日本語[Japanese] / 英語[English]

CURRICULUM VITAE

NAME:  TAKAMI, Hiroshi, E.

NATIONALITY:  JAPAN

DATE AND PLACE OF BIRTH:  March 28, 1946 ; Yokohama, JAPAN

CITIZENSHIP:  JAPAN

EDUCATION: 

1966-1970                School of Medicine, Keio University, Tokyo, Japan -M.D.

1970-1971                Internship    U.S. Naval Hospital    Yokosuka, Japan

1971-1977                Residency Training in General Surgery, Keio University
               Hospital, Tokyo, Japan

1977                         Doctor of Medical Science (Keio University, Tokyo, Japan)

1977-1978                Research Associate, Department of Pharmacology (Prof. Harris Busch)
                                 Baylor Collage of Medicine, Houston, Texas, U.S.A.

1978-1979                Postdoctoral Fellow of Experimental Surgery   (Prof. Marvin M. Romsdahl)

              The University of Texas System Cancer Center, M.D.
              Anderson Hospital and Tumor Institute, Houston,
               Texas, U.S.A.

 

PROFESSIONAL EXPERIENCE:

1979                         Visiting Assistant Professor
                                 Department of Surgery, The
University of Texas System
              Cancer Center,
M.D. Anderson Hospital and TumorInstitute,  

              Houston, Texas, U.S.A.

1979-1986                Instructor and Chief Surgeon
                                 
Department of Surgery,
School of Medicine

                          Keio University, Tokyo, Japan 

1981-1986                Chief of Surgical Oncology
                                 Department of Surgery, School of Medicine
                          Keio University, Tokyo, Japan

 1986-Present           Attending Assistant Professor
                                  Department of Surgery, School of Medicine
                                  Keio University, Tokyo, Japan

1986-1987                Assistant Professor
                                 First Department of Surgery, Teikyo University
                                  School of Medicine, Tokyo, Japan

1987-1991                Associate Professor
                                 First Department of Surgery, Teikyo University
                                  School of Medicine, Tokyo, Japan

1991-2007            Professor
                                 Department of Surgery, Teikyo University
                                  School of Medicine, Tokyo, Japan

2004-Present           Attending Assistant Professor

                Department of Surgery, Faculty of Medicine

                University of Tokyo, Tokyo, Japan

2007-Present        Professor and Chairman,

                Department of Surgery, Teikyo University

                School of Medicine, Tokyo, Japan

 

AWARDS AND HONORS:

1980                  Keio Medical Association Award

1983                  "Tohrin" award
                          (Alumni Association of Keio University)

MEMBERSHIPS IN PROFESSIONAL SOCIETIES:

1979                  International Association of Endocrine Surgeons
                          (Active membership)

1982                   American Society of Clinical Oncology
            (Membership, ID No. 12594)

1983                   American Association for Cancer Research
                           (Corresponding member No.1137)

1984                   International Society of Surgery
            (Active member, No. 43400)

1989-1994     Japanese Association of Endocrine Surgeons
     
              (Councilor)

1990                  International College of Surgeons (Member, No. T9412)

1991                   The Society of Head and Neck Surgeons
                          (Foreign corresponding member, No. HNO-11028)

1992                  The Society of Surgical Oncology
                         (Foreign corresponding member, No. SSO-11817)

1994                  American Association of Endocrine Surgeons
                         (Foreign corresponding member)

1994-2000         Japan Association of Endocrine Surgeons
      
           (Board of Regents)

1995           American College of Surgeons
       
         (Active member, No. 03028650)

1996               World Society of Gastroenterology

1996        New York Academy of Sciences (Member, No. 425249)

1996                  Japanese Chapter of International Society of Surgery
                          (Councilor)

1999               The Japan Endocrine Society
  
                  (Board of Directors)

2000                  Japanese Association of Endocrine Surgeons
                         (Executive Director)

2000                  Branch Office of the Japan Endocrine Society
                         (Director of Council)

2000                       The Japanese College of Surgeons
           
(Board of Regents)

2000                      Japanese Society for Sentinel Node Navigation Surgery
           
(Councilor)

2001      Japan Society for Endoscopic Surgery (Councilor)

2003                International Association of Endocrine Surgeons (IAES)

           (Councilor)

2005       The Japanese Association of Medical Science

                   (Councilor)

2005              Japanese Society of Thyroid Surgery

           (Executive Director)

2006             Japan Association of Endocrine Surgeons

                   (Executive Director)

2007             Japan Surgical Society

                   (Board of Regents)

2007             University-Industry Cooperation and Research Program Division
           Japan Society for the Promotion of Science

 

COMMITTEE:

1989-present          Editorial Board of Medicament News
                             (Japanese Journal)

 1989-2000            Editorial Board of Endocrine Surgery
                             (Official Journal of Japan Association of Endocrine Surgeons)

1992-1994            Editorial Board of KARKINOS
                             (Japanese Journal of Clinical Oncology)

 1994-present        Editorial Board of Official Journal of the Japan Endocrine
              Society

1996-present      Editorial Board of the Japanese Journal of Gastroenterological
    
                 Surgery Nursing

1996-present      Editorial Board of THYROIDOLOGY, Clinical and
             Experimental 
    (International Journal)

1997-present      Editorial Board of Oncology Reports
    
                 (International Journal)

 1999-present      Editorial Board of Internal Medicine
    
                (International Journal)

 1999-present    Editorial Board of Endocrine Journal
     
               (English Official Journal of the Japan Endocrine Society)

 2000-present    Associate Editor in Chief of Asian Journal of Surgery

 2000-present    Editor-in-Chief of Endocrine Surgery
    
              (Official Journal of Japan Association of Endocrine Surgeons)

 2002-present    Chief Editor, Thyroid and other endocrine gland diseases
     
               (International Journal, EDIZIONI PLUS, Univ. Pisa)

 2002-present    Advisory Board, Yonsei Medical College (Korea)

 

 PRESIDENT OF THE CONGRESS:

 1992           Chairperson, Seminar: Endocrine Surgery
  
               27, March; Main Auditorium of Keio University Hospital, Tokyo.

