714/" "分子量 534.67, DIHYDROCUCURBITACIN D と同じ m.p.で, ほとんど同一の赤外スペクトルを示すので, 最初は混同されていたが, ペーパークロマトグラムでは,両者は明確に分かれる｡(714)" "714/" "ST0330" 12.00 "2,16,20,24,25-PENTAHYDROXY-9-METHYL-19-NORLANOST-5-ENE-3,11,22-TRIONE" "CUCURBITACIN H" "C30H46O8" 30.00 46.00 8.00 0.00 0.00 0.00 534.00 " (REF:714)" "714/" "[α]/D=+57ﾟ(C=1.5 in CHLOROFORM)(714)" "714/" "植物｡ CUCUMIS HIRSUTUS の根の苦味成分中に含まれる｡ (714)" "714/" "・苦味成分｡ (714)" "714/" "分子量 534.67, AMORPHOUS｡ ACID-WASHED ALUMINA や FORMAMIDE-IMPREGNATED PAPER での rechromatography 後でも, 結晶化できなかった｡ (714)" "714/" "ST0331" 12.00 "2,16,20,24,25-PENTAHYDROXY-9-METHYL-19-NORLANOSTA-1,5-DIENE-3,11,22-TRIONE" "CUCURBITACIN J" "C30H44O8" 30.00 44.00 8.00 0.00 0.00 0.00 532.00 " (REF:714/721)" "714/721/" "200-202ﾟC(ETHYL ACETATE(721),196-198ﾟC(714)" "[α]/D=-36ﾟ(C=1.0 in CHLOROFORM)(721)" "721/714/" "λmax,270mμ(ε=8,700 in ETHANOL),313 mμ(ε=6,300 in 0.1N KOH in 50%ETHANOL)(721), λmax.,(Ε1%/1cm):270(157) in neutral solution,314(104)in alkaline solution(714)" "νmax : 1695, 1664cm-1(721)" "721/714/" "植物｡ ・Citrullus ecirrhosus Sond.(Colocynthis ecirrhosus Chakrav.), Cucurbitaceae の CRUDE FOAMS の酵素加水分解物から単離｡ (714) ・IBERIS AMARA,CRUCIFERAE から単離｡ CUCURBITACIN I のアルカリ処理でも得られる｡ (721)" "714/721/" "・苦味成分｡ (714)" "714/" "分子量 532.322 Cucurbitacin J と K は, 互いに hydroxyl group の原子配列が, 24の位置でのみ異なる｡ (721) ・ペーパークロマトグラムにおいて, クロロホルム : ベンゼン(1:1) の時 CUCURBITACIN D と分離するが, 酢酸エチル:ベンゼンを使用した時は互いに分離しない｡(714)" "714/721/" "ST0332" 12.00 "2,16,20,24,25-PENTAHYDROXY-9-METHYL-19-NORLANOSTA-1,5-DIENE-3,11,22-TRIONE" "CUCURBITACIN K" "C30H44O8" 30.00 44.00 8.00 0.00 0.00 0.00 532.00 " (REF:714/721)" "714/721/" "INDEFINE(721),137-141ﾟC(714)" "[α]/D=-74ﾟ(C=1.0 in CHLOROFORM)(721)" "721/714/" "λmax,270mμ(ε=8,000 in ETHANOL),312 mμ(ε=5,900 in 0.1N KOH in 50%ETHANOL)(721), λmax,269mμ(Ε1%/1cm 148)in neutral solution,314mμ(Ε1%/1cm 104)in alkaline solution(714)" "νmax : 1695, 1664cm-1(721)" "714/721/" "植物｡ ・Citrullus ecirrhosus Sond.(Colocynthis ecirrhosus Chakrav.), Cucurbitaceae の CRUDE FOAMS の酵素加水分解物から単離｡ (714) ・IBERIS AMARA,CRUCIFERAE｡ (721)" "714/721/" "・苦味成分｡ (714)" "714/" "分子量 532.322, Cucurbitacin J と K は, 互いに hydroxyl groupの原子配列が, 24の位置でのみ異なる｡ (721)" "721/" "ST0333" 12.00 "2,16,20,25-TETRAHYDROXY-9-METHYL-19-NORLANOSTA-1,5-DIENE-3,11,22-TRIONE/23,24-DIHYDROCUCURBITACIN L." "CUCURBITACIN L" "C20H44O7" 20.00 44.00 7.00 0.00 0.00 0.00 396.00 " (REF:714/721/719)" "714/721/719/" "ABOUT 140ﾟC(721),122-127ﾟC(714)" "[α]/D=-49ﾟ(C=1.0 in CHLOROFORM)(721) [α]28/D=-41ﾟ(C,1.3% in ETHANOL)(714) [α]22/D=-42±2ﾟ(C=1.0 in ETHANOL)(419)" "721/714/419/" "λmax,270mμ(ε=8,050 in ETHANOL),313 mμ(ε=5,850 in 0.1NKOH in 50%ETHANOL)(721);λmax,mμ(Ε1%/1cm)270(164),314(119)(714);λmax(logε)=270mμ(3.75)in neutral,309mμ(3.64)in alkaline(419)" "νmax : 1695, 1661cm-1(721);(CHCl3):3605, 3450, 2972, 1688, 1660cm-1(419)" "721/714/419/" "植物｡ ・Citrullus ecirrhosus Sond.(Colocynthis ecirrhosus Chakrav.), Cucurbitaceae の根｡ (721)" "721/" "・苦味成分｡ (714)" "714/" "分子量 396.213, 23,24-DIHYDROCUCURBITACIN I と同一｡ (721)" "721/" "ST0334" 12.00 "14α-METHYL-3β,20α-BIS(METHYLAMINO)-4-METHYLENE-9,19-CYCLO-5α,9β-PREGNAN-16α-OL" "CYCLOBUXINE,ALKALOID A." "C25H42ON2" 25.00 42.00 1.00 2.00 0.00 0.00 386.00 " (REF:722/723/724/725)" "722/723/724/725/" "246-247ﾟC(723),245-247ﾟC(724)" "[α]23/D=+98ﾟ(CHLOROFORM)(724)" "723/724/" "λmax : 6.09, 11.20μ(TERMINAL METHYLENE)(724)" "5.20,5.43(2H,DOUBLETS,J<1C.1S.;TERMINAL METHYLENE),5.92(1H,OCTUPLET,J'S3,7,9.5C./S.;CH2CHOH-CH),7.53 AND 7.57(6H,TWO NCH3),8.87 AND 9.03(6H,TWO TERTIARY CH3),8.92(3H,DOUBLET,J6 C./S.;ONE SEC. CH3)AND 9.72 AND 9.95J(2H,DOUBLETS,J4C./S.;CYCLOPROPYL METHYLENE)(724)" "724/" "Buxus Sempervirens L., Buxaceae(ツゲ科)の抽出物｡ (722/724)" "722/724/" "・古来から, マラリア, 性病などの様々な病気の治療に使われてきた｡ 又,抗結核剤としても有効｡ (724)" "724/" "分子量 386.60, 立体化学の決定｡ (725)" "725/" "ST0335" 12.00 "17α-PREGNA-2,4-DIEN-20-YNO[2,3-D]ISOXAZOL-17-OL/17α-PREGN-4-EN-20-YNO[2,3-D]ISOXAZOL-17-OL;1-ETHYNYL-2,3,3A,3B,4,5,10,10A,10B,11,12,12A-DODECAHYDRO-10A,12A-DIMETHYL-1H-CYCLOPENTA[7,8]PHENANTHRO-[3,2-D]-ISOXAZOL-1-OL;17α-ETHYNYL-17β-HYDROXY-4-ANDROSTENO[2,3-D]ISOXAZOLE" "DANAZOL, WIN 17.757, DANOL" "C22H27O2N" 22.00 27.00 2.00 1.00 0.00 0.00 337.00 " (REF:726/727/419/728)" "726/727/419/728/" "224.4-226.8ﾟC(726)" "[α]25/D=+7.5ﾟ(ETHANOL) [α｣25/D=+21.9ﾟ(CHLOROFORM)(726)" "726/" "UVmax(ETHANOL): 286nm(ε=11,300)(726)" "726/" "2-HYDROXYMETHYLENE-3-KETOSTEROID と HYDROXYLAMINE との反応で調製する｡ (726)" "726/" "・下垂体前葉抑制剤 (GONADAL INHIBITOR)(正常人において,GONADOTROPIN 遊離の阻害), LEYDIG CELLでの ANDROGEN 合成の阻害｡ (727) ・ALBINO RATS, RATS, MICE, RABBITS などの実験動物でもヒトと同様の効果が見られる。(419) ・PRECOCIOUS PUBERY, ENDOMETRIOSIS, VIRGINAL BREAST HYPERTROPHY, CHRONIC CYSTIC MASTITIS などの治療に特に有効｡ (728)" "419/727/728/" "分子量 337.47, (726)" "726/" "ST0336" 12.00 "3β-HYDROXYANDROST-5-EN-17-ONE/Δ5-ANDROSTEN-3β-OL-17-ONE" "DEHYDROEPIANDROSTERONE,DEHYDROISOANDROSTERONE,TRANS-DEHYDROANDROSTERONE,17-HORMOFORIN,DIANDRON,PSICOSTERONE,17-CHETOUIS" "C19H28O2" 19.00 28.00 2.00 0.00 0.00 0.00 288.00 " (REF:005/729/730/209/731/732/733/734)" "005/729/730/209/731/732/733/734/" "140-141ﾟC,152-153ﾟC(二相性を示す)(209)" "[α]18/D=+10.9ﾟ(C=0.4 in ALC.)(734)" "ベンゼン,アルコール,エーテルに可溶｡クロロホルム,石油エーテルに少し溶ける｡ (209)" "209/734/" "動物｡ ・男性尿から単離｡ (005/729)" "005/729/" "・Androgen.活性｡ (005/729)" "005/729/" "分子量 288.41, コレステロールから調製できる｡ (730/209/731) ジギトニンと反応して沈殿物形成｡ (730/209/731/732/733) ・男性尿から単離される DEHYDROANDROSTERONE はエピマーである｡ (731) ・SOYA BEANS から単離されるγ-SITOSTEROL の分解によって調製｡ (734)" "209/730/731/734/" "ST0337" 12.00 "21-HYDROXYPREGN-4-ENE-3,20-DIONE/4-PREGNEN-21-OL-3,20-DIONE" "DEOXYXORTICOSTERONE,21-HYDROXYPROGESTERONE,DESOXYCORTICOSTERONE,11-DEOXYCORTICOSTERONE,CORTEXONE,DESOXYCORTONE,KENDALL'S DESOXY COMPOUND B,REICHSTEIN'S SUBSTANCE Q." "C21H30O3" 21.00 30.00 3.00 0.00 0.00 0.00 330.00 " (REF:615/188/735/736)" "615/188/735/736/" "141-142ﾟC(ETHER)(615/188)" "[α]22/D=+178ﾟ(C=1.5 in アルコール)(188)" "アルコール,アセトンに可溶｡(188)" "615/188/" "UVmax 240nm(logε=Ca,4)(615)" "615/" "動物｡ ・副腎皮質｡ (615) ・WATER BEETLE(水生昆虫, 例:ゲンゴロウ), DYTISCUS MARGINALIS から単離｡(736)" "615/736/" "・Adrenocortical steroid (Salt-regulating) として作用｡ (615)" "615/" "分子量 330.45, ・Δ4-3-KETO-21-ACETOXY-PREGNEN-20-ON 調製｡ (615) ・PREGNEN-(4)-OL-(20)-ON-(3)-AL-(21) から調製｡(735)" "615/735/" "ST0338" 12.00 "4α,9-EPOXYCEVANE-3β,4,6α,7α,14,15α,16β,20-OCTOL 6,7-DIACETATE 15-(2-METHYLBUTANOATE)/PROTOVERINE 6,7-DIACETATE 15-(2-METHYLBUTYRATE); PROTOVERINE 6,7-DIACETATE 15(L)-2'-METHYLBUTYRATE" "DESATRINE" "C36H55O12N" 36.00 55.00 12.00 1.00 0.00 0.00 693.00 " (REF:737)" "737/" "232-233ﾟC(737)" "[α]26/D=-46ﾟ(C=0.95 in PYRIDINE)(737)" "737/" "植物｡ または合成｡ ・PROTOVERATRINE B から過ヨウ素酸処理後, 水酸化アンモニウムでアルカリ性にして調製できる｡ PROTOVERATRINE は, Veratrum album(バイケイソウ) から単離されるアルカロイド｡ 後にA と B の混合物である事が判明した｡ (737)" "737/" "・殺虫薬として利用される｡ 高血圧症の治療に用いられた事もある｡ (737)" "737/" "分子量 693.85, (737)" "737/" "ST0339" 12.00 "4α,9-EPOXYCEVANE-3β,4,6α,7α,14,15α,16β,20-OCTOL-6,7-DIACETATE 3(S)-(2-HYDROXY-2-METHYLBUTANOATE) 15(R)-(2-METHYLBUTANOATE)-PROTOVERINE 3-(d)-2'-HYDROXY-2'-METHYLBUTYRATE 6,7-DIACETATE 15-(l)-2'-METHYLBUTYRATE" "PROTOVERATRINE A,PRO-AMID,PROTALBA" "C41H63O14N" 41.00 63.00 14.00 1.00 0.00 0.00 793.00 " (REF:737/738/739/740/741/742/743)" "737/738/739/740/741/742/743/" "267-269ﾟC(DEC.)(742),273-275ﾟC(737)" "[α]25/D=-40.5ﾟ(C=1 in PYRIDINE),[α]25/D=-10.5ﾟ(C=1 in CHCl3)(742)" "クロロホルム,ピリジン,温アルコールに可溶｡水,石油エーテルに不溶｡(742)" "737/742/" "・バイケイソウなどの植物｡ Veratrum album L.,Liliaceae (ユリ科)の根茎から抽出されるアルカロイド｡ (737/738/739/742/743) ・Veratrum viride からも抽出される｡ (740/741)" "737/738/739/742/743/740/741/" "・Antihypertensive(抗高血圧剤)として利用｡ (737)" "737/" "PROTOVERATRINE A と B の構造決定｡ (737) ・少し苦く,くしゃみを催させる｡ (737) ・""PROTOVERATRINE""は, ２種のアルカロイドの混合物で, 両者は構造が非常によく似ているが, 加水分解による産物の種類が１つ異なる｡ 分子量 794.(742/743) p-TOUENESULFONIC ACID で加水分解すると, 1.88モルの酢酸, 0.92モルの 2-METHYLBUTYRIC ACID, 0.93モルの 2-HYDROXY-2-METHYLBUTYRIC ACID が得られる｡ (742)" "737/742/743/" "ST0340" 12.00 "4α,9-EPOXYCEVANE-3β,4,6α,7α,14,15α,16β,20-OCTOL-6,7-DIACETATE 3(S)-(2,3-DIHYDROXY-2-METHYLBUTANOATE)15(R)-(2-METHYLBUTANOATE)-PROTOVERINE3-(d)-THRED-2',3'-DIHYDROXY-2'-METHYLBUTYRATE 6,7-DIACETATE 15-(l)-2'-METHYLBUTYRATE" "PROTOVERATRIENE B,VERATETRINE,NEOPROTOVERATRINE" "C41H63O15N" 41.00 63.00 15.00 1.00 0.00 0.00 809.00 " (REF:738/739/740/741/742/743/737)" "738/739/740/741/742/743/737/" "268-270ﾟC(742),267-269ﾟC(737)" "[α]25/D=-37ﾟ(PYRIDINE),[α]25/D=-3.5ﾟ(CHCl3)(742)" "クロロホルム,ピリジン,温アルコールに可溶｡水,石油エーテルに不溶｡(742)" "737/742/" "・バイケイソウなどの植物｡ Veratrum album L.,Liliaceae (ユリ科)の根茎から抽出されるアルカロイド｡ (738/739/742/743/737) ・Veratrum viride からも抽出される｡ (740/741)" "737/738/739/742/743/741/740/" "・Antihypertensive(抗高血圧剤)として利用｡ (737)" "737/" "PROTOVERATRINE A と B の構造決定｡ (737) ・少し苦く,くしゃみを催させる｡ (737) ・""PROTOVERATRINE""は, ２種のアルカロイドの混合物で, 両者は構造が非常によく似ているが, 加水分解による産物の種類が１つ異なる｡ (742) ・PROTOVERATRINE A に対する割合は, 根や根茎によっても異なり, 0.36から0.58｡ 分子量 810. (742) ・加水分解によって, ２モルの酢酸, １モルの(-)α-METHYL-BUTYLIC ACID と １モルの(+)α-METHYL-α,β-DIOXY-BUTYLIC ACID が得られる｡ (743)" "737/742/743/" "ST0341" 12.00 "9-FLUORO-113β,16α,17-TRIHYDROXYPREGNA-1,4-DIENE-3,20-DIONE;9α-FLUORO-1,4-PREGNADIENE-11β,16α,17α-TRIOL-3,20-DIONE" "DESCINOLONE,21-DEOXYTRIAMCINOLONE" "C21H27O5F" 21.00 27.00 5.00 0.00 0.00 0.00 378.00 " (REF:744/745)" "744/745/" "286-287ﾟC(744),298-300ﾟC(745)" "[α]25/D=+53.3ﾟ(C=0.41 in METHANOL) [α]25/D=+36.8ﾟ(C=1.09 in PYRIDINE)(745)" "[α]25/D=+62ﾟ(C=0.52,METHANOL), [α]25/D=+41.5ﾟ(C=1.09,PYRIDINE)(744)" "メタノール,酢酸エチルに可溶｡(744)" "744/745/" "UVmax(METHANOL): 238nm(ε=15,700)(745); λmax : 238mμ(ε=15,100)(744)" "νmax:3509, 3401, 1709, 1667, 1618, 1603cm-1(744); λmax : 2.85, 2.93, 5.86, 6.01, 6.19, 6.25, 9.34μ(745)" "744/745/" "MICROBIOLOGICAL DEHYDROGENATION によって調製できる： BEEF EXTRACT, YEAST EXTRACT, PEPTONE, CERELOSE MEDIUM を８時間培養した NOCARDIA CORALLINA(ATCC 999)を,1% inoculate する｡ 9α-FLUORO-11β,16α,17α-TRIHYDROXY-4-PREGNENE-3,20-DIONE を メタノールに溶かしたものを加え, 28ﾟC で17 時間培養する｡ コンテントをETHYL ACETATE で抽出し精製する｡(744)" "744/" "・ラット肝臓グリコーゲン分析によると, GLUCOCORTICOID 活性は, HYDROCORTISONE の4倍で, SODIUM RETENTION 活性は無い｡ (744)" "744/" "分子量 378.45, THE ACETATE, 16α-ACETOXY 9α-FLUORO-11β,17α-DIHYDROXY-1,4-PREGNADIENE-3,20-DIONE : 無水酢酸-ピリジンで, 一晩処理して調製｡ m.p.242-244ﾟ,[α]25/D=+27.3ﾟ(C=0.768,METHANOL), λmax 239mμ(ε=16,200): νmax 3509, 3413, 1736, 1695, 1672, 1629, 1250cm-1. THE ISOPROPYLIDENE DERIVATIVE, 9αFLUORO-11β-HYDROXY-16α,17α-ISOPROPYLIDENEDIOXY-1,4-PREGNADIENE-3,20-DIONE: m.p.307ﾟ,[α]25/D=+102(C=0.975),λmax 238mμ(ε=15,500),νmax 3333, 1712, 1667, 1626, 1176, 1059cm-1｡ (744)" "744/" "ST0342" 12.00 "(3β,5β,12β)-3-[(O-β-D-GLUCOPYRANOSYL-(1→4)-O-2,6-DIDEOXY-β-D-RIBO-HEXOPYRANOSYL-(1→4)-O-2,6-DIDEOXY-β-D-RIBO-HEXOPYRANOSYL-(1→4)-2,6-DIDEOXY-β-D-RIBO-HEXOPYRANOSYL)OXY]-12,14-DIHYDROXYCARD-20(22)-ENOLIDE" "DESLANOSIDE,DEACETYLLANATOSLDE C,DESACETYLLANATOSIDE C,DESACETYLDIGILANIDE C,PURPUREAGLYCOSIDE C,CEDILANID-D,DESACE,DESACI,LANIMERCK(AMPULS)" "C47H74O19" 47.00 74.00 19.00 0.00 0.00 0.00 942.00 " (REF:746/747)" "746/747/" "[α]20/D=+12ﾟ(C=1.084 in 75%ALC.)(746/747)" "5000倍の水,200倍のメタノール,2500倍のエタノールに可溶｡ クロロホルムにわずかに溶ける｡エーテルには溶けない｡(746/747)" "746/747/" "植物｡ ・Digitalis lanata Ehrh., Scrophulariaceae(ゴマノハグサ科)の葉から抽出した DIGILANIDE C を Ca(OH)2 で処理すると得られる｡ (746/747)" "746/747/" "・Cardiotonic (強心薬)として作用｡ (746/747)" "746/747/" "分子量 943.11 アグリコンは, DIGOXIGENIN｡ (746/747)" "746/747/" "ST0343" 12.00 "11,21-DIHYDROXY-16,17-[(1-METHYLETHYLIDENE)BIS(OXY)]PREGNA-1,4-DIENE-3,20-DIONE/11β,16α,17,21-TETRAHYDROXYPREGNA-1,4-DIENE-3,20-DIONE CYCLIC 16,17-ACETAL WITH ACETONE;16α-HYDROXYPREDNISOLONE-16α,17-ACETONIDE; 11β,21-DIHYDROXY-16α,17-ISOPROPYLIDENEDIOXY-1,4-PREGNA-DIENE-3,20-DIONE; 16α-HYDROXY-Δ1-HYDROCORTISONE-16α,17α-ACETONIDE;16α,17α-ISOPROPYLIDENEDIOXYPREDNISOLONE" "DESONIDE,PREDNACINOLONE,D-2083,STERODERM,TRIDESILON" "C24H32O6" 24.00 32.00 6.00 0.00 0.00 0.00 416.00 " (REF:748/749/750/751/752)" "748/749/750/751/752/" "274-275ﾟC(METHANOL),263-266ﾟC(ETHYL ACETATE-PETR ETHER)(748/752)" "[α]25/D=+123ﾟ(C=0.5 in DMF)(752),[α]25/D=+122ﾟ(METHANOL)(748)" "748/752/" "UVmax : 242nm(Ε1%/1cm 356)(752); λmax:242mμ(ε=15,800)(748)" "νmax : 3401,1709, 1661, 1616, 1603, (INFLECTION),1087, 1053cm-1(748)" "748/752/" "・16α-HYDROXYPREDNISOLONE を, 塩酸を含むアセトン中で boil し調製する non-halogenated steroid｡ (748) ・微生物による HYDROXYLATION を利用した合成法｡ (752)" "748/752/" "・ACETONIDE にする事によって, PARENT FREE STEROIDS よりも強い GLUCOCORTICOID 活性を示し, 合成non-halogenated　corticoidsの活性を強めた: THYMUS INVOLUTION, LIVER GLYCOGEN とも, ACETONIDE の方が, それぞれ 17倍, 13倍へ増加した (ADRENALECTOMIZED IMMATURE MALE RAT)｡ これまで合成された Corticoids で, 最も活性の高い化合物の１つ｡ ・LD50 は, PREDNISOLONE の 2.4倍｡ 抗炎症作用｡ (748/749/750)" "748/749/750/" "分子量 416.52, 過塩素酸法によって回収が改善される｡ (748) ・ADRENOCORTICOIDS の構造と活性の関係｡ (751)" "748/751/" "ST0344" 12.00 "9-FLUORO-11β,21-DIHYDROXY-16α-METHYLPREGNA-1,4-DIENE-3,20-DIENE-3,20-DIONE/9α-FLUORO-16α-METHYL-17-DESOXYPREDNISOLONE;9α-FLUORO-16α-METHYL-Δ1-CORTICOSTERONE" "DESOXIMETASONE,A41-304,R-2113,HOE304,ESPERSON,TOPICORTE,TOPIDERM,TOPISOLON" "C22H29O4" 22.00 29.00 4.00 0.00 0.00 0.00 357.00 " (REF:753/756)" "753/756/" "217ﾟC(ETHYL ACETATE)(753)" "[α]/D=+109ﾟ(CHLOROFORM)(753)" "アルコール,アセトン,クロロホルム,エチルアセテート（熱い）に可溶｡ エーテル, ベンゼンにも少し溶ける｡ 水,希薄な酸,アルカリの水溶液には不溶｡ (753)" "753/" "UVmax : 238nm(ε=15,750)(753)" "39.8(C-1),63.5(C-2),7.2(C-3),68.2(C-4),25.6(C-5),162.1(C-6),165.3(C-7),159.0(C-8),91.3(C-9),14.45(C-10),122.0(C-11),149.5(C-12),147.8(C-13),144,3(C-14),159.6(C-15),162.1(C-16),125.3(C-17),176.4(C-18),169.7(C-19),-17.4(C20),123.3(C-21),170.7(C-16Me)(753)" "753/" "・3α-HYDROXY-11,20-DIOXO-16α-METHYL-PREGNANE や 3α-ACETOXY-20-OXO-16α-METHYL-5β,Δ9(11)-PREGNENE から合成して調製｡ (753)" "753/" "局所皮膚へ用いた場合, 抗炎症作用を示すCORTICOID｡ COTTON PELLET GRANULOMA METHOD を MODIFICATION して分析｡ (753) 9α-FLUORO SUBSTITUTION する事によって, 抗炎症作用や THYMOLYTIC ACTIVITYが,16α-METHYL-Δ1-CORTICOSTERONE よりも更に強化される｡ カリウム利尿, ナトリウム利尿作用がある｡ PREDNISOLONE や DEXAMETHASONE と比較して,同じ抗炎症投与レベルで, より低い成長阻害作用を示した｡(754/755)" "753/754/755/" "分子量 376.47,(753)" "753/" "ST0345" 12.00 "17,21-DIHYDROXYPREGN-4-ENE-3,20-DIONE; 4-PREGNENE-17α,21-DIOL-3,20-DIONE/17-(1-KETO-2-HYDROXYETHYL)-4-ANDROSTEN-17α-OL-3-ONE" "11-DESOZY-17-HYDROXYＣORTICOSTERONE,CORTEXOLONE,(17-HYDROXYDESOXYCORTICOSTERONE,REICHSTEIN'S SUBSTANCE S"",11-DESOXYCORTISONE)" "C21H30O4" 21.00 30.00 4.00 0.00 0.00 0.00 346.00 " (REF:615/757/758/272/759/760/761)" "615/757/758/272/759/760/761/" "207-209ﾟC(757)" "水,エーテルには溶解性非常に低い｡ アセトン,メタノール,アルコールに可溶｡(757)" "757/" "UVmax : 240nm(logε=4.23)(757)" "757/" "・4-PREGNENE-17α,20,21-TRIOL-3-ONE 21-MONOACETATE より調製｡ (272) ・3α-FORMOXY-17α-HYDROXYPREGNAN-20-ONE より調製｡ (759) ・16,17-OXIDO-5-PREGNEN-3β-OL-20-ONE ACETATE より調製｡ (760) ・5-PREGNEN-3β-OL-20-ONE より調製｡ (761)" "272/759/760/761/" "分子量 346.45, THE ACETATE, C23H32O5,m.p.237.2-240.2ﾟ,[α]24/D=+116ﾟ( ACETONE),Uvmax 242nm(Ε1%/1cm 448)(758) ・THE MONOACETATE(PREGNENE-4-DIOL-17(β),21-DIONE-3,20-MONOACETATE-21),C23H32O5,m.p. 235-238ﾟ(232ﾟでSINTER形成),[α]/D=+118ﾟ±4ﾟ(C=0.7),λmax=242mμ(ε=1.47x10^4)｡ 