Toshio Nakaki, M.D., Ph.D.  Specially Appointed Professor Teikyo University Faculty of Pharma-Science Emeritus Professor Teikyo University School of Medicine  nakaki@med.teikyo-u.ac.jp  Phone/Fax: +81-3-3964-1211 ext 45203

Defense system for neuronal oxidative stress

Glutathione (GSH) is the major neuroprotective molecule against oxidative stress causing neurodegeneration such as Alzheimer disease and Parkinson disease. The rate-limiting substrate for neuronal GSH synthesis is cysteine, because neurons cannot uptake GSH itself. Therefore, the regulation of neuronal cysteine uptake is important. and we are currently investigating this issue.

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