 1994           President, 10th Annual Meeting of the Japanese Society
          of Polyamine Research
  
              26-27, January; Main Auditorium of Keio University Hospital,
         
Tokyo.

1996           Chairperson, 9th Annual Meeting of the Asia-Pacific Endocrine                   Conference
 
               14-15, January; Hyatt Regency Saujana, Kuala Lumpur, Malaysia.

1997           Chairman, Tokyo Symposium on Multiple Endocrine Neoplasia
  
             17, May; Main Hall of Yamanouchi Pharmaceutical Co. Ltd. Tokyo.

1999           President, 5th Annual Meeting of the Japanese Society
          for Familial
Tumor
  
              18-19, June; Arcadia Ichigaya, Tokyo.

2000            President, 12th Annual Meeting of the Japan Association
           of
Endocrine Surgeons
  
               27-28, June;
Nihon Toshi Center Kaikan, Tokyo.

2000            Chairperson, International Symposium on Diagnostic
           Endocrine Pathology: Update 2000
         
14, October; Nagoya.

2000             Chairperson, 1st Meeting of the Society of Endoscopic
          
Endocrine Surgery
                    13, December; Osaka.

2001             President, 26th Annual Congress of the Japanese College
         
of Surgeons
  
              27-29, June; Keio Plaza Hotel, Shinjuku, Tokyo.

2001            President , 5th Annual Meeting of the Japan Endocrine
          Pathology Society
    
         14-15, October; Tokyo.

2002            President , 35th Annual Meeting of the Japanese Society
          of Thyroid Surgery

                21-23, November; Hamamatsu.

2002            President, 3rd Annual Meeting of the Branch of the
        
Japan EndocrineSociety
                 14-15, February; Tokyo

2005                     President, 78th Annual Congress of the Japan Endocrine Society
 
                 July, Tokyo

2005             President, 48thAnnual Meeting of the Japan Thyroid Association,

         November; Tokyo

2006         President,26th Annual Meeting of the Japan Society for Tumor  Marker Research,

                  September, Tokyo

 

2007            President, 40th Annual Congress of the Japanese Society of Thyroid Surgery

                 October, Tokyo

        ENGLISH PUBLICATIONS
(Surgical Endocrinology & Oncology-related Articles)

1) Takami H, Yamaguchi K, Abe K, Adachi I, Arai S, Kameya T, Yamachika K, Tashiro M, Nakagawa Y, and Abe O. A case of Zollinger-Ellison syndrome whose pancreatic tumor produced multiple hormones and a review of 48 cases reported in the Japanese literature. Jpn J Clin Oncol. 1978;8(1):75-89.

2) Busch H, Ballal NR, Busch RK, Samal B, Choi YC, Davis FM, Kunkle HM, Nall K, Parker D, Rao MS, Rothblum LI, Takami H. Hierarchical controls of nucleolar synthetic functions. Differentiation and Development. New York, Academic Press, pp 187-209, 1978

3) Takami H, Busch H. Two-dimensional gel electrophoretic comparison of proteins of nuclear fractions of normal liver and Novikoff hepatoma. Cancer Res. 1979;39(2):507-518.

4) Takami H, Busch FN, Morris HP, Busch H. Comparison of salt-extractable nuclear proteins of regenerating liver, fetal liver, and Morris hepatoma 9618A and 3924A. Cancer Res. 1979;39(6):2096-2105.

5) Busch H, Takami H, Davis FM, Busch RK, Wu BC, Spohn WH, Raju KS. Nonhistone nuclear proteins of cancer cells. In: Fox M (ed), Advances in medical oncology, research and education, vol.4, Biological basis for cancer diagnosis, 1st ed. Oxford and New York, Pergamon Press, pp 21-26, 1979

6) Takami H, Romsdahl MM, Nishioka K. Polyamines in blood-cells as a cancer marker. Lancet. 1979;2:912-913.

7) Takami H, Nishioka K. Raised polyamines in erythrocytes from melanoma-bearing mice and patients with solid tumors. Br J Cancer. 1980;41(5):751-756.

8) Takami H, Abe O. Alterations of cytoplasmic proteins in rat hepatomas during the administration of chemical carcinogen. Keio J Med. 1980;29(1):9-17.

9) Nishioka K, Takami H, Noyes RD, Babcock GF. CloudmanS-91 melanoma colony assay in the lungs of mice and profiles of the biochemical tumor markers tyrosinase and polyamines. In: Seiji M (eds), Pigment cell 1981: Phenotypic expression in pigment cells. Tokyo, University of Tokyo Press, pp 617-621, 1981

10) Mimura T, Hamada N, Ban Y, Mori H, Momotani N, Takami H, Nishikawa Y, Ito K. Anterior pituitary, thyroid, parathyroid and adrenal responses to subtotal thyroidectomy in patients with Graves' disease. Jpn J Surg. 1982;12(4):235-243.

