| Sterol |
| LIPID_ID | ST0373 |
| CHEM_NA | 6α,9-DIFLUORO-11β,21-DIHYDROXY-16α,17-[(1- |
| METHYLETHYLIDENE)BIS(OXY)]-PREGNA-1,4-DIENE |
| -3,20-DIONE; |
| 6α,9α-DIFLUORO-11β,16α,17,21-TETRAHYDROX |
| YPREGNA-1,4-DIENE-3,20-DIONE CYCLIC |
| 16,17-ACETAL WITH ACETONE; |
| 6α,9α-DIFLUORO-16α-HYDROXYPREDNISOLONE |
| 16,17-ACETONIDE; |
| 6α,9α-DIFLUORO-16α,17α-ISOPROPYLIDENEDIO |
| XY-1,4-PREGNADIENE-3,20-DIONE. |
| COMMON_NA | FLUOCINOLONE |
| ACETONIDE,DERMALAR,JELLIN,LOCALYN,FLUOVITEF |
| ,FLUOCINIL,SYNAMOL, |
| SYNSAC,SYNANDONE,SYNALAR |
| MOL_FORMULA | C24H30O6F2 |
| MOL_WT | 452 |
| MELT_PT | 265-266ﾟC(ACETONE+HEXANE)(824) |
| BOIL_PT |
| OPT_ROT | [α]/D=+95ﾟ(CHCl3)(824) |
| REFRA_IND |
| DENSITY |
| SOLUBILITY |
| UV_SPEC | UVmax : 238nm(logε=4.21)(824) |
| IR_SPEC | figure 参照(825) |
| NMR_SPEC |
| MS_SPEC |
| NOTE_SPEC |
| SOURCE | 容易に手に入る |
| 16α,17α-oxido-Δ5-pregnene-3β,21-diol-20-one |
| 21-acetate を出発物質として合成した |
| 6α,9α-difluoro-16α-hydroxyprednisolone |
| BIOL_ACTIV | ・Glucocorticoid活性｡ |
| 高い抗炎症作用(ナトリウム保持無し)｡ 家畜では |
| adrenocortical steroid として局所に使用｡ |
| 抗炎症活性は, Hydrocortisone を1とした場合, |
| 100倍の活性を示す｡ 臨床試験で, |
| NOTE | 分子量 452.50 (824) |
| 1998年7月17日 | 183 / 486 ページ |