| Sterol |
| LIPID_ID | ST0374 |
| CHEM_NA | 6α-FLUORO-11β,21-DIHYDROXY-16α-METHYLP |
| REGNA-1,4-DIENE-3,20-DIONE/6α-FLUORO-16α- |
| METHYL-1-DEHYDROCORTICOSTERONE; |
| 6α-FLUORO-16α-METHYL-Δ1,4-PREGNADIENE- |
| 11β,21-DIOL-3,20-DIONE |
| COMMON_NA | FLUOCORTOLONE,ULTRALAN ORAL |
| MOL_FORMULA | C22H29O4F |
| MOL_WT | 376 |
| MELT_PT | 188-190.5ﾟC(826) |
| BOIL_PT |
| OPT_ROT | [α]20/D=+100ﾟ(DIOXANE)(826) |
| REFRA_IND |
| DENSITY |
| SOLUBILITY | 295 in WATER(37ﾟ),120 in ETHANOL(20ﾟ),440 iN |
| TOLUENE(20ﾟ)(mg/ml)(826) |
| UV_SPEC | UVmax(METHANOL) : |
| 242nm(ε=16,300)(826),ε242=15,900.(827) |
| IR_SPEC |
| NMR_SPEC |
| MS_SPEC |
| NOTE_SPEC |
| SOURCE | Curvularia lunata による |
| Substrate-Structure-Directed Specific |
| 11β-Hydroxylation を経ての合成｡ (827) |
| BIOL_ACTIV | ・Glucocorticoid活性は Hydrocortisone acetate |
| を１としたら,3-10｡(ED50 |
| 0.003-0.01(mg/animal/day)(マウス糖新生)) |
| Granuloma pouch テストでの |
| ED50:0.0005(0.0002-0.001)(local),0.02(0.01-0.04)(sub |
| cutaneous),0.02(0.01-0.03)(oral)(mg/animal/day) |
| Thymolytic 活性は,Hydrocortisone acetate |
| を１としたら17｡(ED50 |
| 0.006(0.003-0.013)(mg/animal/day),Na,Kの排泄を促進 |
| ｡ (826/828) |
| ・10mgのFluo ortolone は, 45mg の |
| STC407(6-Dehydro-16-methylene-hydrocortisone |
| NOTE | 分子量 376.47, (826) |
| ・静脈注射, 経口投与での代謝｡ |
| Fluocortolone-21-carbonic acid |
| として尿中に可溶性で単離｡ (830) |
| ・窒素バランスに影響なし｡ |
| 17-ketosteroids,17-Hydroxy-corticosteroids |
| の尿中への除去はそれぞれ 50%,55-65% |
| 1998年7月17日 | 132 / 486 ページ |