11) Yamamoto O, Takami H, Motomura Y, Miyata J, Hosoda Y, Mimura T, Ito K, Abe O. Polyamine levels and ornithine decarboxylase activities in human thyroid tumors. In: Ui N, Torizuka K (eds), Current problems in thyroid research. Amsterdam-Oxford-Princeton, Excerpta Medica, pp 533-536, 1983

12) Takami H, Umemoto S, Kodaira S, Ishibiki K, Abe,O. Antitumor effect of α-difluoromethyl ornithine (DFMO) and ornithine decarboxylase activity in a human tumor transplanted into nude mice. In: Imahori K, Suzuki F, Suzuki O & Bachrach U (eds), Polyamines: Basic and clinical aspects. Proceedings of a satellite symposium of the 3rd international congress on cell biology. Utrecht, VNU Science Press, pp 285-291, 1985

13)Taketa K, Ichikawa E, Akamatsu K, Ohta Y, Sekiya C, Namiki M, Takami H, Kaneda H, Higashino K, Taga H, Hirai H. Increased asialo-α-fetoprotein in patients withα-fetoprotein producing tumors: Demonstration by affinity electro- phoresis with erythroagglutinating phytohemagglutinin of Phaseolus vulgaris lectin. Tumor Biol. 1985;6(6):533-544.

14) Mimura H, Hamana G, Ishitobi K, Momotani N, Ito K, Takami H. Graves' disease complicating pregnancy results of surgical treatment in 35 pregnancies. In: Vichayanrat A, Nitiyanant W, Eastman C, Nagataki S (eds), Recent progress in thyroidology. Bangkok, Crystal House Press, pp 483-486, 1987

15) Nakamura K, Kubo A, Hashimoto S, Furuuchi T, Takami H, Abe O. Radioimmunodetection of human pancreatic tumor xenografts using DU-PAN monoclonal antibody. Ann Nuclear Med. 1988;2(1):1-6.

16) Takami H, Bessho T, Kameya T, Mimura T, Ito K, Abe O, Hosoda Y, Shikata J. Immunohistochemical study of medullary thyroid carcinoma: Relationship of clinical features to prognostic factors in 36 patients. World J Surg. 1988;12(4):572-579.

17) Ryusaki M, Konishi K, Kasuga A, Kumagai H, Suzuki H, Abe S, Saruta T, Takami H, Tashiro M. Spontaneous rupture of the quadriceps tendon in patients on maintenance hemodialysis-report of three cases with clinico- pathological observations. Clin Nephrol. 1989;32(3):144-148.

18) Kakudo K, Takami H, Katayama S, Matsuura N, Kamoshida S, Miyauchi A, Watanabe K. Carcinoembryonic antigen and nonspecific cross-reacting antigen in medullary carcinoma of the thyroid. Acta Pathol Japonica. 1990;40(4):261-266.

19) Takami H, Shikata J. Serum bone Gla proteins as an indicator of parathyroidectomy in patients with secondary hyperparathyroidism. World J Surg. 1990;14(3):431-436.

20) Takami H, Shikata J, Horie H, Sekine K, Ito K. PDN-21: Possible tumor marker for medullary thyroid carcinoma. J Surg Oncol. 1990;44(4):205-207.

21) Takami H, Shikata J, Kakudo K, Ito K. Calcitonin gene-related peptide in patients with endocrine tumors. J Surg Oncol. 1990;43(1):28-32.

22) Takami H, Shikata J. Graves' disease with severe iodine allergy: Successful surgery after lithium carbonate treatment. Eur J Surg. 1991;157(8):489-490.

23) Takami H, Ito K. Calcitonin gene-related peptide as a tumor marker for medullary thyroid carcinoma. Int Surg. 1992;77(3):181-185.

24) Miyaji S, Katakura K, Matsufuji S, Murakami Y, Hayashi S, Takami H, Oku Y, Okamoto M, Kamiya M. Polyamine metabolism in Taeniid Metacestodes. Jpn J Parasitol. 1992;41(4):327-333.

25) Takami H, Kodaira S. A rapid immunoperoxidase method for pathological of occult thyroid carcinoma. Int Surg. 1993;78(3):225-228.

26) Takami H, Koudaira H, Kodaira S. Relationship of ornithine decarboxylase activity and human colon tumorigenesis. Jpn J Clin Oncol. 1994;24(3):141-143.

27) Takami H, Kodaira S. Lithium in the surgical treatment of Graves' disease. Int Surg. 1994;79(1):89-90.
                
28) Takami H. Measurement of serum PDN-21 levels by radioimmunoassay in patients with various thyroid disease. Exp Clin Endocrinol. 1994;102(5):370-373.

29) Takami H, Kozakai M. Tuberculous thyroiditis: Report of a case with a review of the literature. Endocr J. 1994;41(6):743-747.

30) Takami H. Clear cell carcinoma of the thyroid. Asian J Surg. 1995;18(3):241-243.

31) Taniguchi-Shirahama S, Koyama K, Miyauchi A, Wakasugi T, Oishi S, Takami H, Hikiji K, Nakamura Y. Germline mutation of the RET proto-oncogene in eight Japanese patients with multiple endocrine neoplasia type 2A(MEN2A). Hum Genet. 1995;95:187-190.

32) Takami H, Takada T. Clinical utility of tumor markers in hepatocellular and pancreatic carcinomas. J Hep Bil Pancr Surg. 1995;2:395-400.

33) Takami H, Kodaira S, Osamura Y. An immunohitochemical and flowcytometric study of gastroenterointestinal carcinoid tumors. J Exp Clin Cancer Res. 1995;14(4):401-407.

34) Takami H, Ozaki O, Ito K. Familial nonmedullary thyroid cancer: An emerging entity that warrants aggressive treatment (Correspondence). Arch.Surg. 1996;131(6):676.