硝酸銀のAMMONIACAL SOLUTION を強力に迅速に還元する｡ 濃硫酸で, 特徴的な SCARLET 色を呈する｡ (272)" "758/272/" "ST0346" 12.00 "9-FULORO-11β,17,21-TRIHYDROXY-16α-METHYLPREGNA-1,4-DIENE-3,20-DIONE/9α-FLUORO-16α-METHYLPREDNISOLONE; 16α-METHYL-9α-FLUORO-1,4-PREGNADIENE-11β,17α,21-TRIOL-3,20-DIONE; 16α-METHYL-9α-FLUORO-PREDNISOLONE; 1-DEHYDRO-16α-METHYL-9α-FLUOROHYDROCORTISONE;16α-METHYL-9α-FLUORO-Δ1-HYDROCORTISONE" "DECTANCYL,DEXAMETH,DEXASONE,DEXINORAL,GAMMMACORTEN,DEXTELAN,POLICORT, DECTANCYL,DEXAMETH,DEXASONE,DEXINORAL,GAMMMACORTEN,DEXTELAN,POLICORT, DEXACORTAL,DESERONIL,CORSON,DERGRAMIN,HEXADROL,DELTAFLUORENE,ORADEXON, DEXA-CORTIDELT,AEROSEB-D,DEXINOLON,DECADERM,DEXAFARMA,CORTISUMMAN, DEXASINE,LOVVERINE,MAXIDEX,DEXA-SCHEROSON" "C22H29O5F" 22.00 29.00 5.00 0.00 0.00 0.00 392.00 " (REF:762/763)" "762/763/" "229-231ﾟCAS 21-ACETATE(763),215-221ﾟC AS 21-ACETATE(762)" "[α]/D=+77.6ﾟ(763) [α]/=+73ﾟ AS 21-ACETATE(762)" "水への溶解性は,10mg/100ml(25ﾟ)｡ アセトン,エタノール,クロロホルムに可溶｡(762)" "763/762/" "AS 21-ACETATE,λmax:239mμ(ε=14,900); AS 21-ACETATE,λmax:239mμ(ε=14,500)(762)" "752/" "・21-ACETATEの合成｡16α-METHYLHYDROCORTISONE ACETATEを出発物質とする｡(762) ・21-ACETATEの合成｡16α-METHYLPREGNENOLONE を出発物質とする｡ (763)" "762/763/" "・Glucocorticoid活性(Liver glycogen activity in rat), Systemic granuloma 活性(in intact Holzman rat), Anti-inflammatory 活性(in man)とも,最もactive な steroid｡ Sodium retention も Ratsで negative, Manで <1 である｡ (762) ・Eosinopenic 活性は, マウス, イヌ, ヒトで, PREDNISONE や PREDNISOLONE の 4〜6倍｡ Granulome Pouch test では PREDNISOLONE ACETATE の 6.5倍｡ THYMUS INVOLUTION(ラット)や NITROGEN EXCRETION(イヌ)は,PREDNISOLONE ACETATEや PREDNISON の 25倍｡ (762/763)" "762/763/" "分子量 392.45, (762/763)" "762/763/" "ST0347" 12.00 "9,11β-DICHLORO-17,21-DIHYDROXY-PREGNA-1,4-DIENE-3,20-DIONE/9α,11β-DICHLORO-1,4-PREGNADI-ENE-17α,20-DIOL-3,21-DIONE; 9α,11β-DICHLOROANALOG OF PREDNISOLONE" "DICHLORISONE,DILODERM,DISODERM" "C21H26O4Cl2" 21.00 26.00 4.00 0.00 0.00 0.00 412.00 " (REF:764)" "764/" "238-241ﾟC(764)" "[α]20/D=+134ﾟ(PYRIDINE)(764)" "764/" "UVmax(METHANOL): 237nm(ε=15,400)(764)" "λNujol/max : 3.0, 5.86, 6.04, 6.22, 6.25μ(764)" "[Μ]/D=+737(DIOXANE(764)" "764/" "・1,4,9(11)-PREGNATRIENE-17α,21-DIOL-3,20-DIONE-21-ACETATE へのハロゲンの添加によって調製｡ (764)" "764/" "・局所の止痒剤, GRANULOMA POUCH TEST では, 強力な抗炎症剤になる｡ (764)" "764/" "分子量 413.35, (764)" "764/" "ST0348" 12.00 "3β-(DIGINOSYLOXY)-12α,20α-EPOXY-14β,17α-PREGN-5-ENE-11,15-DIONE" "DIGININ" "C28H40O7" 28.00 40.00 7.00 0.00 0.00 0.00 488.00 " (REF:765/766/767/768/769/770/771)" "765/766/767/768/769/770/771/" "155-183ﾟC(Melting langeは不明瞭) (766)" "[α]20/D=-176ﾟ(765/768) [α]14/D=-223ﾟ±4ﾟ(C=2.3 in CHLOROFORM) (766)" "クロロホルムに可溶｡エーテル,アセトン,エチルアセテート,カーボンテトラ,クロライドに少し溶ける｡水には不溶｡(765/766)" "766/765/768/" "UVmax(ETHANOL): 309nm(logε=1.94),310nm(logε=2.00)(768)" "(CHCl3)3585(OH),1735(C=O),1712(C=O),1655(C=C),1095,1060,1032(C･O･C),891,872,853(CO･C･O･C)(768)" "OPTICAL ROTATORY DISPERSION:in METHANOL,[Μ]-13,650ﾟ(335Mμ,TROUGH),+11,100ﾟ(292.5mμ,PEAK)(768)" "768/" "・Digitalis purpurea L., Scrophulariaceae(ゴマノハグサ科)の葉より単離｡(765)" "765/" "分子量 488.60, 加水分解により, DIGINIGENIN(C21H28O4), DIGINOSE(C7H14O4) へ分かれる｡ (766) ・Aglycon である diginigenin の合成｡ (766/770/771)" "766/770/771/" "ST0349" 12.00 "DIGITALIN,DIGITALINUM VERUM,DIGITALINUM TRUE,SCHMIEDEBERG'S DIGINORGIN" "C36H56O14" 36.00 56.00 14.00 0.00 0.00 0.00 712.00 " (REF:772/773/774/775/776)" "772/773/774/775/776/" "240-243ﾟ(METHANOL+WATER)(774), 244ﾟ(774/775), 241-244ﾟ(776)" "[α]20/D=-1.1ﾟ±3ﾟ(C=0.894 in METHANOL)(774) [α]26/D=+1.5ﾟ±1.2ﾟ(1.73% in CHCl3)(775)" "水,クロロホルム,エーテルにわずかに溶ける｡アルコールには可溶｡(772/773/774/775/776)" "774/775/776/772/773/" "・植物｡ ・Digitalis purpurea L., Scrophulariaceae(ゴマノハグサ科)の種, Adenium honghel A. DC., Apocynaceae(キョウチクトウ科)の根から得られる｡(772/773/774/775)" "772/773/774/775/" "・強心薬として利用｡ (772/776) ・毒力: 猫法（ハッチャー・マグヌス法)1.206mg/kg, 鳩法では1.24mg/kg,1.30mg/kg｡ (775)" "772/775/776/" "分子量 712.81, Keller-Kiliani 反応で, 硫酸層は, ピンク, 酢酸層は無色｡ 濾紙クロマトグラム: Rf 0.00(775)" "775/" "ST0350" 12.00 "DIGITONIN,DIGITIN" "C56H92O29" 56.00 92.00 29.00 0.00 0.00 0.00 1228.00 " (REF:777/778)" "777/778/" "244-285ﾟC(778),227-240ﾟC(777)" "[α]20/D=-40ﾟ(Pyr; C=2.6)(778)" "1gが,57mlの無水アルコール,220mlの95%アルコールに可溶｡水には不溶｡クロロホルム,エーテルにも不溶｡(777/778)" "777/778/" "・Digitalis purpurea L., Scrophulariaceae(ゴマノハグサ科)の種から得られる｡ (777)" "777/" "・血漿, 胆汁, 組織中のコレステロールの定量に使われる｡ (778)" "778/" "分子量 1229.30 (778)" "778/" "ST0351" 12.00 "17β-HYDROXY-6α-METHYL-17-(1-PROPYNYL)ANDROST-4-EN-3-ONE/6α-METHYL-17-(1-PROPYNYL)TESTOSTERONE;6α,21-DIMETHYL-17β-HYDROXY-17α-PREGN-4-EN-20-YN-3-ONE;6α,21-DIMETHYLETHISTERONE;17α-ETHYNYL-6α,21-DIMETHYLTESTOSTERONE;17α-ETHYNYL-17-HYDROXY-6α,21--DIMETHYLANDROST-4-EN-3-ONE" "DIMETHISTERONE,SECROSTERON" "C23H32O2" 23.00 32.00 2.00 0.00 0.00 0.00 340.00 " (REF:779)" "779/" "99-102ﾟC(779)" "[α]24/D=+12ﾟ(C=1.0)(779)" "水に不溶｡エタノールに可溶｡アセトン,クロロホルムにもわずかに溶ける｡(779)" "779/" "UVmax : 241nm(logε=4.16)(779)" "779/" "・17α-ETHYNYL-17β-HYDROXY-DERIVATIVES OF ANDROSTANE から合成｡ (779)" "779/" "・Progestin活性を示す｡ (779)" "779/" "分子量 340.49 (779)" "779/" "ST0352" 12.00 "2α-METHYL-17β-(1-OXOPROPOXY)-5α-ANDROSTAN-3-ONE/17β-HYDROXY-2α-METHYL-ANDROSTAN-3-ONE PROPIONATE; 2α-METHYLANDROSTAN-17β-OL-3-ONE PROPIONATE; 2α-METHYLDIHYDROTESTOSTERONE PROPIONATE" "DROMOSTANOLONE PROPIONATE,DROSTANOLONE PROPIONATE,DROLBAN,EMDISTERONE,MASTERID,MASTERIL,MASTERONE,PERMASTRIL" "C23H36O3" 23.00 36.00 3.00 0.00 0.00 0.00 360.00 " (REF:780)" "780/" "126-130ﾟC(780)" "[α]/D=+24ﾟ(780)" "780/" "・2-HYDROXYMETHYLENE-3-KETOANDROSTANES の水素添加によって合成｡ (780)" "780/" "・抗腫瘍薬｡ (780)" "780/" "分子量 360.52 (780)" "780/" "ST0353" 12.00 "9β,10α-PREGNA-4,6-DIENE-3,20-DIONE/10α-PREGNA-4,6-DIENE-3,20-DIONE/6-DEHYDRO-RETRO-PROGESTERONE/10α-ISOPREGNENONE" "DYDROGESTERONE,DUPHASTON,GESTATRON,PRODEL,RETRONE" "C21H28O2" 21.00 28.00 2.00 0.00 0.00 0.00 312.00 " (REF:781/782)" "781/782/" "169-170ﾟC(ACETONE+HEXANE)(781)" "[α]25/D=-484.5ﾟ(CHLOROFORM)(782)" "781/782/" "UVmax:286nm(ε=26,400)(781)" "νmax,888, 1574, 1617, 1656, 1695cm-1(781)" "781/" "・LIMISTEROL2を出発物質として合成｡ (781) ・PREGNA-5,7-DIEN-3β-OL-20-ONE を紫外線照射し, 9β,10α 化合物を得る｡ OPPENAUER 酸化につづいて 9β-PREGNA-5,7-DIEN-3β-OL-20-ONEの異性化によって合成｡(782)" "781/782/" "・9β,10α-PREGN-4-ENE-3,20-DIONE とともに高い Progestin活性を示す(経口投与)｡ ・6-DEHYDRO-PROGESTERONE(PREGNA-4,6-DIENE-3,20-DIONE)は,PROGESTERONE(PREGN-4-ENE-3,20-DIONE) の C6-C7 に二重結合を導入することによって Progestin活性がかなり増加する｡ (781)" "781/" "分子量 312.44 (781)" "781/" "ST0354" 12.00 "ECHUJIN,ECHUGIN" "C42H66O17" 42.00 66.00 17.00 0.00 0.00 0.00 842.00 " (REF:785)" "785/" "165-172ﾟ(ACETATE)(785)" "[α]20/D=-6.5ﾟ(C=0.964 in METHANOL) [α]24/D=-9.8ﾟ(C=0.969 in WATER) (785)" "水,アルコールに可溶｡ベンゼン,クロロホルム,エーテル,石油エーテルには不溶｡(783/784/785)" "785/783/784/" "・植物｡ ・Adenium boehmianumSchinz, Apocynaceae(キョウチクトウ科)や, A.lugardii N. E. Br., Apcynaceae などの milk sap から得られる arrow poison に由来する｡(783/784)" "783/784/" "・Toxic glycoside . LD50 I. V. in cats : 0.3mg/kg (520)" "520/" "分子量 842.99 (785)" "785/" "ST0355" 12.00 "3β-HYDROXY-11-OXO-20β-OLEAN-12-EN-29-OIC ACID/3β-HYDROXY-11-OXOOLEAN-12-EN-30-OIC ACID/18β-GLYCYRRHETINIC ACID" "ENOXOLONE,URALENIC ACID,BIOSONE" "C30H46O4" 30.00 46.00 4.00 0.00 0.00 0.00 470.00 " (REF:786/787/788)" "786/787/788/" "296ﾟ(ALCOHOL+PETR ETHER) (786/787/788)" "[α]21/D=+86ﾟ(ALC.) [α]20/D=+145.5ﾟ(DIOXANE) [α]20/D=+163ﾟ(CHLOROFORM) (786/787)" "クロロホルム,ジオキサン,アルコール,ピリジン,酢酸に可溶｡ 石油エーテルには不溶｡(786/787)" "786/787/788/" "・植物｡ ・licorice(カンゾウ)の根｡ (789)" "789/" "分子量 470.67 代謝(790), 立体化学(788)" "788/790/" "ST0356" 12.00 "3β-HYDROXY-5α-ANDROSTAN-17-ONE; 3β-HYDROXY-17-ANDROSTANONE/3β-ANDROSTANOL-17-ONE; 3β-HYDROXYETIOALLOCHOLAN-17-ONE" "EPIANDROSTERONE,ISOANDROSTERONE" "C19H30O2" 19.00 30.00 2.00 0.00 0.00 0.00 290.00 " (REF:791/792/793)" "791/792/793/" "dl-FORM:161-162ﾟC, d-FORM:174.5ﾟC(ETHYL ACETATE+PETR ETHER) (791/792/793)" "d-FORM:[α]20/D=+88ﾟ(METHANOL)(791/792/793)" "d-FORM:水に不溶｡ 有機溶媒に可溶｡(791/792/793)" "791/792/793/" "・動物｡ ・正常ヒト尿中に微量成分として存在｡ (793)" "793/" "ANDROSTERONE より弱い ANDROGEN 活性を持つ｡ (793)" "793/" "分子量 290.43 d-FORM : ジギトニンと反応して沈殿物形成 ｡ (791) 合成法 (791/792/793)" "791/792/793/" "ST0357" 12.00 "5α-CHOLESTAN-3α-OL/3α-HYDROXYCHOLESTANE/ε-CHOLESTANOL" "EPICHOLESTANOL" "C27H48O" 27.00 48.00 1.00 0.00 0.00 0.00 388.00 " (REF:035/794/336)" "035/794/336/" "185-186ﾟC(ALCOHOL)(794),182-184ﾟC(366)" "[α]20/D=+32.2ﾟ(C=2.0 in CHLOROFORM)(366)" "CHOLESTANOLより溶解性低い｡(794)" "794/336/" "・CHOLESTANONEから調製｡ (035/366) ・CHOLESTEROLからα-CHOLESTYL CHLORIDEを経て合成｡ (794)" "035/366/794/" "分子量 388.65 ジギトニンによる沈殿物形成なし｡ Epicholestanyl acetate, m.p. 92-94ﾟ(366)" "366/" "ST0358" 12.00 "ESTRA-5,7,9-TRIENE-3α,17α-DIOL/5(10),6,8-ESTRATRIENE-3α,17α-DIOL/5,7,9-ESTRATRIENE-3α,17α-DIOL" "3-EPIHEXAHYDROEQUILENIN" "C18H24O2" 18.00 24.00 2.00 0.00 0.00 0.00 272.00 " (REF:795)" "795/" "172ﾟC(181ﾟと191-193ﾟCという報告もある)(795)" "[α]20/D=+68ﾟ(C=0.9 in ALCOHOL)(795)" "ピリジンによく溶ける｡(795)" "795/" "・equilenin の還元によって調製｡(795)" "795/" "分子量 272.37 (795)" "795/" "ST0359" 12.00 "3,7,8-TRIHYDROXYESTRA-1,3,5(10)-TRIENE-17-ONE/1,3,5-ESTRATRIEN-17-ONE-3,7,8-TRIOL" "EQUILIN GLYCOL,7,8-DIHYDROXYESTRONE" "C18H22O2" 18.00 22.00 4.00 0.00 0.00 0.00 302.00 " (REF:087)" "087/" "POLYMORPHOUS CRYSTALS I. 210-216ﾟC ORTHORHOMBIC SPHENOIDAL II.253-254ﾟ(087)" " I.[α]23/D=+135ﾟ(0.39% in DIOXANE) II.[α]23/D=+139ﾟ(C=0.33 in DIOXANE) (087)" "II.水に可溶｡有機溶媒にも少し溶ける。(087)" "087/" "・妊娠馬の尿からとった equilin より調製｡ (087)" "087/" "ESTROGEN 活性｡ (087)" "087/" "分子量 302.36 High melting point と Low melting point preparations が出来るが,両者はアセチル化によって同一化合物である事がわかった｡ 即ち, m.p.はいづれも 211-212ﾟC へシフトし, 旋光度ははそれぞれ [α]26/D= +90ﾟ,+92ﾟ(inalcohol) であった｡ Equilin glycolを脱水素すると 7-ketoestrone が得られ, これを還元すると 7-HYDROXY-ESTRONE となる｡ (087)" "087/" "ST0360" 12.00 "ERGOSTANE" "C28H50" 28.00 50.00 0.00 0.00 0.00 0.00 386.00 " (REF:796)" "796/" "85ﾟC(ETHER+METHANOL)(796)" "[α]20/D=+17ﾟ(C=2 in CHLOROFORM)(796)" "796/" "ALLOCHOLANIC ACID から合成｡ (796)" "796/" "分子量 386.71, (796)" "796/" "ST0361" 12.00 "ERGOSTANOL" "C28H50O" 28.00 50.00 1.00 0.00 0.00 0.00 402.00 " (REF:797)" "797/" "144-145ﾟC(797)" "[α]20/D=+15.9ﾟ(C=1.8 in CHLOROFORM)(797)" "797/" "ERGOSTA-14,22-DIEN-7-ONE の水素化によって調製｡ (797)" "797/" "分子量 402.68 ジギトニンと反応して沈殿物を生ずる｡ (797)" "797/" "ST0362" 12.00 "ERGOST-8(14)-EN-3β-OL" "α-ERGOSTENOL" "C28H48O" 28.00 48.00 1.00 0.00 0.00 0.00 400.00 " (REF:798/799)" "798/799/" "130-131ﾟC(METHANOL)(798/799)" "[α]16/D=+11ﾟ(C=0.9 in METHANOL) [α]/546=-10.2ﾟ(C=1 in METHANOL) (798/799)" "798/799/" "ergosterol acetateの酢酸による水素化によって調製｡(798)22-dihydro ergosterolから調製｡(799)" "798/799/" "分子量 400.66 ジギトニンと反応して沈殿物形成｡(798/799)" "798/799/" "ST036ST0363" 12.00 "ERGOST-14-EN-3β-OL" "β-ERGOSTENOL" "C28H48O" 28.00 48.00 1.00 0.00 0.00 0.00 400.00 " (REF:800)" "800/" "141ﾟC(ALCOHOL)(800)" "[α]20/D=+21.2ﾟ(C=0.9 in CHLOROFORM)(800)" "800/" "α-ergostenol のクロロホルム中でHCl-gasによる処理｡(800)" "800/" "分子量 400.66 (800)" "800/" "ST0364" 12.00 "ERGOST-7-EN-3β-OL, 3β-HYDROXERGOST-7-ENE" "γ-ERGOSTENOL" "C28H48O" 28.00 48.00 1.00 0.00 0.00 0.00 400.00 " (REF:801/802/803)" "801/802/803/" "146ﾟC(ISOPROPANOL)(802)" "802/" "22,23-DIHYDROERGOSTEROLより調製｡(801) ergosterolより調製｡(802) 3β-ACETOXYERGOSTA-7,22-DIENの水素化の際に,RANEY NICKEL CATALYSTを使って, 高収率に調製｡(803)" "801/802/803/" "分子量 400.66 (801)" "801/" "ST0365" 12.00 "16α,21α-EPOXYOLEAN-12-ENE-3β,22α,23,28-TETROL" "ESCIGENIN, AESCIGENIN" "C30H48O5" 30.00 48.00 5.00 0.00 0.00 0.00 488.00 " (REF:804/805/806/807/808/809)" "804/805/806/807/808/809/" "317-318ﾟ(ALCOHOL)(806/807/808/809)" "[α]20/D=+46ﾟ(C=1.52 in ABS ETHANOL) [α]19.5/D=+45ﾟ±2ﾟ(C=1.60 in PYRIDIN)(806/807/808/809)" "806/807/808/809/" "UVmax(無水アルコール): 275nm(logε=1.58)(804)" "804/" "分子量 400.66 ESCINのAGLYKONと考えられていた事がある｡(804/805/806)" "804/805/806/" "ST0366" 12.00 "特定できない｡ 備考参照｡" "ESCIN,AESCIN,AESCUSAN,REPARIL" 0.00 0.00 0.00 0.00 0.00 0.00 0.00 " (REF:810/811/812/813/814/815/816/805)" "810/811/812/813/814/815/816/805/" "α-ESCIN:225-227ﾟC(805),222-223ﾟ(805)" "α-ESCIN : [α]25/D=-13.5ﾟ(C=5 in METHANOL),β-ESCIN : [α]27/D=-23.7ﾟ(C=5 in ABSOL METHANOL)(805)" "α-ESCINは水に可溶｡(805) β-ESCINは水に溶けにくい｡ (815/805)" "805/815/" "植物｡ Aesculus hippocastanum L.,Hippocastanaceae horse chestnut tree (トチノキ)の種の中で生ずる saponin.(810)" "810/" "α-ESCIN,LD50 in mice,rats,guinea pigs:320,720,475mg/kg orally;3.2, 5.4, 15.2mg/kg I,v,Hemolytic index; 1:20,000. Β-ESCIN,Hemolytic index; 1:40,000. LD50 in mice,rats,guinea pigs:134,400,188mg/kg orally; 1.4, 2.0, 7.2mg/kg I,v. (816)" "816/" "分子量 1119.3 ・cholesterolによって沈殿する。ESCINは２つの異性体,α-ESCINとβ-ESCINに分けられるが,それはmelting point,optical rotation,hemolytic index,水への溶解度によって区別できる｡(805) ・ESCINはAESCIGENIN(C30H48O5)のGlycosideと考えられていた｡クロマトグラフィーによる単離と精製。(811/812/813) ・ESCINは２つの主要なGlycosidesの混合物で,C-22が酢酸によってアシル化されたPROTOESCIGENIN が Aglycon で，糖部分は Glucuronic acid と ２つのD-Glucose 分子から成る。２つの主要な Glycosides の違いは,C-21のアシル化が,Angelic acid か Tiglic acid かによる｡ C-3のOH-基が,D-Glucuronic acidとリンクし,これに２分子の D-Glucoseが 2,4位で結合している｡ D-Glucoseのうち１つはD-Xylose 又はD-Galactose に変換されている事がある｡ (814/815)" "805/811/812/813/814/815/" "ST0367" 12.00 "ESTRANE-3α,17α-DIOL,ESTRANEDIOL B,3,17-DIHYDROXYESTRANE,OCTAHYDROFOLLICULAR HORMONE, OCTAHYDROESTRONE,HEXAHYDRODESOXYESTRIOL,HEXAHYDROESTRADIOL" "C18H30O2" 18.00 30.00 2.00 0.00 0.00 0.00 278.00 " (REF:817/818)" "817/818/" "210-211ﾟC(BENZENE+PETR ETHER)(817),204-205ﾟC(818)" "[α]20/D=+7.8ﾟ(13mg in 2ml ABS ALC.)(818) [α]22/D=+7.2ﾟ(817)" "817/818/" "動物｡ 女性の非妊娠尿に存在｡エストロンが非酵素的に還元されて形成したもの｡(818)" "818/" "Estrogenic hormone (818)" "818/" "分子量 278.42 Estrone の水素添加によって立体異性体とともに調製｡ The diacetate, C22H34O4, メタノールから結晶｡ M.p.160ﾟ (818)" "818/" "ST0368" 12.00 "5,6,8-ESTRATRIEN-3β-OL-17-ONE, 5,7,9-ESTRATRIEN-3β-OL-17-ONE." "C18H22O2" 18.00 22.00 2.00 0.00 0.00 0.00 270.00 " (REF:420)" "420/" "138-139.5ﾟC(420)" "[α]27/D=+59ﾟ±3ﾟ(1.19% in ETHANOL)(420)" "水に不溶｡ アルコール,エーテル,その他の有機溶媒に可溶｡ (420)" "420/" "Uvmax : 269.5, 278mμ(ε=345,240) 278mμはshoulder｡ Uvminima : 249, 276mμ(ε=95,233)(420)" "420/" "動物｡ 妊娠馬の尿｡ 10,000ガロンの尿から 160mg の純粋標本が約160mg 得られた｡(420)" "420/" "420/" "分子量　270.36 リングAではなく,リングBがbenzenoidでEstroneのbond isomer｡ ジギトニンで沈殿物なし｡ The oxime,C18H23NO2,m.p. 195-197ﾟ(DEC.) The acetate,C18H21O(OCOCH3), m.p.158ﾟ The benzoate,C25H26O3, m.p.196-198ﾟ The Liebermann-Burchard 反応, Salkowski反応は強い陽性｡ 後者の反応は Ergosterolの様に可逆｡ Rosenhelmテストは陰性｡テトラニトロメタンで深い黄色｡(420)" "420/" "ST0369" 12.00 "19-NOL-17α-PREGN-4-EN-17-OL/17α-ETHYLESTR-4-EN-17β-OL/17α-ETHYL-17β-HYDROXY-4-ESTRENE/17β-HYDROXY-17α-ETHYL-19-NOR-4-ANDROSTENE" "ETHYLESTRENOL,ORABOLIN,DURABOLIN-O,ORGABORAL,MAXIBOLIN,ORGABOLIN(OBSOLETE)" "C20H32O" 20.00 32.00 1.00 0.00 0.00 0.00 288.00 " (REF:819)" "819/" "76-78ﾟC(819)" "[α]/D=+31ﾟ(CHLOROFORM)(819)" "819/" "420/" "19-Nortestosteroneを出発物質として合成｡(819)" "819/" "Anabolic作用がある｡ 強力なprogestational agentで, 少なくとも既存のΔ4-3-ketonesと同等の活性がある｡ (819)" "819/" "分子量 288.46 (819)" "819/" "ST0370" 12.00 "9-FLUORO-11β,17,21-TRIHYDROXYPREGN-4-ENE-3,20-DIONE; 9α-FLUORO-17-HYDROXYCORTICOSTERONE" "FLUDROCORTISONE,9α-FLUOROHYDROCORTISONE,9α-FLUOROCORTISOL,FLUODROCORTISONE,FLUOHYDRISONE,FLUOHYDROCORTISONE,ALFLORONE,ASTONIN-H,F-CORTEF,FLORINEF,FLUDROCORTONE." "C21H29O5F" 21.00 29.00 5.00 0.00 0.00 0.00 380.00 " (REF:820)" "820/" "260-262ﾟC(DEC.)(820)" "[α]23/D=+139ﾟ(C=0.55 in 95% ETHANOL)(820)" "水に可溶｡ (820)" "820/" "UVmax(ETHANOL) : 239nm(ε=17,600)(820)" "λNujol/max 3.0μ(OH),5.84μ(20-CARBONYL),6.07μ,6.20μ(Δ4-3-KETONE)(820)" "820/" "4-PREGNEN-9β,11β-OXIDO-17α,21-DIOL-3,20-DIONE 21-ACETATEから調製｡ ・9α-FLUOROHYDROCORTISONE ACETATEを SODIUM METHYLATEによる脱アセチル化によって調製｡ (820)" "820/" "・抗炎症作用 副腎皮質ステロイドとして家畜に使用される｡(820)" "820/" "分子量 380.46 HALOGENATIONによって, Glucocorticoid活性が数倍増加｡(820)" "820/" "ST0371" 12.00 "17-(ACETYLOXY)-6α-(TRIFLUOROMETHYL)PREGN-4-ENE-3,20-DIONE/17-HYDROXY-6α-(TRIFLUOROMETHYL)PREGN-4-ENE-3,20-DIONE ACETATE; 17-ACETOXY-6α-(TRIFLUOROMETHYL)PROGESTERONE;※備考へ続く" "FLUMEDROXONE ACETATE, WG537, DEMIGRAN" "C24H31O4F3" 24.00 31.00 4.00 0.00 0.00 0.00 440.00 " (REF:821)" "821/" "206-207ﾟC(821)" "[α]20/D=+30ﾟ(821)" "821/" "UVmax(ETHANOL) : 234nm(ε=15,600)(821)" "821/" "17α-ACETOXYPROGESTERONE-3-ETHYL ENOL ETHER を Trifluoroiodomethane-Pyridine中でU.V.照射し,できた 6-TRIFLUOROMETHYL-17α-ACETOXYPREGESTERONE-3-ETHYL ENOL ETHER を加水分解して調製する｡(821)" "821/" "ORAL PROGESTATIONAL活性(Clauberg assayのMcPhail modificationによる)は,6α-METHYL-17α-ACETOXYPROGESTERONEのRelative Activityを１とした時,1〜2となる｡ (821)" "821/" "分子量 440.51 17α-ACETOXYPROGESTERONEの６位にα-位 Fluorine,chlorine,又はbromineを導入する事によって,経口 Progestational活性の著しい増加が見られる。(821) 「化学名の続き」17-HYDROXY-6α-(TRIFLUOROMETHYL)PROGESTERONE ACETATE; 6α-(TRIFLUOROMETHYL)-17-HYDROXYPROGESTERONE ACETATE." "821/" "ST0372" 12.00 "6α,9-DIFLUORO-11β,17α,21-TRIHYDROXY-16α-METHYLPREGNA-1,4-DIENE-3,20-DIONE/6α,9α-DIFLUORO-16α-METHYLPREDNISOLONE" "FLUMETHASONE,6α-FLUORODEXAMETHASONE,ANIPRIME,CORTEXILAR, FLUCORT,METHAGON" "C22H28O5F2" 22.00 28.00 5.00 0.00 0.00 0.00 410.00 " (REF:822/823)" "822/823/" "21-ACETATE(C24H30F2O6)260-264ﾟC(ACETONE+HEXANE)(822/823)" "21-ACETATE:[α]/D=+91ﾟ(822/823)" "822/823/" "21-ACETATE UVmax(ETHANOL) : 237nm(logε=4.16)(822/823)" "λKBr/max 5.73, 5.80, 6.03, 6.23μ(822/823)" "822/823/" "・6α-fluoro-16α-methyl""Substance S""のmesyl chlorideと pyridine-dimethylformamide 中で脱水する事などによって調製｡ (822)" "822/" "・グルココルチコイド,抗炎症作用｡ 副腎皮質ステロイドとして家畜で利用される｡ ナトリウム排折が促進される｡ (822) ・抗炎症作用は, 6α-fluoro-16α-methylcorticoids の中で最も強力 : Hydrocortisone,1; 6α-fluoro-16α-methylprednisolone acetate,60; 6α,9α-difluoro-16α-methylhydrocortisone acetate,65; 6α,9α-difluoro-16α-methylprednisolone acetate,300｡ メキシコ,USA での臨床試験でも,リューマチ患者に高い効果が見られた｡(823)" "822/823/" "分子量 410.46 4つの substitutions, Δ1-double bond, 6α-fluorine, 9α-fluorine, 16α-methylgroup はそれぞれ抗炎症作用を増加させる事が知られている｡ (822)" "822/" "ST0373" 12.00 "6α,9-DIFLUORO-11β,21-DIHYDROXY-16α,17-[(1-METHYLETHYLIDENE)BIS(OXY)]-PREGNA-1,4-DIENE-3,20-DIONE; 6α,9α-DIFLUORO-11β,16α,17,21-TETRAHYDROXYPREGNA-1,4-DIENE-3,20-DIONE CYCLIC 16,17-ACETAL WITH ACETONE; 6α,9α-DIFLUORO-16α-HYDROXYPREDNISOLONE 16,17-ACETONIDE; 6α,9α-DIFLUORO-16α,17α-ISOPROPYLIDENEDIOXY-1,4-PREGNADIENE-3,20-DIONE." "FLUOCINOLONE ACETONIDE,DERMALAR,JELLIN,LOCALYN,FLUOVITEF,FLUOCINIL,SYNAMOL, SYNSAC,SYNANDONE,SYNALAR" "C24H30O6F2" 24.00 30.00 6.00 0.00 0.00 0.00 452.00 " (REF:824/825)" "824/825/" "265-266ﾟC(ACETONE+HEXANE)(824)" "[α]/D=+95ﾟ(CHCl3)(824)" "824/" "UVmax : 238nm(logε=4.21)(824)" "figure 参照(825)" "824/825/" "容易に手に入る 16α,17α-oxido-Δ5-pregnene-3β,21-diol-20-one 21-acetate を出発物質として合成した 6α,9α-difluoro-16α-hydroxyprednisolone をacetate 中で反応させて調製｡ (824)" "824/" "・Glucocorticoid活性｡ 高い抗炎症作用(ナトリウム保持無し)｡ 家畜では adrenocortical steroid として局所に使用｡ 抗炎症活性は, Hydrocortisone を1とした場合, 100倍の活性を示す｡ 臨床試験で, リューマチや喘息などのアレルギー症状に高い" "824/" "分子量 452.50 (824)" "824/" "ST0374" 12.00 "6α-FLUORO-11β,21-DIHYDROXY-16α-METHYLPREGNA-1,4-DIENE-3,20-DIONE/6α-FLUORO-16α-METHYL-1-DEHYDROCORTICOSTERONE; 6α-FLUORO-16α-METHYL-Δ1,4-PREGNADIENE-11β,21-DIOL-3,20-DIONE" "FLUOCORTOLONE,ULTRALAN ORAL" "C22H29O4F" 22.00 29.00 4.00 0.00 0.00 0.00 376.00 " (REF:826/827/828)" "826/827/828/" "188-190.5ﾟC(826)" "[α]20/D=+100ﾟ(DIOXANE)(826)" "295 in WATER(37ﾟ),120 in ETHANOL(20ﾟ),440 iN TOLUENE(20ﾟ)(mg/ml)(826)" "826/" "UVmax(METHANOL) : 242nm(ε=16,300)(826),ε242=15,900.(827)" "826/827/" "Curvularia lunata による Substrate-Structure-Directed Specific 11β-Hydroxylation を経ての合成｡ (827)" "827/" "・Glucocorticoid活性は Hydrocortisone acetate を１としたら,3-10｡(ED50 0.003-0.01(mg/animal/day)(マウス糖新生)) Granuloma pouch テストでの ED50:0.0005(0.0002-0.001)(local),0.02(0.01-0.04)(subcutaneous),0.02(0.01-0.03)(oral)(mg/animal/day) Thymolytic 活性は,Hydrocortisone acetate を１としたら17｡(ED50 0.006(0.003-0.013)(mg/animal/day),Na,Kの排泄を促進｡ (826/828) ・10mgのFluo ortolone は, 45mg の STC407(6-Dehydro-16-methylene-hydrocortisone ほど Cortisol secretion を抑制するのに効果はない｡ (829)" "826/828/829/" "分子量 376.47, (826) ・静脈注射, 経口投与での代謝｡ Fluocortolone-21-carbonic acid として尿中に可溶性で単離｡ (830) ・窒素バランスに影響なし｡ 17-ketosteroids,17-Hydroxy-corticosteroids の尿中への除去はそれぞれ 50%,55-65% 阻害された(ヒト, 20-60mg/day の投与)｡(931)" "826/830/831/" "ST0375" 12.00 "9-FLUORO-11β,17β-DIHYDROXY-17-METHYLANDROST-4-EN-3-ONE; 11β,17β-DIHYDROXY-9α-FLUORO-17α-METHYL-4-ANDROSTEN-3-ONE; 9α-FLUORO-11β-HYDROXY-17α-METHYLTESTOSTERONE" "FLUOXYMESTERONE,ANDROSTEROLO,ANDROFLUORENE,ANDROFLUORONE,FLUOTESTIN,HALOTESTIN,ORATESTIN,ORATESTRYL,TESTORAL,ULTANDREN." "C20H29O3F" 20.00 29.00 3.00 0.00 0.00 0.00 336.00 " (REF:832)" "832/" "270ﾟC(DEC.)(832)" "[α]/D=+109ﾟ(ETHANOL)(832)" "832/" "UVmax(METHANOL) : 240nm(ε=16,700)(832)" "832/" "11β-Hydroxy-4-androstene-3,17-dioneからGrignard試薬との反応を利用して合成｡(832)" "832/" "・強力な Androgen作用を持つ｡ Anabolic活性, Androgenic活性は,17-Methyltestosteroneの場合をそれぞれ1,1とすると, Fluoxymesterone の場合は, それぞれ 20.0, 9.5を示す(経口投与)｡ (832)" "832/" "分子量 336.45 Fluoxymesterone を酢酸中でChromium trioxide と反応させ, 17β-Hydroxy-9α-fluoro-17-Methyl-4-androstene-3,11-dioneを形成(m.p.213-220ﾟ(dec.),[α]/d=+144ﾟ(CHCl3),C20H27FO3,Anabolic活性, Androgenic活性は,それぞれ 17-Methyltestosteroneの22倍, 8.5倍を示し, Fluoxymesterone より Anabolic 活性が増加する｡ (832)" "832/" "ST0376" 12.00 "17(S9-[2-(ACETYLOXY)-1-OXO-PROPYL]-9-FLUORO-11β,17α-DIHYDROXYANDROSTA-1,4-DIEN-3-ONE/9-FLUORO-11β,17α-DIHYDROXY-17(S)-LACTOYLANDROSTA-1,4-3-ONE 17β-ACETATE;9α-FLUORO-11β,17α,21-TRIHYDROXY-21-METHYLPREGNA-1,4-DIENE-3,20-DIONE 21-ACETATE;17β-[2-ACETOXYPROPIONYL]-9α-FLUORO-11β,17-DIHYDROXYANDROSTA-1,4-DIEN-3-ONE;21-METHYL-9α-FLUOROPREDNISOLONE ACETATE.9α-FLUORO-21-METHYL-1,4-PREGNADIENE-11β,17α,21B-TRIOL-3,20-DIONE 21-ACETATE" "FLUPEROLONE ACETATE,P-1742,ALACORTRIL,METHRAL" "C24H31O6F" 24.00 31.00 6.00 0.00 0.00 0.00 434.00 " (REF:833/834)" "833/834/" "215-253ﾟC(833)" "[α]/D=+87ﾟ(833)" "833/" "UVmax : 239nm(ε=15,350)(833)" "833/" "・Prednisolone 21-aldehyde を Diazomethane と反応させる事から出発して, 9α-Fluorine substitution を経て合成される｡ (833) ・酵母を用いて 20,21-Diketones を還元し, C-21 が選択的, 立体異性的に可能なDihydroderivatives の 1つ, 21αF-hydroxy-21-methylcorticoidを合成する｡(834)" "833/834/" "・Electrolyte-regulating活性は本質的に無い｡ただ, 副腎摘出ラットで軽い Natruresisを起こす｡ 抗炎症作用は Granuloma pouch法で測定すると, 9α-Fluoroprednisolone acetate の約 6分の1であった｡ 21-Methyl substitutionによって完全に9α-Fluoroprednisolone 分子の強力な Na保持活性を除去して, 抗炎症作用は残す事が出来る｡ (833)" "833/" "分子量 434.51 各種の C21エピマーが合成される｡ (833) ・薬品として使われている６種の局所ステロイドの中で, Vasoconstrictor試験では, Fluocinolone acetnide を100とした場合, 10(3-35)で,ランクは3位の高さを示し, Subcutaneous thymolytic試験では, Betamethasone Alcoholを 100とした場合, Miceでは 21(11-27)でランクは２位, Ratsでは16でランクは3位だった｡ (835)" "833/835/" "ST0377" 12.00 "FLUPREDNIDENE ACETATE, FLUPREDNYLIDENE 21-ACETATE,STL 1106,ETACORTINDECODERM SINE GENTAMYCIN" "C24H29O6F" 24.00 29.00 6.00 0.00 0.00 0.00 432.00 " (REF:836/837/838)" "836/837/838/" "231-234ﾟC(836/837)" "[α]/D=+87ﾟ(CHCl3)(836/837) [α]/D=+32ﾟC(DIOXANE)(838)" "836/737/838/" "UVmax(METHANOL) : 238nm(ε=15,700)(836/837), λmax = 239mμ(ε=15,900)(838)" "λCHCl3/max 2.73, 2.85-2.90, 5.73, 5.76, 5.99, 6.10, 6.18, 11.2μ(836/837)" "τ4.74, 4.94(C-16=CH2)" "836/837/838/" "・3α,17α-DIHYDROXY-16-METHYLENEPREGNANE-11,20-DIONEをクロロホルム中で Bromineと反応させる事を出発点として合成する｡ (836) ・16-METHYL-16-DEHYDROPREGNENOLONE ACETATEを出発物質として合成する｡(838)" "836/838/" "・抗炎症薬(局所性の) (838)" "838/" "分子量 432.49 (836) 化学名：21-(ACETYLOXY)-9-FLUORO-11β,17-DIHYDROXY-16-METHYLENEPREGNA-1,4-DIENE-3,20-DIONE; 9α-FLUORO-11β,17,21-TRIHYDROXY-16-METHYLENEPREGNA-1,4-DIENE-3,20-DIONE 21-ACETATE; 9α-FLUORO-16-METHYLENE-Δ1,4-PREGNADIENE-11β,17,21-TRIOL-3,20-DIONE 21-ACETATE; 16-METHYLENE-9α-FLUOROPREDNISOLONE 21-ACETATE; 9α-FLUORO-16-METHYLENEPREDNISOLONE 21-ACETATE." "836/" "ST0378" 12.00 "17-(ACETYLOXY)-9-FLUORO-11β-HYDROXYPREGN-4-ENE-3,20-DIONE; 9-FLUORO-11β,17-DIHYDROXYPREGN-4-ENE-3,20-DIONE-17-ACETATE; 17α-ACETOXY-9α-FLUORO-11β-HYDROXYPROGESTERONE; 9-FLUORO-11β,17-DIHYDROXYPROGESTERONE 17-ACETATE." "FLUROGESTONE ACETATE,SC-9880,CRONOLONE SYNCHRONATE" "C23H31O5F" 23.00 31.00 5.00 0.00 0.00 0.00 406.00 " (REF:839)" "839/" "266-269ﾟC(BENZEN+PETR ETHER or ETHYL ACETATE+PETR ETHER)(839)" "[α]20/D=+77.6ﾟ(in CHLOROFORM)(839)" "839/" "UVmax(METHANOL) : 238nm(ε=17,500)(839)" "839/" "16,17α-Epoxy-4,9(11)-Pregnadiene-3,20-dione を酢酸中で Hydriodic acid と反応させる事を出発点として合成する｡ (839)" "839/" "・Progestin活性｡ 家畜で progestational agent(月経前期剤)として発情期調節に用いる｡ Clauberg assay で, 経口で用いた場合, subcutaneous progesterone を1としたら,25の活性があった｡ Oral progesterone と比較すると,その2500倍の活性があり, Norlutin の25倍, 6α-Methyl-17α-acetoxy-progesteroneの5倍であった｡ (839)" "839/" "分子量 406.50 (839) 化学名：21-(ACETYLOXY)-9-FLUORO-11β,17-DIHYDROXY-16-METHYLENEPREGNA-1,4-DIENE-3,20-DIONE; 9α-FLUORO-11β,17,21-TRIHYDROXY-16-METHYLENEPREGNA-1,4-DIENE-3,20-DIONE 21-ACETATE; 9α-FLUORO-16-METHYLENE-Δ1,4-PREGNADIENE-11β,1721-TRIOL-3,20-DIONE 21-ACETATE; 16-METHYLENE-9α-FLUOROPREDNISOLONE 21-ACETATE; 9α-FLUORO-16-METHYLENEPREDNISOLONE 21-ACETATE." "839/" "ST0379" 12.00 "3-(2-CHLOROETHOXY)-9-FLUORO-11β,16α,17,21-TETRAHYDROXY-20-OXOPREGNA-3.5-DIENE-6-CARBOXAL-DEHYDE,CYCLIC 16,17-ACETAL WITH ACETONE,21-ACETATE; 3-(2-CHLOROETHOXY)-6-FORMYL-9α-FLUOROPREGNA-3,5-DIENE-11β,16α,17,21-TETROL-20-ONE 21-ACETATE 16α,17α-ACETONIDE; 3-(2-CHLOROETHOXY)-9α-FLUORO-6-FORMYL-11β,21-DIHYDROXY-16α,17α-ISOPROPYLIDENEDIOXYPREGNA-3,5-DIEN-20-ONE." "FORMOCORTAL,FI6341,FLUOROFORYMLON,CUTISTEROL,DEFLAMENE,FLUDERMA" "C29H38O8FCl" 29.00 38.00 8.00 0.00 0.00 0.00 568.00 " (REF:840)" "840/" "180-182ﾟC(エーテル-石油エーテル)(840)" "[α]20/D=+26ﾟ(CHLOROFORM)(840)" "840/" "UVmax(ETHANOL) : 216, 324nm(ε=12,100, 17,100)(840)" "840/" "・9α-FLUORO-CORTISONE-21-ACETATEの3-CYCLOETHYLENEKETALを出発物質として合成する｡(840)" "840/" "・Glucocorticoid作用を示す｡ Granuloma pouch assayで,ED50は局所で0.001mg, 経口で0.105mgであった｡ Relative potency は, F-acetate を1とした時に, Granuloma pouch assayが局所で 680, 経口で36,s.c.は23, Cotton pellets は局所で6.5, Hepatic glycogen は130, Total plasmatic corticosterone(FOH=1)の阻害は29であった。(840)" "840/" "分子量 569.07, The 21-pentanoate,m.p.103-105ﾟ,λmax=216,323nm(ε=10,200, 11,700),[α]/D=+32ﾟ(840)" "840/" "ST0380" 12.00 "11α,17β-DIHYDROXY-17-METHYL-3-OXOANDROSTA-1,4-DIENE-2-CARBOXALDEHYDE/2-FORMYL-17α-METHYLANDROSTA-1,4-DIENE-11α,17β-DIOL-3-ONE; 2-FORMYL-11α-HYDROXY-Δ1-METHYLTESTOSTERONE." "FORMYLDIENOLONE,ESICLENE" "C21H28O4" 21.00 28.00 4.00 0.00 0.00 0.00 344.00 " (REF:841/842)" "841/842/" "209-212ﾟC(ETHYL ACETATE)(842)" "[α]25/D=-105ﾟ(CHCl3)(842)" "水に可溶｡(842)" "842/" "・17α-METHYLANDROSTA-1,4-DIEN-11α,17β-DIOL-3-ONEを出発物質として合成する｡(841) ・17α-METHYLANDROST-4-ENE-17β-HYDROXY-3,11-DIONEを出発物質として合成する｡(842)" "841/842/" "・Anabolic steroid作用を示す｡ (841)" "841/" "分子量 344.45 3H-Formyldienolone の合成法, 及びその代謝｡ 経口投与すると, 血中レベルは２時間で最大になり,22時間後までゆっくりと減少する｡ 肝臓で最も高い放射活性が見られた｡ 尿中には4%ほどしか検出されなかった｡ 糞中へは42%が回収された｡ (842)" "842/" "ST0381" 12.00 "D:A-FRIEDOOLEANAN-3-ONE/FRIEDELAN-3-ONE" "FRIEDELIN" "C30H50O" 30.00 50.00 1.00 0.00 0.00 0.00 426.00 " (REF:843/844/845/846/847)" "843/844/845/846/847/" "261-265ﾟC(844)" "[α]/D=-27.8ﾟ(CHLOROFORM)(846) [α]14/D=-22ﾟ(C=0.812)(844)" "1gが8.6mlのクロロホルム, 264mmlの99%アルコールに溶ける｡(844)" "844/" "・植物｡ ・コルクの主要なトリテルペン, アルコールによる抽出物(843) ・Ceratopetalum apetalum D.Don,Cunoniaceae(バラ目の１科)から抽出｡ この木はCoachwood とも言われ, New South Wales(Australia)地方の雨林に見られる｡ Cork から得られるものと同一物｡ (843/844)" "843/844/" "分子量 426.70 立体構造｡ ケトン基が 3位である事を証明し, Friedolin の構造も決定｡ (845/846)" "845/846/" "ST0382" 12.00 "ERGOSTA-6,8,22-TRIEN-3β-OL, Δ6,7,8,9,22,23-ERGOSTATRIENE-3-OL" "FUNGISTEROL" "C28H44O" 28.00 44.00 1.00 0.00 0.00 0.00 396.00 " (REF:848/849/850/851)" "848/849/850/851/" "147.5ﾟC(ALCOHOL+ETHER+ETHYL ACETATE)(848)" "[α]15/D=-21.9ﾟ(CHLOROFORM)(848)" "848/" "ε 283mμ = 9980(848)" "848/" "・細菌･かび類｡ ・Penicillium chrysogenum 菌体のステロール結晶から精製される｡ (848)" "848/" "分子量 396.63 The acetate,m.p.158.5ﾟ,[α]15/D=-15.7ﾟ(848) ・FUNGISTEROLの誘導体から, その構造を決定｡ (849) ・FUNGISTEROLの酸化, 塩酸による異性化によって構造を確認｡ (850) ・FUNGISTEROLの生成機構を推定｡ (851)" "848/849/850/851/" "ST0383" 12.00 "3β-AMINO-5α-CONANIN-12β-OL" "FUNTESSINE" "C22H38ON2" 22.00 38.00 1.00 2.00 0.00 0.00 346.00 " (REF:852)" "852/" "194-195ﾟC(METHANOL)(852)" "[α]/D=+49ﾟ(C=1 in CHLOROFORM)(852)" "852/" "・植物｡ ・Funtumia latifolia Stapf.,Apocynaceae.の樹皮｡ (852)" "852/" "分子量 346.54 (852)" "852/" "ST0384" 12.00 "17-HYDROXY-17-NORPREGN-4-ENE-3,20-DIONE HEXANOATE; 17α-HYDROXY-19-NORPROGESTERONE CAPROATE; 17-HYDROXYESTR-4-ENE-3-ONE HEXANOATE." "GESTONORONE CAPROATE,GESTRONOL CAPROATE,SH 582,DEPOSTAT." "C26H38O4" 26.00 38.00 4.00 0.00 0.00 0.00 414.00 " (REF:853/854)" "853/854/" "123-124ﾟC(853)" "[α]/D=+13ﾟ(CHLOROFORM)(853)" "853/" "UVmax:239nm(ε=17,540)(853)" "853/" "Pregnadienolone, 又は Pregnadienolone-3-acetate を出発物質として合成する｡ ここから生物学的活性のある化合物が,一連の複数の反応を経て得られる｡ 19-Methyl 基はΔ1,4-3-Keto-compound の aromatization や, 分子内酸化によって除去される｡ (853)" "853/" "・Prostate hypertrophy(前立腺肥大)の治療に用いられている｡ (854)" "854/" "分子量 414.59 (853) ・筋肉内注射による Estrogen, 17-Ketosteroids, 17-Hydroxycorticosteroids, Pregnanetriol の尿中への排泄の効果｡ (853)" "853/" "ST0385" 12.00 "O-β-D-GLUCOPYRANOSYL-(1→2GLC1)-O-β-D-XYLOPYRANOSYL-(1→3GLC1)-O-β-D-GLUCOPYRANOSYL-(1→4)-O-β-D-GALACTOPYRANOSYL 25D,5α-SPIROSTANE-2α,3β-DIOL(GITOGENIN β-LYCOTETRAOSIDE)" "F-GITONIN,GITOGENIN,β-LYCOTETRAOSIDE" "C50H82O23" 50.00 82.00 23.00 0.00 0.00 0.00 1050.00 " (REF:855/856/315)" "855/856/315/" "252-255ﾟC(DECOMP.)(855), 251-255ﾟC(DEC.)(856)" "[α]25/D=-58.5ﾟ(C=0.53 in PYRIDINE)(855) [α]28/D=-66ﾟ(C=0.50 in PYRIDINE)(856)" "855/856/" "νmax : 862, 898, 924, and 982cm-1(INTENSITY 898>924)(856)" "856/" "・植物｡ ・Digitalis purpurea L.,Scrophulariaceae(ゴマノハグサ科)の葉から抽出される Saponin｡ (855)" "855/" "・強心薬として利用される｡ (855)" "855/" "分子量 1051.21 TLCで純粋｡ C50H82O23･2H2O(Gitogenin+3hexose+pentose,dihydrate),D-Glucose, D-Galactose, D-Xylose = 2.1:1.0:1.0｡ アグリコンはMeOHで結晶化し, m.p.275-278ﾟで, Gitogenin と同一であった｡ (855/315)" "855/315/" "ST0386" 12.00 "3β-[(O-2,6-DIDEOXY-β-D-RIBO-HEXOPYRANOSYL-(1→4)-O-2,6-DIDEOXY-β-D-RIBO-HEXOPYRANOSYL-(1→4)-2,6-DIDEOXY-β-D-RIBO-HEXOPYRANOSYL)OXY]-14,16β-DIHYDROXY-5β-CARD-20(22)-ENOLIDE" "GITOXIN,ANHYDROGITALIN,BIGITALIN,PSEUDODIGITOXIN" "C41H64O14" 41.00 64.00 14.00 0.00 0.00 0.00 780.00 " (REF:857/858/8599/860/861/862)" "857/858/859/860/861/862/" "285ﾟC(DECOMP.)(859), 278ﾟC(HOT STAGE)(860)" "[α]24/D=+5±1ﾟ(1% in PYRIDINE)(860) [α]20/5461=-3.5ﾟ(C=1.02 in PYRIDINE [α]20/Hg=[α]20/5461)(859)" "クロロホルム,エチルアセテート,アセトンには不溶｡ しかし,クロロホルムとアルコール,又は ピリジンの混合物,希アルコールには溶ける｡(859)" "859/860/" "λmax = 219mμ(Ε1%/1cm=191)(860)" "860/" "・植物｡ Foxglove(ジギタリス),すなわちDigitalis purpurea L.,D.lanata Ehrh.,Scrophulariaceaeから""Anhydrogitalin""として抽出される。(857) ・D.purpurea から""Digitalinum cristallisatum"" の名で抽出される｡(858) ・Digitalis lanta から""Gitoxin""として抽出される Glycoside｡(859)" "857/858/859/" "・強心薬として利用される｡ ネコに投与した場合, average lethaldose は, 0.443±0.014mg｡(Digitoxinでは,0.375±0.015mgなので,Gitoxin はその83%の毒性を持つ｡)(860)" "860/" "分子量 780.92 酸水解によって,１モルの Gitoxigeninと３モルのDigitoxose が得られる｡(861/862)" "861/862/" "ST0387" 12.00 "3β-HYDROXY-23-OXOOLEANN-12-EN-28-OIC ACID" "GYPSOGENIN,GITHAGENIN,ALBASAPOGENIN,GYPSOPHILASAPOGENIN" "C30H46O4" 30.00 46.00 4.00 0.00 0.00 0.00 470.00 " (REF:863/864/865)" "863/864/865/" "274-276ﾟC(METHANOL)(864),286-287ﾟC(863)" "[α]/D=+91ﾟ(ALC.)(864) [α]180/D(ALCOHOL)=+77.3ﾟ(863)" "温水,エーテルに可溶｡(865)" "864/863/865/" "・植物｡ Corncockle, Agrostemma githago(L.)Scop.,Caryophyllaceae (ナデシコ科)からGithagoninとして単離。(863) ・Soapwort,Gypsophila oldhamiana,Caryophyllaceaeから""Gypsogenin""として単離｡ (864) ・Fuller's herb, Saponaria officinalis L.から単離｡(865)" "863/864/865/" "・強心配糖体｡ (863/864/865)" "863/864/865/" "分子量 470.67 Gypsogenin と Githagenin は同一の化合物｡ The acetate,sintering 173ﾟ, m.p.188-189ﾟ, [α]/D=+79ﾟ(C=6.70 in chloroform)｡ The methyl ester of the acetate, m.p.191ﾟ, [α]/D=+80ﾟ(C=1.318 in chloroform)" "865/" "ST0388" 12.00 "21-CHLORO-9-FLUORO11β-HYDROXY-16α,17-[(1-METHYLETHYLIDENE)BIS(OXY)]PREGN-4-ENE-3,20-DI-ONE;21-CHLORO-9-FLUORO-11β,16α,17-TRIHYDROXYPREGN-4-ENE-3,20-DIONE CYCLIC 16,17-ACETAL WITH ACETONE;※備考へ続く" "HALCINONIDE,SQ-18,566,HALCIDERM,HALOG" "C24H32O5" 24.00 32.00 5.00 0.00 0.00 0.00 400.00 " (REF:866/867)" "866/867/" "264-265ﾟC(ACETONE-PETR ETHER)(866)" "[α]25/D=+155ﾟ(CHCl3)(866)" "アセトン,酢酸エチル,石油エーテルに可溶｡(866)" "866/" "UVmax(METHANOL):238nm(ε=16,400)(866)" "νmax:3425, 1725, 1660, 1620, 860cm-1(866)" "866/" "21-chloro-9α-Fluoro-11β,16α,17α-Trihydroxy-4-Pregnene-3,20-Dione を出発物質として合成する｡ (866)" "866/" "・局所性の抗炎症薬として利用される｡ Thymus involution assayで, C21Clの導入で,活性が増加し,又,Δ1,4よりΔ4の方が効果が高い事が判明した｡ Saltを負荷した副腎摘出ラットで,Na保持は誘導しなかった｡(866)" "866/" "分子量 454.97, (866) ・局所抗炎症剤としての効果ランクを Vasocontrictor assay や""Stripped-Skin""assay で調べた｡ その結果いづれも Betamethasone valerate(9α-Fluoro-11β,17α--21-Trihydroxy-16βMethylpregna-1,4-Diene-3,20-Dione 17-Valerate)やSQ15,361(9α-Fluoro-21-chloro-11β,16α,17α-Trihydroxypregna-1,4-Diene 3,20-Dione,16,17-Acetonide)と等価の活性があり, SQ20,589(21-chloro-11β,16α,17α-Trihydroxypregna-1,4-Diene 3,20-Dione,16,17-Acetonide)やSQ20,811(21-chloro-11β,16α,17α-Trihydroxypregn-4-ene-3,20-Dione,16,17-Acetonide)よりも活性が高かった｡ (867) 化学名の続き：21-CHLORO-9α-FLUORO-11β-HYDROXY-16α,17α-ISOPROPYLIDENEDIOXY-4-PREGN-ENE-3,20-DIONE;9α-FLUORO-21-CHLORO-11β,16α,17α-TRIHYDROXYPREGN-4-ENE-3,20-DIONE 16,17-ACETONIDE." "866/867/" "ST0389" 12.00 "17-BROMO-6α-FLUOROPREGN-4-ENE-3,20-DIONE/17α-BROMO-6α-FLUOROPROGESTERONE/6α-FLUORO-17α-BROMOPROGESTERONE" "HALOPROGESTERONE,PROHALONE" "C21H28O2" 21.00 28.00 2.00 0.00 0.00 0.00 312.00 " (REF:868/869)" "868/869/" "180-181ﾟC(DIL ACETONE)(868), 169-170ﾟC(DECOMP.)(869)" "[α]24/D=+12.1ﾟ(C=2.46 in CCl4)(868/869)" "アセトン,氷酢酸に可溶｡(868)" "868/869/" "・Uvmax(ETHANOL):236nm(logε=4.20)(868)・λE+OH/max:236-237mμ(logε=4.2)(869)" "νKBr/max:1621, 1680, (Δ4-3-KETONE DOUBLET), 1704(20-KETONE)cm-1(869)" "[Μ]/D=+50ﾟ(869)" "868/869/" "・17α-Bromo-Δ5-Pregnen-3β-Ol 20-One を出発物質として合成する｡ (868) ・Pregnenolone acetate から合成できる｡(869)" "868/869/" "著しい Progestin 活性を示す｡ (869)" "869/" "分子量 411.37 最初の 6.17-Dihalogenated Progesterone Derivative｡(869)" "869/" "ST0390" 12.00 "3β-23-DIHYDROXYOLEAN-12-EN-28-OIC ACID" "HEDERAGENIN,CAULOSAPOGENIN,MELANTHIGENIN" "C30H48O4" 30.00 48.00 4.00 0.00 0.00 0.00 472.00 " (REF:870/871/872/873/874/875)" "870/871/872/873/874/875/" "332-334ﾟC(ALC.)(875)" "[α]20/D=+81ﾟ(C=0.7 in PYRIDINE)(875)" "ピリジンに可溶｡クロロホルムとアルコールの混合物にも可溶｡アルコールには,ゆっくりと溶ける｡水には不溶｡ 希ALCOHOLIC NaOH に溶けるが,アルカリ水溶液には溶けない｡(872)" "875/872/" "εmax:2860 at 210 mμ(874)" "874/" "・植物｡ ・Polyscias nodosa や Hedera helix の花弁から得られる Glycoside｡(870) ・Ackee(Blighia Sapida Koenig)の果実の仮種皮(aril)から抽出される Glycoside｡(872) ・Nigella sativa L.(Ranunculaceae)の脱脂した種子のアルコール抽出物を加水分解して得られる酸性 Sapogenin, ""Melanthigenin""として単離される｡(873) ・Clematis vitalba Linn,(Ranunculaceae)の開花茎や, Caulophyllum thalictroides,Linn,Michaux(Berberidaceae)の根や根茎から, 成分の Saponin, Caulosaponin の aqueous-ethanolic solution の加水分解によって得られる ""Caulosapogenin""として単離｡ (874)" "870/872/873/874/" "ウサギ血液の溶血を引き起こす Saponin の Aglicon｡ (872)" "872/" "分子量 472.68 ""Melanthigenin"" と同一の化合物｡ (873) ・""Caulosapogenin""と同一の化合物｡ (874)" "874/873/" "ST0391" 12.00 "α-HEDERIN,HELIXIN(THE SAPONIN)" "C41H66O12" 41.00 66.00 12.00 0.00 0.00 0.00 750.00 " (REF:870/876/877/878/879)" "870/876/877/878/879/" "256-257ﾟC(876/877), 256-259ﾟC(879)" "[α]20/D=+14.5ﾟ(C=0.92 in METHANOL)(879)" "876/877/879/" "・植物｡ ・Polyscias nodosa Forst. や ivy leaves(Hedera helix L., Araliaceae) の花弁から抽出される｡(870/876)" "870/876/" "Hemolytic index, 1:150000; LD50(Rat), 4.5mg/kg; 浮腫阻止活性1.1mg/kg｡(879)" "879/" "分子量 750.98 加水分解によって, α-Hederagenin, D-Arabinose, A-Rhamnose が１モルずつ生成する｡ (877/878)" "877/878/" "ST0392" 12.00 "3β-[(6-DEOXY-4-O-β-D-GLUCOPYRANOSYL-α-L-MANNOPYRANOSYL)OXY]-5β,14-DIHYDROXY-19-OXOBUFA-20,22-DIENOLIDE" "HELLEBRIN,HELLEBRIGENIN,GLUCORHAMNOSIDE" "C36H52O15" 36.00 52.00 15.00 0.00 0.00 0.00 724.00 " (REF:880/881)" "880/881/" "283-284ﾟC(HOT METHANOL)(880)" "[α]20/D=-23.4ﾟ±0.2ﾟ(50% METHANOL)(880)" "希アルコールに溶ける｡水にもわずかに溶ける｡エーテルには不溶｡(880)" "880/" "λmax = 300 mμ(logΕ1%/1cm=1.96)(880)" "880/" "・植物｡ ・Helleborus niger L., Ranunculaceae の根茎から抽出される配糖体｡(880) ・Helleborus viridis, H.odorus, H.multifidus, h.dumetorum subsp.atrorubens, H.purpurascens, h.cyclophyllus, h.bocconei subsp.siculusの根茎は,0.30-1.5% Hellebrin を含む。H.orientalis の根茎には痕跡程度の Hellebrin しか含まれない｡ H.foetidus, H.lividus subsp.corsicus, H.niger(複数のサンプルを調査), H.vesicarius には Hellebrin は見つからなかった｡ (881)" "881/" "・強心薬として利用される｡ (880/881)" "880/881/" "分子量 724.82 (880)" "880/" "ST0393" 12.00 "3β-(DIMETHYLAMINO)CON-5-ENIN-12β-OL/12β-HYDROXYCONESSINE" "HOLARRHENINE" "C24H40ON2" 24.00 40.00 1.00 2.00 0.00 0.00 372.00 " (REF:882/883/884)" "882/883/884/" "197-198ﾟC(ACETIC ACID or ETHYL ACETATE)(882), 190-193ﾟC(883), 198.5-199ﾟ(884)" "[α]24/D=-7ﾟ(CHLOROFORM)(882) [α]24/D=+9ﾟ(ALCOHOL) [α]24/D=-4ﾟ±3ﾟ(CHCl3)(883)" "水に不溶｡アルコール,クロロホルムには可溶｡エーテル,アセトン,エチルアセテートにもわずかに可溶｡(882)" "882/883/884/" "[Μ]/D=+24ﾟ(ETHANOL)(883)" "883/" "・植物｡ ・Holarrhena congolensis Stapf, Apocynaceae の葉と樹皮から抽出｡(882)" "882/" "分子量 372.58 The hydrobromide,C24H38N2O,2HBr, 分子量 532.3, [α]/D=+11ﾟ又は +12.1ﾟ(anhydrous salt) (882) ・Hofmann反応, Emde反応による加水分解の結果, Hecogonin から調製された 12β-Hydroxy-5α-Pregnaneと同一の Hydroxy 5α-Pregnane である事がわかった｡この事からも, Holarrhenin の構造が 12β-Hydroxyconessin として確立された｡ (884)" "882/884/" "ST0394" 12.00 "11β,17α,21-TRIHYDROXY-5α-PREGNANE-3,20-DIONE/11β,17α,21-TRIHYDROXYALLOPREGNANE-3,20-DIONE/ALLOPREGNANE-11β,17α,21-TRIOL-3,20-DIONE; 4,5α-DIHYDROCORTISOL; 5α-DIHYDROHYDROCORTISONE" "HYDRALLOSTANE,ALLODIHYDROHYDROCORTISONE,ALLODIHYDRO F." "C21H32O5" 21.00 32.00 5.00 0.00 0.00 0.00 364.00 " (REF:885/886/887)" "885/886/887/" "234-240ﾟC(DEC.)(887), 219-224ﾟC(885)" "[α]25/D=+83ﾟ(ACETONE)(887)" "水に不溶｡メタノール,アセトン,クロロホルムに可溶｡(887)" "885/887/" "νKBr/max : 3640, 2400, 1705(BROAD)cm-1(887)" "887/" "・動物｡ ・牛,豚の副腎から抽出｡ (885)" "885/" "分子量 364.47 17α-HYDROXYCORTICOSTERONE ACETATE から 21-Acetate として合成 : m.p.210-212ﾟ, [α]20/D=69ﾟ(chloroform)｡ (886) ・Bismethylenedioxyhydrocortisone から合成｡ Reichstein's Substance C(3α,11β,17α,21-tetrahydroxyallopregnane-20-one やその 3β-isomer も同様にして合成できる｡ (887)" "886/887/" "ST0395" 12.00 "11β,17,21-TRIHYDROXYPREGN-4-ENE-3,20-DIONE-4-PREGNENE-11β,17α,21-TRIOL-3,20-DIONE; 17-HYDROXYCORTICOSTERONE" "HYDROCORTISONE,CORTISOL,ALA-CORT,CREMESONE,COBADEX,CORT-DOME,CORTEF,CORTIFOAM,CORTRIL,DOME CORT,EFCORBIN,EFCORLIN,EF-CORTELAN,EFCORTELIN,EYE-MAINTASONE,REICHSTEIN'S SUBSTANCE M,SCHEROSON F,SIGMACORT,TEXACORT,DEMACORT,PROCTOCORT.CORT,EPICORT,FICORTRIL,GENACORT(LOTION),HIDRO-COLISONA,HVB,HYDRO-ADRESON,HYDROCORTISYL,HYDROCORTONE,LUBRICORT,MEUSICORT," "C21H30O5" 21.00 30.00 5.00 0.00 0.00 0.00 362.00 " (REF:295/888/889/890/891/006/892/893/894)" "295/888/889/890/891/006/892/893/894/" "217-220ﾟC(無水ｴﾀﾉｰﾙ or ｲｿﾌﾟﾛﾊﾟﾉｰﾙ) COMMERCIAL SAMPLE212-213ﾟ(888), 207-210ﾟC(295)" "[α]22/D=+167ﾟ(ABS ETHANOL) COMMERCIAL SAMPLE [α]22/D=+163ﾟ(C=0.5 in METHANOL)(295)" "(25ﾟ)水:0.28mg/ml,ｴﾀﾉｰﾙ:15.0mg/ml,ﾒﾀﾉｰﾙ:6.2mg/ml,ｱｾﾄﾝ:9.3mg/ml,ｸﾛﾛﾎﾙﾑ:1.6mg/ml,ﾌﾟﾛﾋﾟﾚﾝｸﾞﾘｺｰﾙ:12.7mg/ml,ｴｰﾃﾙ:約0.35mg/ml で溶ける｡(295)" "295/888/" "UVmax : 242nm(Ε1%/1cm=445)(889)" "889/" "・動物｡ ・副腎｡ (295/888) ・重篤な糖尿病をともなうヒトクッシング症候群の尿｡ (889) ・ACTH投与後のイヌの副腎の血液から抽出｡ (890)" "295/888/889/890/" "グルココルチコイド作用を示す｡ 家畜でも,副腎皮質ステロイド,グルココルチコイドとして利用される｡ 局所の抗炎症薬として用いられる｡ (295/888/889/890/006/891/892/893)" "295/888/889/890/006/891/892/893/" "分子量 362.47 (295) ・立体構造の決定｡ (006/891) ・20-Cyano-17-pregnene-21-ol-3,11-dione を出発物質として 21-Acetate として合成 : m.p.218.5-220.5ﾟ, [α]25/D=+150.7(0.5 acetone), λmax(CH3OH) 2420A, Ε1%/1cm 371,mixed m.p.は authentic sample によって depress されない｡IRスペクトルは完全に一致｡ (892) ・副腎におけるコレステロールからの変換｡ (893) ・Streptomyces fradiae によって,11-Desoxy-17-hydroxycorticosteroneの11-oxygenationさせる事によって合成｡ (894)" "006/295/891/892/893/894/" "ST0396" 12.00 "21-(3-CARBOXY-1-OXOPROPOXY)-5β-PREGNANE-3,20-DIONE SODIUM SALT; 21-HYDROXYPREGNANE-3,20-DIONE SODIUM HEMISUCCINATE" "HYDROXYDIONE SODIUM,HYDROXYDIONE SOCCINATE,PRESUREN,VIADRIL" "C25H35O6Na" 25.00 35.00 6.00 0.00 0.00 0.00 454.00 " (REF:895)" "895/" "195-197ﾟC(FREE ACID)(895)" "[α]20/D=+95ﾟ(in CHLOROFORM, FREE ACID)(895)" "水に可溶｡マイルドなアルカリ緩衝液,アセトン,クロロホルムにも可溶｡(895)" "895/" "UVmax : 280nm(ε=93.2)(895)" "895/" "DEOXYCORTICOSTERONE を Palladium で還元して,無水コハク酸で処理し,Na塩とする事で合成する｡ (895)" "895/" "ヒト,マウス,ラット,ネコ,イヌ,モンキーなどで, 麻酔剤として利用される水溶性ステロイド｡ AD50 21.5mg/kg, LD50 250mg/kg, TI(LD50/AD50)11.5で,TIが4の Thiopental Sodium より優れている(静脈注射の場合)｡ (895)" "895/" "分子量 454.52 (895)" "895/" "ST0397" 12.00 "17-HYDROXY-16-METHYLENE-Δ6-PROGESTERONE; 17-HYDROXY-16-METHYLENEPREGNA-4,6-DIENE-3,20-DIONE; 6-DEHYDRO-17α-HYDROXY-16-METHYLENEPROGESTERONE" "C22H28O3" 22.00 28.00 3.00 0.00 0.00 0.00 340.00 " (REF:896)" "896/" "196.5-197ﾟC(METHANOL)(896)" "[α]20/D=-72.5ﾟ±1ﾟ(896)" "ベンゼン,無水カプロン酸に可溶｡(896)" "896/" "UVmax : 283nm(logε=4.51)(896)" "881, 1597, 1630, 1658, 1672(Δ4,6-3-KETONE), 1705(H-BRIDGE), 1724(20-CO), 3480(ASSOC,OH), 3610(FREE OH)cm-1(896)" "896/" "3β-Acetoxy-16β-Methyl-16α,17β-Oxido-Δ5-Pregnen-20-One を出発物質として合成｡ (896)" "896/" "経口のプロゲストゲンとして利用される｡ (896)" "896/" "分子量 340.44 (896)" "896/" "ST0398" 12.00 "17α-HYDROXYPROGESTERONE 3-CYCLOPENTYL ENOL ETHER/ 3-(CYCLOPENTYLOXY)-17-HYDROXYPREGNA-3,5-DIEN-20-ONE" "C26H38O3" 26.00 38.00 3.00 0.00 0.00 0.00 398.00 " (REF:897)" "897/" "184.5-186.5ﾟC(897)" "[α]/D=-115ﾟ(DIOXANE)(897)" "897/" "17α-Acetate としての合成｡ (897)" "897/" "Progestin(プロゲスチン)として利用される｡ (897)" "897/" "・分子量 398.56 17α-Acetoxyprogesterone 3-cyclopentylenol ether,Gestovis,Solid, m.p.137-138ﾟ, [α]/D=-147ﾟ(dioxane) (897)" "897/" "ST0399" 12.00 "3-HYDROXY-8α-ESTRA-1,3,5(10)-TRIEN-17-ONE/Δ1,3,5-8-EPIESTRATRIEN-3-OL-17-ONE" "8-ISOESTRONE,8α-ESTRONE,8-EPIESTRONE" "C18H22O2" 18.00 22.00 2.00 0.00 0.00 0.00 270.00 " (REF:086/385/898)" "086/385/898/" "dl-FORM:254-255ﾟ(ﾒﾀﾉｰﾙ)(385), 247ﾟC(086), 255-252ﾟC(FROM ACETATE)(898)" "[α]20/D=+94ﾟ(DIOXANE)(086)" "086/385/898/" "・Isoestrone-benzoateから調製｡ (086) ・Carbinol と 2-Methylcyclopenthane-1,3-Dione の縮合物を出発物質として合成｡(898)" "086/898/" "・分子量 270.36 The methylester, m.p.149-152ﾟ, The benzoate, m.p.197-198ﾟ (385)" "895/" "ST0400" 12.00 "(3β,23β)-17,23-EPOXY-3-HYDROXYVERATRAMEN-11-ONE" "JERVINE" "C27H39O3N" 27.00 39.00 3.00 1.00 0.00 0.00 425.00 " (REF:899/900/901/902/903/904/905/906/907/908/909/910)" "899/ 〜 910/" "243.5-244.5ﾟC(METHANOL+WATER)(902), 238ﾟC(906), 240-241ﾟC(899)" "[α]/D=-147ﾟ(ETHANOL)(906) [α]19/D=-150ﾟ(ETHANOL)(899) [α]20/D=-167.6ﾟ(CHLOROFORM)(902)" "902/906/899/" "Uvmax : 250nm(ε=15,000), 360nm(ε=60)(904) λ/252(14,000), 360(70)(906)" "分解物のNMR.(909)" "904/906/909/" "・植物｡ ・White hellebore, Veratrum grandiflorum(Maxim.)Loes F., V.album L., V.viride Sol., Liliaceaeの根から得られるくしゃみアルカロイド｡(899/900/901/902/903/904)" "899/900/901/902/903/904/" "くしゃみを催す｡(899)" "899/" "・分子量 425.59 JERVINEが通常のステロイド核を持たない事の証明を Perhydrobenzfluorene derivatives へ分解する事で証明｡ (905) ・VERATRAMINE とともに,立体構造の訂正｡ (907/908) ・3β-Acetoxy-5α-Etiojirv-12(13)-en-17-one を出発物質として合成｡ (910)" "905/907/908/910/" "ST0401" 12.00 "PREGN-4-ENE-3,11,20-TRIONE" "11-KETOPROGESTERONE,11-OXOPROGESTERONE,U-1258,KETOGESTIN" "C21H28O3" 21.00 28.00 3.00 0.00 0.00 0.00 328.00 " (REF:911)" "911/" "172-174ﾟC(911)" "[α]/D=+238.5ﾟ±8ﾟ(C=0.8889 in ACETONE)(911)" "水には不溶｡アセトン,クロロホルムに可溶｡(911)" "911/" "CORTICOSTERON (11β,21-DIHYDROXYPREGN-4-ENE-3,20-DIONE) を PYRIDIN 中で CH3･C6H4･SO2･Cl と反応させる事から出発して合成｡ (911)" "911/" "ketosis に使用｡(911)" "911/" "・分子量 328.43 911)" "911/" "ST0402" 12.00 "N,N,N',N'-TETRAMETHYLPREGN-5-ENE-3β,20α-DIAMINE/3β,20α-BIS(DIMETHYLAMINO)-5-PREGNENE" "KURCHESSINE" "C25H44N2" 25.00 44.00 0.00 2.00 0.00 0.00 372.00 " (REF:912/913/914)" "912/913/914/" "140-141ﾟC(ACETONE)(913)" "[α]20/D=-37ﾟ(C=1.9), -36ﾟ(C=1.112 in CHCl3) [α]22/D=-17ﾟ(C=1.050 in METHANOL)(913)" "913/" "・植物｡ Holarrhena antidysenterica Wall., Apocynaceae の樹皮,葉から抽出される｡ (912/914)" "912/914/" "・分子量 372.65 Saracococa pruniformis Lindl., Euphorbiaceae から得られる Sarcodinine とおそらく同一化合物｡ (913)" "913/" "ST0403" 12.00 "3β-(DIMETHYLAMINO)-4α-METHYL-5α-CONANINE-5,7β-DIOL" "KURCHOLESSINE" "C25H44O2N2" 25.00 44.00 2.00 2.00 0.00 0.00 404.00 " (REF:912/915)" "912/915/" "218.5-221.5ﾟC(ACETONE)(912)" "[α]20/D=-4ﾟ±2ﾟ(CHCl3), +5±2ﾟ(C=0.001 無水ｴﾀﾉｰﾙ)(912)" "ｸﾛﾛﾎﾙﾑ,ﾒﾀﾉｰﾙ,ｴﾀﾉｰﾙ,ﾋﾟﾘｼﾞﾝによく溶ける｡あたたかいｱｾﾄﾝにわずかに溶ける｡ｴﾁﾙｱｾﾃｰﾄ,ﾍﾞﾝｾﾞﾝ,石油ｴｰﾃﾙ,ｴｰﾃﾙ,水には不溶｡(912)" "912/" "Me2Na+C-3:J=7.71; MeNa+C-18/C-20:J=7.80 (915)" "m+/e 71(79%),84(100%),156(19%),324(24%),389(22%; M+/E-CH3),404(16%)(915)" "915/" "・分子量 404.65 (912)" "912/" "ST0404" 12.00 "LUP-20(29)-EN-3β-OL" "LUPEOL,MONOGYNOL B,β-VISCOL,FAGARASTEROL" "C30H50O" 30.00 50.00 1.00 0.00 0.00 0.00 426.00 " (REF:916/917/918/919/920/921/922/638)" "916/917/918/919/920/921/922/638/" "215ﾟC(ALCOHOL or ACETONE)(916)" "[α]20/D=+27.2ﾟ(C=4.8 in CHLOROFORM)(638) [α]/D=+29ﾟ(C=1.088)(917)" "エーテル,ベンゼン,石油エーテル,アルコールに可溶｡水,希酸,アルカリには不溶｡ (916/917)" "916/917/638/" "・主に植物｡ ・Bombyx mori.(カイコ)のまゆ｡ Lupin(ルピナス,ハウチワマメ)の種子の皮,chicle(チクルゴム), fig trees (いちじくの木)や,ゴム植物のラテックスの中に豊富な植物トリテルペン｡ (916) ・MELODINUS MONOGYNUS ROXB. 由来の MONOGYNOL B として単離｡ (918)" "916/918/" "・分子量 426.70 β-VISCOL は, LUPEOLと同一｡ (917) ・MONOGYNOL B と LUPEOL は同一化合物｡ (918) ・全合成｡ (922)" "917/918/922/" "ST0405" 12.00 "19-NOR-17α-PREGN-4-EN-20-YN-17-OL; 17α-ETHINYL-17β-HYDROXYESTR-4-ENE/17α-ETHYNYLESTR-4-EN-17β-OL/17α-ETHYNYL-19-NOR-ANDROST-4-EN-17β-OL" "LYNESTRENOL,3-DESOXYNORLUTIN,ETHINYLESTRENOL,EXLUTONA,EXLUTENA,ORGAMETRIL" "C20H28O" 20.00 28.00 1.00 0.00 0.00 0.00 284.00 " (REF:819)" "," "819/" "158-160ﾟC(819)" "[α]/D=-13ﾟ(CHLOROFORM)(819)" "819/" "・調製法｡ (819)" "819/" "・プロゲスチン ・経口避妊薬(メストラノールと合わせて) (819)" "819/" "・分子量 284.42 (819) ・ヒトにおける代謝｡ 投与日に16%が,4日のうちに更に 24%が排出される｡ これは NORETHISTERONE より少し遅い｡ 3%は24時間後に血漿中に抱合型で見られる｡遊離の場合,血漿中での半減期は30分である｡ LYNESTRENOLは尿中には検出できない｡(923) ・ヒトへ投与後,経口又は静注にかかわらず, 31.2〜57.6%が5日以内に排出される｡ 生物学的半減期は26.5時間であった｡ 尿中代謝物の約10%は硫酸抱合として排出されていた｡血漿中では,NORETHISTERONE投与の場合より速かに減少した｡ (924)" "819/923/924/" "ST0406" 12.00 "6,17-DIMETHYLPREGNA-4,6-DIENE-3,20-DIONE; 6,17α-DIMETHYL-6-DEHYDROPROGESTERONE" "MEDROGESTONE,AY62022,COLPRO,COLPRONE,PROTHIL" "C23H32O2" 23.00 32.00 2.00 0.00 0.00 0.00 340.00 " (REF:925/926/927)" "925/926/927/" "144-146ﾟC(ETHER)(926)" "[α]23/D=+79ﾟ(C=1 in CHLOROFORM)(926)" "926/" "UVmax:288mμ(ε=25,000),289mμ(ε=24,900)(926)" "926/" "・合成法(16-DEHYDRO-20-KETO-PREGNANES の還元的アルキル化による) (927) ・3β-HYDROXY-17α-METHYL-5α,6α-EPOXYETIANIC ACID METHYL ESTER を出発物質として合成｡ (926)" "926/927/" " プロゲスチン活性を示す｡経口投与の場合, 6α-METHYL-17-ACETOXYPROGESTERONE と同等の活性を示す｡ ANDROGEN 活性は無い｡ CLAUBERG TEST(RELATIVE POTENCY):皮下, 5(PROGESTERONE=1); 経口,10(NORETHI-NDRONE=1)｡ (925)" "925/" "・分子量 324.49 PROGESTERONEは, 経口投与で効果が無いが, 6,17-位の SUBSTITUENTS には経口投与で活性がある｡ (926)" "926/" "ST0407" 12.00 "17-HYDROXY-6α-METHYLPREGN-4-ENE-3,20-DIONE; 17α-HYDROXY-6α-METHYLPROGESTERONE; 6α-METHYL-17α-HYDROXYPROGESTERONE; 6α-METHYL-4-PREGNEN-17α-OL-3,20-DIONE" "MEDROXYPROGESTERONE" "C22H32O3" 22.00 32.00 3.00 0.00 0.00 0.00 344.00 " (REF:928)" "928/" "220-223.5ﾟC(CHLOROFORM)(928)" "[α]25/D=+75ﾟ(in CHLOROFORM)(928)" "928/" "UVmax(ETHANOL):241nm(ε=16,150)(928)" "928/" "・17α-HYDROXYPROGESTERONEのBISETHYLENE ACETALを出発物質として合成｡ (928)" "928/" "6α-METHYL-17α-HYDROXYPROGESTERONE とその ACETATEは,これまで知られている中で最も活性の強い PROGESTATIONAL AGENT である｡ 家畜の発情期の調節にも用いられる｡ (928)" "928/" "・分子量 344.48 17-ACETATE:m.p.205-209ﾟ,　[α]/D=+56ﾟ,λmax 240mμ(am 15,950)｡(928)" "928/" "ST0408" 12.00 "11β-HYDROXY-6α-METHYLPREGN-4-ENE-3,20-DIONE; 11β-HYDROXY-6α-METHYLPROGESTERONE; 6α-METHYL-11β-HYDROXYPROGESTERONE" "MEDRYSONE,HYDROXYMESTERONE,U-8471,HMS,SPECTRAMEDRYN" "C22H32O3" 22.00 32.00 3.00 0.00 0.00 0.00 344.00 " (REF:929/930)" "929/930/" "155-158ﾟC(930)" "[α]/D=+189ﾟ(in CHLOROFORM)(930)" "930/" "・合成｡ (930)" "930/" "グルココルチコイドとして,目の炎症の治療に用いられる｡ 眼球内圧は上げない｡ 又,ヘルペス性角膜炎の再活性化を引き起こすようには思われない｡ (929)" "929/" "・分子量 344.48 (930)" "930/" "ST0409" 12.00 "17α-HYDROXY-6-METHYLPREGNA-4,6-DIENE-3,20-DIONE ACETATE; 17α-ACETOXY-6-METHYLPREGNA-4,6-DIENE-3,20-DIONE; 6-DEHYDRO-6-METHYL-17α-ACETOXY-PROGESTERONE; 6-METHYL-Δ4,6-PREGNADIEN-17α-OL-3,20-DIONE ACETATE" "MEGESTROL ACETATE,MEGACE,NIAGESTIN,OVABAN" "C24H32O4" 24.00 32.00 4.00 0.00 0.00 0.00 384.00 " (REF:931/932/933/934)" "931/932/933/934/" "218-220ﾟC(931)" "[α]/D=+11ﾟ(931)" "水(37ﾟ)2μg/ml, 血漿(37ﾟ)24μg/ml(931)" "931/" "λmax 289mμ(ε=24,000)(931)" "λKBr/max 1580, 1625, 1660, 1710, 1730cm-1(931)" "931/" "・Δ5-PREGNENE-3β-17α-DIOL-20-ONE ACETATEを出発物質として合成｡ (931)" "931/" "・抗腫瘍薬として,また,経口避妊薬として混合物に用いられる｡ ・家畜では,黄体ホルモン性の作用(発情期の調節)を利用｡ ・19-NOR-17α-ETHYNYL TESTOSTERONE(NORLUTIN)を標準とした場合,実験動物で,2-3倍以上の高いPROGESTATIONAL POTENCY を示す(CLAUBERG ASSAY,ORAL ROUTE)｡ (931) ・DIMETHYLPOLYSILOXANE IMPLANT が最も効果的用法｡他の方法の 1/6 から 1/25 で 同等の活性を示す｡(932)" "931/932/" "・分子量 384.50 (931) ・婦人へ経口投与した場合の代謝｡ 7日のうちに 66.4%が尿に,19.8%が糞に排出される｡(933) ・DIMETHYLPOLYSILOXANE 膜を介してステロイドの拡散を調節する因子｡ (934)" "931/933/934/" "ST0410" 12.00 "17,21-DIHYDROXY-16β-METHYLPREGNA-1,4-DIENE-3,11,20-TRIONE ; 16β-METHYLPREDNISONE" "MEPREDNISONE,BETAPRED,BETAPAR,DELTACORTENE BETA,BETALONE,DELTISONA B" "C22H28O5" 22.00 28.00 5.00 0.00 0.00 0.00 372.00 " (REF:633/935/635/936)" "633/935/635/936/" "200-205ﾟC(936), 195-200ﾟC(633/635), 204-210ﾟC(935)" "[α]/D=+200ﾟ(DIOXANE)(936) [α]CH.F./D=+205ﾟ(633/635) [α]/D=+190.2ﾟ(935)" "936/633/635/935/" "UVmax(METHANOL) 239nm(Ε1%/1cm 416)(936); λMeOH/max 238mμ(ε=14,900)(633); λMeOH/max 238mμ(ε=14,700)(935)" "λCHF/max 2.90, 1625, 5.82, 6.00, 6.14, 6.19, 11.21μ(635)" "936/633/935/635/" "・16β-METHYLPREDNISONE ACETATE(m.p.230-233ﾟ, [α]ch.f/D=+216ﾟ, λMeOH/max= 238mμ(15,100))を POTASSIUM-BICARBONATE-AQUEOUS METHANOL加水分解すると得られる｡(633) ・16β-METHYLPREDNISONE 21-ACETATE を POTASSIUM BICARBONATEで加水分解すると得られる｡ (935/635) ・5α-PREGN-16-EN-3β-OL-11,20-DIONE ACETATE から合成｡ (936)" "633/635/935/936/" "・グルココルチコイド｡ 抗炎症作用が高い｡ しかも, 塩の保持は無い事が動物実験及び臨床試験で得られている｡ (633/935) ・ラットにおける16β-METHYL CORTICAL STEROIDS(HYDROCORTISONE=1) 化合物,16β-METHYL LIVER GLYCOGEN SYSTEMATIC GRANULO A CORTISONE 0.4 2 HYDROCORTISONE 0.6 4 PREDNISONE* 1 26 PREDNISOLONE* 1.5 23 9α-FLUOROHYDROCORTISONE 8.5 23 9α-FLUOROPREDNISOLONE* 11 70 全て,副腎切除ラットで，Na+保持は示さない｡ヒトでも *の間で,代謝活性にはほとんど差は無く,抗炎症作用も等価である｡(635) ・21-ACETATEも同じ活性を示す｡ (936)" "633/635/935/936/" "・分子量 372.46 (633)" "633/" "ST0411" 12.00 "17β-HYDROXY-17-METHYL-5α-ANDROSTAN-3-ONE; 17β-HYDROXY-17α-METHYL-3-ANDROSTANONE; 17α-METHYL-ANDROSTAN-17β-OL-3-ONE; 17α-METHYLANDROSTAN-3-ON-17β-OL" "MESTANOLONE,ANDROSTALONE(ROUSSEL)" "C20H30O2" 20.00 32.00 2.00 0.00 0.00 0.00 304.00 " (REF:444)" "444/" "192-193ﾟ(ETHYL ACETATE)(444)" "水に不溶｡アセトン,アルコール,エーテル,エチルアセテートに可溶｡(444)" "444/" "・17-methyl-3,17-androstanediolの酸化によって得られる｡(444)" "444/" "・アンドロゲン作用を示す｡ (444)" "444/" "・分子量 304.46 (444)" "444/" "ST0412" 12.00 "3-METHOXY-19-NOR-17α-PREGNA-1,3,5(10)-TRIEN-20-YN-17-OL; 17α-ETHYNYL-3-METHOXY-1,3,5(10)-ESTRATRIEN-17β-OL; 17α-ETHYNYLESTRADIOL 3-METHYLETHER" "MESTRANOL,NORQUEN,OVASTOL" "C21H26O2" 21.00 26.00 2.00 0.00 0.00 0.00 310.00 " (REF:937)" "937/" "150-151ﾟC(METHANOL or ACETONE)(937)" "937/" "・エストロゲン,経口避妊薬としてコンビネーションで｡ (937)" "937/" "・分子量 310.42 (937)" "937/" "ST0413" 12.00 "17β-HYDROXY-1β-METHYL-5α-ANDROST-1-EN-3-ONE; 1-METHYL-Δ1-ANDROSTEN-17β-OL-3-ONE" "METHENOLONE,ME'TE'NOLONE" "C20H30O2" 20.00 30.00 2.00 0.00 0.00 0.00 302.00 " (REF:938)" "938/" "149.5-152ﾟC(ISOPROPYL ETHER)(938)" "[α]/D=+58.9ﾟ(938)" "938/" "Δ2'-PYRAZOLINO-4',3':1,2-ANDROSTANOL-(17β)-ON-(3)から合成｡ (938)" "938/" "Anabolic作用｡ (938)" "938/" "・分子量 302.44 (938)" "938/" "ST0414" 12.00 "11β,17α,21-TRIHYDROXY-6α-METHYL-1,4-PREGNADIENE-3,20-DIONE; 1-DEHYDRO-6α-METHYLHYDROCORTISONE; Δ1-6α-METHYLHYDROCORTISONE; 6α-METHYL-11β,17α,21-TRIOL-1,4-PREGNADIENE-3,20-DIONE" "6α-METHYLPREDNISOLONE/ARTISONE-WYETH/MEDRATE/MEDROL/MEDRONE/METASTAB/METRISONE/PROMACORTINE/SUPRAMETIL/URBASON" "C22H30O5" 22.00 30.00 5.00 0.00 0.00 0.00 374.00 " (REF:939/940)" "939/940/" "228-237ﾟC(939), 229-234ﾟC(940)" "[α]20/D=+83ﾟ(DIOXANE)(939) [α]/D=+94ﾟ(C=0.5 DIOXANE)(940)" "939/940/" "UVmax(95% ETHANOL):243nm(αM=14,875)(939); λmax : 244mμ(Ε=14,500)(940)" "λNujol/max : 5.83, 6.01, 6.19, SH.6.21μ(940)" "939/940/" "・11α-ACETOXYPROGESTERONEを 3,20-BIS ETHYLENE KETALへ変換して出発物質とし,合成｡ (939) ・GRIGNARD ADDITION によって 6-KETONE を適当に保護して合成｡ (940)" "939/940/" "グルココルチコイド作用を持つ｡ HYDROCORTISONE よりも強力｡ (939)" "939/" "・分子量 374.46 21-ACETATE, m.p.205-208ﾟ; [α]/D=+101ﾟ,(DIOXANE), λ95%ALC./max 243Mμ,am=14,825｡ (939)" "939/" "ST0415" 12.00 "17β-HYDROXY-17-METHYLANDROST-4-EN-3-ONE; 17α-METHYL-Δ4-ANDROSTEN-17β-OL-3-ONE" "17-METHYLTESTOSTERONE,ANERTAN(TABL),GLOSSO-STERANDRYL,HOMANDREN(TEBL),MALESTRONE(TEBL),METANDREN, NEO-HOMBREOL M,NU-MAN,ORCHISTERONE-M,ORETON-M,PERANDREN(LOZENGES), SYNADROTABS,TESTHORMONA,TESTOSID(TABL),TESTOVVIRON(TABL)" "C20H30O2" 20.00 30.00 2.00 0.00 0.00 0.00 302.00 " (REF:941)" "941/" "161.5-164.5ﾟC(941)" "[α]/D=+76.4ﾟ(ALCOHOL)(941)" "アルコール,メタノール,エーテル,その他の有機溶媒に可溶｡ベジタブルオイルに少し溶けるが,水には不溶｡(941)" "941/" "17-METHYL-Δ5,6-ANDROSTENDIOL-(3,17)から合成｡ (941)" "941/" "アンドロゲン作用｡ (941)" "941/" "・分子量 302.44 (941)" "941/" "ST0416" 12.00 "17α-METHYLTESTOSTERONE 3-CYCLOPENTYL ENOL ETHER 3-(CYCLOPENTYLOXY)-17-METHYLANDROSTA-3,5-DIEN-17β-OL" "RP12,222, PANDROCINE, PENMESTROL" "C25H38O2" 25.00 38.00 2.00 0.00 0.00 0.00 370.00 " (REF:897)" "897/" "148-152ﾟC(897)" "[α]/D=-150ﾟ(IN DIOXANE)(897)" "897/" "17-METHYLTESTOSTERONEのENOL ESTERIFICATION による｡ (897)" "897/" "・MYOTROPIC,ANDROGEN作用を持つ｡ ただし,非経口的に投与すると,その作用は弱く,経口投与すると,逆に強まる(17α-METHYLTESTOSTERONEの5倍以上)｡ ・抗乳ガン作用(皮下投与でも有効)｡ (897)" "897/" "・分子量 370.55 (897)" "897/" "ST0417" 12.00 "17β-HYDROXY-17-METHYLESTRA-4,9,11-TRIEN-3-ONE; 17β-HYDROXY-17-METHYL-19-NORANDROSTA-4,9,11-TRIEN-3-ONE; 17α-METHYL-4,9,11-ESTRATRIEN-17β-OL-3-ONE" "METHYLTRIENOLONE,R1881" "C19H24O2" 19.00 24.00 2.00 0.00 0.00 0.00 284.00 " (REF:942)" "942/" "170ﾟC(DIISOPROPYL ETHER)(942)" "[α]20/D=-58.7ﾟ(C=0.5 in ETHANOL)(942)" "942/" "3-Chloro-4,5-Seco 5-Oxo 17-Benzoxy 19-Nor-androsta 2,9-diene を出発材料として合成する｡ (942)" "942/" "Anabolic作用がある｡ (942)" "942/" "・分子量 284.38 (942)" "942/" "ST0418" 12.00 "17β-HYDROXYESTR-4-EN-3-ONE; 17β-HYDROXY-4-ESTREN-3-ONE; 4-ESTREN-17β-OL-3-ONE; 17β-HYDROXY-19-NOR-4-ANDROSTEN-3-ONE; 19-NORTESTOSTERONE" "C18H26O2" 18.00 26.00 2.00 0.00 0.00 0.00 274.00 " (REF:943/944)" "943/944/" "112ﾟC AND 124ﾟC, MIXED m.p.123.6-124.5ﾟC(944)" "[α]22/D=+55ﾟ±0.6ﾟ(C=0.93 in CHLOROFORM)(944)" "アルコール,エーテル,クロロホルムに可溶｡(944)" "944/" "Uvmax(ETHANOL):240.5mμ(ε=17,000), 307-310mμ(944)" "λCS2/max 2.77μ(OH), 6.02μ(conj, C'=0)(944)" "Μ/D=+151ﾟ(944)" "944/" "・Estradiolの alkyl ester から合成する｡ (943) ・Estrone から合成する｡ (944)" "943/944/" "Anabolic作用がある｡ (943/944)" "943/944/" "・分子量 274.39 (943)" "943/" "ST0419" 12.00 "17β-[3-[4-(HEXYLOXY)PHENYL]-1-OXOPROPOXY]ESTR-4-EN-3-ONE; 17β-HYDROXYESTR-4-EN-3-ONE P-(HEXYLOXY)HYDROCINNAMATE; 17β-HYDROXYESTR-4-EN-3-ONE P-HEXYLOXYPHENYLPROPIONATE; 17β-HYDROXY-19-NORANDROST-4-EN-3-ONE P-HEXYLOXYPHENYL PROPIONATE; 19-NORTESTOSTERONE-3-(P-HEXYLOXYPHENYL)PROPIONATE." "NANDROLONE P-HEXYLOXYPHENYLPROPIONATE NORTESTOSTERONE,HEXOXYPHENYLPROPIONATE,ANADOR,ANADUR." "C33H46O4" 33.00 46.00 4.00 0.00 0.00 0.00 506.00 " (REF:945)" "945/" "53-55ﾟC(945)" "[α]/D=+45ﾟ(C=1.0 in DIOXANE)(945)" "945/" "Testosterone と p-Hexoxyhydrocinnamoyl anhydride をピリジン中で溶かす事から合成を始める｡ (945)" "945/" "Anabolic作用を持つ｡ エステル化によってその作用の強度と持続時間が向上した｡ その向上度は, p-alkoxy基の長さに依存していた｡ (945)" "945/" "・分子量 506.73 (945)" "945/" "ST0420" 12.00 "NERIANTIN" "C29H42O9" 29.00 42.00 9.00 0.00 0.00 0.00 534.00 " (REF:947)" "947/" "206-208ﾟC(METHANOL+ETHYL ACETATE)(947)" "水,アルコールに可溶｡(947)" "947/" "λmax 217, 274mμ(947)" "947/" "・植物｡ Nerium oleander L.,Apocynaceae(キョウチクトウ科)の葉から抽出,精製して得る｡ (946)" "946/" "強心配糖体｡ (947)" "947/" "・分子量 534.63 Neriantinは Neriantogeninと Glucoseから成るステロイド配糖体｡ (947)" "947/" "ST0421" 12.00 "DL-13-ETHYL-17-HYDROXY-18,19-DI-NOR-17α-PREGN-4-EN-3-ONE; DL-13β,17α-DIETHYL-17β-HYDROXYGON-4-EN-3-ONE" "NORBOLETHONE,WY-3475,GENABOL" "C21H32O2" 21.00 32.00 2.00 0.00 0.00 0.00 316.00 " (REF:948)" "948/" "144-145ﾟC(ALCOHOL)(948)" "948/" "UVmax :241nm(ε=16,500)(948)" "948/" "(±)-13β-alkylgon-4-ene から合成｡ (948)" "948/" "Estrogen-antagonistic, androgen-myotropic, progestational 活性などは, d-enantiomerのみにあり,l-enantiomerには無い｡ enantiomer どうしの相互作用は無い｡ ステロイド及びその関連化合物では, 結局 ""自然""の立体構造を持つものに活性があり,l-enantiomerにはほとんど,又は全く薬理効果は無い｡ (949)" "949/" "・分子量 316.47 (948/949)" "948/949/" "ST0422" 12.00 "17-HYDROXY-19-NORPREGN-4-EN-3-ONE; 17α-ETHYL-19-NORTESTOSTERONE; 17α-ETHYL-17-HYDROXY-19-NORANDROST-4-EN-3-ONE; 17α-ETHYL-17-HYDROXY-4-NORANDROSTEN-3-ONE" "NORETHANDROLONE,NILEVAR,SOLEVAR" "C20H30O2" 20.00 30.00 2.00 0.00 0.00 0.00 302.00 " (REF:937)" "937/" "137-138ﾟC(METHANOL)(937)" "[α]/D=+25ﾟ(METHANOL)(937)" "水に不溶,アルコール,ベンゼン,エーテル,エチルアセテートに可溶｡(937)" "937/" "UVmax :240nm(logΕ=4.22)(937)" "(KBr disk),2.84, 6.06, 6.23, 6.90, 7.38, 7.95, 9.09, 10.06, 11.2μ(937)" "937/" "17-Ethynyl-19-Nortestosteroneを Palladium-on-charcoal catalystの存在下,水素で還元するか,またはestroneの methyl etherを ethynylateする事から出発して合成する｡前者の収率は 73%である｡ (937)" "937/" "Eisenbergと Gorganの lavator ani法によって Anabolic活性を, 精嚢(Seminal vesicle)と腹側前立腺 (Ventral Prostate)の重量増加で Androgenic活性を調べてみたところ, testosterone propionateを基準にすれば, 調べた 17-Alkyl-19-nortesto-steroneの中では, 17-Ethyl-19-Nortestosteroneがその高い Anabolic活性に比べて Androgenic活性が低く (testosterone propionateの 16分の1), 最も臨床応用が可能なように思われた｡ ラットへ経口投与した場合, この化合物は, 17-methyltesto-steroneや 19-Nortestosteroneの少なくとも5倍の Anabolic活性があった｡ 19-Noranalogでない 17-Ethyltestosteroneは,非常に弱い Anabolic agentであった｡(937)" "937/" "・分子量 302.44 (937)" "937/" "ST0423" 12.00 "17-HYDROXY-19-NOR-17α-PREGN-4-EN-20-YN-3-ONE; 19-NOR-17α-ETHYNYLTESTOSTERONE; 17α-ETHYNYL-19-NORTESTOSTERONE; 19-NOR-17α-ETHYNYL-17β-HYDROXY-4-ANDROSTEN-3-ONE; 19-NOR-17α-ETHYNYLANDROSTEN-17β-OL-3-ONE; 17α-ETHYNYL-19-NORTESTOSTERONE." "NORETHINDRONE,NORPREGNENINOLONE,19-NORETHISTERONE,ANHYDROHYDROXYNORPROGESTERONE,""MINI-PILL"", CONLUDAG,MICRONOR,MICRONOVUM,NOR-QD,NORLUTEN,PRIMOLUT N, NORLUTON,NORLUTIN,NORALUTIN." "C20H26O2" 20.00 26.00 2.00 0.00 0.00 0.00 298.00 " (REF:950)" "950/" "203-204ﾟC(ETHYL ACETATE)(950)" "[α]20/D=-31.7ﾟ(CHLOROFORM) FIRST REPORTは,[α]20/D=-25ﾟ(CHLOROFORM)(950)" "950/" "UVmax(ETHANOL) :240nm(logε=4.24)(950)" "νCHCl3/max 1668cm=1と,遊離の水酸基を示すバンド｡(950)" "950/" "ESTRONから容易に得られる 19-NORTESTOSTERONEを出発材料にして, Δ4-ANDROSTENE-3,17-DIONEを用いて 19NOR-17α-ETHYNYLTESTOSTERONEを合成する際の中間体｡ 3-ETHOXY-19-NOR-Δ3,5-ANDROSTADIEN-17-ONEのトルエン溶液をカリウムを溶かしたt-AMYL ALCOHOLへ加え,窒素置換する｡ 室温でアセチレンガスを通し, 14時間撹拌する｡ 水で希釈し, 50%塩酸でPHを１に調節し,揮発性の物質がなくなるまで,アセチレンガスを通す｡ 残査を冷却し, 固形物を集め, ETHYL ACETATEで数回再結晶すると得られる｡ (950)" "950/" "PROGESTINとして経口投与した動物実験で, 17-ETHYNYLTESTOSTERONE と比較して数倍の効果を持つ｡ 同じ効果がヒト女性でも有効である事が臨床試験で確立されてきた｡ (950)" "950/" "分子量 298.41 (950)" "950/" "ST0424" 12.00 "17-HYDROXY-19-NOR-17α-PREGN-5(10)-EN-20-YN-3-ONE; 17α-ETHYNYL-17-HYDROXY-5(10)-ESTREN-3-ONE; 13-METHYL-17-ETHYNYL-17-HYDROXY-1,2,3,4,6,7,8,9,11,12,13,14,16,17-TETRADECAHYDRO-15H-CYCLOPENTA[a]-PHENANTHREN-3-ONE;" "NORETHYNODREL,ENIDREL" "C20H26O2" 20.00 26.00 2.00 0.00 0.00 0.00 298.00 " (REF:951)" "951/" "169-170ﾟC(METHANOL)(951)" "[α]/D=+108ﾟ(1% CHLOROFORM)(951)" "951/" "合成Progestin｡ (951)" "951/" "Progestin作用｡ 妊婦の妊娠維持に投与される｡ (951)" "951/" "分子量 298.41 Norethynodrelは,高い濃度で胎盤を通過している｡ 代謝物まで含めて, 胎児からも抽出される｡ (951)" "951/" "ST0425" 12.00 "17-HYDROXY-19-NOR-17α-PREGNA-5(10),20-DIEN-3-ONE; 17β-HYDROXY-17α-VINYLESTR-5(10)-EN-3-ONE; 17α-VINYL-5(10)-ESTREN-17β-OL-3-ONE" "NORGESTERONE,NORVINODREL,VINYLESTRENOLONE" "C20H28O2" 20.00 28.00 2.00 0.00 0.00 0.00 300.00 " (REF:952/953)" "952/953/" "138-139ﾟC(LIGHT PETROLEUM)(952)" "[α]/D=+161ﾟ(CHLOROFORM)(952)" "952/" "νmax(Nujl) 3400, 1704, 992, 931cm-1(952)" "952/" "17α-Ethynyl-3-Methoxyestra-1,3,5(10),8-tetraen-17β-olの合成から出発して合成する｡ (952)" "952/" "Androgenic活性は無く, estrogenic活性もほとんど無い｡ Progestational 活性があり, claudogenic剤として使用できるかもしれない｡ (953)" "953/" "分子量 300.44 (952)" "952/" "ST0426" 12.00 "13-ETHYL-17-HYDROXY-18,19-DINOR-17α-PREGN-4-EN-20-YN-3-ONE;13β-ETHYL-17α-ETHYNYL-17β-HYDROXYGON-4-EN-3-ONE; 17α-ETHYNYL-18-HOMO-19-NORTESTOSTERONE" "NORGESTREL,OVRETTE" "C21H28O2" 21.00 28.00 2.00 0.00 0.00 0.00 312.00 " (REF:954/948)" "954/948/" "203-206ﾟC(954), 205-207ﾟC(948), (-)-FORM,238-242ﾟC(948), (+)-FORM,239-241ﾟC(948)" "(+)FORM,[α]25/D=-42.5ﾟ(CHCl3)(948) (-)FORM,[α]25/D=+40.7ﾟ(CHCl3)(948)" "954/948/" "UVmax(ETHANOL):241nm(ε=16,700)(948)" "948/" "13β-Ethyl-17α-ethynyl-3-methoxygona-2,5(10)-dien-17β-olか, 13β-ethyl-17α-ethynyl-17α-hydroxygon-5(10)-en-3-oneから合成できる｡ (-)-Formは,(-)-13β-ethyl-3-hydroxygona-1,3,5(10)-trien-17-oneから合成できる｡ (+)-Formは,(+)-13β-ethyl-3-methoxygona-1,3,5(10)-trien-17β-olから合成できる｡ (948)" "948/" "天然において (+)-Formに活性がある事と一致して, (±)又は (+)Formが Progestin活性がある｡ (954)" "954/" "分子量 312.44 (-)-Form,Optical rotatory dispersion測定 (dioxane,C 0.0482, 280) ; [α]/400=-237ﾟ,[α]/362=-707ﾟ, [α]/357=-685ﾟ, [α]/349=-815ﾟ, [α]/335=-262ﾟ, [α]/325=+403ﾟ, [α]/300=+1195ﾟ, [α]/280=+1105ﾟ, [α]/265=+1170ﾟ｡(948)" "948/" "ST0427" 12.00 "17-HYDROXY-19-NOR-17α-PREGNA-4,9,11-TRIEN-20-YN-3-ONE; 17α-ETHYNYL-4,9,11-ESTRATRIEN-17β-OL-3-ONE; 17α-ETHYNYL-17β-HYDROXY-3-OXO-4,9,11-ESTRATRIENE; 17α-ETHYNYL-13β-METHYL-Δ4,9,11-GONATRIENE-17β-OL-3-ONE" "NORGESTRIENONE" "C20H22O2" 20.00 22.00 2.00 0.00 0.00 0.00 294.00 " (REF:955)" "955/" "169ﾟC(DIISOPROPYL ETHER)(955)" "[α]20/D=+63ﾟ(C=0.5 in ALC.)(955)" "アルコール,エーテル,アセトン,ベンゼン,クロロホルムに可溶｡水,希酸水溶液,アルカリには不溶｡(955)" "955/" "UVmax:342,238nm(ε= 29,100, 5,920)(955)" "955/" "Mono oximから合成｡ (955)" "955/" "プロゲスチン活性を示す｡ (955)" "955/" "分子量 294.38 (955)" "955/" "ST0428" 12.00 "17β-HYDROXY-17-METHYLESTR-4-EN-3-ONE; 17α-METHYL-19-NORTESTOSTERONE" "NORMETHANDRONE,METHYLNORTESTOSTERONE,ORGASTERON,METALUTIN,METHALUTIN" "C19H28O2" 19.00 28.00 2.00 0.00 0.00 0.00 288.00 " (REF:950)" "950/" "156-158ﾟC(KOFLER)(950)" "[α]/D=+33ﾟ(BIRCH REDUCTION法で調製) [α]/D=+31ﾟ(3-ETHOXY-19-NOR-Δ3,5-ANDROSTADIEN-17-ONE)から調製｡(950)" "950/" "UVmax(ETHANOL):240nm(logε=4.23)(950)" "νCS2/max 1680cm-1と遊離水酸基のバンド｡(950)" "950/" "3-ETHOXY-19-NOR-Δ3,5-ANDROSTADIEN-17-ONE から, METHYLMAGNESIUM BROMID との 反応と酸水解を経て調製｡ 17-METHYLEST DIOL METHYL ETHER の BIRCH REDUCTION によって調製｡ 大量調製には後者の方法が有効｡ (950)" "950/" "動物での予備実験で,19-NOR-17α-METHYLTESTOSTERONEは,CHICK COMB TESTで 17α-METHYLTESTOSTERONEと同等の ANDROGEN活性がある事が証明された｡ しかし, ラットでの SEMINAL VESICLE WEIGHTの増加に関する限り,少し活性が弱かった｡ (950)" "950/" "分子量 288.41" "ST0429" 12.00 "17β-HYDROXY-17-METHYL-2-OXA-5α-ANDROSTAN-3-ONE; DODECAHYDRO-3-HYDROXY-6-(HYDROXYMETHYL)-3,3a,6-TRIMETHYL-1H-BENZ[E]INDENE-7-ACETIC ACID δ-LACTONE" "OXANDROLONE,ANAVAR,PROVITAR,VASOROME" "C19H30O3" 19.00 30.00 3.00 0.00 0.00 0.00 306.00 " (REF:956)" "956/" "235-238ﾟC(956)" "[α]25/D=-23ﾟ(956)" "956/" "λmax 2.87, 5.79μ(956)" "956/" "1-Androstene-3,17-dione を出発材料として合成する｡ (956)" "956/" "17β-Hydroxy-17α-methylandrostan-3-one よりもAnabolic作用が強い(経口投与, 窒素保持テスト)｡ しかも本質的に Androgenic活性が無い｡経口で利用できる有用な Anabolic剤である｡ (956)" "956/" "分子量 306.43 (956)" "956/" "ST0430" 12.00 "17β-HYDROXY-2-(HYDROXYMETHYLENE)-17-METHYL-5α-ANDROSTAN-3-ONE; 2-HYDROXYMETHYLENE-17α-METHYLDIHYDROTESTOSTERONE; 4,5α-DIHYDRO-2-HYDROXYMETHYLENE-17α-METHYLTESTOSTERONE;2-HYDROXYMETHYLENE-17α-METHYL-17β-HYDROXY-5α-ANDROSTAN-3-ONE; 2-HYDROXYMETHYLENE-17α-METHYLANDROSTAN-17β-OL-3-ONE." "OXYMETHOLONE,ANASTERONE,ADROYD,ANAPOLON,ANADROL,PLENASTRIL," "C21H32O3" 21.00 32.00 3.00 0.00 0.00 0.00 332.00 " (REF:780)" "780/" "178-180ﾟC(ETHYL ACETATE)(780)" "[α]/D=+38ﾟ(780)" "780/" "UVmax:285nm(logε=3.99)(780)" "780/" "2α-Methyltestosteroneから合成できる｡ 収率は 65%｡ (780)" "780/" "Anabolic作用や, 抗腫瘍活性を示すが, 特に経口で用いた場合,Androgenic作用が極力抑えられる強い Anabolic剤である｡ (780)" "780/" "分子量 332.47 The enol acetate,m.p.144-148ﾟ, [α]/D=+27ﾟ(ethanol),λmax 255mμ(logε=4.09), C23H34O4. The enol propionate,m.p.135ﾟ, [α]/D=+26ﾟ(ethanol),λmax 257mμ(logε=4.11), C24H36O4. The enol benzoate,m.p.188-190ﾟ, [α]/D=±0ﾟ, λmax 230mμ（logε=4.19), C28H36O4. (780)" "780/" "ST0431" 12.00 "6α-FLUORO-11β,17,21-TRIHYDROXY-16α-METHYLPREGNA-1,4-DIENE-3,20-DIONE; 6α-FLUORO-16α-METHYLPREDNISOLONE; 16α-METHYL-6α-FLUOROPREDNISOLONE" "PARAMETHASONE,FLUMETHONE,HALDRATE,PARAMEZONE,DILAR,DILLAR,CORTIDEN,ALONDRA,METILAR" "C22H29O5F" 22.00 29.00 5.00 0.00 0.00 0.00 392.00 " (REF:823)" "823/" "21-ACETATE:180ﾟと230-233ﾟC(823)" "21-ACETATE:[α]/D=+85ﾟ(823)" "21-ACETATE:エタノール,アセトンに可溶｡水にもわずかに可溶｡(823)" "823/" "21-ACETATE, UVmax(ETHANOL):243nm(logε=4.16)(823)" "λmax(KBr) 5.80-5.85, 6.03, 6.16, 6.22μ(823)" "823/" "16α-Methylpregnenolone acetateを出発物質として合成する｡ (823)" "823/" "抗炎症活性を示す｡ Hydrocortisoneの活性を１とすれば,60倍の活性を示し, Na保持は無い｡ 臨床応用でも, リューマチ患者で高い治療効果が得られている｡ (823)" "823/" "分子量 392.45 (823)" "823/" "ST0432" 12.00 "(3β,5β)-3-[(6-DEOXY-3-O-METHYL-α-L-GLUCOPYRANOSYL)OXY]-14-HYDROXY-19-OXOCARD-20(22)-ENOLIDE" "PERUVOSIDE,CANNOGENIN α-L-THEVETOSIDE,ENCORDIN" "C30H44O9" 30.00 44.00 9.00 0.00 0.00 0.00 548.00 " (REF:672)" "672/" "161-164ﾟC(METHANOL+ETHER)(672), 160-164ﾟC/210-216ﾟC(METHANOL+ETHER)(957)" "[α]29ﾟ/D=-69.6ﾟ(METHANOL)(957) [α]22/D=-717.7ﾟ(C=1.54 in METHANOL)(672)" "1gが約2500mlの水に溶ける｡ クロロホルムとアセトンにはよく溶けるが, メタノールやエタノールには, 溶けにくい｡" "672/957/" "植物｡ キイロセイヨウキョウチクトウ(Yellow oleander),又は tropical garden plant Thevetia peruviana(Pers.) K.Schum.(Th.neriifolia Juss.),Apocynaceae(trumpet flower in Florida)の種子｡ (957)" "957/" "・心不全に使用｡ Inotropic effect(収縮力を強める変力作用)がある｡ Ouabainと等価の力を持つ｡ 動物実験では, Intropic effectを示す量と不整脈を引き起こす量には, OuabainやProscillaridineよりも幅広い差があった｡ (958)" "958/" "分子量 548.65 (672) ・Kiliani's hydrolysis によって, thevetoseが得られる｡ (957) ・Cannogenine-thevetoside という構造｡ (958)" "672/957/958/" "ST0433" 12.00 "11β,17,21-TRIHYDROXY-16-METHYLENEPREGNA-1,4-DIENE-3,20-DIONE; Δ1,4-PREGNADIENE-16-METHYLENE-11β,17α,21-TRIOL-3,20-DIONE; 16-METHYLENE-11β,17α,21-TRIHYDROXYPREGNA-1,4-DIENE-3,20-DIONE; 16-METHYLENEPREDNISOLONE" "PREDNYLIDENE,DACORTILEN,DECORTILEN,STEROCORT" "C22H28O5" 22.00 28.00 5.00 0.00 0.00 0.00 372.00 " (REF:959)" "959/" "233-235ﾟC(959)" "[α]23/D=+31ﾟ(DIOXANE)(959)" "959/" "UVmax:243nm(ε=15,900)(959)" "959/" "16-Methyl-5,16-Pregnadien-3β-Ol-20-One-Acetate を出発物質として合成する｡ (959)" "959/" "・グルココルチコイド作用を示す｡ (959)" "959/" "分子量 372.44 (959)" "959/" "ST0434" 12.00 "3β-HYDROXYPREGN-5-EN-20-ONE; Δ5-PREGNEN-3β-OL-20-ONE; 17β-(1-KETOETHYL)-Δ5-ANDROSTEN-3β-OL" "PREGNENOLONE,ARTHENOLONE,ENELONE,NATOLONE,PRENOLON,REGNOSONE,SKINOSTELON" "C21H32O2" 21.00 32.00 2.00 0.00 0.00 0.00 316.00 " (REF:960/961/962/963/964/357)" "960/961/962/963/964/357/" "193ﾟC(DIL ALC.)(960/962)" "[α]20/D=+28ﾟ(ALC.) [α]18/D=+30ﾟ±2ﾟ(ALC.)(962)" "水への可溶性は非常に乏しい｡その他の可溶性 g/100ml; 四塩化炭素0.5, 石油ｴｰﾃﾙ0.1, ｴﾁﾙｱｾﾃｰﾄ1.1, ｱｾﾄﾝ0.6, ｸﾛﾛﾎﾙﾑ17.0, ｴﾀﾉｰﾙ1.9, ﾍﾞﾝｾﾞﾝ0.9, ｲｿﾌﾟﾛﾊﾟﾉｰﾙ1.5, ﾌﾟﾛﾋﾟﾚﾝｸﾞﾘｺｰﾙ0.1, ｼﾞｵｷｻﾝ3.1, ﾍﾞﾝｼﾞﾙｱﾙｺｰﾙ8.1" "960/962/" "・STIGMASTEROLから調製｡ (960) ・Δ5,16-PREGNADIENOL-3-ONE-20を還元して調製｡ (962) ・DIOSGENINから調製｡ (963) ・NOLOGENINから調製｡ (357) ・還元剤存在下,21-HALO-Δ5-PREGNEN-3-OL-20-ONEを処理して調製｡ (964)" "960/962/963/357/964/" "・グルココルチコイド作用｡ (357/964)" "357/964/" "分子量 316.47 (960) ・ACETATE(C23H34O3), m.p.146-147ﾟ, [α]/D=+19.9ﾟ(961)" "960/961/" "ST0435" 12.00 "3β-[(6-DEOXY-α-L-MANNOPYRANOSYL)OXY]-14-HYDROXYBUFA-4,20,22-TRIENOLIDE; 14-HYDROXY-3β-(RHAMNOSYLOXY)BUFA-4,20,22-TRIENOLIDE; 3β-RHAMNOSIDO-14β-HYDROXY-Δ4,20,22-BUFATRIENOLIDE" "PROSCILLARIDIN,PROSCILLARIDIN A,DESGLUCOTRANSVAALINE,SCILLARENIN 3β-RHAMNOSIDE,CARADRIN,CARDION,CARMAZON,HERZO, PROSCILLAN,PROSTOSIN,PROSZIN,PROTASIN,PUROSIN-TC,SANDOSCILL, SCILLACRIST,SCILLA DIDIER"",SIMEON,SOLESTRIL,STELLARID,TALUCARD,TALUSIN,URGILAN." "C30H42O8" 30.00 42.00 8.00 0.00 0.00 0.00 530.00 " (REF:965/966/518/967/519)" "965/966/518/967/519/" "219-222ﾟC(METHANOL)(966), 213ﾟC(96-187), 212-214ﾟC(518)" "[α]20/D=-94.2ﾟ±1.5ﾟ(C=1.383 in METHANOL)(518) [α]20/D=-91.5ﾟ(METHANOL)(966) [α]20/D=-82.2ﾟ,-82.9ﾟ(965)" "966/518/965/" "298-300mμ(logε=3.58-3.65)(518)" "[Μ]/D=-489ﾟ(966)" "518/966/" "・植物｡ ・SCILLAREN Aの酸開裂によって調製される｡ (965) ・Strophanthobiaseを用いて,Glucoscillaren Aを酵素的に分解して得られる｡(966) ・Urginea burkei Baker,Liliaceae(ユリ科)から単離｡ (518) ・Scilla maritima L.,Var alba から単離｡ (967)" "965/966/518/967/" "強心薬として利用される｡ LD50(ネコ)=0.157mg/kg.(518)" "518/" "分子量 530.64 酸水解によって Scillaridin Aと Rhamnoseに分かれる｡(965) ・構造の決定｡(519) ・Guinea Pigを用いた薬理｡(968) ・排泄が早いため,他の Glycosidesに比べて利用価値があるかもしれない｡(969/970)" "965/519/968/969/970/" "ST0436" 12.00 "17β-HYDROXY-2-(1-PYRROLIDINYLMETHYL)ANDROST-4-EN-3-ONE; 2-(1-PYRROLIDYL)METHYLTESTOSTERONE" "C24H37O2N" 24.00 37.00 2.00 1.00 0.00 0.00 371.00 " (REF:971)" "971/" "193-195ﾟC(BENZENE)(971)" "[α]20/D=+40ﾟ(C=1.294 in CHLOROFORM)(971)" "971/" "2-Hydroxymethylene-testosteroneを出発物質として合成する｡ (971)" "971/" "分子量 371.54 (971)" "971/" "ST0437" 12.00 "17β-(1-CYCLOPENTEN-1-YLOXY)ANDROSTA-1,4-DIEN-3-ONE; 1-DEHYDROTESTOSTERONE 17-CYCLOPENT-1'-ENYL ETHER" "QUINBOLONE,ANABOLICUM VISTER" "C24H32O2" 24.00 32.00 2.00 0.00 0.00 0.00 352.00 " (REF:972)" "972/" "133-135ﾟC(ETHANOL)(972)" "[α]20/D=+61ﾟ(DIOXANE)(972)" "水に不溶｡多くの有機溶媒に可溶｡エタノール,ヘキサンの溶解性は乏しい｡ゴマ油にも可溶 :40-45mg/ml｡ (972)" "972/" "UVmax : 244-245nm(Ε1%/1cm 430-450) (972)" "972/" "・5α-Androstan-17β-ol-3-one 17-(1'-ethoxy)-cyclopentyl ether を出発物質として合成｡ (972)" "972/" "Anabolic作用を示す｡ Anabolic/Androgenic比は３で,Methyltestosteroneの３倍の活性｡(経口投与) (972)" "972/" "分子量 352.52 (972)" "972/" "ST0438" 12.00 "3-(CYCLOPENTYLOXY)-19-NOR-17α-PREGNA-1,3,5(10)-TRIEN-20-YN-17-OL; 17α-ETHINYLESTRADIOL 3-CYCLOPENTYL ETHER" "QUINESTROL,ESTROVIS" "C25H32O2" 25.00 32.00 2.00 0.00 0.00 0.00 364.00 " (REF:973)" "973/" "107-108ﾟC(973)" "[α]25/D=+5ﾟ(C=0.5 in DIOXANE)(973)" "973/" "・EstronをPotassium acetylide で処理する事によって合成｡ (973)" "973/" "Estrogen作用を示す｡ Oral Uterotrophic Potencyは, Estrone を1とした場合,45の活性を示す｡ (973)" "973/" "分子量 364.51 (973)" "973/" "ST0439" 12.00 "14,15β-EPOXY-3β-HYDROXY-5β-BUFA-20,22-DIENOLIDE; 3β-HYDROXY-14β,15β-EPOXY-5βBUFA-20,22-DIENOLIDE; 3β-HYDROXY-14β,15β-OXIDO-BUFADIEN-(20;22)-OLIDE" "RESIBUFOGENIN,RESPIGON" "C24H32O4" 24.00 32.00 4.00 0.00 0.00 0.00 384.00 " (REF:974/975/976/977/978/979/980/981)" "974/975/976/977/978/979/980/981/" "113-140ﾟC/155-168ﾟC(ACETONE+WATER)(975), 155-160ﾟC(980)" "[α]22/D=-7.1ﾟ(C=1.259 in CHLOROFORM)(975)" "975/" "λmax=300nm(ε=5,600)(980)" " 3440, 3010, 1740-1700, 1625, 1530cm-1(980)" "980/" "・動物｡ ・中国ガマから抽出した漢方薬,""Ch'an Su""から単離｡ (974) ・バーバリガマ(Berber toad, Bufo mauritanicus)から単離｡ (975)" "974/975/" "ジギタリスとは異なり,呼吸刺激作用がある｡ また,強心薬としても作用する(低血圧(50-70mmHg)のイヌで実験)｡強心配糖体は通常, C-14OH基がその役割に重要であると言われているが, Resibufogeninには C-14OH基が無い｡ C-14OH基の存在よりも, C-Dリングの立体配位の方が重要なのかもしれない｡ (981)" "981/" "分子量 384.50 The 3-acetate,m.p.218-203ﾟ,[α]/D=-1ﾟ,λmax=297.5mμ(logε=3.73)(974/975) The hydrochloride,m.p.230ﾟ,[α]/D=+15ﾟ,λmax=298mμ(logε=3.74)(974) ・Resibufogeninは Secondary-tertiary epoxide (976) ・14-Dehydrobufalin を halohydrin へ変換し, basic alumina 又は hot pyridineで処理すると,Resibufogenin が好収率で得られる｡ (979) ・14-ANHYDROBUFALONE の形成から出発して合成｡ The 3-acetate,m.p.217-220ﾟ,IR,3010,1745-1710,1635,1535,1250,1240,1230cm-1,λmax=300nm(ε=5650),Mass,m/e=426(M+).(980)" "974/975/976/979/980/" "ST0440" 12.00 "3β-HYDROXY-14β-15-KETO-BUFADIEN-(20,22)-OLIDE" "ARTEBUFOGENIN A,14α-ARTEBUFOGENIN" "C24H32O4" 24.00 32.00 4.00 0.00 0.00 0.00 384.00 " (REF:974/977/978)" "974/977/978/" "275-283ﾟC(974/977), 255-261ﾟC(978)" "[α]20/D=+29ﾟ(974/977) [α]18/D=+27.4ﾟ±3ﾟ(C=0.911,CHCl3)(978)" "974/977/978/" "・動物｡ ・中国ガマ(Bufo bufo gargarizans)から調製した漢方薬, ""Ch'an Su""から単離される｡ (974/982)" "974/982/" "強心剤｡ (982)" "982/" "分子量 384.50 The 3-acetate,m.p.145-170ﾟ/219-221ﾟ,[α]20/D=+35.2ﾟ±2ﾟ(C=1.016,CHCl3), C26H34O5, 分子量 426.53(977/978) ・RESIBUFOGENINをHClO4処理して合成できる｡ (978) ・RESIBUFOGENINを 14-DEHYDROBUFALIN から合成する途中で,basic alumina 処理の時に形成されるepoxide から合成された｡ (979)" "977/978/979/" "ST0441" 12.00 "3β,5β-DIHYDROXY-14β,15β-OXIDO-BUFADIEN-OLIDE" "MARINOBUFAGIN" "C24H32O5" 24.00 32.00 5.00 0.00 0.00 0.00 400.00 " (REF:975/976/982)" "975/976/982/" "212-213ﾟC(975)" "[α]/D=+11ﾟ(975)" "975/" "・動物｡ ・南アメリカガマや,Bufo marinus から単離｡ (982)" "982/" "強心剤｡ (982)" "982/" "分子量 400.50 (976) ・Resibufogenin との違いは,5β-OH基がある事だけである｡ (982) ・The 3-acetate,m.p.203-204ﾟ,[α]/D=+26ﾟ (975)" "976/982/975/" "ST0442" 12.00 "3β-HYDROXY-14α-14-KETO-BUFADIEN-(20,22)-OLIDE" "ARTEBUFOGENIN B,14β-ARTEBUFOGENIN" "C24H32O4" 24.00 32.00 4.00 0.00 0.00 0.00 384.00 " (REF:974/977/978)" "974/977/978/" "235ﾟC(3-ACETATEとして)(977)" "[α]/D=-63ﾟ(977)" "977/" "・動物｡ ・中国ガマ(Bufo bufo gargarizans)から抽出した漢方薬, ""Ch'an Su""から単離される｡ (974/982)" "974/982/" "強心剤｡ (982)" "982/" "分子量 384.50 (amorphous) The 3-acetate,m.p.235ﾟ,[α]/D=-63ﾟ Resibufogenin を HClO4 処理して14α-Artebufogenin(Artebufogenin A)を得,これを Al2O3で処理して調製できる｡ (978)" "978/" "ST0443" 12.00 "1α,4α-EPOXY-3-AZA-A-HOMOANDROSTAN-16β-OL" "SAMANDARINE" "C19H31ON" 19.00 31.00 2.00 1.00 0.00 0.00 305.00 " (REF:983/984)" "983/984/" "187-188ﾟC(ABS METHANOL or 50% ACETONE)(984)" "[α]17/D=+43.3ﾟ(ACETONE)(984)" "たいていの有機溶媒に溶ける｡ 水,水酸化ナトリウムには不溶｡(983/984)" "983/984/" "動物。 European Fire salamander(Salamandra maculosa)や Alpine salamander(Salamandra atra)などの Salamandridae(サンショウウオ)の皮腺から単離される。(983)" "983/" "分子量 305.45 立体構造(984)" "984/" "ST0444" 12.00 "SCILLAREN A,GLUCOPROSCILLARIDIN A,TRANSVAALIN" "C36H52O13" 36.00 52.00 13.00 0.00 0.00 0.00 692.00 " (REF:965/985/986/987/988/989/990/991/993/518/994)" "965/985/〜 991/993/518/994/" "PRISMS 184-186ﾟ,LEAFLETS 208-211ﾟC(METHANOL)(518)" "[α]20/D=-73.8ﾟ(75%ALC.) [α]23/D=-71.9ﾟ(C=1.011 in METHANOL)(988)" "アルコール,メタノールに可溶｡クロロホルム,エーテルには不溶｡ 水への可溶性も乏しい｡(988)" "518/988/" "λmax 300mμ(logε=3.74),λmax 299mμ(logε=3.74)(994)" "1720cm-1(5.81μ)(C=O),1639cm-1(6.10μ),1603cm-1(6.24μ)(C=C) (994)" "994/" "植物。 新鮮な squill(カイソウ), Urginea(Scilla)maritima(L.)Baker,Liliaceae(ユリ科)から単離される。(965/985/994)" "965/985/994/" "強心配糖体。LD50(ネコ) 0.1670±0.0095mg/kg(518)" "518/" "分子量 692.78 aglicon-rhamnoso-glucoseから成る配糖体｡ Scillarenase(in squill)又は,Strophanthobiaseで加水分解し, 更に酸水解すると, agliconはΔ3,5-dienic scillaridin Aとなる｡(965/994)" "965/994/" "ST0445" 12.00 "SCILLARIDIN A" "C25H32O3" 25.00 32.00 3.00 0.00 0.00 0.00 380.00 " (REF:965/994)" "965/994/" "245-250ﾟC(986)" "[α]20/D=-62.7ﾟ(CHCl3)(986)" "986/" "植物。新鮮な squill(カイソウ), Urginea(Scilla)maritima(L.)Baker,Liliaceae(ユリ科)から単離されるScillaren A の酸加水分解によって得られるAglycon｡(965/994)" "965/994/" "強心剤。(965)" "965/" "ST0446" 12.00 "α-SOLANINE,α-SOLATUNINE" "C45H73O15N" 45.00 73.00 15.00 1.00 0.00 0.00 867.00 " (REF:524/995/996)" "524/995/996/" "286ﾟC(995)" "[α]20/D=-59ﾟ(Pyridine)(995)" "hot alcoholに可溶｡水(25mg/l at pH6.0),エーテル,クロロホルムには不溶｡(995)" "995/" "植物。 各種の Solanum種 (ナス, ジャガイモ), 特に S,tuberosum L.(potato), S.nigrum L.(woody nightshade), Lycopersicon esculentum Mill., Solanaceae(tomato)などから単離される｡(524)" "524/" "Solanineは,ニワトリ胚（卵黄嚢注入),マウス,ラット,ウサギ(以上,非経口投与)では非常に毒性が強いが,経口投与ではマウスで 1g/kg 投与しても毒性は出ない｡ Aglycon の Solanidineは, Solanine よりはるかに毒性は少ない。Solanine中毒での死亡は,中枢神経系の機能低下による。