| Sterol |
| LIPID_ID | ST0379 |
| CHEM_NA | 3-(2-CHLOROETHOXY)-9-FLUORO-11β,16α,17,21 |
| -TETRAHYDROXY-20-OXOPREGNA-3.5-DIENE-6-C |
| ARBOXAL-DEHYDE,CYCLIC 16,17-ACETAL WITH |
| ACETONE,21-ACETATE; |
| 3-(2-CHLOROETHOXY)-6-FORMYL-9α-FLUOROPR |
| EGNA-3,5-DIENE-11β,16α,17,21-TETROL-20-ONE |
| 21-ACETATE 16α,17α-ACETONIDE; |
| 3-(2-CHLOROETHOXY)-9α-FLUORO-6-FORMYL-1 |
| 1β,21-DIHYDROXY-16α,17α-ISOPROPYLIDENEDI |
| OXYPREGNA-3,5-DIEN-20-ONE. |
| COMMON_NA | FORMOCORTAL,FI6341,FLUOROFORYMLON,CUTIST |
| EROL,DEFLAMENE,FLUDERMA |
| MOL_FORMULA | C29H38O8FCl |
| MOL_WT | 568 |
| MELT_PT | 180-182ﾟC(エーテル-石油エーテル)(840) |
| BOIL_PT |
| OPT_ROT | [α]20/D=+26ﾟ(CHLOROFORM)(840) |
| REFRA_IND |
| DENSITY |
| SOLUBILITY |
| UV_SPEC | UVmax(ETHANOL) : 216, 324nm(ε=12,100, |
| 17,100)(840) |
| IR_SPEC |
| NMR_SPEC |
| MS_SPEC |
| NOTE_SPEC |
| SOURCE | ・9α-FLUORO-CORTISONE-21-ACETATEの3-CYCL |
| OETHYLENEKETALを出発物質として合成する｡(840) |
| BIOL_ACTIV | ・Glucocorticoid作用を示す｡ Granuloma pouch |
| assayで,ED50は局所で0.001mg, |
| 経口で0.105mgであった｡ Relative potency は, |
| F-acetate を1とした時に, Granuloma pouch |
| assayが局所で 680, 経口で36,s.c.は23, Cotton pellets |
| は局所で6.5, Hepatic glycogen は130, Total |
| plasmatic |
| NOTE | 分子量 569.07, The |
| 21-pentanoate,m.p.103-105ﾟ,λmax=216,323nm(ε=1 |
| 1998年7月17日 | 342 / 486 ページ |