35) Takami H, Kodaira S. Spermidine/spermine N1-acetyltransferase as a marker of dimethylhydrazine-induced colonic carcinogenesis in the rat. Oncol Rep. 1996;3(3):575-577.

36) Takami H, Satake S, Nakamura K, Kubo,A. Technetium 99m sestamibi is the useful procedure to locate parathyroid adenomas before surgery. Am J Surg. 1996;172(1):93.

37) Takami H, Thosen T. Familial medullary thyroid carcinoma unassociated with multiple endocrine neoplasia. Thyroidol Clin Exp. 1996;8:9-14.

38) Takami H. Current diagnosis and treatment of medullary thyroid carcinoma. Thyroidol Clin Exp. 1996;8:35-39.

39) Takami H, Hosoda Y. Current status of multiple endocrine neoplasia in Japan. Oncol Rep. 1996;3:943-946.

40) Takami H, Satake S, Nakamura K, Kubo A. What are the indications for 99mTc-sestamibi scintigraphy in hyperparathyroidism? Clin Endocrinol. 1996;45:121-122.

41) Sugawara I, Satake S, Watanabe M, Nakamura K, Takami H, Kubo A, Akiyama S, Itoyama S. Tumor imaging of multidrug-resistant cancers with organotechnetium complex. Tumor Targeting. 1996;2:224-229.

42) Takami H, Miyoshi H, Makuuchi H. Relationship between thyroid diseases and gastric lesions. Thyroidol Clin Exp. 1996;8:41-43.

43) Makuuchi H, Takami H, Hamana G, Kameyama K, Nishi,T. Duodenal carcinoid tumor resected by strip biopsy. Oncol Rep. 1997;4:385-386.

44) Kitamura Y, Goodfellow PJ, Shimizu K, Nagahama M, Ito K, Kitagawa W, Akasu H, Takami H, Tanaka S, Wells SA Jr. Novel germline RET proto-oncogene mutations associated with medullary thyroid carcinoma (MTC): Mutation analysis in Japanese patients with MTC. Oncogene. 1997;14:3103-3106.

45) Takami H. Surgical management of hyperparathyroidism in view of a reliable parathyroid adenoma localization test. Surgery. 1997;122:120.

46) Satake S, Sugawara I, Watanabe M, Takami H. Lack of a point mutation of human DNA topoisomerase Uin multidrug-resistant anaplastic thyroid cell lines. Cancer Lett. 1997;116:33-39.

47) Takami H, Sekine M, Miyoshi H, Kodaira S, Ohgami M. Laparoscopic adrenalectomy in asymptomatic pheochromocytoma. Am Surgeon. 1997;63(9):820-822.

48) Takada T, Takami H. Solitary splenic metastsis of a carcinoid tumor of the lung eight years postoperatively. J Srug Oncol. 1997;67(1):47-48.

49) Sekine M, Takami H. Combination of calcitonin and pamidronate for emergency treatment of malignant hypercalcemia. Oncol Rep. 1997;5:197-199.

50) Sekine M, Takami H, Satake S, Kodaira S, Sugiyama F. Treatment of skeletal and pulmonary metastases of differentiated thyroid carcinoma. Thyroidol Clin Exp. 1997;9(3):89-94.

51) Shan L, Kakudo K, Nakamura M, Nakamura Y, Yokoi T, Ishimoto J, Kawahara K, Takami H. Clonality of the parathyroid nodules with uremic parathyroid hyperplasia. Pathol Oncol Res. 1997;3(3):198-203.

52) Kubo A, Nakamura K, Kawaguchi O, Satake S, Takami H. Successful Tc-99m MIBI imaging of recurrent hyperparathyroidism in parathyroid autotransplanted patients. Clin Nucl Med. 1997;22(12):872-874.

53) Shirahama S, Ogura K, Takami H, Ito K, Tohsen T, Miyauchi A, Nakamura Y. Mutational analysis of the RET proto-oncogene in 71 Japanese patients with medullary thyroid carcinoma. J Hum Genet. 1998;43(2):101-106.

54) Takami H, Ogino Y, Tanaka K, Kubo A. Somatostatin-receptor-negative carcinoid tumor responsible for Cushing’s syndrome. Eur J Surg Oncol. 1998;24:337-338.

55) Takami H, Hayashi M, Konishi K, Maruyama H, Saruta T. Efficacy of combined use of calcitonin and bisphosphonate for the treatment of hypercalcemia. Intern Med. 1998;6(3):155-158.

56) Takami H. RET proto-oncogene mutation analysis for multiple endocrine neoplasia type 2. Arch Surg. 1998;133(6):679.

57) Takami H, Miyoshi H, Makuuchi H. Strip biopsy for gastrointestinal carcinoid tumor. J Surg Oncol. 1998;68:60-61.

58) Takami H, Thosen T, Shirahama S, Ogura K, Hikiji K. Does the syndrome of familial medullary thyroid carcinoma describe a distinct clinical entity? Eur J Cancer. 1998;34(10):1639-1640.

59) Takami HE. Management of medullary thyroid carcinoma (Mini review). Thyroidol Clin Exp. 1998;10(2):59-65.

60) Takami H, Kameyama K, Nagakubo I. Parathyroid carcinoma in a chronic hemodialysis patient. Surgery. 1999;125(2):239-240.