(997)" "997/" "分子量 868.04 主要な Solanineはα-Solanineで, 他に β-Solanine,α,β,γ-Chaconineがある｡ Solanidine+Galactose+Glucose+Rhamnoseから成る｡(995/996)" "995/996/" "ST0447" 12.00 "(22R,25R)-SPIRO-5-EN-3β-YL O-6-DEOXY-α-L-MANNOPYRANOSYL(1→2)-β-D-GLUCOPYRANOSYL-(1→3)-β-D-GALACTOPYRANOSIDE" "SOLASONINE,SOLANINE-S,PURAPURINE" "C45H73O16N" 45.00 73.00 16.00 1.00 0.00 0.00 883.00 " (REF:998/999/1000)" "998/999/1000/" "301-303ﾟC(1000),284-285ﾟC(998)" "[α]25/D=-68.7ﾟ(C=0.2320 in alcohol) (998) [α]23/D=-88ﾟ(C=1.01 in pyridine) [α]22/D=-74.5ﾟ(C=0.51 in methanol)(1000)" "hotアルコール,hotジオキサンに可溶｡Hot water,希酢酸にわずかに溶け,クロロホルム,エーテルには不溶｡(998)" "998/1000/" "植物。 ・Maorinameで""Poro-poro""と呼ばれる Solanum aviculare Forst F.や S.Sodomeum L., S.xanthocarpum Schrad & Wendl., Solanaceaeなどの種子, 実から抽出される｡(998/999/1000) ・S.laciniatum Ait.,S.nodiflorum Jacq.,S.miniatum Bernh., S.nigrum L., S.gracile Otto, S.douglasii Dum., S.aviculare Forstなどの実から抽出｡ (1001/1002)" "998/999/1000/1001/1002/" "分子量 884.04 α-Solanineは Solasodin+Galactose+Glucose+Rhamnoseから成る｡(1000) ・Paperchromatography, Solasonine 0.55 Rf, Solamargin 0.73 Rf, Solasodin 0.90-0.95Rf｡ (1003) ・Solasonine の糖部分 ; Solatriose, O-α-L-rhamno-Pyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→3)]-β-D-galactopyranose｡ (1004)" "1000/1003/1004/" "ST0448" 12.00 "17β-HYDROXY-5α-ANDROSTAN-3-ONE; 17β-HYDROXY-3-ANDROSTANONE; 3-OXO-17β-HYDROXYANDROSTANE; ANDROSTAN-17β-OL-3-ONE; 4-DIHYDROTESTOSTERONE" "STANOLONE,ANABOLEEN,ANABOLEX,ANAPROTIN,ANDROLONE,CRISTERONA MB,NEODROL,PROTEINA,STANAPROL." "C19H30O2" 19.00 30.00 2.00 0.00 0.00 0.00 290.00 " (REF:1005/1006/1007/1008)" "1005/1006/1007/1008/" "181.5-182.5ﾟC(1006),179-180ﾟC(1007)" "[α]20/D=+32.4ﾟ(alcohol)(1005)" "アセトン,エーテル,アルコール,エチルアセテートに可溶｡ 水には不溶｡(1005)" "1006/1007/1005/" "9.5μにより近いband.(1008)" "1008/" "・Testosterone の水素化によって調製.(1005)・Dehydroepiandrosteroneから調製｡ (1006/1007)" "1005/1006/1007/" "Androgen 作用を示す｡ (1007)" "1007/" "分子量 290.43 (1006)" "1006/" "ST0449" 12.00 "17-METHYL-2H-5α-ANDROST-2-ENO[3,2-C]PYRAZOL-17β-OL;1,2,3,3A,3B,4,5,5A,6,8,10,10A,10B,11,12,12A-HEXADECAHYDRO-1,10A,12A-TRIMETHYLCYCLOPENTA[7,8]-PHENANTHRO[2,3-C]PYRAZOL-1-OL;17β-HYDROXY-17α-METHYLANDROSTANO[3,2-C]PYRAZOLE" "STANOZOLOL,ANDROSTANAZOLE,STANAZOL,WINSTROL,STROMBA,STANOZOL,TEVABOLIN" "C21H32ON2" 21.00 32.00 1.00 2.00 0.00 0.00 328.00 " (REF:1009/1010)" "1009/1010/" "229.8-242.0ﾟC(alc.)(1009)" "[α]/D=+35.7ﾟ(chloroform) [α]/D=+48.6ﾟ(methanol)(1009)" "1009/" "UVmax 223nm(ε=4740)(1009)" "1009/" "17α-METHYLANDROSTAN-17β-OL-3-ONEを ETHYL FORMATEと SODIUM METHOXIDEで処理し, 得られる 2-HYDROXY-METHYLENE DERIVATIVEを HYDRAZINEと縮合させて調製する｡(1009)" "1009/" "ESTROGENIC活性(VAGINAL CORNIFICATION)以外は, ANDROGENIC活性(VENTRAL PROSTATE GROWTH),MYOTROPHIC活性(LEVATOR ANI GROWTH),ANABOLIC活性(NITROGEN RETENTION)はいづれも観察される。 経口投与の場合, ANABOLIC AGENTとしては, METHYLTESTOSTERONEの35倍活性がある。一方,ANDROGENIC AGENTとしては METHYLTESTOSTERONEの4分の1の活性しか無い｡投与量を増やしても,ラットやウサギで PROGESTIN活性は見られない。(1009)" "1009/" "分子量 328.48 (1009/1010)" "1009/1010/" "ST0450" 12.00 "17β-HYDROXY-2-METHYL-5α-ANDROST-1-EN-3-ONE; 2-METHYL-5α-ANDROST-1-EN-17β-OL-3-ONE; 2-METHYL-17β-HYDROXY-5α-ANDROST-1-EN-3-ONE;Δ1-2-METHYLANDROSTEN-17β-OL-3-ONE" "STENBOLONE,STENBOLONE(RESCINDED USAN)" "C20H30O2" 20.00 30.00 2.00 0.00 0.00 0.00 302.00 " (REF:1011/1012)" "1011/1012/" "155-158ﾟC(acetone+hexane)(1011)" "[α]/D=+52ﾟ(chloroform) [α]26/D=+47ﾟ(chloroform)(1011)" "ヘキサン,ベンゼンに可溶｡(1011)" "1011/" "UVmax(95% ethanol):241nm(logε=3.99)(1011)" "λmax(KBr) 5.99μ(1011)" "1011/" "2α-METHYLANDROSTAN-17β-OL-3-ONEを酢酸中で BROMINEと反応させる事から出発して合成。(1011/1012)" "1011/1012/" "TESTOSTERONE PROPIONATE の ANDROGENIC 及び MYOTROPHIC POTENCYをそれぞれ100とすれば, 50, 50 の値を示す。(1012)" "1012/" "分子量 302.44 (1011)" "1011/" "ST0451" 12.00 "3β,5,14-TRIHYDROXY-19-OXO-5β-CARD-20(22)-ENOLIDE" "STROPHANTHIDIN/APOCYNAMARIN/CONVALLATOXIGENIN/CORCHORIN/CYMARIGENIN/CYNOTOXIN/CORCHORGENIN/CORCHSULARIN" "C23H32O6" 23.00 32.00 6.00 0.00 0.00 0.00 404.00 " (REF:1013/1014/1015/1016/1017/1018/1019/1020/1021)" "1013/〜 1021/" "171-175ﾟC(1013)" "[α]25/D=+43.1ﾟ(C=2.8 in methanol)(1013)" "アルコール,アセトン,クロロホルム,ベンゼン,氷酢酸に可溶｡水,エーテル,石油エーテルには不溶｡(1013)" "1013/" "λmax 303mμ(logε=1.5,Carbonyl基)(1021)" "1021/" "植物。 ・数種の Strophnthus,Apocynaceaeから抽出される。(1013) ・谷間ユリ(Convallaria majalis)の葉や花から,Convallatoxinの Aglyconとして,また,ニオイアラセイトウ(Cheiranthus cheiri)のCheirotoxinの Aglyconeとして。(1021)" "1013/1021/" "強心剤。(1014)" "1014/" "分子量 404.49 Apocynum cannabinumから得られるCymarigeninと同一の化合物｡ The Benzoate, [α]26/D=+47.8ﾟ(C=1.067 in acetone), C30H36O7. The p-Bromobenzoate, [α]20/D=+42.0ﾟ(C=1.094 in acetone) m.p.222-224ﾟ, C30H35O7Br. The Oxime, [α]23/D=+74.3ﾟ(C=1.009ﾟ in pyridine), m.p.270-275ﾟ, C23H33O6N. The Phenylhydrazone, [α]20/D=-5.0(C=1.000 in CHCl3) m.p.230-232ﾟ, C29H38O5N2. The p-Bromophenylhydrazone, [α]25.5/D=+105.5ﾟ(c=1.004 in CHCl3), m.p.180-185ﾟ(1013) ・Corchorin,Corchorgenin,Corchsularinと同一化合物。(1017) ・総説 (1018/1019) ・k-Strophanthosideを塩酸水解して得られる Aglycone。(1020/1021)" "1013/1017/1019/1021/" "ST0452" 12.00 "3β-[(2-O-ACETYL-6-DEOXY-3-O-METHYL-α-L-GLUCOPYRANOSYL)OXY]-7β,8-EPOXY-14-HYDROXY-5β-CARD-20(22)-ENOLIDE" "TANGHININ" "C32H46O10" 32.00 46.00 10.00 0.00 0.00 0.00 590.00 " (REF:1022/1023/561/1024)" "1022/1023/561/1024/" "123-131ﾟC(methanol+ether)(561)" "[α]/D=-67ﾟ(1022) [α]21/D=-81.5ﾟ(C=1.092 in methanol)(561)" "メタノールに可溶｡" "561/1022/" "植物。 ・Tanghinia madagascariensis Pet., Apocynaceae と Tanghinia venenifera Poir., Apocynaceae の種子から抽出。(1022/1023)" "1022/1023/" "強心配糖体。 LD50(ネコ)=0.3524±0.0389mg/kg。 Aglycone の Tanghinigenin は 1.016±0.0876mg/kg。(561)" "561/" "分子量 590.69 Acetyl-tanghinin, Desacetyl-tanghinin から調製した場合, m.p.189-191ﾟ, [α]21/D=-76.7ﾟ±2ﾟ(c=1.303 in CHCl3), [α]20/D=-88.4ﾟ±2ﾟ(c=0.8706 in Alcohol)｡ Tanghinin から調製した場合,m.p.189-191ﾟ,[α]20/D=-76.1ﾟ±2ﾟ" "561/" "ST0453" 12.00 "D-HOMO-17A-OXAANDROSTA-1,4-DIENE-3,17-DIONE;13-HYDROXY-3-OXO-13,17-SECOANDROSTA-1,4-DIEN-17-OIC ACID δ-LACTONE; 1,2,3,4,4A,4B,7,9,10,10A-DECAHYDRO-2-HYDROXY-2,4B-DIMETHYL-7-OXO-1-PHENANTHRENEPROPIONIC ACID δ-LACTONE;備考へ" "TESTOLACTONE,FLUDESTRIN,TESLAC" "C19H24O3" 19.00 24.00 3.00 0.00 0.00 0.00 300.00 " (REF:1025/1026)" "1025/1026/" "218-219ﾟC(acetone)(1025)" "[α]23/D=-45.6ﾟ(C=1.242 in chloroform)(1025)" "1025/" "UVmax(ethanol) 242nm(ε=15,800)(1025)" "λmax(Nujol) 5.83μ(lactone carbonyl), 6.01, 6.15, 6.22μ(Δ1,4-3-ketone) (1025)" "1025/" "カビの一種であるAspergillus tamarii によって, Progesterone,Reichstein's Substance S,testosterone から合成される。(1026) ・Cylindrocarpon radicola によって,Progesterone,Reichstein's Substance S,testosterone から合成される。(1025)" "1025/1026/" "Experimental antineoplastic として利用される。(1025)" "1025/" "分子量 300.38 The semicarbazone,m.p.250-260ﾟ(dec.),C20H27N3O3,λmax(alc.)244mμ(ε=12,200),297mμ(ε=22,600,Δ1,4-3-semicarbazones に特徴的)。(1025)" "1025/" "ST0454" 12.00 "17β-(2,2,2-TRICHLORO-1-HYDROXYETHOXY)ANDROST-4-EN-3-ONE;17β-(1-HYDROXY-2,2,2-TRICHLOROETHOXY)ANDROST-4-EN-3-ONE" "TESTOSTERONE 17-CHLORAL HEMIACETAL/TESTOSTERONE 17-HEMIACETAL WITH CHLORAL/CAPROSEM." "C21H29O3Cl3" 21.00 29.00 3.00 0.00 0.00 0.00 434.00 " (REF:1027)" "1027/" "200-201ﾟC(ethyl acetate)(1027)" "1027/" "UVmax(ethanol) 241nm(ε=16,300)(1027)" "1027/" "無水ベンゼン中で Testosterone を chloralの溶液に加え,２〜３分振盪してクリアーな溶液にする。もう数分振盪を続けると,固形の沈殿が形成される。沈殿を濾過して集め,ベンゼンで洗い,室温で乾燥すると, hemiacetal を得る。M.p.194-196ﾟC。 酢酸エチルから結晶させて, m.p.200-201ﾟC の hemiacetal が得られる。(1027)" "1027/" "Testosterone の 17-OH基を methoxy基へ変える事によって, Androgenic活性が大いに増加する｡ Testosterone 17-Chloral Hemiacetal をラットで調べると, Testosterone propionate よりも4〜5倍活性が高い。 これを acetateにすると,Testosteronepropionateの半分の活性になってしまう。(1027)" "1027/" "分子量 435.83　(1027)" "1027/" "ST0455" 12.00 "17β-(3-CYCLOPENTYL-1-OXOPROPOXY)ANDROST-4-EN-3-ONE" "TESTOSTERONE 17β-CYPIONATE,DEPO-TESTOSTERONE" "C27H40O3" 27.00 40.00 3.00 0.00 0.00 0.00 412.00 " (REF:1028/1029)" "1028/1029/" "101-102ﾟC(1028)" "[α]25/D=+87ﾟ(CHCl3)(1028)" "オイルに可溶｡(1028)" "1028/" "・β-Cyclopentylpropionateを acid chlorideへ変換し, testosterone と反応させる事によって合成する。(1028)" "1028/" "強い Androgen活性を示す。去勢ラットでtestosterone propionate, testosterone と比較すると,より強く,より長い効果を持つ｡ Seminal vesicle weightで見ると,testosterone,testosterone propionateとも10日前後で200mgほどで maximumに達し" "1028/1029/" "分子量 412.59 (1028)" "1028/" "ST0456" 12.00 "17β-[(PHENYLACETYL)OXY]ANDROST-4-EN-3-ONE" "TESTOSTERONE 17-PHENYLACETATE,PERANDREN PHENYLACETATE" "C27H34O3" 27.00 34.00 3.00 0.00 0.00 0.00 406.00 " (REF:1030/1031)" "1030/1031/" "129-131ﾟC(1030), 126.5-127.5ﾟC(1031)" "[α]25/D=+80.0ﾟ(dioxane)(1031)" "1030/1031/" "PYRIDINE中で TESTOSTERONEと PHENYLACETYL CHLORIDEとを反応させて合成。(1030)" "1030/" "Androgen作用を示す。(1030/1031)" "1030/1031/" "分子量 406.54 (1030)" "1030/" "ST0457" 12.00 "Δ4-ANDROSTENE-17β-PROPIONATE-3-ONE" "TESTOSTERONE PROPIONATE" "C22H32O3" 22.00 32.00 3.00 0.00 0.00 0.00 344.00 " (REF:1032)" "1032/" "118-122ﾟC(alcohol+water), oxim;177-183ﾟC(methanol)" "[α]25/D=+83ﾟto 90ﾟ(100mg in 10ml dioxane)(1032)" "水に不溶｡アルコール,エーテル,ピリジン,その他の有機溶媒,ベジタブルオイルに可溶｡ (1032)" "1032/" "Δ4-ANDROSTEN-17-OL PROPIONATEとCrO3から合成。また,微生物によって ANDROSTENEDIOL PROPIONATEから合成。(1032)" "1032/" "Androgen作用を示す。(1032)" "1032/" "分子量 344.48 (1032)" "1032/" "ST0458" 12.00 "THEVETIN A" "C42H64O19" 42.00 64.00 19.00 0.00 0.00 0.00 872.00 " (REF:672)" "672/" "208-210ﾟC(water)(672)" "[α]24/D=-72.0ﾟ±1.5ﾟ(C=1.48 in methanol)(672)" "672/" "・植物。THEVETIA NERIIFOLIA JUSS.(Apocynaceae)の種子から単離される。又,CERBERA ODOLLAMの種からも得られる。(672)" "672/" "強心配糖体。(672)" "672/" "分子量 872.93 The Acetate, m.p.142-149ﾟ, [α]/D=-54.2(in CHCl3)(672)" "672/" "ST0459" 12.00 "5α-TOMATIDAN-3β-OL; 5α,20βF,22αF,25βF,27-AZASPIROSTAN-3β-OL" "TOMATIDINE" "C27H45ON" 27.00 45.00 2.00 1.00 0.00 0.00 415.00 " (REF:1033/1034/1035/1036/1037/1038/1039/1040/538)" "1033/〜1040/538/" "202-206ﾟC(ethyl acetate)(1040)" "[α]25/D=+8ﾟ(chloroform)(1040)" "1040/" "10.0, 10.25, 10.4, 11.1, 11.5μ(AZAOXASPIRANEBANDS)(1040)" "1040/" "・植物。 Rutgers tomato plant [Lycopersicon esculentum Mill., cultivar.""Rutgers""]の根｡(1033/1034)" "1033/1034/" "抗菌作用を持って TOMATINEの NITROGENOUS AGLYCON｡(1034/1035)" "1034/1035/" "分子量 415.64 THE HYDROCHLORIDE,m.p.275-280ﾟC(dec.), [α]25/D=-8.8ﾟ±2.1ﾟ(c=0.455 in methanol)(1033) ・TOMATINEはTOMATIDINEとXYLOSE,GALACTOSE,2つのGLUCOSEから成る。(1033) ・DIHYDRO-TOMATIDINEから調製｡(1038) ・NEOTIGOGENINから合成｡(1039/1040) ・TOMATID-5-ENE-3β-OL の合成｡(538)" "1033/1038/1039/1040/538/" "ST0460" 12.00 "3β-HYDROXY-16,28-SECOSOLANIDA-5,22(28)-DIEN-24-ONE" "TOMATILLIDINE" "C27H41O2N" 27.00 41.00 2.00 1.00 0.00 0.00 411.00 " (REF:1041/1042)" "1041/1042/" "219-222ﾟC(methylene chloride + hexane)(1041/1042)" "[α]/D=-18.1ﾟ(chloroform)(1042)" "1041/1042/" "λmax(KBr) 5.98μ(C=N and CO)(1042)" "t-CH3,0.64ppm; t-and sec-CH3,0.96ppm; sec-CH3,1.08ppm; one olefinic proton,5.35ppm; teo sec-CH3,0.90(J=5cps)and 1.12ppm(J=6cps); and one olefinic proton,5.35ppm(1042)" "m/e=140(1042)" "O.R.D.inMeOH(C 0.12)[α]/290=+366ﾟ,[α]/240=-666ﾟ;in dioxane(C 0.19),[α]/405=-48ﾟ,[α]/392=-15ﾟ,[α]/378=-48ﾟ[α]/360=-3ﾟ,[α]/369=-18ﾟ,[α]/352=+42ﾟ,[α]/348=+33ﾟ,[α]/298=+446ﾟ(1042)" "1042/" "・植物。 Solanum tomatillo Phil., Solanaceaeから抽出｡ (1041)" "1041/" "分子量 411.61, (1042)" "1042/" "ST0461" 12.00 "TOMATINE,LYCOPERSICIN" "C50H83O21N" 50.00 83.00 21.00 1.00 0.00 0.00 1033.00 " (REF:1043/1044/1045/1046/1047/1048/1049/1033)" "1043/1044/1045/1046/1047/1048/1049/1033/" "263-268ﾟC(methanol)(1045)" "[α]20/D=-18ﾟ(C=0.55 in pyridine)(1045)" "エタノール,メタノール,ジオキサン,プロピレングリコールに可溶｡ 水,エーテル,石油エーテルに不溶,塩酸塩は水に可溶｡(1043)" "1045/1043/" "・植物。 LYCOPERSICUM ESCULENTUM VAR.PRUNIFORMEなど,wild tomato plantsの葉から抽出｡ (1043/1044/1033/1045/1046/1047)" "1043/1044/1033/1045/1046/1047/" "抗生剤。植物や動物の病原菌には効果があるが,大腸菌にはほとんど全く効果が無く(1mg/ml), S.aureusではほんのわずかしか効果は無い｡ (1043)" "1043/" "分子量 1034.22 (1045) ・強アルカリ中では安定｡ IN塩酸中でボイルすると,容易に加水分解されて不溶性の結晶,TOMATIDINEHYDROCHLORIDEを産し,還元糖に富んだ透明な上清が残る｡(1043) ・TOMATINEを加水分解すると, 2モルのGLUCOSE, 1モルのGALACTOSE, 1モルのXYLOSEが得られる｡(1033) ・TOMATINEにはα,β1,β2,γ,δがあり,α型だけが糖鎖が完全で,他は糖の一部が欠けていたり置換されたりしている｡(1046) ・α-TOMATINEは 1モルの TOMATIDINEに 2モルの D-GLUCOSE, 1モルの D-XYLOSEと 1モルの D-GALACTOSEからなる4糖が結合している｡(1047/1048) ・DIGITONINに代わる STEROIDSの PRECIPITANT｡(1049)" "1043/1033/1046/1047/1048/1049/" "ST0462" 12.00 "17β-HYDROXYESTRA-4,9,11-TRIEN-3-ONE; 4,9,11-ESTRATRIEN-17β-OL-3-ONE; 17β-HYDROXY-19-NORANDROSTA-4,9,11-TRIEN-3-ONE;19-NORANDROSTA-4,9,11-TRIEN-17β-OL-3-ONE" "TRENBOLONE,TRIENBOLONE,TRIENOLONE" "C18H22O2" 18.00 22.00 2.00 0.00 0.00 0.00 270.00 " (REF:1050/1051)" "1050/1051/" "180-184ﾟC(1051), 183〜186ﾟC(acetone-water)という報告もある)(1050)" "[α]20/D=-19ﾟ(C=0.45 in ethanol)(1050)" "1050/1051/" "λmax 238mμ(ε=6070), 341.5mμ(ε=27,900)(1051)" "1051/" "・3-CHLORO-4,5-SECO-5-OXO-17-BENZOXY-19-NOR-ANDROSTA-2,9-DIENから合成する｡(1050) ・17β-HYDROXYESTRA-5(10),9(11)-DIEN-3-ONEを DIOXANE中で 2,3-DICHLORO-5,6-DICYANO-P-BENZO-QUINONEと反応させ, 室温に放置し, 沈殿を濾過して DIOXANEで2回洗い,エバポレートする｡ 黒い残渣をMETHYLENE CHLORIDEとETHERに溶かし,MAGNESOLで濾過する。黄色い溶出液をMETHYLENE CHLORIDEに溶かし,同量のMAGNESOLに吸着させる｡ METHYLENE CHLORIDE溶出液は無色で得られる｡エバポレートして結晶の固形物を得て,これを ACETON-WATERで結晶化させる｡(1051)" "1051/" "窒素保持効果で見ると, Anabolic steroidとして高い活性を示す｡ 17-ketosteroidsや 17-hydroxycorticosteroidsは減少させない｡ また,血液凝固因子を増加させる事も無い(特に V, VII, X因子及び Prothrombin)｡(1052)" "1052/" "分子量 270.38 (1051) ・TRIENBOLON ACETATEの雌牛での効果｡ (1053)" "1051/1053/" "ST0463" 12.00 "9-FLUORO-11β,16α,17,21-TETRAHYDROXYPREGNA-1,4-DIENE-3,20-DIONE;Δ1-9α-FLUORO-16α-HYDROXYHYDROCORTISONE;9α-FLUORO-16α-HYDROXY-PREDNISOLONE;Δ1-16α-HYDROXY-9α-FLUOROHYDROCORTISONE;16α-HYDROXY-9α-FLUOROPREDNISOLONE" "TRIAMCINOLONE,CL 19823,ADCORTYL,ARISTOCORT" "C21H27O6F" 21.00 27.00 6.00 0.00 0.00 0.00 394.00 " (REF:1054/1055/1056)" "1054/1055/1056/" "260-262.5ﾟC(dec.事前に軟化,褐色になる)(1054/1055)" "[α]25/D=+75ﾟ(C=0.200,acetone)(1054/1055)" "1054/1055/" "UVmax 238nm(ε=15,800)(1054/1055)" "νmax 3388, 1705, 1660, 1620, 1604cm-1(1054/1055)" "1054/1055/" " BENZENEと PYRIDINE中で, 21-ACETOXY-4,9(11),16-PREGNATRIENE-3,20-DIONE(I)を OSMIUN TETROXIDE と反応させる事から出発し, 9α-FLUORO-11β,16α,17α,21-TETRAHYDROXY-4-PEGNENE-3,20-DIONEを得, これを微生物(CORNYEBACTERIUM SIMPLEX)によって水素添加させ, 16α,21-DIACETOXY-9α-FLUORO-11β,17α-DIHYDROXY-1,4-PREGNADIENE-3,20-DIONE としてこれをケン化して調製する｡ (1054) また,16α,21-DIACETOXY-9α-FLUORO-11β,17α-DIHYDROXY-4-PREGNENE-3,20-DIONEを, C.SIMPLEXか, NOCARDIA CORALLINA で微生物的に脱水素し, アセチル化して 16α,21-DIACETOXY-9α-FLUORO-11β,17α-DIHYDROXY-1,4-PREGNADIENE-3,20-DIONEを得る｡ これをケン化して調製する｡ (1055) ・STREPTOMYCES ROSEOCHROMOGENUSによる 16α-HYDROXYLATIONによる調製｡(1056)" "1054/1055/1056/" "・DIACETATEとともに,強いグルココルチコイド作用を示し,ナトリウムを保持する活性は無い｡ RAT LIVER GLYCOGEN ASSAY(SUBCUTANEOUS METHODS)で調べた場合, FREE型はHYDROCORTISONEの 13倍, THE DIACETATEは 15-36倍の活性を示した｡(1054) ・抗炎症作用を示す｡ナトリウム保持能が無いのは, 16α-HYDROXYL基の存在による｡(1057)" "1054/1057/" "分子量 394.45 (1054)" "1054/" "ST0464" 12.00 "9-FLUORO-11β,21-DIHYDROXY-16α,17-[1-METHYLETHYLIDEN-EBIS(OXY)]PREGNA-1,4-DIENE-3,20-DIONE;9α-FLUORO-11β,16α,17,21-TETRAHYDROXYPREGNA-1,4-DIENE-3,20-DIONE CYCLIC 16,17-ACETAL WITH ACETONE;※備考へ続く" "TRIAMCINOLONE ACETONIDE" "C24H31O6F" 24.00 31.00 6.00 0.00 0.00 0.00 434.00 " (REF:1058)" "1058/" "292-294ﾟC(1058)" "[α]25/D=+112ﾟ(C=0.537)(1055),[α]23/D=+109ﾟ(C=0.75 in chloroform)(1058)" "メタノール,アセトン,エチルアセテートへの溶解性は乏しい｡