| Sterol |
| LIPID_ID | ST0341 |
| CHEM_NA | 9-FLUORO-113β,16α,17-TRIHYDROXYPREGNA-1, |
| 4-DIENE-3,20-DIONE;9α-FLUORO-1,4-PREGNADIE |
| NE-11β,16α,17α-TRIOL-3,20-DIONE |
| COMMON_NA | DESCINOLONE,21-DEOXYTRIAMCINOLONE |
| MOL_FORMULA | C21H27O5F |
| MOL_WT | 378 |
| MELT_PT | 286-287ﾟC(744),298-300ﾟC(745) |
| BOIL_PT |
| OPT_ROT | [α]25/D=+53.3ﾟ(C=0.41 in METHANOL) |
| [α]25/D=+36.8ﾟ(C=1.09 in PYRIDINE)(745) |
| REFRA_IND | [α]25/D=+62ﾟ(C=0.52,METHANOL), |
| [α]25/D=+41.5ﾟ(C=1.09,PYRIDINE)(744) |
| DENSITY |
| SOLUBILITY | メタノール,酢酸エチルに可溶｡(744) |
| UV_SPEC | UVmax(METHANOL): 238nm(ε=15,700)(745); λmax : |
| 238mμ(ε=15,100)(744) |
| IR_SPEC | νmax:3509, 3401, 1709, 1667, 1618, |
| 1603cm-1(744); λmax : 2.85, 2.93, 5.86, 6.01, 6.19, |
| 6.25, 9.34μ(745) |
| NMR_SPEC |
| MS_SPEC |
| NOTE_SPEC |
| SOURCE | MICROBIOLOGICAL DEHYDROGENATION |
| によって調製できる： BEEF EXTRACT, YEAST |
| EXTRACT, PEPTONE, CERELOSE MEDIUM |
| を８時間培養した NOCARDIA CORALLINA(ATCC |
| 999)を,1% inoculate する｡ |
| 9α-FLUORO-11β,16α,17α-TRIHYDROXY-4-PRE |
| GNENE-3,20-DIONE を |
| メタノールに溶かしたものを加え, 28ﾟC で17 |
| BIOL_ACTIV | ・ラット肝臓グリコーゲン分析によると, |
| GLUCOCORTICOID 活性は, HYDROCORTISONE |
| の4倍で, SODIUM RETENTION 活性は無い｡ (744) |
| NOTE | 分子量 378.45, |
| THE ACETATE, 16α-ACETOXY |
| 9α-FLUORO-11β,17α-DIHYDROXY-1,4-PREGNAD |
| IENE-3,20-DIONE : 無水酢酸-ピリジンで, |
| 一晩処理して調製｡ |
| m.p.242-244ﾟ,[α]25/D=+27.3ﾟ(C=0.768,METHANOL), |
| λmax 239mμ(ε=16,200): νmax 3509, 3413, |
| 1736, 1695, 1672, 1629, 1250cm-1. |
| THE ISOPROPYLIDENE DERIVATIVE, |
| 9αFLUORO-11β-HYDROXY-16α,17α-ISOPROPY |
| LIDENEDIOXY-1,4-PREGNADIENE-3,20-DIONE: |
| 1998年7月17日 | 65 / 486 ページ |