61) Takami H. Nationwide survey and analysis of the RET proto-oncogene in inherited medullary thyroid carcinoma in Japan. In: Utsunomiya J, Mulvihill JJ, Weber W (eds), Familial Cancer and Prevention. New York, Wiley-Liss, pp 371-375, 1999

62) Takami H, Niimi M, Ikeda Y. Prognosis of a family with familial medullary thyroid carcinoma. J Exp Clin Cancer Res. 1999;18(2):223-224.

63) Takami H, Ikeda Y, Niimi M. Ultrasonically activated scalpel for subtotal thyroidectomy in Graves’ disease. Am J Surg. 1999;178(5):433-444.

64) Kameyama K, Takami H. Pigmented granules in functional black adenoma of the adrenal gland a histochemical and ultrastructural study. Endocr Pathol. 1999;10(4):353-357.

65) Takami H , Ikeda Y, Hayashi K, Hayashi M, Konishi K, Saruta T, Carpi A. Clinical assessment of collagen cross-linked N-telopeptides as a marker of bone metabolism in patients with primary hyperparathyroidism. Biomed Pharmacother. 1999;53(7):329-333.

66) Kameyama K, Takami H. DNA cytofluorometric analysis using HP/DAPI double staining of parathyroid carcinoma arising in a patient with chronic renal failure and secondary hyperparathyroidism. Oncol Rep. 1999;6:1345-1347.

67) Takami H, Oshima M, Sugawara I, Satake S, Ikeda Y, Nakamura K. Kubo A. Pre-operative localization and tissue uptake study in parathyroid imaging with technetium-99m-sestamibi. ANZ J Surg. 1999;69:629-631.

68) Kameyama K, Takami H. Schwannoma of the neck mimicking a thyroid tumor: a case report. Asian J Surg. 2000;23(2):175-176.

69) Niimi M, Shirasugi N, Hamano K, Esato K, Matsumoto K, Ikeda Y, Shatari T, Takami H, Kodaira S. Oral delivery of xenoantigen combined with non-depleting anti-CD4 monoclonal antibody induced significant prolonged survival of concordant skin xenografts. Transplant Proc. 2000;32(5):1035.

70) Takami H, Ikeda Y, Wada N. Surgical management of primary hyperparathyrodism. Biomed Pharmacother. 2000;54(Suppl 1):17-20.

71) Niimi M, Takashina M, Ikeda Y, Shirasugi N, Shatari T, Takami H, Kodaira S, Kameyama K, Matsumoto K, Hamano K, Esato K. Mice treated with Anti-CD4 monoclonal antibody accept fully allogeneic thyroid grafts but reject second-donor-type thyroid grafts in maintenance phase. Transplant Proc. 2000;32(7):2086.

72) Takami H, Shirahama S, Ikeda Y, Sasaki Y, Wada N, Nimi M, Kameyama K. Familial hyperparathyrodism. Biomed Pharmacother. 2000;54(Suppl 1):21-24.

73) Niimi M, Ikeda Y, Shirasugi N, Shatari T, Takami H, Kodaira S, Matsumoto K, Hamano K, Esato K, Wood KJ. The thymus is essential for the development of operational tolerance induced by donor-specific transfusion plus anti-CD4 monoclonal antibody. Transplant Proc. 2000;32(7):2067.

74) Kameyama K, Takami H, Sanders D, Giordano TJ. Surgical pathology of hyperparathyroidism. Biomed & Pharmacother. 2000;54(Suppl 1):42-45.

75) Niimi M, Ikeda Y, Shirasugi N, Shatari T, Takami H, Kodaira S, Matsumoto K, Hamano K, Esato K, Wood KJ. Intrathymic inoculation of donor B cells induced indefinite prolongation of fully allogeneic cardiac grafts but not islet or skin grafts. Transplant Proc. 2000;32:2020.

76) Ikeda Y, Takami H. Endoscopic parathyroidectomy. Biomed Pharmacother. 2000;54 (Suppl 1):52-56.

77) Nimi M, Takashina M, Takami H, Shirasugi N, Hamano K, Esato K, Matsumoto K, Ikeda Y, Shatari T, Kodaira S. Kameyama K. Experimental parathyroid transplantation: human parathyroid grafts survived and functioned in mice treated with anti-CD4 monoclonal antibody. Biomed Pharmacother. 2000;54(Suppl 1):80-82.

78) Hanatani Y, Kobayashi H, Kodaira S, Takami H, Asagoe T, Kaneshiro E. An in vitro chemosensitivity test for gastric cancer using collagen gel droplet embedded culture. Oncol Rep. 2000;7(5):1027-1033.

79) Niimi M, Ikeda Y, Shirasugi N, Shatari T, Takami H, Kodaira S, Matsumoto K, Hamano K, Esato K, Hara M, Wood KJ. Oral delivery of alloantigen combined with non-depleting anti-CD4 monoclonal antibody induces indefinite survival of cardiac allografts and generates CD4(+) regulatory T cells. Transplant Proc. 2000;32(7):2035.

80) Kameyama K, Takami H, Umemura S, Osamura YR, Wada N, Sugino K, Mimura T, Ito K. PCNA and Ki-67 as prognostic markers in human parathyroid carcinomas. Ann Surg Oncol. 2000;7(4):301-305.

81) Ikeda Y, Takami H, Sasaki Y, Kan S, Niimi M. Endoscopic neck surgery by the axillary approach. J Am Coll Surg. 2000;191(3):336-340.

82) Niimi M, Takashina M, Shirasugi N, Hamano K, Esato K, Matsumoto K, Ikeda Y, Takami H, Kodaira S, Kameyama K. Human parathyroid grafts survived and functioned in mice treated with anti-CD4 monoclonal antibody. Transplant Proc. 2000;32(5):1040.