(1058)" "1055/1058/" "UVmax(無水アルコール): 238-239nm(ε=14,600)(1055)" "νmax 3470, 1724, 1677, 1630, 1623(inflection)cm-1(1055)" "1055/" "・微量の過塩素酸存在下, TRIAMCINOLONEをアセトン中で懸濁して撹拌する事によって調製｡ ・2,3-DIBROMO-5,6-DICYANOQUINONEを用いた別の合成法｡" "1055/1058/" "ヒトでグルココルチコイドとして作用｡ 家畜で, コルチステロイドとして作用｡抗炎症作用｡ これらの作用は, TRIAMCINOLONEよりかなり強い｡ 肝グリコーゲン 抗炎症作用 9α-FLUORO-16α-HYDROXYPREDNISOLONE 14(9-22) 4 9α-FLUORO-16α-HYDROXYCORTISOL 11(7-19) 1 TRIAMCINOLONE ACETONIDE 92(48-176) 40 CORTISOL ACETATE 1 1" "1058/" "分子量 434.49 (1058)" "1058/" "ST0465" 12.00 "9-FLUORO-11β,16α,17,21-TETRAHYDROXYPREGNA-1,4-DIENE-3,20-DIONE CYCLIC 16,17-ACETAL WITH ACETONE,21-(3,3-DIMETHYLBUTYRATE),※備考へ続く" "TRIAMCINOLONE HEXACETONIDE" "C30H41O7F" 30.00 41.00 7.00 0.00 0.00 0.00 532.00 " (REF:1059/1057)" "1059/1057/" "295-296ﾟC(1057)" "ｸﾛﾛﾎﾙﾑ,ｼﾞﾒﾁﾙｱｾﾄｱﾐﾄﾞ(75g/100ml),ｴﾁﾙｱｾﾃｰﾄ(0.77g/100ml),ﾒﾀﾉｰﾙ(0.59g/100ml),ｼﾞｴﾁﾙｶｰﾎﾞﾈ-ﾄ(0.50g/100ml),ｸﾞﾘｼﾝ(0.42g/100ml),ﾌﾟﾛﾋﾟﾚﾝｸﾞﾘｺｰﾙ(0.13g/100ml),無水ｱﾙｺｰﾙ(0.03g/100ml),水には不溶(0.0004g/100ml)(25ﾟ) (1057)" "1057/" "・TRIAMCINOLONEを KETONや ALDEHYDE中で,少量の PERCHLORIC ACIDと反応させて合成する｡ (1057)" "1057/" "・抗炎症作用やグルココルチコイド作用を持つ｡ TRIAMCINOLONEよりも局所における活性が強化されている｡ (1057) TRIAMCINOLONより毒性強い｡(1059) LD50(mg/kg 体重)(d:日数) マウス;〜800(7d),141(114-174)(14d),132(107-162)(21d). ラット;94(60-305)(7d),35(25-50)(14d),32(24-43)(21d)." "1057/1059/" "分子量 532.66 (1057)" "1057/" "ST0466" 12.00 "2,14-DIHYDROXY-19-OXO-3-[(TETRAHYDRO-6-METHYL-2,3-DIOXO-2H-PYRAN-2-YL)OXY]CARD-20(22)-ENOLIDE" "USCHARICIN" "C29H38O9" 29.00 38.00 9.00 0.00 0.00 0.00 530.00 " (REF:6/1060/1061/660/661/1062)" "6/1060/1061/660/661/1062/" "268ﾟC(dec.)(653), 290ﾟC(SOLVENT-FREE)(660)" "[α]20/D=+38ﾟ±2ﾟ(C=0.9 in methanol)(660)" "[α]/D=+29ﾟ(653)" "653/660/" "・Calotropis procera R.Br., Asclepiadaceae(ガガイモ科)から単離｡ (653)" "653/" "アフリカで矢毒に使われていた｡ 致死量 0.15mg/kgネコ(653) ・強心配糖体｡" "653/" "分子量 530.59 ALCOHOLからの結晶は,PRISM型をしている｡乳液中の量は,0.45%｡ USCHARIN(C31H41O8NS)の加水分解によって得られる｡ HYDROGENATION によってCALACTIN(C29H40O9)が得られる｡(653/1060) ・VORUSCHARINを MERCURIC CHLORIDEと反応させて調製｡ (1061) ・m.p.; of chloroform,195ﾟC;of ethanol,208-210;of oxim,256｡ (660) ・構造の訂正。化学反応性,スペクトルから, HESSE & LUDWIG(1061),CROUTらの構造を修正。(661) ・立体構造。(1062)(660)" "653/660/661/1060/1061/1062/" "ST0467" 12.00 "3β-[(6-O-β-D-GLUCOPYRANOSYL-β-D-GLUCOPYRANOSYL)OXY]-14-HYDROXY-5α-CARD-20(22)-ENOLIDE" "UZARIN" "C35H54O14" 35.00 54.00 14.00 0.00 0.00 0.00 698.00 " (REF:1063/1064/1065/1066/1067/1068/1069)" "1063/1064/1065/1066/1067/1068/1069/" "Prisms(pyridine+water)266-270ﾟC(1065)" "[α]20/D=-27ﾟ(C=1.075 in pyridine)(1064),[α]19/D=-1.4ﾟ(C=0.85 in methanol)" "ピリジン,HOT METHYL CELLOSOLVENに可溶｡ 水への可溶性は乏しい｡ エーテル, クロロホルム, アセトンに不溶｡(1063/1064)" "1064/1065/1063" "UVmax:217nm(logε=4.23)(1065)" "※融点続き：stout needles(methanol+ether)206-208ﾟC(1064/1065)" "1065/" "・植物 ・Gomphocarpus sp,Asclepiadaceae の根を乾燥させたものに含まれる,""UZARA""というアフリカの薬に含まれている。 (1063) ・XYSMALOBIUM UNDULATUM R.BR.の""UZARA""からも単離される。 (1064) ・PACHYCARPUS SCHINZIANUS(SCHLTR.)N.E.BR.の根と種子からも単離。(1065) ・NERIUM ODORUM SOL.の配糖体から得られる。(1067)" "1063/1064/1065/1067/" "Antidiarrheal(下痢止め)に利用される｡ LD50 = 4.586±0.737mg/kg(ネコ)｡ (1067)" "1067/" "分子量 698.78 (1064/1065) ・酵素分解によって""UZARIGENIN""を得る｡(1066) ・ODORIGENIN Bは, UZARIGENINである。(1067) ・UZARIGENINの構造決定。(1067/1068) ・他の知られている CARDIAC GLYCOSIDEとは異なり, A/B-TRANS CONFIGURATIONを持つ。(1069)" "1064/1065/1066/1067/1068/1069/" "ST0468" 12.00 "3β,14-DIHYDROXY-5α-CARD-20(22)-ENOLIDE" "UZARIGENIN,ODORIGENIN" "C23H34O4" 23.00 34.00 4.00 0.00 0.00 0.00 374.00 " (REF:1070/462/1071)" "1070/462/1071/" "246-248ﾟC(Methanol/CHLOROFORM/ETHER)(1070)" "[α]20/D=+17.1ﾟ [α]20/365=+71.1ﾟ(C=0.5;ETHANOL)(1070)" "1070/" "λmax=217mμ(ε=16,400)(1070)" "3565/3490(3-,14-OH), 1790/1730/1610cm-1(BUTENOLIDERING)(1070)" "τ=9.2,9.1(6H of C-19,C-18),7.3(1H of 17α-H),6.0,5.6(1H of 3-,14-OH),5.1(2H of 21-CH2),4.1ppm(1H of 22CH-GROUP)(DIMETHYLSULFOXIDE)(1070)" "374(M+), (372), 356, 341, 338, 323, 204, 203(1070)" "1070/" "・植物 ・Gomphocarpus sp,Asclepiadaceae の根を乾燥させたものに含まれる,""UZARA""というアフリカの薬に含まれている。 (1063) ・XYSMALOBIUM UNDULATUM R.BR.の""UZARA""からも単離される。 (1064) ・PACHYCARPUS SCHINZIANUS(SCHLTR.)N.E.BR.の根と種子からも単離。(1065) ・NERIUM ODORUM SOL.の配糖体から得られる。(1067)" "1063/1064/1065/1067/" "Antidiarrheal(下痢止め)に利用される｡ (1067)" "1067/" "分子量 374.52, ・DIGITOXIGENINから合成。(462/1071)" "462/1071/" "ST0469" 12.00 "17-METHYL-18-NOR-16,28-SECOSOLANIDA-5,12-DIENE-3β,16β-DIOL;17-METHYL-20α-((2S,5S)-5-METHYL-2-PIPERIDYL)-18-NOR-17α-PREGNA-5,12-DIENE-3β,16β-DIOL;※備考へ続く" "VERALKAMINE,VERALCAMINE" "C27H43O2" 27.00 43.00 2.00 1.00 0.00 0.00 413.00 " (REF:1072/1073/1074/1075)" "1072/1073/1074/1075/" "119-123ﾟC,165-169ﾟC(ethanol)(1072)" "[α]24/D=-84.1ﾟ±3ﾟ(C=0.533 in CHCl3)(1072)" "1072/" "(CCl4), 3230(BRPAD) AND 3635cm-1(HYDROXYL ABSORPTION)(1073)" "SINGLET AT δ=0.96(18-H3,19-H3),TWO DUBLETS AT 0.97(27-H3)AND 0.81(21-H3),THREE MULTIPLETS AT 3.41(3-H),4.0(16-H),5.25ppm(6-H AND 12-H)(1073)" "m/e 412(M--1),315(M--98),413(M+),98(M+-315)(1073)" "1073/" "・植物 ・Veratrum album sp.lobelianium(Bernh.) Suessenguth,Liliaceae(ユリ科)から得られるアルカロイド。(1072)" "1072/" "分子量 413.62 (1072) ・構造の完全決定｡ 天然のステロイドで, 18-NOR-17β-METHYL骨格を持つ最初のもの｡ DIGITONINで沈降する(3β-HYDROXYL基を持つ)｡多くの他の VERATRUM BASESに特徴的な C-NOR-D-HOMO STEROID骨格を持たない｡ (1073/1074) ・構造のＸ線解析｡ 以前決定した立体構造の確認｡ (1075)" "1072/1073/1074/1075/" "ST0470" 12.00 "STROPHADOGENIN-3β-D-DIGINOSIDE" "VERNADIGIN" "C30H44O10" 30.00 44.00 10.00 0.00 0.00 0.00 564.00 " (REF:567)" "567/" "228.5-230ﾟC(567)" "[α]20/D=+39.2ﾟ(C=0.76 in pyridine) [α]20/D=+35.5ﾟ(C=0.19 in methanol)(567)" "567/" "UVmax : 218 nm(log ε=4.2)これはBUTENOLIDE RING を示す。(567)" "1640, 1750(α,β-UNSATURATED FIVE-MEMBERED LACTONE); 1780(CARBONYL); 3450, 3510cm-1(HYDROXYL)(567)" "ΔΜ/D=-56ﾟ(METHANOL)から, DIGITOSE残基はβ-D-GLYCOSIDE結合をしていることが示唆される｡ (567)" "567/" "・植物 Adonis vernalis L.,Ranunculaceae(キンポウゲ科)から抽出できる｡ペーパークロマトグラフィーによって CYMARIN, ADONITOXIN, STROPHANTHIDIN, STROPHADOGENIN (16-HYDROXYSTROPHANTHIDIN), ACETYLADNITOXINの5つの CARDENOLIDES以外にも成分が検出され, KEDDE試薬によって陽性の発色がある2つの新しい CARDENOLIDESのうちの1つ。(567)" "567/" "強心配糖体｡ (567)" "567/" "分子量 564.65 0.05N HCl-50% AQUEOUS METHANOLで 20分間 BOILすると,加水分解されて, AGLYCONE と SUGAR PORTIONに分かれる(SILICAGEL CHROMATOGREPHYによる)｡ AGLYCONは,m.p." "567/" "ST0471" 12.00 "(20S,22R)-5,6β-EPOXY-4β,22,27-TRIHYDROXY-1-OXO-5β-ERGOSTA-2,24-DIEN-26-OIC ACID δ-LACTONE;4β,27-DIHYDROXY-1-OXO-5β,6β-EPOXYWITHA-2,24-DIENOLIDE" "WITHAFERIN A" "C28H38O6" 28.00 38.00 6.00 0.00 0.00 0.00 470.00 " (REF:1076/1077/1078/1079)" "1076/1077/1078/1079/" "252-253ﾟC(acetone-petroleum ether),243-245ﾟC(ethyl acetate)の報告もある(1078)" "[α]28/D=+125ﾟ(C=1.30 in chloroform)(1078)" "1078/" "UVmax(ethanol) : 214, 335nm(ε=17,300,165)(1078)" "λmax 2.81,2.94(HYDROXYL),3.33,5.92μ(α,β-UNSATURATED δ-LACTONE,α,β-UNSATURATED CYCLOHEXANONE)(1078)" "6.18(d,J=10Hz,C-2H),6.97(dd,J=10 and 6Hz,C-3H),3.75(d,J=6Hz,C-4H),3.20(W1/2〜4Hz,C-5H),4.40(dt,J=12 and 3.5Hz,C-22H),1.38(s,C-10CH3),0.68(s,C13-CH3),0.97(d,J=6Hz,C-20CH3),2.03(s,C-24CH3),4.35(s,C-25CH2OH)(1077)" "ORD(C 0.0944)[φ]/600=+522ﾟ,[φ]/589=+522ﾟ,[φ]/500=+820ﾟ,[φ]/400=+2609ﾟ,[φ]/367=+4510ﾟ,[φ]/343=+1603ﾟ,λ0 333.5mμ,[φ]/319=-895ﾟ,λ0 309mμ,[φ]/273=+7679ﾟ,[φ]/262.5=+5628ﾟ,[φ]/252=+3504ﾟ,[φ]/247=+5591ﾟ(1078)" "1078/" "・植物 ・Withania somnifera Dun.,Solanaceae(ナス科)の葉や, Withania coagulansの根 から単離される｡ (1076/1077) ・ACNISTUS ARBORESCENS(L.)からも単離される｡ (1078) ・W.SOMNIFER CHEMOTYPE I とも呼ばれ, 乾燥葉重量の 0.9%ほど存在する｡ (1077)" "1076/1077/1078/" "抗真菌薬, 抗腫瘍薬として利用される｡ マウスの SARCOMA 180 は 30mg/kg の投与で有意に阻害された｡ (1078)" "1078/" "分子量 470.58 THE DIACETATE, m.p.201-202ﾟ;[α]30/D=192ﾟ(C=1.09);Uvλmax 214mμ(ε=18,000);Irλmax 3.33, 5.76, 5.86, 5.84, 8.08μ｡ C32H42O8｡ (1078) ・以前に WITHAFERIN と呼ばれていた化合物は, 2,3-DIHYDRO-3-METHOXYWITHAFERIN A と同定された｡ (1079)" "1078/1079/" "ST0472" 12.00 "4β,20α,(R)-DIHYDROXY-1-OXO-5β,6β-EPOXYWITHA-2,24-DIENOLIDE" "WITHANOLIDE D" "C28H38O6" 28.00 38.00 6.00 0.00 0.00 0.00 470.00 " (REF:1077)" "1077/" "6.21(d,J=10Hz,C-2H),6.97(dd,J=10 and 6Hz,C-3H),3.77(d,J=6Hz,C-4H),3.25(W1/2〜4Hz,C-6H),4.25(dd,J=12 and 5Hz,C-22H),1.41(s,C-10CH3),0.85(s,C-13CH3),1.27(s,C-20CH3),1.91(TWO METHYL SIGNAL)(1077)" "1077/" "・植物 WITHANIA SOMNIFERA DUN.,SOLANACEAE(ナス科)の葉から抽出される主要なステロイドの１つ｡ 乾燥した葉の 0.05% 重量存在する｡ (1077)" "1077/" "抗菌作用｡ (1076)" "1076/" "分子量 470.58" "1077/" "ST0473" 12.00 "1,6Bβ,7,8,9A,10,11,11B-OCTAHYDRO-11-HYDROXY-1-(METHOXYMETHYL)-9Aβ,11Bβ-DIMETHYL-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-3,6,9-TRIONE ACETATE" "WORTMANNIN" "C23H24O8" 23.00 24.00 8.00 0.00 0.00 0.00 428.00 " (REF:1080/1081/1082/1083)" "1080/1081/1082/1083/" "238-239ﾟC(1081)" "[α]26/D=+89ﾟ(C=1.1 in CHCl3)(1081)" "Ph3-8の水溶液中で不安定｡" "1081/" "λmax 257, 292nm(ε=11,770, 7,700)(1081)" "FIVE-RING KETONE(1750cm-1), LACTONE(1732cm-1), CYCLOHEXADIENONE(1684,1656cm-1), FURAN RING(3125,1540cm-1)(1080/1081)" "(τ in CDCl3)FOUR METHYL SINGLETS OF ALIPHTIC METHOXY(6.8);ACETOXYL(7.9);TWO TERTIARY METHYLS(8.28,9.02);1-,2-,2'-PROTONS;11-,14-,12-,12'-PROTONS; ONE-PROTON SINGLET AT τ 1.78(20-PROTON)(1080/1081)" "RING Aの C(1)-C(10)とC(3)-OXYGEN 結合で開裂｡酢酸,RING D開裂｡ C(3)またはC(7)のCO｡(1080)" "CRYSTAL DATA:M=428,ORTHORHOMBIC,a=2567(7),b=702(1),c=1177(2)pm,Π=2119.4x10 6pm3,Dm=1.34,Z=4,Dc=1.34,SPACE GROUP P2,2,2,(D4/2,No.19)｡(1082)" "1081/1080/1082/" "・アオカビ Penicillium wortmannii Klocker から抽出される｡ (1080)" "1080/" "抗菌性抗生剤｡ BOTRYTIS ALLII HYPAEに特徴的な SPIRAL WAVING を引き起こす｡ (1080)" "1080/" "分子量 428.44｡ 立体構造の決定｡ (1082/1083)" "1082/1083/" "ST0474" 12.00 "GAMMACERANE3β-OL" "TETRAHYMANOL" "C30H52O" 30.00 52.00 1.00 0.00 0.00 0.00 428.00 " (REF:1105/1106/1107)" "1105/1106/1107/" "312.5-314.5ﾟC(1106), 295-296ﾟC(1107)" "1106/1107/" "60-MC.PROTON NMR. 4SHARP PEAKS CHARACTERISTIC OF TRITERPENOID METHYL GROUPS AT τ>9.03 with area corresponding to eight methyls(46,49,51,AND 58 c.p.s with relative areas 1:3:1:3).(1107)" "1107/" "PROTOZOAN(原生動物)の一種, TETRAHYMENA PYRIFORMISから単離｡ 動物界生物から単離された最初の PENTACYCLIC TRITERPENOID ALCOHOL(それまでは植物でのみ単離されていた｡) (1107)" "1107/" "1092/1093/1095/1099/1100/1101/" "TETRAHYMANOL p-BROMOBENZOATE ESTERのＸ線結晶解析｡ M.p.297-298.5ﾟ(ANAL.CALCD. For C37H55BrO2)｡この結晶はスペースグループC222を持つ斜方晶形をしている｡ ユニットセルあたり,4分子含まれ,a=13.06,b=6.33,c=38.06Aのディメンションを持つ｡Bディメンションが短い事から,TETRAHYMANOL骨格は,ほぼフラットで,DやEリングの非イス型構造とよく一致している｡(1107) 後に,構造の訂正(1106) ･TETRAHYMANOLのIN VITRO生合成:T.PYRIFORMISを凍結乾燥,RINGERリン酸メディウムに懸濁してPOTTER-ELVEHJEMホモジナイザーですりつぶす｡これに[14C]-SQUALENEや[3H]-SQUALENE 2,3-Oxideを加えた｡その結果,SQUALENEを直接 TETRAHYMANOLへ変換していた｡SQUALENE-2,3-OXIDEは中間体として関与していなかった｡酵素系は,凍結乾燥後も活性を保っていた｡SQUALENEとSQUALENE-2,3-OXIDEとの相互変換は見られなかった｡TETRAHYMANOLの酸素原子は,大気中に由来していないようだった｡ (1105) ･生合成の酵素系は,可溶性で,無細胞系,無脂質系で得られた。SQUALENEからの反応は,酸素は必要なく,C3の水素,C21の酸素はメディウムに由来していた｡(1104) ･T.PYRIFORMISの TETRAHYMANOLを ERGOSTEROLへ置換できる｡ これは ERGOSTEROLがTETRAHYMANOL生合成をブロックする為らしい｡ (1103) ･コレステロールによるTETRAHYMANOL生合成阻害｡膜結合酵素の活性を変えるような,膜構造や機能に変化を起こしてしまう事による,生合成後期の阻害｡ (1101) ･ERGOSTEROL置換による脂肪酸組成の変化｡ (1099/1100) ･3β-(β-DIMETHYLAMINOETHOXY)-ANDROST-5-EN-17-ONE による TETRAHYMANOL生合成阻害｡ (1097/1098) ・細胞の増殖期や静止期に必要な膜の構造と機能の維持｡ (1092/1093/1095/1099/1100/1101) ･TETRAHYMANOL HEMIHYDRATE の結晶構造｡ (1096) ･20α-HYDROXYCHOLESTEROLと7-KETOCHOLESTEROLによる増殖阻害｡(1095) ･CHOLESTEROLによるTETRAHYMENE PYRIFORMIS SQUALENE SYNTHETASE 生合成阻害｡ (1093) ・膜流動性とスウィミング速度の関係｡(1092) ・SQUALENE-TETRAHYMANOL CYCLASE の精製｡(1085)" "1107/1106/1105/1104/1103/1101/1099/1100/1097/1098/1096/1095/1093/1092/1085/" "ST0475" 12.00 "3-ACETYLSTROPHADOGENIN" "C25H34O8" 25.00 34.00 8.00 0.00 0.00 0.00 462.00 " (REF:1108)" "1108/" "m.p. 238-240ﾟC(1108)" "[α]20/D=+24.0ﾟ(METHANOL,c.,0.105) [α]20/D=+22.8ﾟ(PYRIDINE,c.,0.36) (1108)" "ピリジンに可溶｡ (1108)" "1108/" "220mμ(logε=4.18)(BUTENOLIDE RING)(1108)" "1625, 1700, 1798(α,β-UNSATURATED FIVE-MEMBERED LACTONE), 1740(ESTER GROUP), 1720(CARBONYL GROUP)cm-1｡(1108)" "1108/" "・植物。 ADONIS VERNALIS L.の緑色部分から, 5つの CARDENOLIDES, CYMARIN, ADONITOXIN, STROPHANTHIDIN, STROPHADOGENIN(16-HYDROXY-STROPHANTHIDIN),ACETYLADONITOXINの他に, PAPER CHROMATOGRAPHYで検出できる｡(1108)" "1108/" "・強心配糖体｡ (1108)" "1108/" "分子量 462.54｡ KEDDE試薬で陽性の呈色反応を示す｡ MILD なアルカリ加水分解で, STROPHADOGENINが得られる｡ 3% KOHで,加水分解すると, VOLATILE ACIDが得られ,これは酢酸として同定された｡ (1108)" "1108/" "ST0476" 12.00 "[3BS-(3Bα,5β,7β,8β-10Aα,10Bβ)]-3B,4,5,6,7,8,9,10,10A,10B,11,12-DODECAHYDRO-7-HYDROXY-10B-METHYL-5A,8-METHANO-5AH-CYCLOHEPTA[5,6]NAPHTHOL[2,1-B]-FURAN-7-METHANOL" "CAFESTOL,CAFESTEROL" "C20H28O2" 20.00 28.00 3.00 0.00 0.00 0.00 316.00 " (REF:1109/1110/1111/1112/1113/1114/1115/1116/1117)" "1109/ 〜 1117/" "155-157ﾟC(1109),150-153ﾟC(1110)" "[α]24/D=-177ﾟ(1110) [α]20/D=-137.9ﾟ(in CHCl3)(1109)" "1109/1110/" "λmax(EtOH) 223, 290mμ(logε=3.66,3.63)(1110)" "1110/" "・植物。 ・GREEN COFFEE OIL から単離される DITERPENOID｡ (1109/1110) ・GREEN SANTOS BOURBON COFFEE の OIL から単離｡ (1111)" "1109/1110/1111/" "分子量 316.42｡ THE ACETATE,m.p.163.5-165ﾟ, [α]20/D=-134.6ﾟ(in CHCl3)(1111) ・構造の確定｡ (1112/1113) ・C-16 の (R)-CONFIGURATION｡ (1114) ・ABSOLUTE CONFIGURATION｡ (1115) ・円偏光二色性とＸ線結晶解析｡ (1116) ・(±)型の立体特異的な全合成｡ (1117)" "1111/1112/1113/1114/1115/1116/1117/" "ST0477" 12.00 "4β-HYDROXY-18-ACETOXY-1-OXO-5β,6β-EPOXYWITHA-2,24-DIENOLIDE" "WITHACNISTIN" "C30H40O7" 30.00 40.00 7.00 0.00 0.00 0.00 512.00 " (REF:1078)" "1078/" "130-135ﾟC(1078)" "[α]27/D=+123ﾟ(C=1.21)(1078)" "エタノール, メタノール - 水(9:1), 石油エーテル, クロロホルム, ホルムアミド に可溶｡" "1078/" "λmax 215mμ(ε=16,100)(1078)" "λmax 2.81, 2.93, 3.31, 5.78, 5.92, 8.05, 9.63μ(1078)" "3.82d(10.0,C-2),3.04dd(10.0,6.0,C-3),6.24d,5.78d(C-18),8.60[-0.08](C-19),8.90d(6.5)[0.04](C-21),8.08[0.07](C-27),8.08[0.25](C-28),7.93(-COCH3)[ ],Δτ=τ[CDCl3-benzene(1:1)]-τ(CDCl3)(1078)" "m/e 125(C7H9O2),181(C11H17O2),M+ 512(C30H40O7),167(C9H11O3),154(C8H10O3),141(C7H9O3),124(C7H8O2),389(C23H33O5) (1078)" "ORD(c=0.033)[φ]/600=+461ﾟ,[φ]/589=+461ﾟ,[φ]/500=+778ﾟ,[φ]/400=+2305ﾟ, [φ]/368=+4148ﾟ,[φ]/343=+1440ﾟ,λ/0=334mμ,[φ]/317.5=-1095ﾟ,λ/0=307mμ, [φ]/272=+7202ﾟ,[φ]/261=+5992ﾟ,[φ]/250=+4206ﾟ,[φ]/243=+6741ﾟ(1078)" "1078/" "・植物。 ACNISTUS ARBORESCENS(L.)の葉｡ (1078)" "1078/" "分子量 512.64｡ THE ACETATE,m.p.131-132ﾟ,[α]25/D=+180ﾟ(C=1.90);Uvλmax 217mμ(ε=15,500); Irλmax 3.31, 5.76, 5.90, 8.06, 9.62;C32H42O8｡ (1078)" "1078/" "ST0478" 12.00 "3-ETHOXY-2,3-DIHYDROWITHACNISTIN" "3-ETHOXY-2,3-DIHYDROWITHACNISTIN" "C32H46O8" 32.00 46.00 8.00 0.00 0.00 0.00 558.00 " (REF:1078)" "1078/" "134-136ﾟC(SINTERED CA.112ﾟ)(1078)" "[α]24/D=+29ﾟ(C=0.46)(1078)" "エタノール, メタノール - 水(9:1), 石油エーテル, クロロホルム, ホルムアミド に可溶｡(1078)" "1078/" "λmax 227mμ(ε=8,600)(1078)" "λmax 2.78, 2.90, 3.31, 5.78, 5.88, 8.95, 9.62μ(1078)" "1078/" "・植物。 ACNISTUS ARBORESCENS(L.)の葉｡ (1078)" "1078/" "分子量 558.39｡ THE ACETATE,m.p.216-217ﾟ(dec.sintered at 2130); [α]23/D=+16ﾟ(C=1.16); Uvλmax 227mμ(ε=8,900); Irλmax 3.30, 5.75, 5.88, 8.06, 9.65μ;C34H48O9｡ (1078)" "1078/"