| Sterol |
| LIPID_ID | ST0346 |
| CHEM_NA | 9-FULORO-11β,17,21-TRIHYDROXY-16α-METHYL |
| PREGNA-1,4-DIENE-3,20-DIONE/9α-FLUORO-16α |
| -METHYLPREDNISOLONE; |
| 16α-METHYL-9α-FLUORO-1,4-PREGNADIENE-11 |
| β,17α,21-TRIOL-3,20-DIONE; |
| 16α-METHYL-9α-FLUORO-PREDNISOLONE; |
| 1-DEHYDRO-16α-METHYL-9α-FLUOROHYDROCO |
| RTISONE;16α-METHYL-9α-FLUORO-Δ1-HYDROC |
| COMMON_NA | DECTANCYL,DEXAMETH,DEXASONE,DEXINORAL,GA |
| MMMACORTEN,DEXTELAN,POLICORT, |
| DECTANCYL,DEXAMETH,DEXASONE,DEXINORAL,GA |
| MMMACORTEN,DEXTELAN,POLICORT, |
| DEXACORTAL,DESERONIL,CORSON,DERGRAMIN,HEX |
| ADROL,DELTAFLUORENE,ORADEXON, |
| DEXA-CORTIDELT,AEROSEB-D,DEXINOLON,DECADE |
| RM,DEXAFARMA,CORTISUMMAN, |
| DEXASINE,LOVVERINE,MAXIDEX,DEXA-SCHEROSON |
| MOL_FORMULA | C22H29O5F |
| MOL_WT | 392 |
| MELT_PT | 229-231ﾟCAS 21-ACETATE(763),215-221ﾟC AS |
| 21-ACETATE(762) |
| BOIL_PT |
| OPT_ROT | [α]/D=+77.6ﾟ(763) |
| [α]/=+73ﾟ AS 21-ACETATE(762) |
| REFRA_IND |
| DENSITY |
| SOLUBILITY | 水への溶解性は,10mg/100ml(25ﾟ)｡ |
| アセトン,エタノール,クロロホルムに可溶｡(762) |
| UV_SPEC | AS 21-ACETATE,λmax:239mμ(ε=14,900); AS |
| 21-ACETATE,λmax:239mμ(ε=14,500)(762) |
| IR_SPEC |
| NMR_SPEC |
| MS_SPEC |
| NOTE_SPEC |
| SOURCE | ・21-ACETATEの合成｡16α-METHYLHYDROCORTIS |
| ONE ACETATEを出発物質とする｡(762) |
| ・21-ACETATEの合成｡16α-METHYLPREGNENOLON |
| E を出発物質とする｡ (763) |
| BIOL_ACTIV | ・Glucocorticoid活性(Liver glycogen activity in rat), |
| Systemic granuloma 活性(in intact Holzman rat), |
| Anti-inflammatory 活性(in man)とも,最もactive な |
| steroid｡ Sodium retention も Ratsで negative, Manで |
| <1 である｡ (762) |
| ・Eosinopenic 活性は, マウス, イヌ, ヒトで, |
| PREDNISONE や PREDNISOLONE の 4〜6倍｡ |
| 1998年7月17日 | 122 / 486 ページ |