83) Ikeda Y, Takami H, Sasaki Y, Kan S, Niimi M. Endoscopic resection of thyroid tumors by the axillary approach. J Cardiovasc Surg. 2000;41(5):791-792.

84) Niimi M, Ikeda Y, Shirasugi N, Shatari T, Takami H, Kodaira S, Matsumoto K, Hamano K, Esato K, Hara M, Wood KJ. Oral administration of alloantigen plus nondepleting anti-CD4 monoclonal antibody induces indefinite prolongation of fully allogeneic cardiac allografts. Transplant Proc. 2000;32(2):259.

85) Miyaki M, Iijima T, Ishi R, Hishima T, Mori T, Yoshinaga K, Takami H, Kuroi T, Iwama T. Molecular Evidence for Multicentric Development of Thyroid Carcinomas in Patients with Familial Adenomatous Polyposis. Am J Pathol. 2000;157(6):1825-1827

86) Niimi M, Takashina M, Takami H, Ikeda Y, Shatari T, Hamano K, Esato K, Matsumoto K, Kameyama K, Kodaira S, Wood KJ. Overexpression of heme oxygenase-1 protects allogeneic thyroid grafts from rejection in naive mice. Surgery. 2000;128:910-917.

87) Alsanea O, Wada N, Ain K, Wong M, Taylor K, Ituarte PHG, Treseler PA, Weier HU, Freimer N, Siperstein AE, Duh QY, Takami H, Clark OH. Is familial non-medullary thyriud carcinoma more aggressive than sporadic thyroid cancer? A multicenter series. Surgery. 2000;128(6):1043-1051.

88) Shirasugi N, Matsumoto S, Hamano K, Esato K, Matsumoto K, Bashuda H, Yagita H, Okumura K, Ikeda Y, Takami H, Kodaira S, Niimi M. Survival of fully allogeneic cardiac allografts induced by delivery of alloantigen via respiratory mucosa is abrogated by blockade of the B7 pathway. Transplant Proc. 2000;32(7):2034.

89) Ikeda Y, Niimi M, Sasaki Y, Shatari T, Takami H, Kodaira S. Thoracoscopic repair of a spontaneous perforation of the esophagus with the endoscopic suturing device. J Thorac Cardiovasc Surg. 2001;121(1):178-179.

90) Takami H, Ikeda Y, Takayama J, Sasaki Y, Kan S, Niimi M, Inada E, Kameyama K. Adrenal-sparing adrenalectomy in hereditary bilateral pheochromocytoma. ANZ J Surg. 2001;71(10):623-624.

91) Ikeda Y, Takami H, Niimi M, Kan S, Sasaki Y, Takayama J. Laparoscopic partial or cortical-sparing adrenalectomy by dividing the adrenal central vein. Surg Endosc. 2001;15(7):747-750.

92) Ikeda Y, Takami H, Niimi M, Kan S, Sasaki Y, Takayama J. Endoscopic thyroidectomy and parathyroidectomy by the axillary approach: a preliminary report. Surg Endosc 2001;16(1):92-95.

93) Ikeda Y, Takami H, Niimi M, Kan S, Sasaki Y, Takayama J. Endoscopic total parathyroidectomy by the anterior chest approach for renal hyperparathyroidism. Surg Endosc. 2001;16(2):320-322.

94) Shirasugi N, Ikeda Y, Akiyama Y, Matsumoto K, Hamano K, Esato K, Bashuda H, Yagita H, Okumura K, Takami H, Kodaitra S, Niimi M. Induction of hyporesponsiveness to fully allogeneic cardiac grafts by intratracheal delivery of alloantigen. Transplantation. 2001;71(4):561-564.

95) Niimi M, Shirasugi N, Ikeda Y, Kan S, Takami H, Hamano K. Importance of thymus to maintain operational tolerance to fully allogeneic cardiac grafts. Ann Thorac Surg. 2001;72(3):735-739.

96) Ikeda Y, Niimi M, Kan S, Sasaki Y, Shatari T, Takami H, Kodaira S. Mediastinoscopic esophagectomy using carbon dioxide insufflation via the neck approach. Surgery. 2001;129(4):504-506.

97) Kameyama K, Takami H, Miyajima K, Miura T, Hosoda Y, Ito K, Ito K. Papillary carcinoma occurring within an adenomatous goiter of thyroid gland in Cowden’s disease. Endocr Pathol. 2001;12(1):73-86.

98) Niimi M, Shirasugi N, Ikeda Y, Kan S, Takami H, Hamano K. Operational tolerance induced by pretreatment with donor dendritic cells under blockade of CD40 pathway1. Transplantation. 2001;72(9):1556-1562.

99) Niimi M, Takashina M, Shirasugi N, Hamano K, Esato K, Matsumoto K, Ikeda Y, Takami H, Kameyama K. Oral delivery of xeno-antigen combined with non-depleting Anti-CD4 monoclonal antibody induces significantly prolonged survival of concordant skin xenograft. Xenotransplantation. 2001;8(1):75-79.

100) Ikeda Y, Takami H, Niimi M, Kan S, Sasaki Y, Takayama J. Endoscopic thyroidectomy by the axillary approach. Surg Endosc, 2001;15(11):1362-1364.

101) Ikeda Y, Niimi M, Kan S, Shatari T, Takami H, Kodaira S. Clinical significance of tissue blood flow during esophagectomy by laser Dopplerflowmetry. J Thorac Cardiovasc Surg. 2001;122(6):1101-1106.

