| Sterol |
| LIPID_ID | ST0463 |
| CHEM_NA | 9-FLUORO-11β,16α,17,21-TETRAHYDROXYPREG |
| NA-1,4-DIENE-3,20-DIONE;Δ1-9α-FLUORO-16α- |
| HYDROXYHYDROCORTISONE;9α-FLUORO-16α-HY |
| DROXY-PREDNISOLONE;Δ1-16α-HYDROXY-9α-F |
| LUOROHYDROCORTISONE;16α-HYDROXY-9α-FLU |
| OROPREDNISOLONE |
| COMMON_NA | TRIAMCINOLONE,CL |
| 19823,ADCORTYL,ARISTOCORT |
| MOL_FORMULA | C21H27O6F |
| MOL_WT | 394 |
| MELT_PT | 260-262.5ﾟC(dec.事前に軟化,褐色になる)(1054/1055) |
| BOIL_PT |
| OPT_ROT | [α]25/D=+75ﾟ(C=0.200,acetone)(1054/1055) |
| REFRA_IND |
| DENSITY |
| SOLUBILITY |
| UV_SPEC | UVmax 238nm(ε=15,800)(1054/1055) |
| IR_SPEC | νmax 3388, 1705, 1660, 1620, |
| 1604cm-1(1054/1055) |
| NMR_SPEC |
| MS_SPEC |
| NOTE_SPEC |
| SOURCE | BENZENEと PYRIDINE中で, |
| 21-ACETOXY-4,9(11),16-PREGNATRIENE-3,20-DIO |
| NE(I)を OSMIUN TETROXIDE |
| と反応させる事から出発し, |
| 9α-FLUORO-11β,16α,17α,21-TETRAHYDROXY- |
| 4-PEGNENE-3,20-DIONEを得, |
| これを微生物(CORNYEBACTERIUM |
| SIMPLEX)によって水素添加させ, |
| 16α,21-DIACETOXY-9α-FLUORO-11β,17α-DIHY |
| DROXY-1,4-PREGNADIENE-3,20-DIONE |
| としてこれをケン化して調製する｡ (1054) |
| また,16α,21-DIACETOXY-9α-FLUORO-11β,17α- |
| DIHYDROXY-4-PREGNENE-3,20-DIONEを, |
| C.SIMPLEXか, NOCARDIA CORALLINA |
| で微生物的に脱水素し, アセチル化して |
| 16α,21-DIACETOXY-9α-FLUORO-11β,17α-DIHY |
| DROXY-1,4-PREGNADIENE-3,20-DIONEを得る｡ |
| これをケン化して調製する｡ (1055) |
| BIOL_ACTIV | ・DIACETATEとともに,強いグルココルチコイド作用を示し |
| ,ナトリウムを保持する活性は無い｡ RAT LIVER |
| GLYCOGEN ASSAY(SUBCUTANEOUS |
| METHODS)で調べた場合, |
| 1998年7月17日 | 102 / 486 ページ |