| Sterol |
| LIPID_ID | ST0375 |
| CHEM_NA | 9-FLUORO-11β,17β-DIHYDROXY-17-METHYLAND |
| ROST-4-EN-3-ONE; |
| 11β,17β-DIHYDROXY-9α-FLUORO-17α-METHY |
| L-4-ANDROSTEN-3-ONE; |
| 9α-FLUORO-11β-HYDROXY-17α-METHYLTESTO |
| COMMON_NA | FLUOXYMESTERONE,ANDROSTEROLO,ANDROFLUOR |
| ENE,ANDROFLUORONE,FLUOTESTIN,HALOTESTIN,OR |
| ATESTIN,ORATESTRYL,TESTORAL,ULTANDREN. |
| MOL_FORMULA | C20H29O3F |
| MOL_WT | 336 |
| MELT_PT | 270ﾟC(DEC.)(832) |
| BOIL_PT |
| OPT_ROT | [α]/D=+109ﾟ(ETHANOL)(832) |
| REFRA_IND |
| DENSITY |
| SOLUBILITY |
| UV_SPEC | UVmax(METHANOL) : 240nm(ε=16,700)(832) |
| IR_SPEC |
| NMR_SPEC |
| MS_SPEC |
| NOTE_SPEC |
| SOURCE | 11β-Hydroxy-4-androstene-3,17-dioneからGrignard |
| 試薬との反応を利用して合成｡(832) |
| BIOL_ACTIV | ・強力な Androgen作用を持つ｡ Anabolic活性, |
| Androgenic活性は,17-Methyltestosteroneの場合をそ |
| れぞれ1,1とすると, Fluoxymesterone の場合は, |
| それぞれ 20.0, 9.5を示す(経口投与)｡ (832) |
| NOTE | 分子量 336.45 |
| Fluoxymesterone を酢酸中でChromium trioxide |
| と反応させ, |
| 17β-Hydroxy-9α-fluoro-17-Methyl-4-androstene- |
| 3,11-dioneを形成(m.p.213-220ﾟ(dec.),[α]/d=+144ﾟ(CH |
| Cl3),C20H27FO3,Anabolic活性, |
| Androgenic活性は,それぞれ |
| 17-Methyltestosteroneの22倍, 8.5倍を示し, |
| 1998年7月17日 | 54 / 486 ページ |