102) Shirasugi N, Akiyama Y, Ikeda Y, Kan S, Hamano K, Takami H, Kodaira S, Niimi M. Intratracheal delivery of alloantigen induces donor-specific hyporesponsiveness: dendritic cells play a pivotal role as regulatory cells. Transplant Proc. 2001;33(1-2):86.

103) Shirasugi N, Ikeda Y, Akiyama Y, Matsumoto K, Hamano K, Esato K, Bashuda H, Yagita H, Okumura K, Takami H, Kodaitra S, Niimi M. Induction of hyporesponsiveness to fully allogeneic garafts by intratracheal delivery of alloantigen. Transplantation. 2001;71(4):561-564.

104) Shirasugi N, Akiyama Y, Ikeda Y, Kan S, Hamano K, Takami H, Kodaira S, Niimi M. Intratracheal delivery of alloantigen induces donor-specific hyporesponsiveness: dendritic cells play a pivotal role as regulatory cells. Transplant Proc. 2001;33(1-2):86.

105) Takami H, Ikeda Y. Endoscopic thyroidectomy via an axillary and anterior chest approach. In: Gagner M, Inabnet WB (eds), Minimally Invasive Endocrine Surgery, 1st ed. Philadelphia, Lippincott Williams & Wilkens Publishers, pp 55-63, 2002

106) Takami H, Ikeda Y, Kan S, Kameyama K. New operative strategies in primary hyperparathyroidism. Asian J Surg. 2002;25(2):184-187.

107) Ikeda Y, Niimi M, Kan S, Takami H, Kodaira S. Thoracoscopic Esophagectomy Combined with Mediastinoscopy via the Neck. Ann Thorac Surg. 2002;73(4):1329-1331.

108) Kameyama K, Takami H. FAP associated thyroid carcinoma in mother and her daughter. Familial Cancer. 2001;1:83-86.

109) Niimi M, Ikeda Y, Kan S, Takami H. Gas Gangrene in patient with atherosclerosis obliterans. Asian Cardiovasc Thorac Ann. 2002;10(2):178-180.

110) Ikeda Y, Takami H, Sasaki Y, Takayama J, Kan S, Niimi M. Minimally invasive video-assisted thyroidectomy and lymphadenectomy for micropapillary carcinoma of the thyroid. J Surg Oncol. 2002;80:218-221.

111) Takami H, Ikeda Y. Minimally invasive thyroidectomy. ANZ J Surg. 72:841-842.

112) Ikeda Y, Sasaki Y, Niimi M, Kan S, Takami H, kodaira S. Hand-assisted laparoscopic proximal gastrectomy with jejunal interposition and lymphadenectomy. J Am Coll Surg. 2002;195(4):578-581.

113) Ikeda Y, Takami H, Sasaki Y, Takayama J, Kan S, Niimi M. Minimally invasive video-assisted thyroidectomy and lymphadenectomy for micropapillary carcinoma of the thyroid. J Surg Oncol. 2002;80:218-221.

114) Takami HE, Kameyama K, Sano T, Kakudo K, Sasano H, Osamura R. Y. JEPS: Preface. Endocr Pathol. 2002;13:123.

115) Sano T, Kovacs K, Asa SL, Yamada S, Sanno N, Yokoyama S, Takami H. Pituitary adenoma with “Honeycomb golgi” appearance showing a phenotypic change at recurrence from clinically nonfunctioning to typical Cushing disease. Endocr Pathol. 2002;13(2):125-130.

116) Kakudo K, Katoh R, Sakamoto A, Asa S,. DeLellis RA, Carney JA, Naganuma H, Kameyama K, Takami H. Thyroid gland: International case conference. Endocr Pathol. 2002;13(2):131-134.

117) Kameyama K, DeLellis RA, Recardo V, Kakudo K, Takami HE. Parathyroid carcinomas: Can clinical outcomes parathyroid carcinomas be determined by histologic evaluation alone? Endocr Pathol. 2002;13(2):135-139.

118) Sasano H, Suzuki T, Irie J, Kawai K, Aiba M, McNicol M, Takami H. Adrenal cortical diseases: International case conference. Endocr Pathol. 2002;13:141-148.

119) Kumaki N, Kajiwara H, Kameyama K, Delellis RA, Asa SL, Osamura RY, Takami H. Prediction of malignant behavior of pheochromocytomas and paragangliomas using immunohistochemical techniques. Endocr Pathol. 2002;13:149-156.

120) Takami HE. Minimally invasive endocrine surgery: Preface. Biomed Pharmacother. 2002;56: 3s.

121) Takami H. Parathyroid: Introduction. Biomed Pharmacother. 2002;56:5s-6s.

122) Ikeda Y, Takami H, Tajima G, Sasaki Y, Takayama J, Kurihara H, Niimi M. Direct mini-incision parathyroidectomy. Biomed Pharmacother 2002;56:14s-17s.

123) Ikeda Y, Takami H, Tajima G, Sasaki Y, Takayama J, Kurihara H, Niimi M. Total endoscopic parathyroidectomy. Biomed Pharmacother. 2002;56:22s-25s.

124) Takami H, Sasaki Y, Ikeda Y, Tajima G. Intraoperative quick parathyroid hormone assay in the surgical management of hyperparathyroidism. Biomed Pharmacother. 2002;56:26s-30s.

125) Takami H, Takayama J, Ikeda Y, Tajima G. Minimally invasive radioguided parathyroidectomy. Biomed Pharmacother. 2002;56:37s-40s.

126) Takami H. Thyroid: Introduction. Biomed Pharmacother. 2002;56:53s-54s.

