| Sterol |
| LIPID_ID | ST0294 |
| CHEM_NA | BATRACHOTOXININ A |
| 20-(2,4-DIMETHYL-1H-PYRROLE-3-CARBOXYLATE |
| )/3α,9α-EPOXY-14β,18β-(EPOXYETHANO-N-M |
| ETHYLIMINO)-5β-PREGNA-7,16-DIENE-3β,11α,20 |
| α-TRIOL,20α-ESTER WITH |
| 2,4-DIMETHYLPYRROLE-3-CARBOXYLIC ACID |
| COMMON_NA | BATRACHOTOXIN |
| MOL_FORMULA | C30H42O6N2 |
| MOL_WT | 538 |
| MELT_PT |
| BOIL_PT |
| OPT_ROT | [α]/589=+5-10ﾟ,[α]/300=-260ﾟ(625) |
| REFRA_IND |
| DENSITY |
| SOLUBILITY |
| UV_SPEC | Uvmax(METHANOLIC |
| HCl):262,234nm(logε=3.70,3.99),END |
| IR_SPEC | A SHARP ABSORPTION BAND AT |
| 5.9μ(AMIDOCARBONYL GROUP), 1695, |
| 1250cm-1(624/625) |
| NMR_SPEC | 0.85, 1.48(DOUBLET), 2.25, 2.2 ; 2.25 ; 2.45, 2.35, |
| 3.40(2H), 5.6-6.3(-3H), 8.74BROAD(<0.4H)(625) |
| MS_SPEC | MOL,WT,399,2413(C24H33NO4 9RINGS OR DOUBLE |
| BONDS),CH17/17(CARBON SKELETON C17 |
| (POTENTIALLY)HIGHLY UNSATURATED OH-GROUPS |
| IN RING SYSTEM),NO INTENSE C4H7NO(NOT RING A |
| OF SAMAN.DARINE),NO INTENSE C6H12NO(NOT |
| RING F NO TOMATIDINE) |
| C4H10NO,C7H6-8NO,C7H8NO2(NO WITHIN 4C,NO2 |
| WITHIN 7C)(625/626) |
| NOTE_SPEC |
| SOURCE | 植物。 |
| Columbian arrow poison frog(KOKOI FROG), genus |
| Phyllobates bicolor の皮フから抽出｡(624) |
| BIOL_ACTIV | STEROIDAL ALKALOIDSの中で, もっとも毒性が強い｡ |
| 損傷していない皮フでは, |
| 毒液は無効｡しかし,持続性の鋭い痛みの原因となる｡ |
| さらに,消耗性疾患(口腔内の傷,消化管の潰瘍をもつ時 |
| でさえ)毒素にさらすと危険である｡ |
| 毒性は, SELECTIVEで,IRREVERSIBLEな Na |
| イオンの膜透過性の増加による｡ |
| LD50=1.15-2.7μg/kg |
| mice(関連する化合物の中でも最も毒性が強い)(625/6 |
| 1998年7月17日 | 443 / 486 ページ |