127) Ikeda Y, Takami H, Tajima G, Sasaki Y, Takayama J, Kurihara H, Niimi M. Direct mini-incision thyroidectomy. Biomed Pharmacother. 2002;56:60s-63s.

128) Ikeda Y, Takami H, Tajima G, Sasaki Y, Takayama J, Kurihara H, Niimi M. Total endoscopic thyroidectomy: axillary or anterior chest approach. Biomed Pharmacother. 2002;56:72s-78s.

129) Takami H, Sasaki K, Ikeda Y, Tajima G, Kameyama K. Sentinel lymph node biopsy in patients with thyroid carcinoma. Biomed Pharmacother. 2002;56:83s-87s.

130) Ikeda Y, Takami H. Adrenal overview. Biomed Pharmacother. 2002;56:104s-106s.

131) Ikeda Y, Takami H, Tajima G, Sasaki Y, Takayama J, Kurihara H, Niimi M. Laparoscopic partial adrenalectomy. Biomed Pharmacother. 2002;56:126s-131s.

132) Otani Y, Furukawa T, Suganuma K, Yoshida M, Saikawa Y, Kubota T, Kumai K, Mukai M,
Kameyama K, Takami H, Kitajima M. Minimally in invasive surgery for gastric carcinoid 
tumor. Biomed Pharmacother. 2002;56:217s-221s.

133) Ikeda Y, Takami H, Niimi M, Kan S. Sasaki Y. Takayama J. Endscopic total parathyroidectomy by the anterior chest approach for renal hyperparathyroidism. Surg Endosc. 2002;16:320-322.

134) Ikeda Y, Takami H, Niimi M, Kan S, Sasaki Y. Takayama J. Endoscopic thyroidectomy and parathyroidectomy be the axillary approach. Surg Endosc. 2002;16:92-95.

135) Ikeda Y, Takami H, Sasaki Y, Takayama J, Niimi M, Kan S. Comparative study of thyroidectomies. Endoscopic surgery versus conventional open surgery. Surg Endosc. 2002;16(12):1741-1745.

136) Niimi M, Ikeda Y, Kan S, Takami H. Superficialization of hemodialysis access using a video-assisted procedure. Surg Endosc. 2002;16(1):218.

137) Niimi M, Ikeda Y, Kan S, Takami H, Furui S, Takeshita K. Spontaneous rupture of an intercostal artery due to neurofibromatosis type I disease treated by percutaneous embolization. Cardiovasc Intervent Radiol. 2002;25(2):160-161.

138) Ikeda Y, Takami H, Sasaki Y, Takayama J, Niimi M. Kan S. Clinical benefits in endoscopic thyroidectomy by the axillary approach. J Am Coll Surg. 2003;196:189-195.

139) Wada N, Duh QY, Sugino K, Iwasaki H, Kameyama K, Mimura T, Ito K, Takami H, Takanami Y. Lymph node metastasis from 259 papillary thyroid microcarcinoma: Frequency, pattern of occurrence and recurrence, and optimal strategy for neck dissection. Ann Surg. 2003;237(3):399-407.

140) Ikeda Y, Niimi M, Kan S, Shatari T, Takami H, Kodaira S. Conformal radiation therapy for liver metastasis of esophageal carcinoma. Hepatogastroenterology. 2003;50:532-534.

141) Takami H. Ikeda Y. Total endoscopic thyroidectomy. Asian J Surg. 2003;26:82-85.

142) Ikeda Y, Takami H, Sasaki Y, Takayama J, Niimi M, Kan S. Is laparoscopic partial or cortical-sparing adrenalectomy worthwhile? Eur Surg. 2003;35(2):89-92.

143) Kawabata W, Suzuki T, Moriya T, Fujimori K, Naganuma H, Inoue S, Kinouchi Y, Kameyama K, Takami H, Shimosegawa T, Sasano H. Estrogen receptors (alpha and beta) and 17betahydroxysteroid dehydrogenase type 1 and 2 in thyroid disorders:Possible in Situ estrogen synthesis and action. Modern pathlogy. 2003;16(5):437-444.

144) Takami H. Medullary thyroid carcinoma and multiple endocrine neoplasia type 2. Endocr Pathol. 2003;14(2):123-132.

145) Ikeda Y, Tobari S, Niimi M, Kan S, Takami H, Kodaira S. Reliable cervical anastomosis through the retrosternal route with stepwise gastric tube. J Thorac Cardiovasc Surg. 2003;125(6):1306-1312.

146) Takami H, Sasaki K, Ikeda Y, Tajima G, Kameyama K. Detection of sentinel lymph nodes in patients with papillary thyroid cancer. Asian J Surg. 2003;26(3):145-148.

147) Ikeda Y, Niimi M, Takami H, Kodaira S. Successfully treated carcinoma erysipeloides from gastric cancer. Ann Oncol. 2003;14(8):1328-1329.

148) Shirasugi N, AkiyamaY, Aramaki O, Shibutani S, Matsumoto K, Bashuda H, Yagita H, Okumura K, Ikeda Y, Niimi M, Kan S, Shatari T, Takami H, Kodaira S, Uchida N, Shimazu M, Kitajima M, Hamano K. Role of the CTLA4 pathway in hyporesponsiveness induced by intratracheal delivery of alloantigen. Transplantation. 2003;75(10):1636-1639.

149)Takami H, Ikeda Y, Okinaga W, Kameyama K:Review:Recent advances in the management of primary hyperparathyroidism. Endocrine J. 2003;50(4):369-377.

150)Kameyama K, Takami H. Double parathyroid carcinoma. Endocr J. 2003;50(4):477-479.